Viewing affirmative mentions of gene expression of IL2 (H. sapiens) in spleen

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Romagnani et al. (1986)IL-2spleensThese data indicate that T lymphocytes which concentrate in spleens of patients with HD consist at least in part of an infrequent T4+ cell subset co-expressing cytolytic activity and production of IL-2.
Tanaka et al. (1981)TCGFspleenVarious cell culture conditions and agents supporting the active TCGF production of the spleen cells were examined.
Tanaka et al. (1981)TCGFspleenProduction of TCGF from spleen cells depended markedly on their individual sources.
Tanaka et al. (1981)TCGFspleenFurther, addition of irradiated cells of an Epstein-Barr virus (EBV)-transformed lymphoblastoid cell line (LCL) to spleen cell cultures stimulated with PHA greatly enhanced TCGF production.
Moretta et al. (1981)cell growth factorspleenHuman spleen cells were tested for the ability to produce T cell growth factor (TCGF) upon stimulation with PHA.
Moretta et al. (1981)TCGFspleenMoreover, in contrast to PBL, there was no significant difference in TCGF production between individual spleen cell populations.
Burger et al. (1984)IL-2spleenThe collective data suggest that TBH spleen cells were capable of producing IL-2 and of responding to the IL-2 amplification signal when tumor-induced Ts cells were depleted.
Kern et al. (1981)IL-2spleenMitogen (Con A, PHA) stimulation of spleen cells and K/D or I region stimulation in primary MLC all led to IL-2 production, as measured by the growth of an IL-2 dependent T cell clone, and to the production of a "helper" factor necessary for cytotoxic T lymphocyte (CTL) differentiation against metabolically inactivated stimulator spleen cells.
Kushko et al. (1988)IL-2spleenLymph node cells show an increased level of IL-2 production at early stages of the tumour growth whereas spleen cells produced IL-2 in minimal amounts.
Kushko et al. (1988)IL-2spleenA decrease in the IL-2 production by lymph node cells with the tumour growth and a relative increase of IL-2 production in the spleen cell pool are observed.
Ting et al. (1986)IL 2spleenThe production of TCDF and IL 2 peaked at day 4 to 5 in cultures containing normal spleen cells, syngeneic peritoneal macrophages, and indomethacin.
Kwong and Teh (1987)IL-2spleenThus, clone 9, which is a non-IL-2 producer, increased the production of IL-2 by irradiated B6 spleen cells and by CBA anti-B6 cultures by 4.7-and 5.7-fold, respectively.
Kwong and Teh (1987)IL-2spleenASHF did not increase the amount of IL-2 produced by irradiated B6 spleen cells but increased the amount of IL-2 produced in CBA anti-B6 cultures by 3.8-fold.
Ibrahim et al. (1988)IL-2spleenCephalothin, chloramphenicol and gentamicin decreased IL-2 production by mouse spleen cells in vitro.
Tatsumi and Yabe (1986)interleukin 2spleenCynomolgus monkey spleen cells and peripheral blood lymphocytes were tested for their ability to produce interleukin 2 (IL 2) upon stimulation with phytomitogens.
Devos et al. (1984)interleukin 2spleenPurified recombinant human interleukin 2, produced in Escherichia coli, was sufficient to generate cytolytic cells in concanavalin A-stimulated, T helper cell-depleted (Lyt-1.1-) or accessory cell-depleted (Ia-) murine spleen cell cultures.
Ranjan et al. (2004)IL-2SP-LMitogens [final concentrations of 2 microg/ml concanavalin A (Con A), 5 microg/ml phytohemagglutinin (PHA), and 20 ng/ml of phorbol-12-myristate-13-acetate (PMA)] were added to the designated wells in a 96-well plate with 0.2 million SP-L and cultured for 48 h and then assayed for IL-2 synthesis by ELISA and 3H-thymidine uptake.
Ranjan et al. (2004)IL-2SP-LCurcumin inhibited IL-2 synthesis in Con A, PHA, and PMA stimulated SP-L in a concentration-dependent manner with an ED50 (concentration required for 50% inhibition) measured at 3.5 microg/ml.
Pronin et al. (2002)IL-2spleenThe drug was found to inhibit an early phase of IL-1 and Con A interaction in spleen cells as well as lypoxigenase activity and expression of IL-2 receptors.
