Viewing affirmative mentions of localization of Ifng (M. musculus) in T cells

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Karpuzoglu-Sahin et al. (2001)IFN-gammaT cellsCell mixing experiments suggested that the DES-induced increase in IFN-gamma secretion is due to hormonal effects on T cells but not on APC.
Park et al. (2007)IFN-gammaT cellsIFN-gamma secreting T cells specific for survivin was found after temozolomide (TMZ) treatment in C57BL/6 mice intracranial (i.c.) inoculated with GL26 cells.
Huang et al. (2009)IFN-gammaT-cellImmunogenicity studies in mice have shown that antigen-specific antibody titers and T-cell proliferative responses, as well as the secretion of IFN-gamma, were significantly enhanced for ovalbumin after formulation with PEG-b-PLACL-based emulsions.
Hodgson et al. (1996)IFN-gammaT lymphocyteAllergen-activated draining lymph node cells (LNC) isolated from mice exposed topically to the contact allergen oxazolone mount vigorous proliferative responses and secrete substantial amounts of interferon-gamma (IFN-gamma) when cultured with the T lymphocyte mitogen concanavalin A (con A).
Periwal et al. (2005)interferon-gammaT-cellsStatistical evaluation for detection of peptide specific interferon-gamma secreting T-cells induced by HIV vaccine determined by ELISPOT assay.
Periwal et al. (2005)Interferon-gammaT-cellsInterferon-gamma (IFN-gamma) secreting T-cells play an important role in immunodeficiency virus (HIV) disease pathogenesis.
Periwal et al. (2005)IFN-gammaT-cellsA common technique to determine the efficacy of the HIV vaccines in murine models is to compare the number of IFN-gamma secreting T-cells induced by HIV vaccine to a control group.
Periwal et al. (2005)IFN-gammaT-cellsThe measurement of IFN-gamma secreting T-cells relies on an ELISPOT assay.
Rubio and Torres (1999)IFN-gammaT-lymphocytesInterferon-gamma (IFN-gamma) is a cytokine mainly secreted by activated T-lymphocytes.
Bancroft et al. (1987)IFN-gammaT cellsThe ability of T cells to induce these responses has been extensively documented and occurs via their secretion of interferon-gamma (IFN-gamma) after interaction with antigen (2-6).
Yoneda and Yoshida (1998)IFN-gammaT cellsThe role of T cells in allografted tumor rejection: IFN-gamma released from T cells is essential for induction of effector macrophages in the rejection site.
Landolfo et al. (1981)gamma-IFNT lymphocytesThese findings show that T lymphocytes can recognize alloantigens by releasing gamma-IFN even without displaying proliferation.
Oh et al. (2006)IFN-gammaT lymphocytesOur results demonstrate that one of the potentially beneficial antitumor and immunostimulatory effects of WEPL may be mediated through the enhancement of IFN-gamma secretion by T lymphocytes.
Becker et al. (2007)IFN-gammaT cellsDespite constitutive retroviral IFN-gamma mRNA transcription, translation and secretion of IFN-gamma protein was tightly regulated and only observed in activated T cells.
George (1996)IFN-gammaT cellsThis study shows that T cells in PP of mice immunized orally with live Salmonella typhimurium secrete large amounts of gamma interferon (IFN-gamma) when they are stimulated with bacterial sonicate in vitro.
Krenger et al. (1996)IFN-gammaT cellsFurthermore, the prevention of IFN-gamma production in vivo after allogeneic BMT, by transplantation of polarized type 2 donor T cells (secreting interleukin-4 but not IFN-gamma), also prevented NO production and restored splenocyte responses to mitogen.
Straub et al. (2008)interferon-gammaT cellsNeuronally released sympathetic neurotransmitters stimulate splenic interferon-gamma secretion from T cells in early type II collagen-induced arthritis.
Straub et al. (2008)IFNgammaT cellT cell depletion markedly reduced splenic secretion of IFNgamma and KC.
