Viewing negative mentions of regulation of IL2 (H. sapiens)

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Azogui et al. (1983)IL 2The IL 2 production was not restored or was slightly affected by irradiation early after BMT.
Lomnitzer et al. (1984)IL-2Glutaraldehyde-treated S cells (which retained the ability to absorb IL-2) did not affect the proliferative response or IL-2 production by the R cells, indicating that passive absorption of IL-2 was not entirely responsible for suppression induced by S cells.
Roosnek et al. (1985)IL2In contrast, the IL2 production by the Jurkat line was not influenced by addition of thiols.
Matsui et al. (1992)IL-2Cocaine treatment alone had no effects on proliferation, IL-2 production, or Ca2+ mobilization.
Mazingue et al. (1987)IL-2IL-2 production was not altered by SDIF but utilization of IL-2 was decreased, suggesting that SDIF blocked cells before or in the early s phase.
Slauson et al. (1984)IL-2The cellular production of IL-2 was not affected by serotonin, as supernatants of treated cultures contained essentially the same IL-2 titers as did control cultures.
Anikeeva et al. (1991)IL-2Deletion of 3'-flanking region on did not affect the IL-2 expression.
Nath et al. (1984)IL-2Non-adherent cell supernatants and MoF from tuberculoid and healthy individuals had little effect on IL-2 production.
Malec et al. (1989)IL-2Epinephrine did not affect spontaneous IL-2 receptor expression and it significantly inhibited PHA-induced IL-2 receptor expression and IL-2 generation at 30 min. following injection.
Wilkinson and Euhus (2001)interleukin-2Cyclosporin A does not affect adenoviral-mediated transgene expression of interleukin-2.
Wilkinson and Euhus (2001)IL-2The immunosuppressive drug CsA is known to block native IL-2 transcription but has no affect on the adenoviral-mediated IL-2 or lac-Z transgene.
Gelfand et al. (1986)IL2In parallel the drug prevents the lectin-induced increase in concentration of [Ca2+]i and interleukin 2 (IL2) secretion; IL2 receptor expression is unaffected.
Liang et al. (1986)IL-2Although substitution of serine for cysteine 125 did not affect IL-2 activity, deletion of cysteine 125 or deletion of amino acids in the vicinity of this cysteine yielded mutant proteins with little, if any, activity.
Draeger et al. (1986)IL-2Thus, in this group of SLE patients no abnormalities in IL-2 production or response could be demonstrated.
Santoli and Zurier (1989)IL-2Incubation of cells in the presence of oleic, stearic, and palmitic acids, which are not PG precursors, did not affect mitogen-induced IL-2 production.
McElhaney et al. (1992)IL2Subgroup analysis of the elderly group revealed that previous influenza vaccination in 1989 did not significantly affect IL2 levels measured in the present study.
Jordan et al. (1989)IL-2However, IL-2 receptor (IL-2R) expression and mRNA accumulation in stimulated PBMC was not affected by 1,25-D3.
Eisenstein et al. (1988)interleukin-2Antithyroid drugs and triiodothyronine had no effect on interleukin-2 production in vitro.
Bessler et al. (2002)IL-2No change in IL-2 levels was observed.
Aihara et al. (1999)IL-2ISO, which reduced Con A-induced secretion of IL-2 in a dose-dependent manner, had no effect on Candida-induced secretion of IL-2.
Bruserud and Lundin (1987)IL-2Heparin had no effect on PHA-stimulated proliferation, IL-2 production or expression of IL-2 receptors.
Rump et al. (1993)IL-2Serum levels of soluble IL-2 receptors were unaffected by the therapy.
McCarthy et al. (1990)IL 2Concentrations of IL 2 increased 7-fold in DFMO-treated, PHA-stimulated PBMC cultures, compared with untreated cells; whereas IL 2 receptor expression as measured by the anti-Tac monoclonal antibody was not affected by the inhibition of ODC.
Middleton et al. (2002)interleukin-2Histamine dihydrochloride administered 10 minutes prior to injection of interleukin-2 also had no effect on interleukin-2 kinetics.
Wu et al. (1996)interleukin 2No significant changes in mitogenic response or interleukin 2 production were found after ALA diets.
Alfonzo et al. (2003)IL-2However, the levels of specific IL-2 produced did not change during therapy, and no specific IL-2 was detected during the follow-up period.
Samelson et al. (1983)IL 2Lectin-induced IL 2 release was not affected by these antibodies.
Weinberg (2001)Interleukin-2Interleukin-2 (IL-2) and IL-10 production was not affected by HU.
June et al. (1987)IL-2 mRNACyclosporine was found not to affect the accumulation of IL-2 mRNA after CD28 plus PMA stimulation, although there was no detectable IL-2 mRNA after stimulation by CD3 in the presence of the drug.
Lomnitzer (1988)interleukin-2Isoprinosine had no effect on the expression of receptors for interleukin-2.
Yücesoy et al. (1997)IL-2Our findings suggest that chronic lead and cadmium exposure in humans resulted in significant suppression of the serum IL-1beta level, but did not alter IL-2 and TNF-alpha levels.