Nishi et al. (1988)IL-2spleenStudies on the L-chain transgenic mice showed that functionally active IL-2 receptors with high affinity were expressed on unstimulated spleen and thymus cells.
Stout (1984)IL 2spleenTo examine the effect of the suppressors on IL 2 production and responsiveness, spleen cells were stimulated with Con A in the presence of the suppressors and assayed both for ability to produce IL 2 and for ability to bind IL 2.
Stout (1984)IL 2spleenThe culture supernates of suppressed spleen cells contained normal titers of biologically active IL 2, indicating that the suppressors do not inhibit IL 2 production or inactivate IL 2 after it is produced.
Gullberg and Larsson (1982)TCGFspleenNormal spleen cells, activated by Con A for 24 hr, develop suppressive cells that inhibit de novo production of TCGF by fresh spleen cells.
Burger et al. (1984)IL-2spleenAbsorption investigations indicated that ligand-activated tumor-bearing host (TBH) spleen cells were less receptive to IL-2 than their normal counterparts.
Carroll et al. (1983)IL-2spleenSimultaneous administration of interleukin 2 (IL-2) with labeled cells resulted in enhanced recovery from recipient spleen.
Young et al. (2001)IL-2spleenPreliminary studies on the effect of dehydroepiandrosterone (DHEA) on both constitutive and phytohaemagglutinin (PHA)-inducible IL-6 and IL-2 mRNA expression and cytokine production in human spleen mononuclear cell suspensions in vitro.
Zhang et al. (1995)IL-2spleensOn day 6 after induction of 11%-12% TBSA full-thickness burn, the animals were sacrificed, and proliferation and IL-2 production of splenic lymphocytes, LPO levels of the plasma, livers and spleens were measured.
Zhang et al. (1993)IL-2spleenThe augmentation by GL of IL-2 production was also found in spleen cells stimulated with A23187 plus phorbol 12-myristate 13-acetate (PMA), suggesting that GL primarily affects some post-receptor stage of the signal transduction.
Beck et al. (1982)IL-2spleenFurthermore, spleen cell populations depleted of asialo GM1-bearing cells showed a decreased ability to produce IL-2 in response to mitogenic stimulation.
Romagnani et al. (1986)IL-2spleensIn addition, most of the T4+ cytolytic clones derived from HD spleens produced particularly high amounts of interleukin-2 (IL-2).
Ketlinsky et al. (1991)IL-2spleenComitogenic activity depended on the degree of lymphocyte preactivation and was similar to that of natural human IL-1 beta. rIL-1 beta enhanced IL-2 production by murine spleen cells and EL-4 cell line and IL-2 receptor expression by human peripheral blood mononuclear cells.
Merluzzi et al. (1984)interleukin 2spleenMurine spleen cells developed into nonspecific cytotoxic cells within 72 hr of culture in the presence of highly purified sources of human interleukin 2.
Garcia et al. (1986)lymphokinespleenPhytohaemagglutinin stimulated spleen cell production of the lymphokine mitogenic factor, but exposure to SEA or SWAP did not.
Miescher et al. (1987)IL 2spleenA total of 624 microcultures proliferating in the presence of irradiated allogeneic spleen cells and interleukin 2 (IL 2) were expanded for clonal analysis.
Watari and Yokomuro (1995)IL-2SpleenSpleen cells were able to provide the signals needed to stimulate the production of IL-2, IL-4, IL-6 and IFN-gamma, while B lymphomas the signals leading to only IL-2 production.
Imamura et al. (1990)IL-2spleenAn increased IL-2 production in spleen cells from chimeras injected with cytokine was observed shortly after the cessation of cytokine administration.
Wee and Bach (1984)lymphokinespleenThese lymphokine producing clones are not only dependent on exogenous growth factors provided in the form of crude phytohemagglutinin (PHA)-induced spleen conditioned medium for growth but can themselves be driven to proliferate by their own lymphokines.
Uhm et al. (1993)IL-2spleenWhen normal spleen cells were treated with 2.5 ng of TGF-beta/ml, a 3.4-fold decrease in IL-2 production was observed.
Zamkoff et al. (1984)TCGFspleenLeu-2-positive prolymphocytes from the spleen of the patient were constitutive producers of TCGF.
Sjölander et al. (1997)IL-2spleenThe response in the spleen developed more slowly, sustained for 12 weeks and was characterized by cells producing in particular IL-2 and IFN-gamma but also IL-4.