Dimayuga et al. (2005)IFN-gammaT cellsCONCLUSIONS: T cells inhibit intimal thickening in the early stages of the response to injury through basal IFN-gamma secretion.
Halloran et al. (1992)IFN-gammaT cellsMHC induction was inhibited by the in vivo administration of cyclosporine or anti-IFN-gamma mAb and did not occur in nude mice, confirming the key role of IFN-gamma released from T cells.
Tuttle et al. (1993)IFN-gammaT-cellsSecretion of IFN-gamma was primarily a function of CD8+ T-cells.
Squires et al. (1989)IFN-gammaT cellThe capacity of BALB/c mice to acquire resistance to and eliminate intracellular visceral Leishmania donovani is T cell dependent, associated with a granulomatous tissue reaction, and correlates with the ability to secrete the macrophage-activating lymphokine, IFN-gamma.
Krammer et al. (1982)IFN-gammaT cellsThese results provide the first frequency estimate of IFN-producing cells and are discussed with respect to the physiological role of IFN-gamma release from T cells.
Huber and Irschick (1988)IFN-gammaT lymphocytesStimulation of T lymphocytes with alloantigen leads to release of both IL-2 and IFN-gamma.
Zier and Gansbacher (1996)IFN gammaT cellsTumour cell vaccines that secrete interleukin-2 (IL-2) and interferon gamma (IFN gamma) are recognised by T cells while resisting destruction by natural killer (NK) cells.
Zier and Gansbacher (1996)IFN gammaT cellsOur results demonstrated that T cells recognised tumour cells secreting IFN gamma better than those secreting IL-2.
Zier and Gansbacher (1996)IFN gammaT cellThe findings suggest that, in addition to upregulating adhesion molecules, MHC molecules, and correcting defects in antigen presentation pathways, IFN gamma secretion may protect tumour cell vaccines from early NK-mediated destruction, keeping them available for T cell priming.
Cantin et al. (1995)IFN-gammaT-cellSecreted IFN-gamma was present up to 6 months into latency in areas of the T-cell infiltration.
Rana et al. (2010)IFN-gammaT cellsTherefore, UVA does not inhibit the expansion, migration or IFN-gamma secretion of CD8 T cells during a primary immune response.
Beinborn et al. (2010)IFN-gammaT cellsProviding a link to amplified immune function, SP and TGF-beta, when applied in combination, trigger a strong release of the proinflammatory cytokines IFN-gamma and IL17 from intestinal inflammatory T cells, whereas either agonist alone shows no effect.
Cheung et al. (2010)IFN-gammaT cellsThe results from cytotoxicity and ELISPOT assays indicated that a significant amount of IFN-gamma was secreted by the T cells of the vaccinated mice, and the T cells were able to eliminate the corresponding peptide-loaded T2 cells.
Skarica et al. (2009)IFN-gammaT cellsIL-17- and IFN-gamma-secreting T cells play an important role in autoimmune responses in multiple sclerosis and the model system experimental autoimmune encephalomyelitis (EAE).
Hu et al. (2009)IFN-gammaT cellsThese potent antitumor effects were induced primarily by CD8(+)T cells, secreting IFN-gamma while CD4(+)T cells were also involved as a help of antitumor immunity.
Bialecki et al. (2009)IFN-gammaT lymphocytesWhen pulsed with OVA peptide (but not whole OVA), MZB cells promote the release of IFN-gamma and IL-4 by Ag-specific CD4(+) T lymphocytes and their stimulation with the TLR9 agonist CpG oligodeoxynucleotide (ODN), a potent MZB cell activator, biases them toward more Th1 inducers.
Cabrera et al. (2009)interferon gammaT-cellIn vitro stimulation of splenocytes from vaccinated mice with either recombinant IF3 (rIF3) or crude Brucella protein extracts resulted in a T-cell proliferative response and induction of interferon gamma secretion, but not interleukin-4.
Wahl et al. (2009)IFN-gammaT cellsBy generating a knockout mouse strain deficient for the common IL-20R beta-chain (IL-20R2), we show that IFN-gamma and IL-2 secretion is significantly elevated after stimulation of IL-20R2-/--deficient CD8 and CD4 T cells with Con A or anti-CD3/CD28 in vitro.
