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| Karpuzoglu-Sahin et al. (2001) | IFN-gamma | | T cells | Cell mixing experiments suggested that the DES-induced increase in IFN-gamma secretion is due to hormonal effects on T cells but not on APC. |
| Park et al. (2007) | IFN-gamma | | T cells | IFN-gamma secreting T cells specific for survivin was found after temozolomide (TMZ) treatment in C57BL/6 mice intracranial (i.c.) inoculated with GL26 cells. |
| Huang et al. (2009) | IFN-gamma | | T-cell | Immunogenicity studies in mice have shown that antigen-specific antibody titers and T-cell proliferative responses, as well as the secretion of IFN-gamma, were significantly enhanced for ovalbumin after formulation with PEG-b-PLACL-based emulsions. |
| Hodgson et al. (1996) | IFN-gamma | | T lymphocyte | Allergen-activated draining lymph node cells (LNC) isolated from mice exposed topically to the contact allergen oxazolone mount vigorous proliferative responses and secrete substantial amounts of interferon-gamma (IFN-gamma) when cultured with the T lymphocyte mitogen concanavalin A (con A). |
| Periwal et al. (2005) | interferon-gamma | | T-cells | Statistical evaluation for detection of peptide specific interferon-gamma secreting T-cells induced by HIV vaccine determined by ELISPOT assay.
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| Periwal et al. (2005) | Interferon-gamma | | T-cells | Interferon-gamma (IFN-gamma) secreting T-cells play an important role in immunodeficiency virus (HIV) disease pathogenesis. |
| Periwal et al. (2005) | IFN-gamma | | T-cells | A common technique to determine the efficacy of the HIV vaccines in murine models is to compare the number of IFN-gamma secreting T-cells induced by HIV vaccine to a control group. |
| Periwal et al. (2005) | IFN-gamma | | T-cells | The measurement of IFN-gamma secreting T-cells relies on an ELISPOT assay. |
| Rubio and Torres (1999) | IFN-gamma | | T-lymphocytes | Interferon-gamma (IFN-gamma) is a cytokine mainly secreted by activated T-lymphocytes. |
| Bancroft et al. (1987) | IFN-gamma | | T cells | The ability of T cells to induce these responses has been extensively documented and occurs via their secretion of interferon-gamma (IFN-gamma) after interaction with antigen (2-6). |
| Yoneda and Yoshida (1998) | IFN-gamma | | T cells | The role of T cells in allografted tumor rejection: IFN-gamma released from T cells is essential for induction of effector macrophages in the rejection site.
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| Landolfo et al. (1981) | gamma-IFN | | T lymphocytes | These findings show that T lymphocytes can recognize alloantigens by releasing gamma-IFN even without displaying proliferation.
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| Oh et al. (2006) | IFN-gamma | | T lymphocytes | Our results demonstrate that one of the potentially beneficial antitumor and immunostimulatory effects of WEPL may be mediated through the enhancement of IFN-gamma secretion by T lymphocytes.
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| Becker et al. (2007) | IFN-gamma | | T cells | Despite constitutive retroviral IFN-gamma mRNA transcription, translation and secretion of IFN-gamma protein was tightly regulated and only observed in activated T cells. |
| George (1996) | IFN-gamma | | T cells | This study shows that T cells in PP of mice immunized orally with live Salmonella typhimurium secrete large amounts of gamma interferon (IFN-gamma) when they are stimulated with bacterial sonicate in vitro. |
| Krenger et al. (1996) | IFN-gamma | | T cells | Furthermore, the prevention of IFN-gamma production in vivo after allogeneic BMT, by transplantation of polarized type 2 donor T cells (secreting interleukin-4 but not IFN-gamma), also prevented NO production and restored splenocyte responses to mitogen. |
| Straub et al. (2008) | interferon-gamma | | T cells | Neuronally released sympathetic neurotransmitters stimulate splenic interferon-gamma secretion from T cells in early type II collagen-induced arthritis.
