Viewing affirmative mentions of localization of Il4 (M. musculus) in T cells

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Golumbek et al. (1991)interleukin-4T cellWhen cells from a spontaneously arising murine renal cell tumor were engineered to secrete large doses of interleukin-4 (IL-4) locally, they were rejected in a predominantly T cell-independent manner.
Khodoun et al. (2004)IL-4T cellsMice were primed by immunization with goat anti-mouse immunoglobulin (Ig)D antibody (GaMD), which stimulates naive CD4+ T cells to secrete IL-4 in 3-4 d.
Ranger et al. (1998)IL-4T lymphocyteFurthermore, NF-ATc deficiency impaired T lymphocyte activation and secretion of IL-4.
Karulin et al. (2002)IL-4T cellsThis IL-4 was not produced by T cells, but soluble factors secreted by the recall Ag-activated T cells, including IL-3, triggered cells of the innate immune system, primarily mast cells, to secrete IL-4.
Noben-Trauth et al. (2002)IL-4T cellsIL-4 secreted from individual naive CD4+ T cells acts in an autocrine manner to induce Th2 differentiation.
Julia and Glaichenhaus (1999)interleukin-4T cellsCD4(+) T cells which react to the Leishmania major LACK antigen rapidly secrete interleukin-4 and are detrimental to the host in resistant B10.D2 mice.
Erb et al. (1999)interleukin 4T cellsConstitutive expression of interleukin 4 in vivo does not lead to the development of T helper 2 type CD8+ T cells secreting interleukin 4 or interleukin 5.
Wang et al. (1992)IL-4T cellEvidence for the existence of IL-4 and IFN gamma secreting cells in the T cell repertoire of naive mice.
Hahn et al. (2003)IL-4T cellsIn addition, bronchoalveolar lavages were performed and checked for airway eosinophilia, IL-5 levels, and the number of IL-4 secreting CD4(+) T cells.
Hahn et al. (2003)IL-4T cellsRESULTS: The inhibition of the IL-4/IL-13 system during allergic sensitization resulted in a dose-dependent reduction of ovalbumin-specific IgEs and inhibition of airway eosinophilia together with decreased IL-5 levels and decreased numbers of IL-4 secreting CD4(+) T cells.
Chen et al. (2001)IL4T cellInterestingly, Sig/E7/LAMP-1 vaccinia induced both E7-specific IFN-gamma- and IL4-secreting CD4(+) T cell precursors while Sig/E7/LAMP-1 DNA induced only E7-specific IFN-gamma-secreting CD4(+) T cell precursors.
Nawijn et al. (2001)IL-4T cellsMoreover, CD4(+) T cells manifested rapid secretion of the Th2 cytokines IL-4, IL-5, and IL-10, reminiscent of Th2 memory cells.
Abramowicz et al. (1990)IL 4T cellsTaken together, these findings indicate that neonatal injection of alloantigens in BALB/c mice induces a state of dissociated tolerance, with unresponsiveness of anti-donor T cells secreting IL 2 on the one hand, and persistence of T cells responsible for B cell help and IL 4 secretion on the other hand.
Metwali et al. (2002)IL-4 mRNAT cellsGranuloma IL-4 mRNA localized to the non-T cells and IL-5 to T cells.
Kaneko et al. (2003)IL-4T-cellsT-cells primed in vivo 7 days previously with Ad-IL-4 DC displayed enhanced secretion of Th2 (IL-4, IL-10) but also higher Th1 cytokine (IFNgamma) production following ex vivo challenge with donor alloAg.
Saha et al. (1993)IL-4T cellsBy contrast, H-2b mice were possibly incapable of inducing IL-4-secreting T cells and therefore parasite replication remains under control at any point post infection.
Mueller et al. (1991)IL-4T cellsIn this report we extend the in vitro clonal anergy model to examine the regulation of proliferation in T cells that secrete both IL-2 and IL-4.
