Viewing affirmative mentions of localization of Cd4 (M. musculus) in T cells

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Watanabe et al. (2005)CD4T cellsCD4+CD25+ T cells regulate colonic localization of CD4 T cells reactive to a microbial antigen.
Orme et al. (1993)CD4T cellsThe results of the present study, however, indicate that the emergence of interferon-gamma secreting protective CD4 T cells in such mice is not absent, but merely delayed.
Kumar and Sercarz (1998)CD4T cellsInduction or protection from experimental autoimmune encephalomyelitis depends on the cytokine secretion profile of TCR peptide-specific regulatory CD4 T cells.
Kumar and Sercarz (1998)CD4T cellsIn this report, we reveal that the cytokine secretion pattern of TCR peptide-specific regulatory CD4 T cells can profoundly influence whether a type 1 or type 2 population predominates among MBP-specific CD4 effectors.
Barbey et al. (2004)CD4T cellCONCLUSION: INT with OVA but not with OVAp led to regional (as opposed to systemic) T cell activation and the induction of IL-10 secreting CD4(+) T cells in BLN, potentially critical steps in the induction of T cell-specific tolerance via the nasal route.
Chen et al. (2001)CD4T cellInterestingly, Sig/E7/LAMP-1 vaccinia induced both E7-specific IFN-gamma- and IL4-secreting CD4(+) T cell precursors while Sig/E7/LAMP-1 DNA induced only E7-specific IFN-gamma-secreting CD4(+) T cell precursors.
Curotto de Lafaille et al. (2004)CD4T cellsThe maintenance of CD25 expression by CD4(+)CD25(+) cells depends on IL-2 secreted by cotransferred CD4(+)CD25(-) or by Ag-stimulated T cells in peripheral lymphoid organs.
Mottram et al. (2000)CD4T cellThe use of C57BL/6 bml mice transgenic for a rat anti-CD4 antibody (GK5 mice) as pancreas donors provided allografts that secreted sufficient anti-CD4 antibody to cause CD4 T cell depletion in the recipients (CD4 cells decreased from 30 to < 5% of small lymphocytes).
Sacquin et al. (2008)CD4T cellsAfter a single injection of P9, the number of IFN-gamma secreting CD4+ T cells was also reduced in mice 8- to 10-wk postinfection compared with healthy mice.
Ostler and Ehl (2002)CD4T cellsThis was accompanied by preferential pulmonary recruitment of CD4(+) T cells secreting IL-5.
Surman et al. (2001)CD4T cellLocalization of CD4+ T cell epitope hotspots to exposed strands of HIV envelope glycoprotein suggests structural influences on antigen processing.
Nishimura et al. (1992)CD4T cellsWhen stimulated by an immobilized CD3 mAb, the CD45RC+CD4+ T cell subset preferentially secreted IL-2 and CD45RC-CD4+ T cells produced IL-4.
Hoffmann et al. (2002)CD4T cellsThis protective effect depended in part on the ability of the transferred CD4(+)CD25(+) T cells to secrete interleukin 10 and occurred if the T(reg) cells were of donor, but not host, origin.
Lin et al. (2010)CD4T cellsIn summary, these findings reveal quantitative and qualitative differences in the CD4(+) T cell response to a persistent virus infection and demonstrate that naive antiviral CD4(+) T cells are recruited during chronic polyomavirus infection.
Uhlig et al. (2006)CD4T cellsCharacterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis.
Barclay et al. (2008)CD4T cellA fluorescence-activated cell sorter (FACS) was used to confirm CD4+T cell depletion.
Roman et al. (2010)CD4T-cellHere we report that stimulation under hypoxic conditions augments the secretion of effector CD4(+) T-cell cytokines, especially IFN-gamma.
Leavenworth et al. (2010)CD4T cellAnalyses of the underlying mechanism revealed that administration of anti-NKG2A F(ab')(2) Ab reduces CD4(+) T recall responses to MOG and skews the proportion of IL-17- and IFNgamma-producing CD4(+) T cells toward the protective IL-4- and IL-10-secreting CD4(+) T cell subpopulations.
Alwan et al. (1992)CD4T cellThe unseparated T cell line and the CD4+ cell fraction secreted significant amounts of IL-3, IL-4 and IL-5 (P less than 0.001).
Liu et al. (2008)CD4T cellsWe show that mice with targeted-deletion of Stat3 in CD4(+) T cells (CD4(Stat3)(-/-)) do not develop experimental autoimmune uveoretinitis (EAU) or experimental autoimmune encephalomyelitis.