Morris et al. (2009)interferon-gammaT cellStimulation of host DCs by G-CSF subsequently unleashed a cascade of events characterized by donor natural killer T cell (NKT cell) activation, interferon-gamma secretion and CD40-dependent amplification of donor cytotoxic T lymphocyte function during the effector phase of GVHD.
Belyakov et al. (2008)IFN-gammaT cellsA single systemic immunization with rMVA was sufficient to induce high-avidity IFN-gamma secreting CD8+ T cells in systemic organs, whereas a single mucosal immunization with rMVA was not sufficient to elicit high-avidity CD8+ T cells in mucosa.
Kaiko et al. (2008)IFN-gammaT cellsOVA peptide-pulsed infected BMDC induced significant proliferation of transgenic CD4(+) DO11.10 (D10) T cells, strongly inhibited IFN-gamma secretion by D10 cells, and promoted a Th2 phenotype.
Cottingham et al. (2008)IFN-gammaT-cellsIn addition, we found a higher frequency of triple-positive IFN-gamma, TNF-alpha and IL-2 secreting E3-specific CD8+ T-cells 8 weeks after vaccination with MVA lacking B15R.
Jarnicki et al. (2008)IFN-gammaT cellsIn addition, inhibition of p38 enhanced the antitumor therapeutic efficacy of DC pulsed with Ag and CpG and this was associated with an enhanced frequency of IFN-gamma-secreting T cells and a reduction of Foxp3(+) Treg cells infiltrating the tumors.
Bungener et al. (2008)IFNgammaT cellsWIV induced a TH1 skewed humoral and cellular immune response, characterized by strong influenza-specific IgG2a responses and a high number of IFNgamma-secreting T cells.
Walton et al. (2008)IFN-gammaT cellsFurthermore, MCMV-specific CD4 T cells displayed a Th1 phenotype, secreting high levels of IFN-gamma and TNF-alpha and to some extent IL-2, cytokines which are involved in protection from CMV disease.
Jiang et al. (2008)IFN-gammaT cellsThis may due to the induction of a Th2-bised immune response specified with decreased expression of tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma but increased expression of IL-10 and IL-4 in serum and heart tissue, more IL-4 but less IFN-gamma secreting splenic CD4+ T cells, an immunoglobulin G1 isotype switch, increased expression of GATA-3 and low proliferation of CD8+ T cells, without significant change of virus titer in heart tissue.
Gurer et al. (2008)IFN-gammaT cellsIn addition, using a novel mouse model with reconstituted human immune system components, we demonstrated that vaccination with alphaDEC-205-EBNA1 antibodies primed EBNA1-specific IFN-gamma-secreting T cells and also induced anti-EBNA1 antibodies in a subset of immunized mice.
Gray et al. (2008)IFN-gammaT cellsIn particular, anti-4-1BB/anti-CD25 resulted in excellent expansion of specific CD8+ T cells but produced fewer IFN-gamma-secreting effector cells than the other combinations.
Iglesias et al. (2008)IFN-gammaT cellsAccording to our studies in mice, the nasal-subcutaneous co-administration of this multiantigenic formulation induces a strong Th1-biased specific response against CR3, CD8+ T cells in mice spleen and IFN-gamma-secreting cells in mesenteric lymph nodes.
Lian et al. (2007)IFN-gammaT cellsIn addition, T cells from lymph nodes of mice vaccinated with pIL-18 or pAPOPTIN + pIL-18 secreted high levels of the Th1 cytokine IL-2 and IFN-gamma, indicating that the regression of tumor cells is related to a Th1-type dominant immune response.
Scheiblhofer et al. (2007)IFN-gammaT-cellsGene gun immunization has been associated with the induction of a heterologous type of immune response characterized by a T(H)1-like immune reaction on the cellular level, i.e. generation of IFN-gamma secreting CD8(+) T-cells, yet a T(H)2 biased serology as indicated by high IgG1:IgG2a ratios and induction of IgE.