Cambier and Peltier (1978)LymphokinespleenLymphokine and synthesis of complement by guinea pig spleen cells.
Klimpel et al. (1990)IL-2spleenThis inhibition was not associated with a reduction in lymphokine production since spleen cells or Th1 T cell clones cultured with Con A and IFN-alpha/beta had no decrease in IL-2 or IFN-gamma production when compared to Con A-stimulated control cultures.
Aune et al. (1994)IL-2spleenIn addition, production of Th1 cytokines, such as IL-2 and IFN-gamma, by Ag-stimulated, immune murine spleen cells is inhibited by 5HT1A receptor antagonists in vitro but not by 5HT1C/2 receptor antagonists.
Chang et al. (1991)IL-2spleenFurthermore, the average IL-2 levels among positive IL-2 producers was also approximately threefold higher in spleen CD4+8- T cells than their thymic counterparts.
Chang et al. (1991)IL-2-producingspleenThe frequency of IL-2-producing cells in spleen CD4+8- T cells (40.0%) was approximately threefold that of thymus CD4+8- T cells (14.5%).
Langeberg et al. (1987)IL-2spleenWe have utilized two depletion protocols to characterize the spleen cells of the South African clawed toad, which bind specifically mouse-anti-human IL-2 receptor (anti-Tac) antibody and recombinant DNA produced IL-2.
Dröge et al. (1986)interleukin-2spleenThe production of interleukin-2 in concanavalin A-activated spleen cell cultures was also strongly augmented by 1 X 10(-2) M histamine or by a combination of 2 X 10(-3) M histamine and histaminase (diamine oxidase).
Rink et al. (1992)IL-2spleenT-cell products such as IL-2, IL-4, and IFN-gamma were also induced by MAS in PBM and spleen cells.
Shimizu et al. (1980)TCGFspleenPurified TCGF-E from this source had an approximately 30,000 mol wt and the biological activity of TCGF produced by whole spleen cells, including: augmentation of T cell-mitogen responses, cytotoxic T lymphocyte (CTL) proliferation support dependence, augmented generation of CTL, lack of strain specificity, and failure to stimulate resting T cells.
Lauria et al. (1993)Interleukin-2spleenCirculating hairy cells and spleen enlargement, when present, disappeared within 2 weeks after completing treatment; furthermore, a rapid normalization of soluble Interleukin-2 receptor serum levels was observed in all complete responders but one, and in 2 of the 6 partial responders.
Ogawa and Tsunematsu (1987)cell growth factorspleenThe effects of transfer of T cell growth factor (TCGF)-expanded spleen cells after concanavalin A (Con A) stimulation into syngeneic Lewis rats were studied.
Antoni et al. (1986)interleukin 2spleenOne of these peptides, a fragment of nine residues of human IL 1 beta (VQGEESNDK, fragment 163-171), showed high T cell activation capacity, as judged by its ability to stimulate murine thymocyte proliferation and to potently induce interleukin 2 production in spleen cells.
Stout et al. (1986)IL-2spleenAnalysis of spleen cells stimulated for 48 hr in the presence of M phi-c indicated that both blastogenesis (increased cell mass) and expression of IL-2 receptors (7D4 determinants) were reduced.
Taylor-Robinson (1997)IL-2spleensThe proliferation of, and IL-2-IFN-gamma production by, naive CD4+ T cells from normal spleens activated with Con A in vitro can be similarly inhibited by SNAP.
Gladue et al. (2006)IL-2spleenIn a more generalized model of inflammation, delayed-type hypersensitivity, CP-481,715 significantly inhibited footpad swelling and decreased the amount of IFN-gamma and IL-2 produced by isolated spleen cells from sensitized animals.
Bengtsson and Sjölander (1996)IL-2spleenBoth iscoms and flu-Ag mixed with iscom-matrix induced antigen-specific antibodies with similar IgG subclass distribution and activated spleen cells producing high levels of IL-2 and IFN-gamma in vitro.
Kollmann et al. (1994)interleukin 2spleensSignificantly more of the HIV-1-infected SCID-hu mice expressed mRNA for human tumor necrosis factors alpha and beta, and interleukin 2 in their spleens, lymph nodes, and PBMC than did uninfected SCID-hu mice.
Gullberg and Larsson (1983)TCGFspleenNormal spleen cells, pretreated with monoclonal anti-Lyt-1 or anti-Lyt-2 antibodies and complement were assayed for their capacity to respond to TCGF, as well as for their ability to produce TCGF after Con A stimulation.