Beharka et al. (2001)IL-2IEL's ability to proliferate and produce IL-2 was not affected by subject age.
Komada et al. (1996)IL-2Chelation of calcium 12 hr after Con A stimulation decreased IL-2R expression, but had no effect on IL-2 production.
Swift et al. (1988)IL 2The immunosuppressive drug cyclosporin A inhibited IL 2 release without altering induction of IL 2 receptors or phosphorylation of the Mr 70,000 protein.
Donati et al. (1992)IL-2It was observed that a single session of in vitro dialysis did not induce production of interleukin-2 (IL-2) and did not alter the expression of IL-2 receptor (IL-2R) on the cytoplasmic membrane and the secretion of soluble IL-2R, whereas it induced transcription of mRNA for IL-2R.
Chouaib et al. (1985)IL 2This was associated with a similar degree of inhibition of IL 2 production while the expression of IL 2 receptor was not affected.
Teodorczyk-Injeyan et al. (2008)IL-2No significant alterations in serum-associated IL-2 levels were observed in any of the study groups.
Dröge et al. (1985)interleukin 2The same concentration of L-ornithine had no effect on the production of the lymphokines interleukin 2 (IL 2) and gamma-interferon (IFN-gamma).
Beilin et al. (2007)IL-2The production of IL-2 did not change from that of the preoperation samples.
Szekeres-Bartho et al. (1989)IL-2The inhibitory material, on the other hand, did not affect either production or function of IL-2.
Figueroa et al. (1993)IL-2No concomitant changes in soluble or membrane receptor expression or IL-2 production were observed.
Chae et al. (1988)interleukin-2Although natural and recombinant IFN-alpha significantly inhibited these proliferative responses, they did not affect interleukin-2 (IL-2) production in these cultures, suggesting that they inhibit proliferation by a mechanism that does not involve inhibition of IL-2 production. rIFN-gamma did not affect the generation of specific cytotoxicity in MLC, although it was significantly enhanced by natural IFN-alpha and rIFN-alpha 2.
Poulton et al. (1988)IL-2This suggests that regulation of the IL-2 receptor is not responsible for the reduction in the number of cells that proceed to proliferation.
Katagiri et al. (1990)IL-2CCA had no significant effect on IL-2 receptor expression, an early G1 event, but did inhibit transferrin receptor expression, a late G1 event.
Haga et al. (1996)interleukin-2However, no significant change of interleukin-2 (IL-2) production was observed after this incubation between bilirubin-treated and -untreated PBMNC.
Mullen et al. (2007)IL-2CLA supplementation had no significant effect on transcription of IL-2.
Holter et al. (1994)IL-2Taken together, our experiments show that the IL-2 dependent cytokines IL-4 and IFN-gamma are both negatively controlled by TGF-beta under conditions where IL-2 production is unaffected by a mechanism which partially involves an inhibition of IL-2/IL-2R signal transduction.
Senchina et al. (2009)IL-2No tinctures modulated IL-2 production.
Bonnefoy-Berard et al. (1992)IL-2 mRNANorthern blot analysis revealed increased levels of CD25 and IFN-gamma mRNA, suggesting a post-transcriptional inhibition of these molecules, whereas IL-2 mRNA levels were unchanged.
Shon et al. (2004)IL-2This effect was concentration-dependent, because the levels of IL-2 and IL-4 expressions were not affected by the addition of a low concentration (5 microg/ml) of sonicated extract.
Kikuchi et al. (1988)IL-2On the other hand, the IL-2 receptor expression was not affected by this treatment.
Kolb et al. (1993)IL-2PKC inhibitors and PK-C depletion did not significantly alter the response to IL-2 and IL-4.
Kawano and Noma (1996)IL-2The IL-2 responsiveness induced by concanavalin A (Con A), however, was not changed.
Kaplan et al. (1988)IL-2These IL-2 epitopes could not be accounted for by soluble IL-2 binding to its specific receptor or adsorbing nonspecifically to the cells.
Pattanapanyasat et al. (1992)interleukin-2In contrast to their inhibition of DNA synthesis, these iron chelators showed little effect on protein synthesis and the expression of transferrin receptors and interleukin-2 (IL-2) receptors.
Stopeck et al. (1998)IL-2IL-2 secretion by tumor cells persisted for at least 30 days post-transfection and was unaffected by freeze thawing or irradiation to 8000 rads.
Gearing et al. (1989)IL-2Challenge with toxoided pertussis toxin had no effect on either proliferation or IL-2 production in any of the groups.
Smith et al. (1983)IL 2The neutralization of cellular proliferation was specific for IL 2-reactive cells, coincided with an inhibition of IL 2 receptor binding, could be completely overcome by affinity-purified IL 2 and was species-specific; human and murine IL 2 were neutralized, whereas rat IL 2 activity remained unaffected.
Medveczky et al. (1993)IL-2Analysis of deletion mutant infected cells suggests that at least two open reading frame sequences of a bicistronic mRNA encoded by the viral genome is involved in controlling IL-2 independence.
Liu and Rosenberg (2001)IL-2 geneMoreover, transduction of an IL-2 gene did not affect the high degree of recognition and specificity of transductants against melanoma targets.