Seo et al. (2007)IFN-gammaT cellSplenocytes of mice immunized with irradiated OVA showed a significant reduction in OVA-specific T cell proliferation and the secretion of Th1-type (IFN-gamma and IL-2) and Th2-type cytokines (IL-4 and IL-6).
Kim et al. (2007)IFN-gammaT cellsSplenocytes from the mice vaccinated with Bac-VSV-G expressing mTERT (Bac-VSVG-mTERT) showed significantly increased numbers of mTERT-specific IFN-gamma-secreting T cells using an ELISPOT technique, and also showed increased NK cell activity.
Belyakov et al. (2007)IFN-gammaT cellsTranslating to the CD8(+) CTL avidity distribution in rhesus macaques, intrarectal vaccination induced more high-avidity mucosal CTL than s.c. vaccination and protection of mucosal CD4(+) T cells from AIDS viral depletion, whereas systemic immunization induced higher avidity IFN-gamma-secreting cells in the draining lymph nodes but no protection of mucosal CD4(+) T cells, after mucosal challenge with pathogenic simian/human immunodeficiency virus.
Ordway et al. (2007)IFN-gammaT cellIn addition, we further demonstrate that the HN878 infection was associated with a potent TH1 response, characterized by the emergence of both CD4 and CD8 T cell subsets secreting IFN-gamma.
Lysaght et al. (2007)IFN-gammaT cellsPeritumoral administration of CpG enhanced the frequency of IFN-gamma-secreting and reduced IL-10-secreting CD4(+) and CD8(+) T cells, in the tumor and in the draining lymph nodes, whereas, CT significantly enhanced the frequency of CD4(+)CD25(+)Foxp3(+) Treg cells, but reduced IFN-gamma-secreting T cells infiltrating the tumor.
Zhu et al. (2007)IFN-gammaT cellsThe number of IFN-gamma secreting T cells reached over 350SFU per million splenocytes against a CD8+ T cell-specific epitope of GFP.
Claassen et al. (2007)IFN-gammaT cellAnalysis of post-challenge T cell responses in immunized mice indicated that G-specific pulmonary CD4 T cells displayed a mixed Th1/Th2 phenotype, which was characterized by the presence of both IL-5 and IFN-gamma secreting cells, in the absence of overt pathology.
Pop et al. (2007)interferon-gammaT-cellsDespite differences in efficacy, a similar frequency of GAD65-specific CD4(+) T-cells secreting IL-4, IL-10, or interferon-gamma were detected in mice treated with pGAD65+pIL4+pIL10 and pGAD65+pIL10.
Hu et al. (2006)IFN-gammaT cellsHere, we show a recombinant form of extracellular domain of mouse EGFR, in the presence of DCs, could activate human peripheral T cells to proliferate, secret IFN-gamma, the induced responses could cross-react with human EGFR and kill autologous EGFR-positive lung cancer cells which could be blocked by anti-CD8 and anti-MHC class I antibody.
Brischwein et al. (2006)interferon gammaT cellsMT110 induced a costimulation independent polyclonal activation of CD4- and CD8-positive T cells as seen by de novo expression of CD69 and CD25, and secretion of interferon gamma, tumor necrosis factor alpha, and interleukins 2, 4 and 10.
Hahn et al. (2006)IFN-gammaT cellsThis triple combination therapy elicits a tumor-specific immune response evidenced by elevated IFN-gamma and IL-4 secretion by CD4+ T cells and results in increased infiltration of CD4+ and CD8+ T cells to the tumor site.
Van Rhijn et al. (2006)IFN-gammaT cellIn mice and humans, CD1d is known to present Ag to NKT cells, a T cell lineage that is characterized by a limited TCR repertoire, capable of rapidly secreting large amounts of IFN-gamma and IL-4.
Xiang et al. (2006)IFN-gammaT cellIn both strains of mice inoculated with DC transduced with an adenovirus, the generated NS3 specific antibody response and IFN-gamma-secreting T cell response were stronger than that generated by rNS3-pulsed DC.