Liu et al. (2010)CD4T cellsThe localization of CD4+Foxp3+T cells was captured by a confocal laser scanning microscope (TCS sp2/AOBS,LEICA) and analyzed with the leica confocal software package.
Bardos et al. (2003)CD4T cellsPurification of CD4+CD25+ and CD4+CD25- T cells and cell transfer in SCID mice
Codias and Malek (1993)CD4T lymphocytesSubsets of activated CD4 T lymphocytes refractory for secretion of IL-2 are distinguished by expression of Ly-6A/E in BALB/c mice.
Fraser et al. (2009)CD4T cellsRESULTS: Dasatinib inhibited antigen-specific proliferation of murine CD4(+) and CD8(+) transgenic T cells in vitro and in vivo.
Peters et al. (2009)CD4T cellWe conclude that the generation of CD4 T cells producing IL-2, IFN-gamma and IL-4 requires CD4 T cell cooperation and that this cooperation is not mediated simply by CD40-CD40L interactions.
Overstreet et al. (2011)CD4T cellIndeed, IL-2 secreting CD4+ T cells are associated with slower HIV disease progression [33] and studies evaluating the functionality of anti-HIV CD8+ T cell responses point to a role of IL-2 in supporting recall responses [34], [35].
Lysaght et al. (2007)CD4T cellsPeritumoral administration of CpG enhanced the frequency of IFN-gamma-secreting and reduced IL-10-secreting CD4(+) and CD8(+) T cells, in the tumor and in the draining lymph nodes, whereas, CT significantly enhanced the frequency of CD4(+)CD25(+)Foxp3(+) Treg cells, but reduced IFN-gamma-secreting T cells infiltrating the tumor.
Yao et al. (2007)CD4T cellsWe examined the IFN-gamma, IL-2, IL-4 and IL-10 of T-cell type cytokines transcriptions and the proportions of IFN-gamma, IL-4 and IL-10-secreting CD4(+)/CD8(+) T cells.
Berzins et al. (1998)CD4T cellsAs a population, RTE are phenotypically mature, but were distinct from resident T cells in the periphery, being released in a CD4/CD8 ratio approximately twice that of established peripheral T cells.
Yoshida et al. (2001)CD4T cellCo-transfer of an IL-10-secreting OVA-specific CD4 T cell line prevented colitis.
Chen et al. (2009)CD4T cells-secreting CD4+CD25+ T cells indicates that p570 is a protective epitope.
Funderburg et al. (2010)CD4T cellWhen both arms were combined, however, decreases in CD38 expression on both CD4+ and CD8+ T cells were linked to the magnitude of CD4+ T cell restoration.
Berges et al. (2006)CD4T cellAlthough capable of causing persistent infection as assessed by PCR, the GFP virus harboring additional genomic burden might not be robust enough to produce CD4 T cell depletion.
Berges et al. (2006)CD4T cellThis data adds further evidence for CD4 T cell depletion as seen in peripheral blood assayed by FACS.
Berges et al. (2006)CD4T cellThe above proof-of-concept data also showed that viral infection leads to CD4 T cell depletion.
Berges et al. (2006)CD4T cellCD4 T cell levels were calculated as a ratio of the entire CD3 population (CD4+CD3+:CD4-CD3+).
Bradley et al. (1991)CD4T cellsMice depleted of precursor CD4+ T cells by adult thymectomy exhibited limited capacity to generate lymphokine secreting CD4+ T cells in response to primary immunization with KLH, suggesting that the majority of lymphokine producing T cells arise from short-lived and/or precursor cells.
Kasai et al. (2008)CD4T cellsBone marrow-derived DC (BMDC) from newly generated gp49B-deficient (gp49B(-/-)) mice induced enhanced proliferation and IL-2 release of antigen-specific CD4(+) and CD8(+) T cells compared with BMDC from wild-type mice, in a cell-cell contact manner.
Peng et al. (2000)CD4T cellsThese data indicate that even without specific vaccine maneuvers, progressive tumor growth leads to independent sensitization of both CD4(+) and CD8(+) anti-tumor T cells in TDLN, phenotypically L-selectin(low) at the time of harvest, each of which requires only culture activation to unmask highly potent stand-alone effector function.