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| Straub et al. (2008) | IFNgamma | | T cell | T cell depletion markedly reduced splenic secretion of IFNgamma and KC. |
| Dimayuga et al. (2005) | IFN-gamma | | T cells | CONCLUSIONS: T cells inhibit intimal thickening in the early stages of the response to injury through basal IFN-gamma secretion. |
| Halloran et al. (1992) | IFN-gamma | | T cells | MHC induction was inhibited by the in vivo administration of cyclosporine or anti-IFN-gamma mAb and did not occur in nude mice, confirming the key role of IFN-gamma released from T cells. |
| Tuttle et al. (1993) | IFN-gamma | | T-cells | Secretion of IFN-gamma was primarily a function of CD8+ T-cells. |
| Squires et al. (1989) | IFN-gamma | | T cell | The capacity of BALB/c mice to acquire resistance to and eliminate intracellular visceral Leishmania donovani is T cell dependent, associated with a granulomatous tissue reaction, and correlates with the ability to secrete the macrophage-activating lymphokine, IFN-gamma. |
| Krammer et al. (1982) | IFN-gamma | | T cells | These results provide the first frequency estimate of IFN-producing cells and are discussed with respect to the physiological role of IFN-gamma release from T cells.
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| Huber and Irschick (1988) | IFN-gamma | | T lymphocytes | Stimulation of T lymphocytes with alloantigen leads to release of both IL-2 and IFN-gamma. |
| Zier and Gansbacher (1996) | IFN gamma | | T cells | Tumour cell vaccines that secrete interleukin-2 (IL-2) and interferon gamma (IFN gamma) are recognised by T cells while resisting destruction by natural killer (NK) cells.
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| Zier and Gansbacher (1996) | IFN gamma | | T cells | Our results demonstrated that T cells recognised tumour cells secreting IFN gamma better than those secreting IL-2. |
| Zier and Gansbacher (1996) | IFN gamma | | T cell | The findings suggest that, in addition to upregulating adhesion molecules, MHC molecules, and correcting defects in antigen presentation pathways, IFN gamma secretion may protect tumour cell vaccines from early NK-mediated destruction, keeping them available for T cell priming.
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| Cantin et al. (1995) | IFN-gamma | | T-cell | Secreted IFN-gamma was present up to 6 months into latency in areas of the T-cell infiltration. |
| Krenger et al. (1996) | IFN-gamma | | T-cell | We demonstrate that the transplantation of polarized type 2 murine T cells (i.e., cells secreting IL-4 but not IFN-gamma) together with T-cell-depleted bone marrow results in a significant increase in survival (P<0.001) after bone marrow transplantation across minor histocompatibility barriers (B10.BR-->CBA/J). |
| Rana et al. (2010) | IFN-gamma | | T cells | Therefore, UVA does not inhibit the expansion, migration or IFN-gamma secretion of CD8 T cells during a primary immune response. |
| Beinborn et al. (2010) | IFN-gamma | | T cells | Providing a link to amplified immune function, SP and TGF-beta, when applied in combination, trigger a strong release of the proinflammatory cytokines IFN-gamma and IL17 from intestinal inflammatory T cells, whereas either agonist alone shows no effect. |
| Cheung et al. (2010) | IFN-gamma | | T cells | The results from cytotoxicity and ELISPOT assays indicated that a significant amount of IFN-gamma was secreted by the T cells of the vaccinated mice, and the T cells were able to eliminate the corresponding peptide-loaded T2 cells. |
| Skarica et al. (2009) | IFN-gamma | | T cells | IL-17- and IFN-gamma-secreting T cells play an important role in autoimmune responses in multiple sclerosis and the model system experimental autoimmune encephalomyelitis (EAE). |