Krauss et al. (1994)IL-4T-cellThus, genetic modification of tumor cells to secrete IL-4 can stimulate an increase in the preeffector cell response in the tumor-draining LN, suggesting an enhancement in T-cell-mediated immune function against the parental tumor.
Zhang et al. (2003)IL-4T-cellSplenocytes from OVA-primed BALB/c mice proliferated in response to stimulation with a syngeneic OVA-specific T-cell clone, OVA-T3, and secreted interferon-gamma (IFN-gamma) but not interleukin-4 (IL-4).
Cheng et al. (2006)IL-4T cellsThe expression of CD(80) and CD(86) on DC, which were isolated from the spleen, were detected by fluorescein-activated cell sorter. (3)H-thymidine ((3)H-TdR) incorporation assay was used to determine the response of splenic T and the secretion of interleukin-4 (IL-4) and IL-5 was assayed with the use of ELISA after coculture of T cells with DC.
Cheng et al. (2006)IL-4T cellsThe production of IL-4 by splenic T cells in group B (8.4 +/- 4.3) pg/ml was less than that of group A [(32.4 +/- 12.1) pg/ml, P < 0.05], but there was no significant difference between group B and group C [(5.1 +/- 1.1) pg/ml, P > 0.05]. (2) The expression of CD(86) on splenic DC cells from group B (58.23%) was significantly lower than that from group A (77.59%) and group C (77.84%), while the expressions of CD(80) in group A (96.98%) and group B (95.63%) were higher than that in group C (77.37%). (3) When untreated T cells were cocultured with DC from the individual groups and stimulated by OVA, the secretion of IL-4 from T cells in group B [(10.8 +/- 2.3) pg/ml] was significantly lower than that in group A [(17.3 +/- 4.7) pg/ml, P < 0.05], but there was no significant difference when compared to group C [(5.7 +/- 2.7) pg/ml, P > 0.05], and the secretion of IL-5 from T cells in group B [(18.8 +/- 3.8) pg/ml] was significantly lower than that in group A [(35.7 +/- 7.9) pg/ml, P < 0.05], but there was no significant difference when compared to group C [(11.0 +/- 2.2) pg/ml, P > 0.05].
Burstein and Abbas (1993)IL-4T cellsAdministration of tolerizing antigen itself primes splenic CD4+ T cells for secretion of lymphokines, both IL-2 and IL-4.
Tang et al. (1997)IL-4T lymphocytesThese experiments begin to define the kinetics of cytokine expression and phenotypes of cytokine-producing cells following RSV infection, supporting previous findings that suggested aberrant infiltration of CD4+ T lymphocytes and excessive IL-4 secretion may play a role in the vaccine-enhanced disease associated with RSV.
Yoshimoto and Paul (1994)IL-4T cellsThese results suggest that possibility that this rare population of T cells may be capable of secreting IL-4 at the outset of immune responses and thus may act to regulate the pattern of priming of naive T cells, by providing a source of IL-4 to favor the development of T cell helper 2-like IL-4-producing cells.
Collins et al. (1998)IL-4T cellCharacterization of the cell type responsible indicated that it was distinct from the NK1+ or CD4+ T cell previously ascribed the function of rapid IL-4 secretion.
Wang et al. (1992)IL-4T cellsAt the same time, studies of IL-4-secreting cell frequencies directly ex vivo have argued that T cells with the potential to become IL-4 secretors exist in vivo, in the form of precursors requiring stimulation and 4-12 days of culture as well as restimulation with mitogen or Ag before they become detectable as lymphokine-secreting cells.
Wang et al. (1992)IL-4-secretingT cellsThe data support and extend those obtained through analysis of cytokine mRNA synthesis alone, thereby providing evidence that "fresh" T cells are indeed capable of producing IL-4 directly ex vivo and are consistent with the existence of IL-4-secreting cells as a normal component of the T cell repertoire of naive mice.
Wang et al. (1992)IL-4-secretingT cellThe kinetics with which IgE responses develop in vivo following immunization of experimental animals indirectly support the existence of IL-4-secreting T cells as a normal component of the T cell repertoire.