Palma et al. (2007)CD4T cellLoss of protection was associated with a overwhelming CD4+ T cell proliferation and IFN-gamma production in response to Ag85B protein, despite restraint of Th1 response by CD8+ T cell-dependent mechanisms and activation of CD4+ T cell-dependent IL-10 secretion.
Yog et al. (2010)CD4T cellTherefore, we hypothesized that n-3 PUFAs suppress CD4(+) T cell mitochondrial translocation during the early stages of IS formation and downmodulate Ca(2+)-dependent Th cell activation.
Erb et al. (1991)CD4T-cellSeveral effector functions and the lymphokine secretion pattern of 30 antigen-specific CD4+ T-cell clones have been investigated.
Saban et al. (2008)CD4T cellWe then assessed whether T cell proliferation plays a role in these observed alterations of CD4+ and CD8+ T cell percentages during the induction and expression of ACAID.
Bendelac (1992)CD4T lymphocytesThis may impart different functional capabilities--such as the potential to secrete IL-4--to a subset of emerging CD4+ T lymphocytes that express TCRs with intermediate affinities for self.
Kelchtermans et al. (2005)CD4T cellsTo purify CD4+CD25+ and CD4+CD25- cells, the enriched CD4+ T cells were incubated for 20 min at 4°C with FITC-conjugated anti-CD25 and phycoerythrin (PE)-conjugated anti-CD4 antibodies (10 ?
Zhang et al. (2008)CD4T cellSome mouse strains expressing single HIV proteins developed symptoms of AIDS such as wasting and CD4+ T cell depletion.
Fei et al. (2010)CD4T cellsCD4+CD25+ T cells and CD4+CD25- T cells were stimulated with anti-CD3, anti-CD28 and IL-2 in the presence or absence of 25 ?
Fei et al. (2010)CD4T cellsCD4+CD25+ T cells and CD4+CD25- T cells were stimulated and treated with or without 25 ?
Fei et al. (2010)CD4T cellsNilotinib shows inhibitory effects on cytokine secretion of CD4+CD25+ T cells and CD4+CD25- T cells
Walton et al. (2008)CD4T cellsFurthermore, MCMV-specific CD4 T cells displayed a Th1 phenotype, secreting high levels of IFN-gamma and TNF-alpha and to some extent IL-2, cytokines which are involved in protection from CMV disease.
De Winter et al. (1999)CD4T cellsHowever, their lymphokine profile when activated is different, and anti-inflammatory cytokines secreted and/or induced by CD4(+)CD45RBlow T cells prevent colitis.
Elvang et al. (2009)CD4T cellThis clearly demonstrated that combining rH4 and Ad-H4 had a strong additive effect on priming for both the CD4 and CD8 T cell response.
Lamb et al. (2010)CD4T cellAs expected, CD4+ T cell responses to S. mansoni were impaired by Bcl10 deletion, as measured by acquisition of an activated phenotype (Figures S1A and B) and cytokine production (Figure S1C), suggesting that activation of CD4+ T cells through the TCR and subsequent CD4+ T cell responses are dispensable for normal schistosome development.
Kanagawa et al. (1992)CD4T cellWe have established V beta 5+ T cell lines, clones, and hybridomas expressing identical TCR with different CD4/CD8 phenotypes and demonstrated that T cell reactivity to B6-1710 is, although not absolute, dependent on the presence of CD4 molecules.
Kennedy et al. (1995)CD4T lymphocytesCytokines released from CD4+ T lymphocytes contribute to the pathogenesis of asthma by influencing the differentiation and function of eosinophils, the primary effector cells that cause airway epithelial damage.
Veltkamp et al. (2006)CD4T cellsIn the absence of regulatory CD4+CD25+ T cells, recipient CD4 cells secreted IFN-gamma in response to stimulation with intestinal bacterial antigen that was prevented in vivo and in vitro by regulatory CD4+CD25+ cells.
Ji et al. (2006)CD4T cellsFlow cytometry analysis was used to determine type 1 and type 2 cytokine-secreting CD4+ T cells, to test apoptosis of CD4+ T cells and to count CD4+CD25+ T cells, a kind of regulatory subpopulation of CD4+ T cells.
Barclay et al. (2008)CD4T cellsIn addition, the presence of CD4+T cells did not cause suppression of the dominant genotype (figure 2b; table 4).
Nagata and Yoon (1992)CD4T-cellsCD4+ T-cells may secrete cytokines, which in turn activate effector cell populations, whereas CD8+ T-cells may act as a final effector directly involved in beta-cell destruction.
