Viewing affirmative mentions of positive regulation of IL2 (H. sapiens) in mononuclear cells

Full-text article links are indicated by after the article reference.

Document Target Regulator Anatomy Sentence
Smith and Roberts-Thomson (1989)IL-2mononuclear cellsIn contrast, in the seronegative arthritis patient group only SF mononuclear cells were hyporesponsive to mitogenic stimulation and there were no significant differences in IL-2 production or IL-2 receptor upregulation as compared with control subjects.
Smith and Roberts-Thomson (1989)IL-2mononuclear cellsNo significant correlations were observed between IL-2 inhibitor levels and mitogenic responses, IL-2 production and IL-2 receptor upregulation on peripheral blood and SF mononuclear cells but an inverse correlation was noted between SF mitogenic responses and the expression of selected activation markers.
Bruserud and Moen (1984)interleukin 2mononuclear cellsCulture conditions which would enhance production of interleukin 2 (IL-2) from PHA-stimulated peripheral blood mononuclear cells (PBM) were studied.
McElhaney et al. (1990)IL2PBMCAfter stimulation with a 1/320 dilution of the same influenza vaccine, cultures of PBMC from young controls showed a significantly greater increase in IL2 production than the cultures of PBMC from the elderly group of patients.
Clouse et al. (1984)TCGFmononuclear cellsSecretion of TCGF is induced after stimulation of human peripheral blood mononuclear cells ( PBMNC ) with herpes simplex virus type 1 (HSV-1).
Tsang et al. (1986)IL-2PBMCTreatment (of human PBMC) with ISO enhanced IL-2 production by PBMC from 7 of 10 normal individuals.
Donnelly et al. (1986)IL-2PBMCCoculture of PBMC with NPT-15392 and concanavalin A (Con A) for 24 h resulted in significant increase of IL-2 in the supernatants of such cultures as compared with the IL-2 levels of control, non-NPT-treated, Con A-activated cultures.
Donnelly et al. (1986)IL-2PBMCPretreatment of PBMC with NPT-15392 for 2-4 h prior to activation with Con A was sufficient to achieve maximum enhancement of IL-2 production (20-40% average increase).
Rappaport and Dodge (1982)IL-2mononuclear cellRemoval of adherent cells from mononuclear cell populations also resulted in enhanced IL-2 production.
Venkataraman (1992)IL-2MNCsSimilar to freezing, L-leucine methyl ester (Leu-OMe) treatment (to eliminate IL-1 and prostaglandin E-2 (PGE-2)-secreting cells) also increased the IL-2-producing activities of fresh cells, but freezing no longer enhanced the production of IL-2 by Leu-OMe-treated cells, suggesting that (1) both the freezing process and Leu-OMe treatment have similar effects on IL-2 production, (2) the increased IL-2 secretion by frozen MNCs is independent of IL-1, and (3) inactivation of PGE-2-secreting cells during the freezing procedure is responsible for increased IL-2 secretion.
Hopkins and Failla (1997)IL-2mononuclear cellsFinally, incubation of human peripheral blood mononuclear cells (PBMC) with 2,3,2-tet decreased mitogen-induced IL-2 production by 50% compared with untreated controls.
Kabuki et al. (1990)IL2mononuclear cellsSaibokuto suppressed the induction of IL2 responsiveness induced by Dermatophagoides farinae (Df) antigen in peripheral blood mononuclear cells from patients with bronchial asthma.
Kabuki et al. (1990)IL2mononuclear cellsSaibokuto suppressed the induction of IL2 responsiveness induced by Dermatophagoides farinae (Df) antigen in peripheral blood mononuclear cells from patients with bronchial asthma.
Teodorczyk-Injeyan et al. (2008)IL-2PBMCIL-2 synthesis in PBMC cultures was induced by two different methods.
Shannon and Sandoval (1995)IL-2mononuclear cellsThalidomide increases the synthesis of IL-2 in cultures of human mononuclear cells stimulated with Concanavalin-A, Staphylococcal enterotoxin A, and purified protein derivative.
McElhaney et al. (1992)IL2PBMCWe find that after influenza vaccination, there was an insignificant increase in IL2 activity when PBMC from the young control group were stimulated with A/Shanghai/16/89 (pre, 5.14 U/mL/10(6) PBMC; post, 6.64 U/mL/10(6) PBMC) but there was a significant increase in IL2 activity when stimulated with A/Phillippine/2/82 (pre, 1.5 U/mL/10(6) PBMC; post, 8.3 U/mL/10(6) PBMC).