Collins et al. (1988)rBSF-1T cellHowever, LAg1- thymocytes developed high levels of CTL activity when incubated with B cell stimulatory factor-1 (BSF-1), provided as the supernatant of the rBSF-1-secreting T cell hybridoma D9-C1.12.17.
Bocek et al. (2004)IL-4T cellsTitrating IFNgamma into such cultures showed a striking increase in the proportion of T cells that secreted IL-4 upon challenge; this effect was completely IL-4-dependent in that it was blocked with anti-IL-4 antibody.
Chilton and Fernandez-Botran (1993)IL-4T cellThese results suggest that the production of sIL-4R is regulated by stimuli leading to T cell activation and IL-4 secretion and are consistent with sIL-4R having an important role in the regulation of IL-4 activity in vivo.
Donckier et al. (1995)IL-4T cellsAnalysis of T cell functions after in vitro restimulation with A/J spleen cells indicated that early IL-4 neutralization did not prevent donor-specific CTL unresponsiveness but allowed the emergence of alloreactive T cells secreting increased levels of IL-2 and IFN-gamma.
Atlan-Gepner et al. (1997)interleukin-4T-cellThese results suggest that diabetes induction is preceded by V beta + subset-specific functional changes in the ability of various T cells to respond to or secrete interleukin-2 and interleukin-4, indicating a functional imbalance of the T-cell repertoire expanded by the autoimmune process.
Ksander et al. (1992)IL-4T cellsIn the former, T cells capable of secreting IL-2 and IL-4 were found whereas in the latter only IL-2-secreting T cells were detected.
Ksander et al. (1992)IL-4T cellsThe failure of AC tumor-bearing mice to destroy their tumors correlates not only with defective delivery of local help but with a systemic inability to produce tumor-specific T cells that can secrete IL-2 and IL-4.
Moll and Röllinghoff (1990)IL4T cellsOur results allow a better understanding of the relative contribution of these cell types at various stages of disease and can be summarized as follows: (a) secretion of IL4 can be demonstrated in short-term clonal cultures of CD4+ cells from L. major-infected mice, (b) CD4+ cells releasing IL2, suggested to be a characteristic of TH1 cells that predominate in resistant mice, can also be detected in susceptible mice at any time of infection, (c) both IL2 and IL4 are released by the progeny of individual T cells from susceptible mice and (d) the kinetics of precursor frequencies in genetically susceptible mice protected against the disease by prophylactic treatment are different from those of congenitally resistant mice, thus indicating that the development of lymphokine-producing T cells and the establishment of protective immunity may be regulated differently in those mice.
Schmitt et al. (1994)IL-4T cellThese data were confirmed by time-course experiments which revealed that the delayed addition of IL-4 to IL-12-primed T cell cultures resulted in a gradual restoration of IFN-gamma production whereas in parallel the secretion of IL-4 was not reduced over a wide period of delay (6-72 h).
Choi et al. (2005)IL-4T-cellLinkage analysis of the genetic determinants of T-cell IL-4 secretion, and identification of Flj20274 as a putative candidate gene.
Choi et al. (2005)IL-4T cellsWe employ two complementary genetic techniques to identify genes that regulate the default IL-4 secretion profiles of T cells from BALB/c and B6 mice.
Choi et al. (2005)interleukin-4T-cellWe performed a genome-wide linkage analysis of the progeny of a backcross between BALB/c and B6 mice to identify three loci, T-cell secretion of interleukin-4 (Tsi)1-3, on chromosomes 7, 19 and 15, respectively, which regulate in vitro T-cell IL-4 production.
Choi et al. (2005)IL-4T cellsWe have also employed mRNA representational difference analysis to isolate a gene, Flj20274, which is differentially expressed in T cells that secrete high levels of IL-4.
Powell and Streilein (1990)IL-4T cellsNeonatal tolerance induction by class II alloantigens activates IL-4-secreting, tolerogen-responsive T cells.
Schmidt et al. (1994)interleukin-4T cellsBy secretion of interleukin-4 and interleukin-5, TH2-type T cells are thought to play an important role in the pathogenesis of asthma.