Corthay et al. (2005)CD4T cellsUpon recognition of tumor-derived antigenic peptides presented on MHC-II by macrophages, the myeloma-specific CD4+ T cells were reactivated and started to secrete cytokines.
Kropf et al. (2002)CD4T cellsSince the majority of parasites persist at the local site of infection in nonhealing BALB/c mice, these results show that CD4(+) T1/ST2(+) T cells are localized at the site of active infection and inflammation in this model.
Hopkins et al. (2005)CD4T-cellsIn conclusion, the data presented indicates that subcutaneous administration to mice of SMX-NO, but not the parent drug, stimulated the secretion of high levels of IL-5 from activated CD4(+) T-cells, which is consistent with the clinical profile of the drug.
Pop et al. (2007)CD4T-cellsDespite differences in efficacy, a similar frequency of GAD65-specific CD4(+) T-cells secreting IL-4, IL-10, or interferon-gamma were detected in mice treated with pGAD65+pIL4+pIL10 and pGAD65+pIL10.
Voice et al. (2003)CD4T cellDependence of the Th phenotype of T mice, but not of N or K mice, on T cell-derived VIP now is proven by showing that eliminating VIP from TCR-stimulated T cell cultures with VIPase IgG normalizes the elevated number of IL-4-secreting CD4 T cells, decreases the secretion of IL-4 and IL-10, and increases the secretion of IFN-gamma.
Voice et al. (2003)CD4T cellsFlexible responsiveness of CD4 T cells from N and K mice, but not T mice, to exogenous VIP in vitro and in vivo is shown by increased numbers of IL-4-secreting CD4 T cells, greater secretion of IL-4 and IL-10, and lesser secretion of IFN-gamma after TCR stimulation with VIP.
Lutz and Kurts (2009)CD4T-cellInduction of peripheral CD4+ T-cell tolerance and CD8+ T-cell cross-tolerance by dendritic cells.
McKnight et al. (1994)CD4T lymphocytesThus, the requirement for costimulation is related more to lymphokine secretion profiles than to the previous activation status of CD4+ T lymphocytes.
Tsang et al. (2006)CD4T cellsImportantly, they were more potent than freshly isolated CD4(+)CD25(+) T cells in suppressing proliferation and cytokine secretion by effector CD4(+) T cells.
Kianizad et al. (2007)CD4T-cellElevated frequencies of self-reactive CD8+ T cells following immunization with a xenoantigen are due to the presence of a heteroclitic CD4+ T-cell helper epitope.
Luqman and Bottomly (1992)CD4T cellsActivation of memory CD4 T cells to proliferate and secrete IL-2/IL-4 only required occupancy of the TCR complex, whereas activation of naive CD4 T cells required an APC-derived signal as well.
Nagata et al. (1993)CD4T cellWhen BALB/c CD4+ T cell subsets were sorted and cultured with irradiated (25 Gy) antigen-presenting cells, stimulation with immobilized anti-CD3 mAb for 2 days resulted in CD4+25T3+ cells secreting more interleukin-2 and less interleukin-4 than did CD4+25T3- subsets, although the proliferative responses of the cells on day 2 of culture were similar.
Haring et al. (2001)CD4T cellsIn mice with chronic demyelination, 10 to 15% of the CD4 T cells secreted IFN-gamma in response to MHV-specific peptides.
Gilfillan et al. (1998)CD4T cellsThese CD4+ T cells also secreted IFN-gamma in response to various stimuli (e.g., protein Ag, bacterial superantigen, and alloantigen), but were deficient in IL-2 secretion.
Chiarella et al. (2007)CD4T cellThus, in pulmonary PCM: (a) irrespective of the host susceptibility pattern, fungal loads are mainly controlled by CD8+ T cells, whereas antibody production and DTH reactions are regulated by CD4+ T cells; (c) CD4+ T cells play a protective role in the resistant and intermediate mouse strains, whereas in susceptible mice they are deleted or anergic; (d) genetic resistance to PCM is associated with concomitant CD4+ and CD8+ T cell immunity secreting type 1 and type 2 cytokines.
Gauvrit et al. (2004)CD4T cellsSimultaneously, DNA immunization induced GAD-specific CD4 T cells secreting interleukin (IL)-4 (P < 0.05) and transforming growth factor (TGF)-beta (P = 0.03).