| Hu et al. (2009) | IFN-gamma | | T cells | These potent antitumor effects were induced primarily by CD8(+)T cells, secreting IFN-gamma while CD4(+)T cells were also involved as a help of antitumor immunity. |
| Bialecki et al. (2009) | IFN-gamma | | T lymphocytes | When pulsed with OVA peptide (but not whole OVA), MZB cells promote the release of IFN-gamma and IL-4 by Ag-specific CD4(+) T lymphocytes and their stimulation with the TLR9 agonist CpG oligodeoxynucleotide (ODN), a potent MZB cell activator, biases them toward more Th1 inducers. |
| Cabrera et al. (2009) | interferon gamma | | T-cell | In vitro stimulation of splenocytes from vaccinated mice with either recombinant IF3 (rIF3) or crude Brucella protein extracts resulted in a T-cell proliferative response and induction of interferon gamma secretion, but not interleukin-4. |
| Wahl et al. (2009) | IFN-gamma | | T cells | By generating a knockout mouse strain deficient for the common IL-20R beta-chain (IL-20R2), we show that IFN-gamma and IL-2 secretion is significantly elevated after stimulation of IL-20R2-/--deficient CD8 and CD4 T cells with Con A or anti-CD3/CD28 in vitro. |
| Morris et al. (2009) | interferon-gamma | | T cell | Stimulation of host DCs by G-CSF subsequently unleashed a cascade of events characterized by donor natural killer T cell (NKT cell) activation, interferon-gamma secretion and CD40-dependent amplification of donor cytotoxic T lymphocyte function during the effector phase of GVHD. |
| Belyakov et al. (2008) | IFN-gamma | | T cells | A single systemic immunization with rMVA was sufficient to induce high-avidity IFN-gamma secreting CD8+ T cells in systemic organs, whereas a single mucosal immunization with rMVA was not sufficient to elicit high-avidity CD8+ T cells in mucosa. |
| Kaiko et al. (2008) | IFN-gamma | | T cells | OVA peptide-pulsed infected BMDC induced significant proliferation of transgenic CD4(+) DO11.10 (D10) T cells, strongly inhibited IFN-gamma secretion by D10 cells, and promoted a Th2 phenotype. |
| Cottingham et al. (2008) | IFN-gamma | | T-cells | In addition, we found a higher frequency of triple-positive IFN-gamma, TNF-alpha and IL-2 secreting E3-specific CD8+ T-cells 8 weeks after vaccination with MVA lacking B15R. |
| Jarnicki et al. (2008) | IFN-gamma | | T cells | In addition, inhibition of p38 enhanced the antitumor therapeutic efficacy of DC pulsed with Ag and CpG and this was associated with an enhanced frequency of IFN-gamma-secreting T cells and a reduction of Foxp3(+) Treg cells infiltrating the tumors. |
| Bungener et al. (2008) | IFNgamma | | T cells | WIV induced a TH1 skewed humoral and cellular immune response, characterized by strong influenza-specific IgG2a responses and a high number of IFNgamma-secreting T cells. |
| Walton et al. (2008) | IFN-gamma | | T cells | Furthermore, MCMV-specific CD4 T cells displayed a Th1 phenotype, secreting high levels of IFN-gamma and TNF-alpha and to some extent IL-2, cytokines which are involved in protection from CMV disease.
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| Jiang et al. (2008) | IFN-gamma | | T cells | This may due to the induction of a Th2-bised immune response specified with decreased expression of tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma but increased expression of IL-10 and IL-4 in serum and heart tissue, more IL-4 but less IFN-gamma secreting splenic CD4+ T cells, an immunoglobulin G1 isotype switch, increased expression of GATA-3 and low proliferation of CD8+ T cells, without significant change of virus titer in heart tissue.