Mekori et al. (1989)IL-2Reserpine also interfered with the mitogen-induced IL-2 production by these cells, but the IL-2 receptor expression, as measured by immunofluorescence, was unaffected.
Weir et al. (1991)IL-2Although 5-LO potently inhibited IL-2 production, it had no effect on IL-2 responsiveness or IL-2 receptor acquisition.
Tsang et al. (1986)IL-2The pI values of the IL-2 isolated from ISO-treated and untreated HUT-78 culture supernatants were identical (pI = 7.8) and were not modified by neuraminidase treatment.
Rump et al. (1997)IL-2Serum levels of soluble IL-2 receptors were unaffected by the therapy. nhuIL-2 and placebo groups did not differ significantly with respect to requirement of IVIG substitutions which were performed whenever serum IgG levels dropped below 5 g/l: a total of 53 IVIG infusions (corresponding to 17.6 g IgG/month per patient) was necessary during the placebo phase, and 48 infusions (16.4 g IgG/month per patient) during the nhuIL-2 treatment phase.
Farrar and Humes (1985)IL 2 growth promotionAlthough leukotrienes could replace IL 2 for IFN-gamma secretion, they had no effect on IL 2 growth promotion.
Lai et al. (1989)IL2The mitogen-stimulated cellular IL2 receptor expression, IL2 receptor release, and IL2 production did not differ between patients with or without carbimazole therapy.
Hengst et al. (1985)IL-2Similarly, the inhibition of proliferation was probably not related to endogenous IL-2 levels: addition of exogenous IL-2 to PM-containing cultures did not result in any restoration of proliferation.
Ohno et al. (1994)IL-2The inhibitory effect of IL-2 on the production of progesterone was unaffected by indomethacin, which inhibits the production of arachidonate cycloxygenase metabolites such as prostaglandin E2.
Povlsen et al. (1989)IL-2Although the number of IL-2 receptors was reduced, the turnover of the remaining high affinity IL-2 receptors on CsA treated cells was unaffected.
Liu et al. (2006)IL-2Whereas in group T, IL-2 was unchanged 1 h after operation but was significantly elevated 3 and 24 h after operation.
Irwin et al. (1999)IL-2Nocturnal levels of circulating IL-2 did not change with sleep onset or in relation to PSD-L or the various sleep stages.
Cesario et al. (1986)interleukin-2Yields of interleukin-2 (IL-2) and lymphotoxin were also found to be sensitive to the effects of the steroids, but expressions of TAC antigen was not generally affected by these agents.
Wilkinson and Euhus (2001)IL-2CsA at various concentrations had no affect on IL-2 or lac-Z transgene expression.
Kikuchi et al. (2002)IL-2 geneTogether, our findings suggest that IL-2 gene polymorphisms do not influence the susceptibility to MS or the clinical characteristics of MS in Japanese patients.
McElhaney et al. (1995)IL-2In the first 12 weeks after vaccination, there was no difference in IL-2 levels between SVV and WVV recipients in either the young or elderly groups.
Toribio et al. (1983)IL 2Our results suggest that: (a) either IL 2 is not responsible for the induction of NK-like cytotoxicity or its action is modulated by other molecules, and (b) the precursor-responder population is preferentially included in the mature T3+ subset.
Kumagai et al. (1988)IL-2In contrast, addition of CsA to cells after they had been treated for 30 min with PDB/ionomycin and then washed did not affect their responses to subsequent addition of either IL-2 or PDB.
Kudla et al. (2006)IL2We demonstrated that GC content does not significantly affect the cellular mRNA lifetimes of GFP, IL2, and Hsp70 genes.
Härtel et al. (2004)IL-2 mRNAOur approach is potentially valuable for identifying transplant patients in whom IL-2 mRNA expression is unaffected or even enhanced after initiation of immunosuppressive therapy.
Lewis et al. (1993)IL-2These concentrations are below those at which IL-2 mRNA synthesis was shown to be unaffected.
Fox et al. (1994)IL-2The expression of IL-2 receptors (TAC Ag) on concanavalin A-activated cultures at 12- or 36-hr time points was not affected by treatment with the SFs.
Haynes and Cohen (1993)IL-2Xenopus TCGF and mammalian IL-2, anti-human IL-2 monoclonal antibodies do not
Ruscetti et al. (1980)TCGFIn addition, colchicine and cytosine arabinoside inhibited DNA synthesis but had no effect on TCGF release.
Granot et al. (2000)IL-2ICAM-1 and sIL-2R levels at POD 3-6 were significantly higher than at baseline but did not differ in presence or absence of rejection.
Zhang and Rogers (2000)IL-2Surprisingly, the expression of several other cytokine receptor chains including the common gamma-chain, IL-2Rbeta, or the IL-2Ralpha, IL-4Ralpha, and IL-15Ralpha chains, was not altered.
Ember et al. (1994)il-2There was no effect of Cyclosporine A on the expression of c-sis and il-2 receptor genes.
Quast et al. (2005)IL-2In contrast, the simultaneous detection of IL-2 did not affect the numbers of IL-4 spots.