Pourshafie et al. (1999)IL-2spleenThe data indicate that GPL is capable of inducing in-vitro interleukin (IL)-6 and IL-2 production by whole spleen or purified spleen T lymphocytes.
Ceredig et al. (1988)interleukin-2spleenWhen leukemia cells were reisolated from experimental animals, it was found that levels of interleukin-2 (IL-2) receptor (IL-2R) expression were greater on cells isolated from the lymph node than on cells isolated from the spleen.
Maggi et al. (1988)lymphokinespleensA large panel of phytohemagglutinin (PHA)-induced T cell clones (690 in total), established from four different human lymphoid tissues (peripheral blood, tonsils, lymph nodes and spleens) by a high-efficiency cloning technique, was characterized according to their pattern of lymphokine production.
Fox (1993)IL-2spleenAlthough LB cells could not stimulate IL-4 production, they were more potent than were spleen cells at inducing IL-2 production, demonstrating that the difference between the two APC populations was qualitative rather than quantitative.
Lee et al. (2002)IL-2spleenExpressions of IL-2 and IFN-gamma were increased in the chitosan-treated porcine spleen cells.
Shimizu et al. (1982)TCGFspleenTCGF production by EL-4 G12 showed dose response kinetics similar to TCGF production by anti-Thy-1-stimulated, purified normal spleen T cells.
Akiyoshi et al. (1983)TCGFspleen[NK activity, TCGF production and generation of cell-mediated cytotoxicity in spleen cells from gastric cancer patients].
Zuo et al. (2001)IL-2spleenCONCLUSIONS: (1) Inhibition of IL-2, gamma-IFN and IL-4 mRNA expression might be responsible for inhibition of cell proliferation by AT-III in ConA-stimulated rat spleen cells, (2) AT-III inhibits cell proliferation in the MLR-, OKT3- and PHA-stimulated human PBMCs, and Ig production in PWM-stimulated human PBMCs, (3) The immune regulatory effects of AT-III are independent of its interaction with thrombin since similar levels of suppression were seen in SF media, and (4) These results suggest that AT-III has potent inhibitory effects on lymphocyte activation and cytokine production and may have potential applications as an immunomodulatory agent.
Wang et al. (2002)IL-2spleenThe possible mechanism of this phenomenon was also investigated in this research, which included the effects of SH on the phagocytosis of macrophages, the production of lysozyme, acid phosphotase and IL-1beta generated by macrophages, the proliferation of the lymphocytes in spleen and the production of IL-2 generated by lymphocytes.
Zuo et al. (2001)IL-2spleenRESULTS: mRNA expression of IL-2, gamma-IFN and IL-4 in ConA-stimulated rat spleen cells was nearly completely inhibited by AT-III at 15 IU/ml. mRNA levels for IL-6, IL-2R and TGF-beta1 were not significantly affected by AT-III.
Goso et al. (1992)cell growth factorspleenMoreover, injection of THF-gamma 2 was found to restore T cell growth factor (TCGF) production by mitogen-stimulated spleen cells.
Tripp et al. (2000)IL-2spleenTo address the relationship between activation antigen and cytokine expression, intracellular levels of IL-2, IL-4, IL-5 and IFN-gamma were determined for CD3, CD44, CD49d, CD54, CD62L and CD102 lymphocytes from the bronchoalveolar lavage and spleen.
Badenoch-Jones (1981)lymphokinespleenThe production of the lymphokine activity macrophage aggregating factor (MAgF) by Concanavalin A (Con A)-pulsed guinea-pig spleen cells has been investigated.
Melby et al. (2001)IL-2spleenUncontrolled parasite replication in the hamster liver, spleen, and bone marrow occurred despite a strong Th1-like cytokine (IL-2, IFN-gamma, and TNF/lymphotoxin) response in these organs, suggesting impairment of macrophage effector function.
Li et al. (2008)IL-2spleenThe levels of IFN-gamma, IL-2, and TNF-alpha were increased in the spleen, kidney, and heart throughout the study period.
Gartner et al. (2008)IL-2spleenVaccination with pro-apoptotic plasmids triggered more Ag85A specific IFN-gamma producing spleen cells, and more efficient IL-2 and IFN-gamma producing memory cells in spleen and lungs after M. tuberculosis challenge.