Kirman et al. (1996)IL-4T cellsThe age-associated increase in IL-4 secretion is associated with a significantly increased concentration of intracellular IL-4 and its mRNA, although there is no increase in the number of activated T cells with intracellular IL-4.
Adkins et al. (1993)IL-4T cellsBy 6 days postbirth, T cells secrete IL-4 at low levels, similar to those produced by T cells from naive, adult animals.
Smiley et al. (1997)interleukin-4T cellA lymphocyte population that expresses surface markers found on T cells and natural killer (NK) cells secretes large amounts of interleukin-4 (IL-4) immediately after T cell receptor ligation.
Ruffner et al. (2010)IL-4T cellsDC/sIL-4 treatment increases IL-4 secretion by islet-antigen specific T cells
Dieli et al. (1998)IL-4T lymphocytesThe spontaneous release of IL-4 at day 1 was due to the alphabeta+ double-negative (CD4- CD8-) T lymphocytes that also expressed NK1.1 and showed V(alpha)14 rearrangement, while alphabeta+ CD4+ T lymphocytes were the source of the antigen-specific IL-4 production at day 4.
Inobe et al. (1998)IL-4T cellT cells in lymphoid organs drained by mucosal sites secrete IL-4 as a primary T cell growth factor.
Okamoto et al. (2009)IL-4T cellsT helper type 2 (T(H)2) bias, which is the propensity of naive CD4(+) T cells to differentiate into interleukin 4 (IL-4)-secreting T(H)2 cells, is a genetic trait that affects susceptibility to infectious, autoimmune and allergic diseases.
Gollob and Coffman (1994)IL-4T cellsA minority subpopulation of CD4+ T cells directs the development of naive CD4+ T cells into IL-4-secreting cells.
Gollob and Coffman (1994)IL-4T cellsMoreover, Mel-14high T cells could generate IL-4-secreting cells only in the presence of Mel-14low T cells or rIL-4.
Gollob and Coffman (1994)IL-4T cellsIn addition, co-culture of CD4+, Mel-14low T cells from IL-4-deficient mice with CD4+, Mel-14high T cells from wild-type mice did not lead to the development of IL-4-secreting cells.
Erb et al. (1999)IL-4T cellsTaken together these results suggest that CD8+ T cells are not necessarily switched to a Th2 phenotype by the presence of IL-4 and that some other factor(s) may be important in the switch process of CD8+ T cells in vivo, since the addition of IL-4 during CD8+ T cell activation in vitro leads to Th2 type CD8+ T cells secreting IL-4 and IL-5.
Lan et al. (2001)IL-4T cellsCytokine secretion and adoptive transfer studies using wild-type and IL-4(-/-) mice showed that protection afforded by NK1.1+ and DX5+asialo-GM1+ T cells derived from either donors or hosts conditioned with lymphoid irradiation is dependent on their secretion of high levels of IL-4.
Rodolfo et al. (1999)IL-4Tc2Tc2 lymphocytes lacked in vitro tumor cytotoxicity, but released IL-4 upon stimulation with tumor cells, as shown by limiting dilution analysis of the frequencies of tumor-specific pCTL and of CD8 cells producing the cytokine.
Olver et al. (2006)IL-4-secretingT cellsThe IL-4-secreting P.CW3 tumor cells led to markedly higher mRNA expression of IL-4 and granzyme A and B but no differences in IFN-gamma and IL-2 production, cell proliferation, or ex vivo CTL activity in primary Vbeta10+ CD8+ T cells when compared with the control tumor cells.
Jiang et al. (2008)IL-4T cellsThis may due to the induction of a Th2-bised immune response specified with decreased expression of tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma but increased expression of IL-10 and IL-4 in serum and heart tissue, more IL-4 but less IFN-gamma secreting splenic CD4+ T cells, an immunoglobulin G1 isotype switch, increased expression of GATA-3 and low proliferation of CD8+ T cells, without significant change of virus titer in heart tissue.