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| Gurer et al. (2008) | IFN-gamma | | T cells | In addition, using a novel mouse model with reconstituted human immune system components, we demonstrated that vaccination with alphaDEC-205-EBNA1 antibodies primed EBNA1-specific IFN-gamma-secreting T cells and also induced anti-EBNA1 antibodies in a subset of immunized mice. |
| Gray et al. (2008) | IFN-gamma | | T cells | In particular, anti-4-1BB/anti-CD25 resulted in excellent expansion of specific CD8+ T cells but produced fewer IFN-gamma-secreting effector cells than the other combinations. |
| Iglesias et al. (2008) | IFN-gamma | | T cells | According to our studies in mice, the nasal-subcutaneous co-administration of this multiantigenic formulation induces a strong Th1-biased specific response against CR3, CD8+ T cells in mice spleen and IFN-gamma-secreting cells in mesenteric lymph nodes. |
| Lian et al. (2007) | IFN-gamma | | T cells | In addition, T cells from lymph nodes of mice vaccinated with pIL-18 or pAPOPTIN + pIL-18 secreted high levels of the Th1 cytokine IL-2 and IFN-gamma, indicating that the regression of tumor cells is related to a Th1-type dominant immune response. |
| Scheiblhofer et al. (2007) | IFN-gamma | | T-cells | Gene gun immunization has been associated with the induction of a heterologous type of immune response characterized by a T(H)1-like immune reaction on the cellular level, i.e. generation of IFN-gamma secreting CD8(+) T-cells, yet a T(H)2 biased serology as indicated by high IgG1:IgG2a ratios and induction of IgE. |
| Seo et al. (2007) | IFN-gamma | | T cell | Splenocytes of mice immunized with irradiated OVA showed a significant reduction in OVA-specific T cell proliferation and the secretion of Th1-type (IFN-gamma and IL-2) and Th2-type cytokines (IL-4 and IL-6). |
| Kim et al. (2007) | IFN-gamma | | T cells | Splenocytes from the mice vaccinated with Bac-VSV-G expressing mTERT (Bac-VSVG-mTERT) showed significantly increased numbers of mTERT-specific IFN-gamma-secreting T cells using an ELISPOT technique, and also showed increased NK cell activity. |
| Belyakov et al. (2007) | IFN-gamma | | T cells | Translating to the CD8(+) CTL avidity distribution in rhesus macaques, intrarectal vaccination induced more high-avidity mucosal CTL than s.c. vaccination and protection of mucosal CD4(+) T cells from AIDS viral depletion, whereas systemic immunization induced higher avidity IFN-gamma-secreting cells in the draining lymph nodes but no protection of mucosal CD4(+) T cells, after mucosal challenge with pathogenic simian/human immunodeficiency virus. |
| Ordway et al. (2007) | IFN-gamma | | T cell | In addition, we further demonstrate that the HN878 infection was associated with a potent TH1 response, characterized by the emergence of both CD4 and CD8 T cell subsets secreting IFN-gamma. |
| Lysaght et al. (2007) | IFN-gamma | | T cells | Peritumoral administration of CpG enhanced the frequency of IFN-gamma-secreting and reduced IL-10-secreting CD4(+) and CD8(+) T cells, in the tumor and in the draining lymph nodes, whereas, CT significantly enhanced the frequency of CD4(+)CD25(+)Foxp3(+) Treg cells, but reduced IFN-gamma-secreting T cells infiltrating the tumor. |
| Zhu et al. (2007) | IFN-gamma | | T cells | The number of IFN-gamma secreting T cells reached over 350SFU per million splenocytes against a CD8+ T cell-specific epitope of GFP. |
| Claassen et al. (2007) | IFN-gamma | | T cell | Analysis of post-challenge T cell responses in immunized mice indicated that G-specific pulmonary CD4 T cells displayed a mixed Th1/Th2 phenotype, which was characterized by the presence of both IL-5 and IFN-gamma secreting cells, in the absence of overt pathology.
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| Pop et al. (2007) | interferon-gamma | | T-cells | Despite differences in efficacy, a similar frequency of GAD65-specific CD4(+) T-cells secreting IL-4, IL-10, or interferon-gamma were detected in mice treated with pGAD65+pIL4+pIL10 and pGAD65+pIL10. |
| Hu et al. (2006) | IFN-gamma | | T cells | Here, we show a recombinant form of extracellular domain of mouse EGFR, in the presence of DCs, could activate human peripheral T cells to proliferate, secret IFN-gamma, the induced responses could cross-react with human EGFR and kill autologous EGFR-positive lung cancer cells which could be blocked by anti-CD8 and anti-MHC class I antibody. |
