Viewing affirmative mentions of binding of IL2 (H. sapiens) and IL2 (H. sapiens) in T cells

Full-text article links are indicated by after the article reference.

Document Target Regulator Anatomy Sentence
Duprez et al. (1992)IL2IL2T lymphocytesIL2 binds to high-affinity IL2 receptors on the surface of T lymphocytes, mediates cell growth, and is internalized.
Baroja and Ceuppens (1987)IL-2IL-2T-cellsPrecise measurement of IL-2 production in vitro is hampered by binding of IL-2 to IL-2 receptors on activated T-cells which results in IL-2 consumption.
Torsella et al. (1992)TCGFTCGFT-cellsAn example of biological transduction, analyzed in this report, is the triggering of T-cell proliferation by the binding of T-cell growth factor (TCGF) to specific TCGF-binding sites on responsive T-cells.
Hakimi et al. (1987)IL-2IL-2T-cellThe binding of interleukin-2 (IL-2) to the IL-2 receptor (IL-2R) on human T-cells is a key regulatory event which is absolutely required for T-cell-mediated immune responses.
Karlsson and Nässberger (1991)interleukin-2interleukin-2T-lymphocytesProliferation of T-lymphocytes is induced by interleukin-2 binding to the interleukin-2 receptor.
Podwi?ska et al. (1995)IL-2IL-2T cellThese findings suggest that sIL-2R may be bound to IL-2 and in this way would lead to weakening of T cell function and of resistance against Treponema pallidum infection.
Benjamin et al. (1989)IL-2IL-2T cellThe following similarities in the functional biological characteristics of T cell and B cell IL-2 suggest that B cell IL-2 is not a factor which mimics IL-2 activity in the CTLL-2 assay: (i) neutralization of IL-2 by anti-IL-2 monoclonal antibody (DMS-1); (ii) elution of IL-2 following its adsorption to CTLL-2 cells; (iii) determination of the MW of IL-2 by SDS-PAGE and Western blot analysis; and (iv) ability of B cell IL-2 to support T cell proliferation and blocking of this activity by anti-tac monoclonal antibody. cDNA probes for T cell IL-2, however, did not detect IL-2 mRNA in B cells.
Olive et al. (1986)IL2interleukin 2T cellFunctional studies, using mainly interleukin 2 (IL2)-dependent growth of human T cell lines or clones but also mixed lymphocyte cultures and mitogen T cell activation, allowed a collection of locally produced anti-IL2 receptor monoclonal antibodies (mAb) to be classified.
Wano et al. (1987)IL-2IL-2T-cellsDespite the loss of IL-2 responsiveness, the infected CEM T-cells continued to express Tac antigen and displayed 50 to 200 high-affinity IL-2 receptors per cell that bound IL-2 with a dissociation constant of 4.3 pM.
Robb et al. (1981)TCGFTCGFT cellMoreover, compared with lectin- or alloantigen-activated T cells, long-term TCGF-dependent cytolytic and helper T cell lines and TCGF-dependent neo-plastic T cell lines bound TCGF with a similar affinity (dissociation constant of 5-25 pM) and expressed a similar number of receptor sites per cell (5,000-15,000).
Robb et al. (1981)TCGFTCGFT cellsBinding of radiolabeled TCGF to TCGF-dependent cytolytic T cells occurred rapidly (within 15 rain at 37 degrees C) and was both saturable and largely reversible.
Lipkowitz et al. (1984)IL 2IL 2T lymphocytesProliferation of uncommitted, IL 2 receptor-bearing T lymphocytes was inhibited by interfering with IL 2 binding to its receptor by IL 2 receptor blockade with the anti-Tac antibody.
Debatin et al. (1989)IL-2IL-2T cellsHowever, binding studies using radiolabeled IL-2 indicated that the receptors present on malignant T cells were not able to bind to IL-2 with high affinity.
Whittington and Faulds (1993)IL-2IL-2T lymphocyteThe interaction of IL-2 with the IL-2 receptor induces proliferation and differentiation of a number of T lymphocyte subsets, and stimulates a cytokine cascade that includes various interleukins, interferons and tumour necrosis factors.
Arora et al. (2002)IL-2interleukin-2T cellsBasiliximab (Bx) is a human/mouse chimeric monoclonal antibody that inhibits binding of interleukin-2 (IL-2) to IL-2 receptors and thus prevents proliferation of T cells, which is the main step in the development of acute cellular rejection.
