Viewing affirmative mentions of localization of Il2 (M. musculus) in T cells

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Prowse (1982)IL2T lymphocytesThe lymphokine Interleukin 2 (IL2) is secreted by T lymphocytes from mice infected by the murine parasitic nematode Nematospiroides dubius upon in vitro re-stimulation by specific parasite antigens.
Stark et al. (1992)IL-2T lymphocytesThe data suggest that IL-2 may potentiate GVHD and alloreactivity induced by an adequate number of irradiated, nondividing but viable allogeneic spleen cells and/or that secretion of IL-2 by alloactivated T lymphocytes, supplied exogenously in the present study, may play a role in the GVHD syndrome.
Lacosta et al. (1999)Interleukin-2T cellsInterleukin-2 (IL-2), released from activated T cells, influences central neurochemical functioning, and IL-2 immunotherapy in cancer patients may provoke neuropsychiatric and cognitive disturbances.
DosReis et al. (1986)IL-2T-cellClAdo inhibited both IL-2 secretion and induction of IL-2 responsiveness up to control levels in the same dose range it inhibited T-cell mitogenesis.
DosReis et al. (1986)IL-2T cellsExtracellular administration of dbcAMP to splenic T cells stimulated by Con A mimicked the effects of ClAdo on T-cell activation parameters, as revealed by a dose-dependent blockade of both IL-2 secretion and IL-2 responsiveness induction, without affecting IL-2 receptor expression.
Salvadori and Zier (1996)IL-2T cellsTo test this, we compared the signal-transducing ability of T cells from mice inoculated with parental tumors (PTB) with that of T cells from mice immunized with IL-2-secreting tumor cells (ITB).
Li et al. (2010)IL-2T lymphocytesIn the current study, Nodosin suppressed the overproduction of the T lymphocytes; moreover, cell mitosis cycle was modulated by interfering with DNA replication in G1 stages via inhibition of IL-2 cytokine secretion at the mRNA level by Nodosin.
Kasempimolporn et al. (1997)IL-2T-cellThere was also a marked suppression of IL-2 secretion in parallel with a decrease of the T-cell proliferative response to mitogen.
Sileghem et al. (1986)IL-2T-cellFurthermore, lymph node cells derived from infected mice suppressed both secondary T-cell proliferative responses and IL-2 secretion, indicating that the trypanosome-induced suppression is mediated by a suppressive cell which interferes at the level of IL-2 secretion.
Horowitz et al. (1986)IL-2T cellsWe propose that this inhibitor of IL-2 responses may play a role in preventing "bystander" activation of T cells by IL-2 released in vivo and could be a potent pharmacologic agent.
Miyajima et al. (1985)TCGFT-cellThe resulting recombinant plasmid directed the synthesis of mature mouse IL-2 in S. cerevisiae, with most of the T-cell growth-factor (TCGF) activity secreted into the culture fluid and extracellular space.
Zier et al. (1994)IL-2T cellsVaccination with IL-2-secreting tumor cells stimulates the generation of IL-2-responsive T cells and prevents the development of unresponsiveness.
Porgador et al. (1993)IL-2T-cellThese results seem to indicate that low levels of IL-2 secreted by tumor cells are sufficient to activate T cells, while higher levels are needed in order to activate non-T-cell effectors.
Matsui and Arai (1994)IL-2T cellThe T cell proliferation suppression paralleled the level of interleukin-2 (IL-2) secretion.
Matsui and Arai (1994)IL-2T cellsThese results suggest that the suppression of T cell proliferation induced by a soluble Salmonella fraction is associated with inhibition of IL-2 secretion and the response of T cells to IL-2 and the former effect is dependent upon the inhibition of the stimulatory activity of protein kinase C on IL-2 secretion.
Bowlin et al. (1988)IL-2T-cellActivated cells secreted normal levels of the endogenous T-cell proliferative signal interleukin-2 (IL-2) and expressed high-affinity IL-2 receptors.
Ertesvag et al. (2009)IL-2T cellsWe have previously reported that all-trans retinoic acid (atRA) enhances the secretion of IL-2 from human peripheral blood T cells in vitro, followed by increased proliferation and inhibition of spontaneous cell death.
Jolly et al. (1998)IL-2T-lymphocyteDietary eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) suppress interleukin-2 (IL-2) secretion and impair T-lymphocyte proliferation.
Nakamura et al. (1994)interleukin 2T lymphocytesAdoptive immunotherapy with murine tumor-specific T lymphocytes engineered to secrete interleukin 2.
Stull and Gillis (1981)IL-2T cellIn this communication we report the successful isolation of a T cell hybridoma that constitutively synthesizes and secretes biologically active IL-2.