Carlsson and Sj÷gren (1985)interleukin 2mononuclear cellsStaphylococcal Enterotoxin A (SEA) at picogram amounts induces high levels of interleukin 2 (IL-2) and interferon in human mononuclear cells.
Hawrylko et al. (1991)IL-2mononuclear cellsPeripheral blood mononuclear cells (PBMC) from patients with systemic sclerosis (SSc) produced increased amounts of interleukin-2 (IL-2), in a dose-dependent manner, in response to stimulation with human type I collagen, whereas PBMC from normal subjects did not.
Todoroki et al. (1990)IL-2mononuclear cellsAzelastine suppressed the induction of IL-2 responsiveness induced by Df antigen in peripheral blood mononuclear cells from patients with bronchial asthma in a dose dependent manner.
Phi et al. (1989)IL-2PBMCWe suggest an intrinsic (not disease activity-related) impairment of the adenylate cyclase-dependent regulatory mechanism in the PBMC of SLE patients, which may result in a defective IL-2 production and IL-2 dependent biological functions.
Anderson et al. (1988)IL2mononuclear cellsIn summary, OKT3 + IL2 activation resulted in a large increase in cell yield and the development of high level LAK activity using peripheral blood mononuclear cells from children with cancer.
Flescher et al. (1989)IL-2MNCPolyamine biosynthesis by mononuclear cells (MNC) appears to regulate T cell activity since 1) inhibition of polyamine biosynthesis increases IL-2 production and 2) H2O2 (a product of polyamine oxidase, PAO), suppresses lymphocyte proliferation.
Chou et al. (2009)IL-2PBMCTherefore, 2-OH enhanced IL-2 and IFN-gamma production in PBMC by modulation their gene expression.
Murray et al. (1986)Interleukin-2PBMCInterleukin-2 (IL-2) production following concanavalin A stimulation and the response of peripheral blood mononuclear cells (PBMC) to both IL-2 alone and IL-2 plus indomethacin, a prostaglandin synthetase inhibitor, were examined in 16 melanoma patients and 12 healthy controls.
Murray et al. (1986)IL-2PBMCIndomethacin restored IL-2 production in Stage III PBMC to levels equivalent to that produced by control PBMC.
Kaczmarek et al. (1989)Il-2mononuclear cellsThe TNLC obtained in culture of small thymic fragments in Eagle's minimal essential medium with 30% of fetal calf serum have been found to be biologically active as indicated by their ability to enhance proliferative activity and Il-2 production of peripheral blood mononuclear cells derived from ataxia telangiectasia patients.
Kikuchi et al. (1988)IL-2PBMCAlthough IL-2 production in PBMC of patients with good prognosis was significantly elevated after chemotherapy, that in PBMC of patients with poor prognosis declined to about a half of pre-operative levels.
Cathely et al. (1986)IL2MNCThe prior irradiation of unfractionated MNC induced a marked increase of the PHA-stimulated IL2 production in both active and quiescent patients compared to the moderate augmentation observed for controls.
Wang et al. (1986)IL 2mononuclear cellsThe oxidizing mitogens induce expression of IL 2 receptors on peripheral blood mononuclear cells.
Amendola et al. (2000)IL-2PBMCAnother effect induced by HAART was a significant increase in IL-2Ralpha expression on total PBMC (P < 0.05), independently of cytokine addition.
Zoukos et al. (1994)IL-2mononuclear cellsIncreased expression of high affinity IL-2 receptors and beta-adrenoceptors on peripheral blood mononuclear cells is associated with clinical and MRI activity in multiple sclerosis.
Yoshimura et al. (1996)interleukin-2PBMCLVFX increased interleukin-2 (IL-2) production by PBMC stimulated with PHA in a dose-dependent manner, with more than 10 micrograms/ml of LVFX causing a significant increase.
Sriwanthana and Chavalittumrong (2001)IL-2mononuclear cellsFurthermore, the extract was shown to induce the IL-2 secretion from normal peripheral blood mononuclear cells (PBMC), whereas the IL-4 was not induced in the presence of the D. scandens extract.
