Viewing affirmative mentions of gene expression of IL2 (H. sapiens) in LAK cells

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Tuschl et al. (2006)IL-2LAK cellsThe following immune parameters were evaluated: (1) the intracellular production of interleukin-2 (IL-2) and interferon (INF) gamma in lymphocytes, and IL-1 and tumor necrosis factor (TNF)-alpha in monocytes were evaluated with monoclonal antibodies. (2) The activity of immune-relevant genes (IL 1-alpha and beta, IL-2, IL-2-receptor, IL-4, macrophage colony stimulating factor (MCSF)-receptor, TNF-alpha, TNF-alpha-receptor) and housekeeping genes was analyzed with real time PCR. (3) The cytotoxicity of lymphokine activated killer cells (LAK cells) against a tumor cell line was determined in a flow cytometric test.
Akiyoshi et al. (1988)IL 2LAK cellsBoth the ability to produce IL 2 and to generate LAK cells were shown to be significantly increased in SP cells when compared to PBM cells.
Sedman et al. (1988)interleukin 2lymphokine activated killer cellNatural killer cell, lymphokine activated killer cell cytotoxicities and endogenous interleukin 2 production were measured 1 day before surgery and on the first, third, fifth and tenth postoperative days.
Sedman et al. (1988)interleukin 2lymphokine activated killer cellTreatment with r-HuIFN alpha did not prevent the postoperative impairment of interleukin 2 production or lymphokine activated killer cell cytotoxicity.
Stötter and Lotze (1991)IL-2LAK cellOur studies of the processes involved using 21-mer phosphorothioate antisense oligonucleotides to the sequence adjacent to the start codon of IL-2 mRNA or IL-4 mRNA (effective concentration, 5 to 10 mumol/L) and cyclosporine (0.01 to 1.0 microgram/mL) or FK506 (0.01 to 1.0 ng/mL) demonstrate that IL-7-induced LAK cell activity is independent of IL-2 production and is regulated by endogenously generated IL-4.
Galustian et al. (1994)interleukin 2LAKA novel finding was that SW enhanced the interleukin 2 (IL-2) beta chain receptor subunit expression on both LAK and NK cells to a greater extent than its enhancement of the IL-2R alpha (CD25 or TAC) receptor expression on LAK effectors.
Baxevanis et al. (1993)IL-2LAK cellFACS and northern blot analyses demonstrated a PGE2-mediated down-regulation of IL-2 receptor (IL-2R) expression on CD56+ cells that correlated with reduced LAK cell activity.
Yanagawa et al. (1991)IL-2LAK cellsIntrapleural instillations of 6.7 x 10(9) autologous LAK cells in Case 1, or 11.3 x 10(9) allogeneic LAK cells in Case 2, with daily injections of IL-2 resulted in reductions of the pleural effusions in each case and in a decline in the level of hyaluronic acid in the effusion, in Case 1.
Baker et al. (1989)IL-2LAK cellsThey noted an increased synthesis of total "biopterins," i.e., biopterin; 7,8-dehydrobiopterin; and L-neopterin in LAK cells and plasma which correlated with IL-2 exposure.
Harker et al. (1990)interleukin 2-inducedLAK cellsOur studies suggest that interleukin 2-induced LAK cells may be useful in the therapy of some chemotherapy-resistant cancers.
Lu (1992)IL-2LAK cellsRegulation of IL-2-induced LAK cells].
Yoshida et al. (1988)IL-2LAK cellsUsing these LAK cells plus IL-2, local adoptive immunotherapy was undertaken in 23 patients with recurrent malignant glioma.
Glassman (1989)Interleukin-2LAK cellInterleukin-2/LAK cell therapy has promise for some wide spread tumors for which no other therapy is available.
Jadus et al. (1991)IL2LAK cellsWhen cells were cultured in both IL2 and IL4 during the generation of LAK cells (3-7 days), better cell recoveries were frequently observed.
Gallagher et al. (1990)IL-2LAK cellsThe results show that substitution of IL-6 for IL-2 did not lead to the development of functional LAK cells, nor was IL-6 able to alter the lytic capacity of established LAK cells.
De et al. (1991)interleukin-2Lymphokine activated killer cellsLymphokine activated killer cells and interleukin-2 production in patients with cervical carcinoma.
Favrot et al. (1990)IL-2LAK cellThe effect of IL-4 upon IL-2-induced LAK cell expansion is thus very different on PBMC pre-activated in vivo by alpha IFN + IL-2 therapy than on PBMC pre-treated in vitro with IL-2.
Clerigue et al. (1990)IL-2-inducedLAK cellsThese experiments show that inhibition of haematopoietic progenitor cells by IL-2 is not dependent on generation of cytotoxic LAK cells, but rather the result of IL-2-induced cytokine production.