Beharka et al. (1997)IL-2T cellsCo-cultures containing T cells and M phi from old mice had reduced ConA-stimulated proliferation and IL-2 secretion than those consisting of T cells and M phi from young mice.
Beharka et al. (1997)IL-2T cellsAddition of M phi from old mice suppressed proliferation and IL-2 secretion by T cells from young mice.
Beharka et al. (1997)IL-2T cellsLikewise, T cells from old mice secreted more IL-2 when cultured with M phi from young mice compared to those cultured with M phi from old mice.
Huang and Stott (1993)IL-2T-cellsCon A-induced cell proliferation and IL-2 receptor expression on CD3+ cells from lupus mice occur only in the presence of exogenous IL-2, whereas normal T-cells from BALB/c and CBA control mice are activated by the mitogen and undergo complete cell cycling in the absence of exogenous IL-2, as they are able to secrete sufficient endogenous IL-2.
Mills et al. (1989)interleukin 2T-cellPhorbol esters, potent activators of PKC, augment secretion of the T-cell growth factor, interleukin 2 (IL2).
Mills et al. (1989)IL2T-lymphocyteWe have determined whether IL2 secretion can be induced in the murine cell T-lymphocyte line LBRM 331A5, where PKC is inhibited by staurosporine or sphingosine or in cells where PKC is depleted by prolonged incubation with high concentrations of phorbol esters.
Mills et al. (1989)IL2T-cellIn cells in which PKC was either inhibited or depleted, antibodies against the T3 portion of the T-cell receptor complex and the mitogenic lectin phytohemagglutinin (PHA) still triggered IL2 secretion.
Mills et al. (1989)IL2T-lymphocytesThese data indicate that activation of PKC is not an obligatory step for IL2 secretion in LBRM 331A5 murine T-lymphocytes.
Nóbrega et al. (1986)IL-2T cellA marked synergism between A23187 and PMA was noted in induction of T cell enlargement, IL-2 release, and induction of IL-2 responsiveness.
Nóbrega et al. (1986)IL-2T cellThe results indicate that T cell mitogenesis by A23187/PMA is IL-2-dependent, and suggest a critical role for protein kinase C in IL-2 release and induction of IL-2 responsiveness.
Centurelli and Abate (1997)IL-2T cellsDHEA appears to possess immunomodulating effects, perhaps by enhancing the secretion of IL-2 from activated T cells as demonstrated in a murine model.
Nicholas et al. (1987)IL2T-lymphocyteDuring recovery from cytomegalovirus infection T-lymphocyte subsets become selectively responsive to activation and have depressed interleukin 2 (IL2) secretion and IL2 receptor expression.
Lindqvist et al. (1988)IL-2T cellSorting of populations on the basis of antigenic phenotype showed that the cell mediating the blockage in IL-2 secretion is a large T cell expressing markers for both Lyt-1 and Lyt-2.
Salvadori et al. (1994)IL-2T cellsThus, IL-2 secretion by tumors seems to be able to prevent immunosuppression by maintaining normal signal transduction in T cells, facilitating the generation of antitumor responses.
Jan and Kaminski (2001)IL-2T-cellIn primary murine splenocytes and EL4.IL-2 T cells, the contrasting effects of cannabinol on IL-2 secretion depended on the magnitude but not the mode of T-cell activation.
Jan and Kaminski (2001)IL-2T cellsSuboptimal activation of T cells in the presence of cannabinol produced an enhancement of IL-2 secretion, which was paralleled by an increase in nuclear phospho-extracellular-regulated kinase (ERK) 1/2.
Jan and Kaminski (2001)IL-2T cellsIn contrast, T cells activated with stimuli that were optimized to induce maximal IL-2 secretion elicited a marked suppression in the production of this cytokine when cultured in the presence of cannabinol.
Matsui and Arai (1993)interleukin-2T-cellThe suppression of T-cell proliferation did not necessarily parallel the level of interleukin-2 (IL-2) secretion, and was not restored by treatment with a calcium ionophore, indomethacin or IL-2.
Matsui and Arai (1993)IL-2T-cellThese results suggest that the suppression of T-cell proliferation induced by Salmonella infection may be regulated by inhibition of tyrosine phosphorylation in T-cells, although the inhibition is not associated with PKC activation and subsequent IL-2 secretion of T cells.
Marcinkiewicz et al. (1997)IL-2T-cellIn this study, we compare the influence of alveolar and peritoneal macrophages on T-cell-dependent interleukin-2 (IL-2) release.