McCabe and Lawrence (1990)IL-4T cellsThe modulation of the B cell phenotype caused by Pb was not due to release of IL-4 from residual T cells or endotoxin contamination of any culture reagents.
Zhao et al. (2005)IL4T cellsMETHODS: T cell subgroups, suppressor T cells (CD8+ CD28-, CD4+ CD25+, CD3+ CD4- CD8- T cells), expression of CD28 on T cells, and spleen T cells intracellular IL4/IFN-gamma secretion were determined by multicolor flow cytometry.
Brown et al. (1997)IL-4T cellsIn the presence of rIL-12 or rIL-4 naive parasite-specific transgenic T cells could mature into IFN-gamma-or IL-4-secreting T helper cells, respectively, even when antigen presentation was suboptimal or antigen dose was submitogenic.
Lichtman et al. (1987)BSF-1T cellThe KiSV-D10 lines show certain differences from one another and parent D10.G4 cells in their secretory and proliferative responses to T cell receptor- and BSF-1 mediated signals.
Yeh et al. (2010)IL-4T cellsIn fact, human and mice basophils have been demonstrated to have more IL-4 per cell than T cells and to be responsible for IL-4 secretion in allergic reactions [36], [37].
Saha et al. (1993)IL-4T cellsIt was observed that in H-2d mice at the early and later stages of the disease IFN-gamma-secreting T cells predominate, whereas in between the above stages IL-4-secreting T cells predominate.
Fehr et al. (1994)IL-4T-cellFour DNP-specific, CD4+ T-cell clones were characterized: clone 5S4 secreted IL-4 and required Il-4 for optimal growth; clone 5S10 secreted IL-2 and required IL-2 for optimal growth; clone 5S2 secreted IL-4 but required IL-2 for optimal growth; and clone 5S8 secreted IL-2 predominantly at 5 months, but switched to production of IL-4 at 7 months.
Asea and Stein-Streilein (1998)IL-4T cellsNK-specific antibody best signals the apoptotic process in susceptible NK cells when resistant NK T cells are present, activated, and secrete IL-4.
Jin and Malek (2006)IL-4T cellsB cells likely encounter IL-4 and IL-21 in vivo, as both are secreted by activated T cells.
Lacour et al. (1994)IL-4T cellsFinally, since IL-4 has been reported to amplify IL-4 release from activated CD4+ T cells, the autoinduction of IL-4 may very well function via cAMP.
Sundar and Menezes (1986)IgG blocking factorT-lymphocytesThe sera of patients with acute IM contain an IgG blocking factor which binds to T-lymphocytes and decreases their responses to antigens and mitogens.
Marcinkiewicz and Chain (1993)IL-4T cellsWe have investigated in vitro the ability of T cells from mice primed for contact hypersensitivity to release cytokines of the TH2 subtype, in particular IL-4 and IL-6.
Adkins and Hamilton (1992)IL-4T cellsIn striking contrast to adult T cells, neonatal T cells secreted large amounts of IL-4 upon primary stimulation in vitro.
Kezuka and Streilein (2000)IL-4T cellsSimilar cells were coinjected with primed OVA-specific BALB/c T cells plus OVA-pulsed APCs into ear pinnae of normal BALB/c mice (assay for delayed hypersensitivity expression) or coinjected with OVA-pulsed APCs into footpads of naive DO11.10 mice whose draining lymph node cells were harvested 4 days later and assayed in vitro for capacity to secrete interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) when stimulated with OVA (assay for induction of delayed hypersensitivity).
Yagi et al. (2003)IL-4T cellsNeutralization of IL-4 with mAbs in culture of BALB/c naive CD4(+) T cells strongly down-regulated both H4/ICOS expression on activated CD4(+) T cells and IL-4 production upon subsequent restimulation.
Huang et al. (2009)interleukin-4T-cellIn addition, T-cell proliferative responses, as well as interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) secretion were significantly enhanced after immunization with PELC-adjuvanted inactivated virus.