Rebollo et al. (1992)IL-2IL-2T cellThese two groups neutralize IL-2 activity in a T cell proliferation assay equally well, due to their similar inhibition of IL-2 binding to high affinity IL-2R.
Zhang et al. (2002)IL2G129R-IL2T-cellA bacterial expression system was used to produce G129R-IL2 fusion protein that maintained both G129R and IL2 activities as demonstrated by cell-based assays such as signal transducer(s) and activator(s) of transcription (STAT)5 phosphorylation, breast cancer cell proliferation, and T-cell proliferation.
Eriksen et al. (2001)IL-2IL-2T cellsWe show that (1) STAT3 (a transcription factor known to regulate IL-2Ralpha transcription) is constitutively tyrosine-phosphorylated in SS tumor cells, but not in non-malignant T cells; (2) STAT3 binds constitutively to a STAT-binding sequence in the promotor of the IL-2Ralpha gene; (3) the Janus kinase inhibitor, tyrphostine AG490, inhibits STAT3 activation, STAT3 DNA binding, and IL-2Ralpha mRNA and protein expression in parallel; and (4) tyrphostine AG490 inhibits IL-2 driven mitogenesis and triggers apoptosis in SS tumor cells.
Goebel et al. (2002)IL-2IL-2T cellsThese results show that the IL-2/15R beta-chain is enriched in rafts obtained from low-dose, PHA-stimulated T cells, that IL-2 binding alters this enrichment, and that this enrichment may be functionally relevant as a possible mechanism to ensure cytokine selectivity and specificity.
Drachman (1996)IL2IL2T cellsAgents that are now being used clinically, or are in advanced stages of development include: cyclosporin A, which interferes with synthesis of the cytokine interleukin 2 (IL2); IL2 toxin, which binds to IL2 receptors on activated T cells, is endocytosed, and kills the cells; and CTLA4Ig, which blocks costimulatory molecules, thus preventing full activation of T cells.
Rebollo et al. (1992)IL-2IL-2T cellAll eight mAb anti-human IL-2 recognize murine IL-2 and with the exception of one, 17F4 mAb are also able to neutralize it in a T cell proliferation assay.
Butscher et al. (2001)IL-2 promoterIL-2 promoterT-cellsThese findings provide evidence that p300 assembles at the IL-2 promoter to form an enhanceosome-like signal transduction target that is centrally integrated at the CD28RE-TRE element of the IL-2 promoter through specific protein module-targeted associations in activated T-cells.
Nagel et al. (1989)IL-2interleukin 2T cellsHigh affinity interleukin 2 receptors (HA-IL-2R) on mitogen- or antigen-stimulated T cells have been shown to efficiently bind interleukin 2 (IL-2) and to transduce the activation signal(s) that facilitate proliferation.
Mills et al. (1986)IL-2non-IL-2T cellsWe have identified in these supernatants a non-IL-2 factor (synergistic factor, SF) which synergizes with JURKAT IL-2 in the long-term growth of human T cells. [3H]TdR incorporation by IL-2-dependent human T cells after growth in IL-2 or SF alone for 14 days was slight, but significant.
Tsytsikov et al. (1996)IL-2rhIL-2T cellHowever, both inhibited IL-2 costimulation of T cell proliferation, and both inhibited cellular binding of rhIL-2 to high affinity IL-2 receptors.
Jacques et al. (1987)interleukin 2interleukin 2T cellA soluble interleukin 2 receptor produced by a normal alloreactive human T cell clone binds interleukin 2 with low affinity.
Heuser et al. (2004)IL-2HRS3-scFv-Fc-IL-2T cellsThe HRS3-scFv-Fc-IL-2 fusion protein is expressed as a 140 kDa homodimer, has binding specificities to both the CD30 antigen and the IL-2 receptor and stimulates proliferation of preactivated T cells in vitro, demonstrating its IL-2 bioactivity.
Komada et al. (1987)IL-2IL-2T cellsWe concluded that cytochalasin b acts on an early phase of T cell mitogenesis and augments the expression of IL-2 receptor which enables certain nonresponsive T cells to respond to IL-2.
Lucas et al. (1995)IL-2IL-2T lymphocytesThus, increased accumulation of the protein and its activity begin before IL-2/IL-2 receptor interaction, suggesting that the cdk6-cyclin D2 complex might be involved in acquisition of the competent state in human T lymphocytes.