Altman et al. (1982)TCGFT cellMany, but not all, clones of one of these hybridomas, i.e., hybridoma 24, secreted TCGF constitutively, but production was markedly enhanced by stimulation with T cell mitogens.
Heeg et al. (1987)IL2T cellsIn both responder cell types proliferative responses are associated with IL2 secretion, while only Lyt-2+ T cells develop measurable cytotoxic effector cells.
Marrack and Kappler (1983)interleukin 2T cellKeyhole limpet hemocyanin (KLH)/I region-specific T cell hybridomas have been prepared by fusing KLH/I-specific T cell blasts from mice with single pairs of metacentric chromosomes to the inducible, interleukin 2 (IL-2)-secreting T cell hybridoma FS6-14.13.AG2.1.
Marrack and Kappler (1983)IL-2T cellT cell hybridomas with KLH/I receptors were identified by their ability to secrete IL-2 in response to KLH and the appropriate antigen-presenting cells.
Prowse (1981)IL2T cellThe secretion of the lymphokine, Interleukin 2 (IL2), from cells obtained from the lymph nodes of mice infected by the murine nematode, Nematospiroides dubius, is used an indication of T cell recognition of parasite antigens.
Prowse (1981)IL2T cellIt is demonstrated that IL2 secretion is T cell-dependent and occurs only when the lymph node cells are cultivated in the presence of at least 5 micrograms/ml of a parasite antigen preparation.
Kirman et al. (1996)IL-2T cellsIn contrast, the age-associated decrease in IL-2 secretion is associated with a significant decrease in the number of activated T cells with intracellular IL-2.
Lechler et al. (1985)IL 2T cellIn striking contrast, anti-LFA-1 antibody, which totally blocked B lymphoma-induced responses, had no effect on L cell antigen presentation, measured as interleukin 2 (IL 2) release by T hybridomas, proliferation, IL 2 release, or IL 2 receptor upregulation by a T cell clone.
Simons et al. (2006)IL-2T lymphocytesBoth in-flight studies and ground-based studies using microgravity analogs, such as rotating wall vessel (RWV) bioreactors, have demonstrated that mitogen-stimulated T lymphocytes exhibit decreased proliferation, IL-2 secretion, and activation marker expression in true microgravity and the dynamic RWV-culture environment.
Simons et al. (2006)IL-2T-lymphocyteThe T-lymphocyte fraction of splenocytes was assayed during the recovery period for IL-2 secretion, expansion of the T-lymphocyte population, and expression of the activation marker CD25.
Tang et al. (1999)IL-2T cellIL-2 secretion and T cell stimulating activity of the DC were detected.
Tang et al. (1999)IL-2T cellsRESULTS: IL-2 gene-modified, antigen-pulsed DC could secrete high level of IL-2 in vitro, stimulate proliferation of syngeneic T cells markedly.
Furtado et al. (2002)IL-2T cellsWe conclude that T cells with regulatory potential can develop, undergo thymic selection, and migrate to the peripheral lymphoid organs in the absence of IL-2, and do not protect from disease by means of IL-2 secretion.
Speiser et al. (1991)interleukin 2T cellsHowever, when such non-deleted V beta 6+ T cells were tested in vitro, no interleukin 2 (IL-2) secretion or proliferation was observed after MIs-1a stimulation.
Sojka et al. (2004)IL-2T cellsIL-2 secretion by CD4+ T cells in vivo is rapid, transient, and influenced by TCR-specific competition.
Sojka et al. (2004)IL-2T cellThe secretion of IL-2 is a critical and early landmark in the activation program of CD4(+) T cells in vitro, but the lack of sensitive assays has limited its application for studying T cell activation in vivo.
Zhao and Hu (1996)IL-2T-cellsIL-2 production declined significantly on the 7th (P < 0.05) and 14th days (P < 0.01) in RBX and bBMP groups, an evidence of inhibiting effect of RBX on the T-lymphocyte function leading to lowered secretion of IL-2 by spleen T-cells in BALB/C mice.
Alosco et al. (1993)interleukin-2T lymphocytesAntitumor response independent of functional B or T lymphocytes induced by the local and sustained release of interleukin-2 by the tumor cells.
Alosco et al. (1993)IL-2T cellsThe failure of the IL-2-secreting tumor to grow in conventional (immunocompetent) mice was attributed to the activation of CD8+ T cells that exhibited tumor specificity and memory.
McKean et al. (1985)IL 2T cellThe same B lymphoma cells are capable of stimulating IL 2 release and proliferative responses from other T cell clones.