Dunussi-Joannopoulos et al. (1998)IL-4T-cellOur studies show that (1) mice vaccinated with a leukemogenic number of AML cells engineered to express B7.2 (B7.2-AML) or to secrete GM-CSF, IL-4, or TNF-alpha (GM-, IL-4-, TNF-alpha-AML) do not develop leukemia; (2) GM-AML cells are tumorigenic in sublethally irradiated SJL/J mice but not in Swiss nu/nu mice, indicating that killing of tumor cells is not T-cell-dependent; (3) vaccines with irradiated GM-AML, but not B7.2-, IL-4-, or TNF-alpha-AML cells, can elicit leukemia-specific protective and therapeutic immunity; and (4) in head-to-head comparison experiments, vaccination with irradiated GM-AML is more potent than B7.1-AML, curing 80% and providing 20% prolonged survival of the leukemic mice at week 2, as opposed to cures only up to 1 week with B7.1-AML vaccines.
Croft and Swain (1995)IL-4T cellsRecently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines.
Hogan et al. (1997)IL-4T cellsThe cytokines IL-4 and IL-5 secreted from antigen-activated CD4+ T cells are thought to play central roles in the clinical expression and pathogenesis of asthma.
Brys et al. (2005)IL-4T cellsFurthermore, cells from early stage-infected mice triggered T cells to secrete IFN-gamma and IL-4, whereas in the late stage of infection, they only induced IL-4 production.
Röcken et al. (1991)IL-4T cellThe induction of IL-4 and the down-regulation of IL-2 1) were not reproduced with alpha-methyl-mannoside-treated supernatant of Con A-stimulated spleen cells, 2) were not dependent on the presence of large numbers of APC, 3) did not result from differential consumption of lymphokines after restimulation, 4) were not due to a difference in the time course of IL-2 or IL-4 release in either T cell population, and 5) were obtained regardless of the agents used to activate or to restimulate the T cells.
Ryelandt et al. (1995)IL-4T cellThe pattern of IL-2 and IL-4 secretion by T cells isolated from tolerant animals could not be distinguished from the corresponding cells in control mice, suggesting that neonatal exposure to dHGG did not affect T cell reactivity or Th1/Th2 in vivo balance.
Schmidt et al. (1994)interleukin-4T cellsThe effect of different corticosteroids and cyclosporin A on interleukin-4 and interleukin-5 release from murine TH2-type T cells.
Kirman et al. (1996)IL-4T cellsSplenic T cells from old BALB/c mice, activated in vitro with antibody to CD3epsilon, secrete more IL-4 but less IL-2 than splenic T cells from young mice.
Arca et al. (1996)IL-4T cellsThe combined secretion of GM-CSF and IL-4 did not lead to enhanced induction of immune T cells.
Arca et al. (1996)IL-4T cellNevertheless, GM-CSF and IL-4 secretion significantly enhanced T cell immune reactivity to the poorly immunogenic BL6 tumor.
Bendelac (1995)IL-4T cellsMouse NK1+ T cells constitute a special subset of alpha beta TCR+ T cells that express natural killer surface receptors and are thought to play an immunoregulatory role because of their unique ability to secrete IL-4 within minutes of primary activation.
von der Weid et al. (1996)IL-4 mRNAT cellsSplenic CD4+NK1.1+ T cells have been shown to secrete large and transient amounts of IL-4 mRNA 90 min after i.v. injection of anti-CD3 Ab, suggesting that this novel subset of T cells may induce Th2 responses in the spleen by quickly providing IL-4 at the onset of an immune response. beta2-microglobulin-deficient (beta2m(o/o)) mice have been shown to contain strongly reduced numbers of NK1.1+ T cells and to be severely impaired in their capacity for rapid induction of IL-4 mRNA in response to anti-CD3, demonstrating that these cells are MHC class I dependent.
Marcinkiewicz and Chain (1993)IL-4T cellRegulation of in vitro release of TH2 type cytokines (IL-4, IL-6) in the T cell response to the trinitrophenyl (TNP) hapten.