Weil-Hillman et al. (1990)IL-2Interleukin 2T-cellsInterleukin 2 (IL-2) induced activation of unstimulated resting natural killer (NK) cells or resting T-cells initially occurs following binding of IL-2 through the p75 receptor that is expressed primarily by these cells.
Teshigawara et al. (1987)IL-2IL-2T cellsMoreover, when IL-2 binding to normal T cells was performed under conditions that favored the proportion of high-affinity receptors occupied, two distinct proteins identical to those already identified on the leukemic cells could be crosslinked covalently to radiolabeled IL-2.
Kumar et al. (1987)IL-2IL-2T cellInternalization of interleukin 2 (IL-2) by high affinity IL-2 receptors is required for the growth of IL-2-dependent T cell lines.
Taniguchi (1992)IL-2IL-2T cellsIn fact, IL-2 plays a major role in the clonal expansion of T lymphocytes (T cells) by interacting with specific cell surface receptor (IL-2 receptor).
Rodriguez et al. (1990)IL-2IL-2T cellsPhytohaemagglutinin (PHA)-activated T cells treated with IFN-gamma showed higher IL-2 binding and greater IL-2 internalization and degradation than cells treated with PHA alone.
Chistiakov et al. (2008)IL-2Interleukin-2T-cellInterleukin-2 (IL-2) plays an established role in T-cell regulation through binding to the high-affinity IL-2 receptor (IL-2R).
Collins (1989)IL 2IL 2T lymphocytesMurine IL 2 showed a 10-fold higher affinity than human IL 2 for the murine high-affinity receptor expressed on T lymphocytes, whereas human IL 2 bound 100-fold more strongly than murine IL 2 to the human high-affinity receptor.
Katz et al. (1994)IL-2IL-2T lymphocytesBy up-regulating functional cell surface receptors for IL-2 on T lymphocytes and priming them to respond to exogenous IL-2, ED-LCA is a competence growth factor.
Saito et al. (1988)IL-2IL-2T lymphocytesTo distinguish the affinity conversion model and the binary complex model we have carried out kinetic studies on the IL-2 binding to the high affinity IL-2-R on T lymphocytes expressing various numbers of L chains and a relatively constant number of H chains.
Adibzadeh et al. (1992)IL-2lip-IL-2T cellsThese results suggest that lip-IL-2 can interact with activated T cells and LAK cells in the same way as free IL-2, but that it is much less efficient at activating LAK-cell precursors.
Shipp and Reinherz (1987)IL-2IL-2T cellsIn T cells, initial activation from G0 to G1 results from stimulation of either the antigen/major histocompatibility complex receptor (T3-Ti) or the T11 structure; further cycle progression and proliferation follow interaction of interleukin 2 (IL-2) with the IL-2 receptor.
Eriksen et al. (2001)IL-2Interleukin-2T cellsInterleukin-2 (IL-2) is a growth factor which upon binding to high-affinity receptors (IL-2Ralphabetagamma) triggers mitogenesis in T cells.
Lowenthal et al. (1986)IL 2IL 2T cellIn investigating this phenomenon in greater detail, we observed that the IL 2 receptors (IL 2-R) on freshly isolated immature thymocytes bound IL 2 with about fivefold lower affinity (Kd approximately 100 pM) than IL 2-R on activated mature T cells and T cell lines (Kd approximately 20 pM).
Tkaczuk et al. (2002)IL-2interleukin-2T cellsAcute allograft rejection is driven by production of cytokines such as interleukin-2 (IL-2) that activate and expand alloreactive T cells by ligating high-affinity IL-2 receptors composed of three subunit chains: alpha, beta, gamma The alpha chain, expressed only on activated T cells, has become an important therapeutic target.
Karnitz et al. (1992)IL-2interleukin-2T lymphocytesThe growth, differentiation, and functional activities of antigen-stimulated T lymphocytes are regulated by the interaction of the T-cell-derived cytokine, interleukin-2 (IL-2), with the high-affinity IL-2 receptor (IL-2R).
Germann et al. (1988)IL 2interleukin 2T cellsProliferation of T lymphocytes (T cells) requires the interaction of interleukin 2 (IL 2) with the high affinity form of the IL 2 receptor (IL 2R).