McKean et al. (1985)IL 2T cellThe absence of comparable IL 1-induced stimulation of IL 2 secretion suggests that IL 1 primarily enhances antigen specific T cell proliferation through mechanisms other than acting as a co-stimulant for IL 2 release.
Ksander et al. (1992)IL-2T cellsIn the former, T cells capable of secreting IL-2 and IL-4 were found whereas in the latter only IL-2-secreting T cells were detected.
Ksander et al. (1992)IL-2T cellsThe failure of AC tumor-bearing mice to destroy their tumors correlates not only with defective delivery of local help but with a systemic inability to produce tumor-specific T cells that can secrete IL-2 and IL-4.
Goud et al. (1993)IL-2T cellsThe proliferation of T cells was not accompanied by secretion of IL-2 or expression of IL-2 receptors on T cells.
Schweighoffer et al. (1996)IL-2T cellsIt has been postulated that IL-2 secreting cancer vaccines establish antitumor immunity because the cytokine acting in a paracrine fashion would deliver a helper signal directly to the T cells making contact with the modified tumor cells at the site of vaccination.
Lichtor et al. (2008)IL-2T cellsecretion by T cell clones while not inhibiting IL-2 induced proliferation of
Lian et al. (2007)IL-2T cellsIn addition, T cells from lymph nodes of mice vaccinated with pIL-18 or pAPOPTIN + pIL-18 secreted high levels of the Th1 cytokine IL-2 and IFN-gamma, indicating that the regression of tumor cells is related to a Th1-type dominant immune response.
Maraskovsky et al. (1991)IL-2T cellsHigh-frequency activation of single CD4+ and CD8+ T cells to proliferate and secrete cytokines using anti-receptor antibodies and IL-2(1).
Abramowicz et al. (1990)IL 2T cellsTaken together, these findings indicate that neonatal injection of alloantigens in BALB/c mice induces a state of dissociated tolerance, with unresponsiveness of anti-donor T cells secreting IL 2 on the one hand, and persistence of T cells responsible for B cell help and IL 4 secretion on the other hand.
Reske-Kunz et al. (1987)interleukin 2T cellsSoluble interleukin 2 receptors are released by long term-cultured insulin-specific T cells transiently after contact with antigen.
Reske-Kunz et al. (1987)interleukin 2T cellsAn enzyme-linked immunosorbent assay was used to quantitate soluble interleukin 2 receptors (IL 2R) released by antigen-dependent, insulin-specific murine T cells into the culture supernatant, as well as cell-associated IL 2R present in cell lysates.
Singhai and Levy (1987)interleukin 2T-cellThe T-cell line and T-cell clones derived from it release interleukin 2 not only in the presence of anti-Fd-B2 idiotype antibody but in the presence of ferredoxin.
Moldwin et al. (1986)IL-2T lymphocytesProliferation of T lymphocytes can be induced by IL-2, either through an autocrine pathway in which the responding cell produces its own IL-2 or through an exocrine pathway in which IL-2 secreted by Th stimulates proliferation of IL-2-dependent CTL.
Van Vlasselaer et al. (1991)IL-2T cellIdentification of a factor(s) from cloned murine natural suppressor cells that inhibits IL-2 secretion during antigen-driven T cell activation.
Zhou et al. (2005)IL-2T cellsPrevious data suggested that CD4(+) T cells may support CD8(+) T cells through secretion of interleukin-2 (IL-2).
Pandey et al. (2003)IL-2T cellsMAMPDM did not block the secretion of IL-2 or expression of CD25 though it inhibited the proliferation of con A stimulated T cells.
Cho et al. (2007)IL-2T cellsTreatment with myricetin significantly inhibited the secretion of the IL-2 protein from mouse EL-4 T cells activated with phorbol 12-myristate 13-acetate (PMA) plus ionomycin (Io) in a dose-dependent manner.
Demanet et al. (1992)IL2T cellThe dual specificity of the hybrid-hybridoma produced monoclonal antibodies (MAbs) could be demonstrated by flow cytometry, the induction of T cell proliferation, the induction of IL2 secretion by polyclonal T cells, and redirected lysis of the relevant target cells.
Pak et al. (1995)IL-2T cellsThese intratumoral T cells also had an increased cytolytic capacity toward autologous tumor cells and an increased capacity to proliferate and secrete IL-2.
Schmitt et al. (1989)TCGF IIIT cellsIn addition, naive CD4+ T cells secreted TCGF III/P40 upon activation by lectin or allo-major histocompatibility complex structures.
Berndt et al. (1994)IL-2T-cellsInterleukin-2 (IL-2) is a 133 amino acid alpha-helical protein secreted by activated T-cells.