Vingert et al. (2010)CD4T cellOne should note that excessive chronic activation may be deleterious in the long term, as suggested by a trend toward CD4+ T cell decrease in controller patients with the highest degree of immune activation, even in the persistence of undetectable viral load [9].
Kumar and Sercarz (1998)CD4T cellsThus, the encephalitogenic potential of the MBP-reactive effector population is crucially and dominantly influenced by the cytokine secretion phenotype of regulatory CD4 T cells.
Jing et al. (2007)CD4T cellsTreatment of HSC transplant recipients with an anti-CD25 mAb before tumor vaccination inhibited antitumor immunity and significantly decreased the number of IFN-gamma-secreting tumor-specific CD4 T cells.
Akova et al. (1993)CD4T cellsNaive and immune T cells and HSV-1 immune CD4+ and CD8+ subsets from Igh-1 disparate BALB/c congenic mice were adoptively transferred into athymic BALB/c nude mice, which normally do not develop HSK.
Parietti et al. (2008)CD4T cellsThe capacity of CD4+,CD25+ T cells to inhibit the proliferation and cytokine secretion of CD4+,CD25- T cells was assessed after polyclonal activation.
Kägi et al. (1997)CD4T cellsInsulitis with infiltration of CD4(+) and CD8(+) T cells occurred similarly in both groups of animals.
Nagaleekar et al. (2008)CD4T cellsIP3 receptor-mediated Ca2+ release in naive CD4 T cells dictates their cytokine program.
Papiernik and Banz (2001)CD4 CD25T cellsCD4 CD25(+) T cells spontaneously secrete IL-10, which is involved in some of their regulatory functions.
Wang et al. (2000)CD4T cellsLNCs from CD4 and CD8 KO mice produced significant amounts of IFN-gamma, indicating that both CD4(+) and CD8(+) T cells are able to secrete IFN-gamma.
Sun et al. (2009)CD4T lymphocytesThe tumor size changes were observed, and the tumor-infiltrating lymphocytes (TIL) including CD3+CD4+T, CD3+CD8+T, and CD3+CD4+CD25+T lymphocytes were counted with flow cytometry.
Kolbus et al. (2010)CD4T cellsand IL-10 secreted by polyclonally activated CD4+ and CD8+ T cells as depicted in Figure 5.
Kolbus et al. (2010)CD4T cellsremained elevated in CD8+CD28+ T cells (Figure 6F), while no changes in the population of CD4+CD25+FoxP3+ (8.6 ± 2.1% vs. 7.2 ± 1.6% of CD4+ cells, n.s.), CD4+CD28+ IFN-?
Ise et al. (2000)CD4T cellsNaive CD4(+) T cells secreted either Th1- or Th2-type cytokines immediately after stimulation with OVA323-339 or its single amino acid-substituted analogs.
Huang et al. (2007)CD4T cellsIn addition, DTG CD4 T cells stimulated by OVA secrete a mean of 2.5-fold more IL-17 than those from OTII single transgenic mice with concomitantly higher levels of mRNA encoding IL-17 by real-time PCR and of CD4 T cells with intracellular IL-17 detected by ELISPOT assays.
Iijima et al. (2008)CD4T cellsCD4 T cells secrete cytokines such as IFN-?
Schneider et al. (2010)CD4T cellsIFN-gamma secreted by natural killer, CD4 Th 1 and CD8 T cells upon instruction by IL-12 and -18 activates MPhi to restrict mycobacterial growth.
Vicari et al. (2009)CD4T cellsFinally, gene expression profiling and studies of tumor-associated immune cells revealed a complex modulation of the PF-3512676-induced immune response by paclitaxel, including a decrease of IL-10 expression and an increase in IL-17-secreting CD4(+) T cells.
Jiang et al. (2008)CD4T cellsThis may due to the induction of a Th2-bised immune response specified with decreased expression of tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma but increased expression of IL-10 and IL-4 in serum and heart tissue, more IL-4 but less IFN-gamma secreting splenic CD4+ T cells, an immunoglobulin G1 isotype switch, increased expression of GATA-3 and low proliferation of CD8+ T cells, without significant change of virus titer in heart tissue.
Feleszko et al. (2007)CD4T cellsOral LGG administration particularly suppressed allergen-induced proliferative responses and was associated with an increase in numbers of TGF-beta-secreting CD4+/CD3+ T cells in mesenteric lymph nodes (6.5, 16.7%) as well as nearly 2-fold up-regulation of Foxp3-expressing cells in peribronchial lymph nodes.