| Brischwein et al. (2006) | interferon gamma | | T cells | MT110 induced a costimulation independent polyclonal activation of CD4- and CD8-positive T cells as seen by de novo expression of CD69 and CD25, and secretion of interferon gamma, tumor necrosis factor alpha, and interleukins 2, 4 and 10. |
| Hahn et al. (2006) | IFN-gamma | | T cells | This triple combination therapy elicits a tumor-specific immune response evidenced by elevated IFN-gamma and IL-4 secretion by CD4+ T cells and results in increased infiltration of CD4+ and CD8+ T cells to the tumor site. |
| Van Rhijn et al. (2006) | IFN-gamma | | T cell | In mice and humans, CD1d is known to present Ag to NKT cells, a T cell lineage that is characterized by a limited TCR repertoire, capable of rapidly secreting large amounts of IFN-gamma and IL-4. |
| Xiang et al. (2006) | IFN-gamma | | T cell | In both strains of mice inoculated with DC transduced with an adenovirus, the generated NS3 specific antibody response and IFN-gamma-secreting T cell response were stronger than that generated by rNS3-pulsed DC. |
| Westendorf et al. (2006) | interferon gamma | | T cells | Transgenic CD8+ T cells secreted vigorous amounts of proinflammatory cytokines like interferon gamma/tumor necrosis factor alpha. |
| Gotsman et al. (2006) | interferon-gamma | | T cells | CD4+ T cells from ICOS-deficient chimeras proliferated more and secreted more interferon-gamma and tumor necrosis factor-alpha than T cells from control mice, which suggests a lack of regulation. |
| Pennington et al. (2006) | interferon-gamma | | T-cell | Here we show that without any obvious effect on TCR-mediated selection, the normal differentiation of mouse gammabeta T cells into potent cytolytic and interferon-gamma-secreting effector cells is switched towards an aggregate regulatory phenotype by limiting the capacity of CD4+CD8+ T-cell progenitors to influence in trans early gammabeta cell progenitors. |
| Okada (2006) | IFN-gamma | | T cells | Protective efficacy of this vaccine was associated with the emergence of IFN-gamma-secreting T cells and activation of proliferative T cells as well as CTL induction upon stimulation with the HSP 65 and antigens from M. tuberculosis. |
| Arens et al. (2005) | IFN-gamma | | T cells | CD95-deficient (lpr/lpr) T cells massively expanded and differentiated into IFN-gamma-secreting effector cells in transgenic mice that constitutively express the CD27 ligand, CD70. |
| Burns et al. (2005) | IFN-gamma | | T cells | These data explain the recruitment of IFN-gamma-secreting T cells to the vessel wall, and reinforce the suggestion that the arterial media may be a site of immunological privilege.
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| Lee et al. (2005) | IFN-gamma | | T cell | Furthermore, when WKYMVm was codelivered with HIV, HBV and Influenza DNA vaccines, WKYMVm selectively enhanced the vaccine-induced CD8(+) T cell responses in a dose-dependent manner, in terms of IFN-gamma secretion and cytolytic activity. |
| Wei et al. (2005) | IFN-gamma | | T cells | The tumors grew, then regressed, and neu-specific antibodies and IFN-gamma-secreting T cells were induced. |
| Owen et al. (2005) | IFN-gamma | | T lymphocytes | This increased production may be involved in the downregulation of IFN-gamma by the T cells of tumor-bearing mice previously reported in this model, as treatment of splenic T lymphocytes with CCL2 resulted in a decreased secretion of IFN-gamma by those cells.
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| McAllister et al. (2004) | IFN-gamma | | T cells | In this study, we show that CD8+ T cells that have a T cytotoxic-1 response to PC in BALB/c mice, as determined by secretion of IFN-gamma, have in vitro killing activity against PC and effect clearance of the organism in adoptive transfer studies. |
| Pinto et al. (2004) | interferon-gamma | | T cells | Protection afforded by this attenuated strain coincided with a number of factors that were not associated with BCG vaccination: long-term persistence of the strain within the host, sustained and potent induction of antimycobacterial interferon-gamma-secreting cells equal to that induced by virulent M. tuberculosis, and elicitation of T cells recognizing dominant M. tuberculosis antigens absent from BCG. |