Westendorf et al. (2006)interferon gammaT cellsTransgenic CD8+ T cells secreted vigorous amounts of proinflammatory cytokines like interferon gamma/tumor necrosis factor alpha.
Gotsman et al. (2006)interferon-gammaT cellsCD4+ T cells from ICOS-deficient chimeras proliferated more and secreted more interferon-gamma and tumor necrosis factor-alpha than T cells from control mice, which suggests a lack of regulation.
Okada (2006)IFN-gammaT cellsProtective efficacy of this vaccine was associated with the emergence of IFN-gamma-secreting T cells and activation of proliferative T cells as well as CTL induction upon stimulation with the HSP 65 and antigens from M. tuberculosis.
Arens et al. (2005)IFN-gammaT cellsCD95-deficient (lpr/lpr) T cells massively expanded and differentiated into IFN-gamma-secreting effector cells in transgenic mice that constitutively express the CD27 ligand, CD70.
Burns et al. (2005)IFN-gammaT cellsThese data explain the recruitment of IFN-gamma-secreting T cells to the vessel wall, and reinforce the suggestion that the arterial media may be a site of immunological privilege.
Lee et al. (2005)IFN-gammaT cellFurthermore, when WKYMVm was codelivered with HIV, HBV and Influenza DNA vaccines, WKYMVm selectively enhanced the vaccine-induced CD8(+) T cell responses in a dose-dependent manner, in terms of IFN-gamma secretion and cytolytic activity.
Wei et al. (2005)IFN-gammaT cellsThe tumors grew, then regressed, and neu-specific antibodies and IFN-gamma-secreting T cells were induced.
Owen et al. (2005)IFN-gammaT lymphocytesThis increased production may be involved in the downregulation of IFN-gamma by the T cells of tumor-bearing mice previously reported in this model, as treatment of splenic T lymphocytes with CCL2 resulted in a decreased secretion of IFN-gamma by those cells.
McAllister et al. (2004)IFN-gammaT cellsIn this study, we show that CD8+ T cells that have a T cytotoxic-1 response to PC in BALB/c mice, as determined by secretion of IFN-gamma, have in vitro killing activity against PC and effect clearance of the organism in adoptive transfer studies.
Pinto et al. (2004)interferon-gammaT cellsProtection afforded by this attenuated strain coincided with a number of factors that were not associated with BCG vaccination: long-term persistence of the strain within the host, sustained and potent induction of antimycobacterial interferon-gamma-secreting cells equal to that induced by virulent M. tuberculosis, and elicitation of T cells recognizing dominant M. tuberculosis antigens absent from BCG.
Le Gall et al. (2004)IFN-gammaT-cellIn mixed lymphocyte cultures, both diabody and scFv, but not the monoclonal antibody OKT3, were able to suppress T-cell activation and secretion of IL-2 and IFN-gamma in a dose-dependent manner.
Rosset et al. (2004)IFN-gammaT cellsWhen CpG were used, vaccination with peptides P143-172 and P158-187 generated IFN-gamma-secreting splenic T cells, and only P158-187 significantly stimulated IL-4-secreting T cells.
WŁest et al. (2004)IFN-gammaT-lymphocytesA single injection of this non-replicating vector into BALB/c mice resulted in a strong induction of NS3-specific, IFN-gamma secreting T-lymphocytes as measured by direct ex vivo ELISpot assay.
Takagi et al. (2004)interferon-gammaT lymphocytesElispot assay showed a higher population of interferon-gamma secreting T lymphocytes in mice immunized with fusion cells.
Hsieh et al. (2004)IFN-gammaT cellsIntraperitoneal vaccination of C57BL/6 mice with Vac-CRT/E7 led to a dramatic increase in E7-specific IFN-gamma-secreting CD8+ T cells and a potent antitumor effect against E7-expressing tumors compared to immunization with Vac-E7 or Vac-CRT.