Saijo et al. (1986)interleukin 2lymphokine activated killer cells[Strategy of cancer treatment using human recombinant interleukin 2 and lymphokine activated killer cells].
Walewski et al. (1989)interleukin-2LAK cellsEvaluation of natural killer and lymphokine-activated killer (LAK) cell activity in vivo in patients treated with high-dose interleukin-2 and adoptive transfer of autologous LAK cells.
Marincola et al. (1990)IL-2LAK cellsThe mice were randomly divided into four groups: group IA (LAK + IL-2) (N = 25) received 2 X 10(7) human lymphokine-activated killer (LAK) cells from normal donors by tail vein injection followed by 10,000 units of human recombinant interleukin-2 (IL-2) given intraperitoneally every 12 hours for 28 days; group IB (IL-2) (N = 27) was given the same dose of IL-2 alone; group IC (RPMI-1640) (N = 18) received a placebo consisting of 1 ml of RPMI-1640 intraperitoneally every 12 hours; and group ID (LAK) (N = 14) received 2 X 10(7) LAK cells but no IL-2.
Singh et al. (1993)IL-2LAK cellsThe coculture of peripheral blood mononuclear cells (PBMC) with various concentrations of ASTA-Z (0, 10(-6), 10(-5), 10(-4), and 10(-3) dilution) and IL-2 (50 U/ml) for 4 days produced significant suppression of cytotoxicity and lytic ability of the LAK cells against NK-sensitive (K562) and NK-resistant (M14) tumor cell lines.
Ueda et al. (1999)IL-2LAK cellsThe remaining 11 patients received systemic transfer of LAK cells with IL-2 against metastatic lesions located in organs other than the liver (systemic therapy group).
Fujiwara and Grimm (1992)IL-2LAK cellsIL-1, a pleiotropic cytokine shown to synergize with IL-2 on LAK induction, is endogenously synthesized and secreted by LAK cells.
Schendel et al. (1993)IL-2LAK cellsTIL were 20-fold more potent than LAK cells in eliminating the IL-2 expressing tumor cells in vitro.
Yamamoto et al. (1990)IL2LAK cellsIn this study we investigated the generation of human LAK cells with low-dose IL2 (1-10 U) in combination with human tumor cell lines.
Muul et al. (1986)lymphokinelymphokine activated killer cellsLarge scale production of human lymphokine activated killer cells for use in adoptive immunotherapy.
Bailet et al. (1997)lymphokinelymphokine activated killer cellRESULTS: All conditioned supernatant fluids significantly inhibited the generation of lymphokine activated killer cell cytotoxicity relative to controls, and this inhibition was dose dependent.
Muul et al. (1987)lymphokinelymphokine activated killer cellsStudies of serum-free culture medium in the generation of lymphokine activated killer cells.
Tvede et al. (1993)interleukin 2lymphokine activated killer cellsThe effect of light, moderate and severe bicycle exercise on lymphocyte subsets, natural and lymphokine activated killer cells, lymphocyte proliferative response and interleukin 2 production.
Horiuchi et al. (1994)IL-2LAK cellsBy a further cultivation of mLT expressing (mLT-positive) LAK cells for 24 h without IL-2, mLT disappears (mLT-negative LAK cells).
Urba et al. (1989)IL-2LAK cellsIp levels of IL-2 were maintained well above those required to generate and maintain LAK cells in vitro.
Indrová et al. (1992)IL-2LAK cellImmunoregulatory lymphokines IL-2 and IL-4 produced by IL-2- and IL-4-cDNA-transformed somatic cells were used for LAK cell generation.
Watanabe et al. (1994)lymphokinelymphokine activated killer cellsCell cycle assessment of adoptive transferred lymphokine activated killer cells.
Gambacorti-Passerini et al. (1988)lymphokinelymphokine activated killer cellsWith this procedure therefore large quantities of lymphokine activated killer cells (LAK) can be easily produced to be used in adoptive immunotherapy trials.
Norris et al. (1990)lymphokinelymphokine activated killer cellGeneration of lymphokine activated killer cell activity was normal in the two xeroderma pigmentosum lines tested.
Sawamura and de Tribolet (1990)IL2LAK cellsTIL as well as LAK cells can be expanded in vitro with IL2 and it is feasible to reinject these cells into the tumor site.
Lamm and Riggs (2000)IL-2LAK cellsGarlic is reported to stimulate immunity, including macrophage activity, natural killer and killer cells, and LAK cells, and to increase the production of IL-2, TNF, and interferon-gamma.
LeFever and Funahashi (1991)Interleukin-2LAK cellInterleukin-2, which is required for LAK cell activation, was detected only in BALF recovered from the six patients with pulmonary LAK lytic activity.
Ting et al. (1995)IL-2-inducedLAK cellDifferential requirement of protein tyrosine kinase and protein kinase C in the generation of IL-2-induced LAK cell and alpha CD3-induced CD3-AK cell responses.