| Le Gall et al. (2004) | IFN-gamma | | T-cell | In mixed lymphocyte cultures, both diabody and scFv, but not the monoclonal antibody OKT3, were able to suppress T-cell activation and secretion of IL-2 and IFN-gamma in a dose-dependent manner. |
| Rosset et al. (2004) | IFN-gamma | | T cells | When CpG were used, vaccination with peptides P143-172 and P158-187 generated IFN-gamma-secreting splenic T cells, and only P158-187 significantly stimulated IL-4-secreting T cells. |
| Wüest et al. (2004) | IFN-gamma | | T-lymphocytes | A single injection of this non-replicating vector into BALB/c mice resulted in a strong induction of NS3-specific, IFN-gamma secreting T-lymphocytes as measured by direct ex vivo ELISpot assay. |
| Takagi et al. (2004) | interferon-gamma | | T lymphocytes | Elispot assay showed a higher population of interferon-gamma secreting T lymphocytes in mice immunized with fusion cells. |
| Hsieh et al. (2004) | IFN-gamma | | T cells | Intraperitoneal vaccination of C57BL/6 mice with Vac-CRT/E7 led to a dramatic increase in E7-specific IFN-gamma-secreting CD8+ T cells and a potent antitumor effect against E7-expressing tumors compared to immunization with Vac-E7 or Vac-CRT. |
| Alonzi et al. (2004) | IFN-gamma | | T lymphocytes | Among these cells, a large fraction of CD8(+) T lymphocytes released mainly IL-10 and, to a lesser extent, IFN-gamma upon mitogenic stimulation in vitro. |
| Subramanian et al. (2003) | IFN-gamma | | T cells | Treatment with EE significantly decreased the secretion of proinflammatory cytokines (IFN-gamma, TNF-alpha, and IL-6) by activated T cells as well as the expression of a key matrix metalloproteinase, disease-mediating chemokines/receptors, and IgG2a levels, but increased the expression of TGF-beta 3 in the CNS. |
| Flohé et al. (2003) | IFN-gamma | | T cells | Again, a Th1 bias was noted in that cocultures of allogeneic T cells and HSP60-treated DC released IFN-gamma but only small amounts of IL-10 and no detectable IL-4. |
| Fachado et al. (2003) | IFN-gamma | | T-cell | This immunization resulted in a Th1-type response with predominance of IgG2a and a specific T-cell proliferation with high levels of interferon-gamma (IFN-gamma) secretion, whereas no IL-4 was detected. |
| Vasconcelos et al. (2003) | interferon-gamma | | T cells | Sequential immunization consisting of two priming doses of p154/13 followed by booster injections with recombinant Trypanosoma cruzi trans-sialidase protein significantly improved specific type 1 immune response, as revealed by a drastic reduction of the serum IgG1/IgG2a ratio and by an increase in the in vitro interferon-gamma secretion by CD4 T cells. |
| Jang et al. (2003) | IFN-gamma | | T cells | Also, increased numbers of IFN-gamma-secreting CD8(+) T cells were elicited when CT-treated BM-DCs were co-cultured with allogenic CD8(+) CTLs. |
| Tsuji et al. (2003) | IFN-gamma | | T cells | OPP clones secrete TGF-beta, IFN-gamma and low levels of IL-10, a cytokine pattern similar to that secreted by anergic T cells. |
| Zhang et al. (2003) | interferon-gamma | | T-cell | Splenocytes from OVA-primed BALB/c mice proliferated in response to stimulation with a syngeneic OVA-specific T-cell clone, OVA-T3, and secreted interferon-gamma (IFN-gamma) but not interleukin-4 (IL-4). |
| Kipnis et al. (2003) | interferon-gamma | | T cells | Such animals showed similar numbers of activated T cells as wild-type mice, as determined by their expression of the CD44hi CD62lo phenotype, but a transient reduction in cells secreting interferon-gamma. |
| Goonetilleke et al. (2003) | IFN-gamma | | T cells | Protection in the lung correlated with the induction of Ag 85A-specific, IFN-gamma-secreting T cells in lung lymph nodes. |
| Loirat et al. (2003) | IFN-gamma | | T cells | In these mice, injection of plasmid DNA encoding HBsAg induced a high frequency of CD8(+) T cells secreting IFN-gamma in the periphery, with in vitro cytolytic activity and specificity for two dominant HBs-specific HLA-A2-restricted epitopes. |
| Loirat et al. (2003) | IFN-gamma | | T cell | In the absence of a CD4(+) T cell response, the IFN-gamma-secreting CD8(+) T cells primed by DNA-based immunization were unable to exert their antiviral functions in vivo on liver cells expressing the transgene product. |
| Rouard et al. (2003) | IFN-gamma | | T cells | Compared to AdUb(-)-transduced DC, AdUb(+)-transduced DC triggered a higher number of pol 476-specific IFN-gamma-secreting CD8(+) T cells. |
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