Alonzi et al. (2004)IFN-gammaT lymphocytesAmong these cells, a large fraction of CD8(+) T lymphocytes released mainly IL-10 and, to a lesser extent, IFN-gamma upon mitogenic stimulation in vitro.
Subramanian et al. (2003)IFN-gammaT cellsTreatment with EE significantly decreased the secretion of proinflammatory cytokines (IFN-gamma, TNF-alpha, and IL-6) by activated T cells as well as the expression of a key matrix metalloproteinase, disease-mediating chemokines/receptors, and IgG2a levels, but increased the expression of TGF-beta 3 in the CNS.
Flohť et al. (2003)IFN-gammaT cellsAgain, a Th1 bias was noted in that cocultures of allogeneic T cells and HSP60-treated DC released IFN-gamma but only small amounts of IL-10 and no detectable IL-4.
Fachado et al. (2003)IFN-gammaT-cellThis immunization resulted in a Th1-type response with predominance of IgG2a and a specific T-cell proliferation with high levels of interferon-gamma (IFN-gamma) secretion, whereas no IL-4 was detected.
Vasconcelos et al. (2003)interferon-gammaT cellsSequential immunization consisting of two priming doses of p154/13 followed by booster injections with recombinant Trypanosoma cruzi trans-sialidase protein significantly improved specific type 1 immune response, as revealed by a drastic reduction of the serum IgG1/IgG2a ratio and by an increase in the in vitro interferon-gamma secretion by CD4 T cells.
Jang et al. (2003)IFN-gammaT cellsAlso, increased numbers of IFN-gamma-secreting CD8(+) T cells were elicited when CT-treated BM-DCs were co-cultured with allogenic CD8(+) CTLs.
Tsuji et al. (2003)IFN-gammaT cellsOPP clones secrete TGF-beta, IFN-gamma and low levels of IL-10, a cytokine pattern similar to that secreted by anergic T cells.
Zhang et al. (2003)interferon-gammaT-cellSplenocytes from OVA-primed BALB/c mice proliferated in response to stimulation with a syngeneic OVA-specific T-cell clone, OVA-T3, and secreted interferon-gamma (IFN-gamma) but not interleukin-4 (IL-4).
Kipnis et al. (2003)interferon-gammaT cellsSuch animals showed similar numbers of activated T cells as wild-type mice, as determined by their expression of the CD44hi CD62lo phenotype, but a transient reduction in cells secreting interferon-gamma.
Goonetilleke et al. (2003)IFN-gammaT cellsProtection in the lung correlated with the induction of Ag 85A-specific, IFN-gamma-secreting T cells in lung lymph nodes.
Loirat et al. (2003)IFN-gammaT cellsIn these mice, injection of plasmid DNA encoding HBsAg induced a high frequency of CD8(+) T cells secreting IFN-gamma in the periphery, with in vitro cytolytic activity and specificity for two dominant HBs-specific HLA-A2-restricted epitopes.
Loirat et al. (2003)IFN-gammaT cellIn the absence of a CD4(+) T cell response, the IFN-gamma-secreting CD8(+) T cells primed by DNA-based immunization were unable to exert their antiviral functions in vivo on liver cells expressing the transgene product.
Rouard et al. (2003)IFN-gammaT cellsCompared to AdUb(-)-transduced DC, AdUb(+)-transduced DC triggered a higher number of pol 476-specific IFN-gamma-secreting CD8(+) T cells.
Chapdelaine et al. (2003)IFN-gammaT cellsInfection of mice with either recombinant Mycobacterium bovis (BCG) expressing IL-15 (BCG-IL-15) or BCG and purified IL-15 resulted in an increased CD44, IL-2Rbeta expression and increased frequency of IFN-gamma-secreting CD8(+) T cells.
Fiscella et al. (2003)IFN-gammaT cellsTreatment of primary human and murine T cells with TIP in vitro resulted in the secretion of IFN-gamma, TNF-alpha, and IL-10, whereas in vivo TIP had a protective effect in a mouse acute graft-versus-host disease (GVHD) model.