Tabata et al. (1988)IL-2PBMFour weeks of oral administration of 0.5 micrograms/day of 1 alpha-OHD3 enhanced the IL-2 production of PBM from the patients.
StŘber et al. (1989)interleukin 2mononuclear cellsThe lack of proliferation in KLEBS M-stimulated mononuclear cells is shown to be due to the inability of this PBA to induce the production of interleukin 2 in T cells.
Downing and Taylor (1987)IL-2mononuclear cellInterleukin-2 (IL-2) production in phytohemagglutinin-stimulated mononuclear cell cultures was also elevated when cells were isolated from hyperthermic individuals relative to a paired normothermic control sample.
Rosztˇczy et al. (1986)IL-2PBMCPretreatment of PBMC with greater than or equal to 100 IU/ml of human-alpha (HuIFN-alpha) or interferon-beta (HuIFN-beta), or with greater than or equal to 10 IU/ml HuIFN-gamma for 4 h enhanced the IL-2 production.
Hassan and Reen (1996)IL-2MNCSince no IL-2 was detected in cell lysates, the presence of high levels of IL-2 mRNA and low IL-2 production suggests inability by neonatal MNC to translate IL-2.
Taylor et al. (1986)IL 2PBMCPHA-induced proliferation and IL 2 receptor expression peaked early in the culture period (routinely to 100,000 cpm and 50% respectively within 3 days), and colchicine did not inhibit the early induction of IL 2 receptors on PBMC.
Hsia et al. (1994)interleukin-2mononuclear cellsSerum antibody against influenza A/Beijing and B/Panama, influenza antigen-stimulated blastogenesis and antigen-stimulated interleukin-2 production by peripheral blood mononuclear cells in vitro were increased following vaccination.
Arinaga et al. (1986)interleukin 2PBMFurthermore, PBM obtained after treatment produced significantly higher levels of interleukin 2.
Uchiyama et al. (1987)interleukin 2mononuclear cellsInduction of the proliferative response and the interleukin 2 production by T cells from human peripheral blood mononuclear cells stimulated with the toxin.
Ma et al. (1995)interleukin-2mononuclear cell[Study on effect of polysaccharides of ginseng on peripheral blood mononuclear cell induced interleukin-2 production and activity of its receptors in vitro].
Lomnitzer (1988)interleukin-2mononuclear cellsIncreased interleukin-2 activity was detected in three out of nine supernatants from PHA activated mononuclear cells which were cultured in the presence of isoprinosine.
Kouttab et al. (1988)IL-2PBMCIt was observed that stimulation of BCGF-12kD and IL-2 was most significantly obtained when the PBMC were activated with lectin.
Reed et al. (1985)IL 2PBMCNorthern blot analysis performed with the use of a cDNA probe specific for the human IL 2 receptor gene demonstrated that OKT11A antibody also decreased the accumulation of IL 2 receptor mRNA induced by PHA in PBMC.
Reed et al. (1985)IL 2PBMCIn combination with PHA or with PHA plus OKT11A, however, rIL 2 augmented both the expression of IL 2 receptor protein on PBMC and the accumulation of IL 2 receptor mRNA in PBMC.
Reed et al. (1985)IL 2PBMCAdding anti-Tac antibody to PBMC cultures to block the interaction of IL 2 with its receptor diminished the accumulation of IL 2 receptor mRNA induced by PHA.
Ebina et al. (1990)IL-2PBMCFurthermore, IL-4 suppresses IL-2 induced IL-1 production in PBMC.
Fuggetta et al. (1993)IL2MNCWhen MNC were treated with IFNs on day 4, after IL2 induction of LAK cells, increase or no change in cytotoxic activity was found.
LeFever et al. (1991)recombinant interleukin-2mononuclear cellsKinetic analysis was used to define lytic events in peripheral blood mononuclear cells (PBMC) activated in lymphokine conditioned medium (LCM) and recombinant interleukin-2 (rIL-2).
Noma et al. (1984)IL2PBMBestatin (1 - 10 micrograms/ml) also increases (1.4 - 21 fold) IL2 production by PHA-stimulated PBM.
Gauchat et al. (1988)lymphokinemononuclear cellsStimulation-dependent lymphokine mRNA levels in human mononuclear cells.
Punturee et al. (2005)IL-2mononuclear cellsIn human peripheral blood mononuclear cells (PBMCs), CA (water extract) and RN (water and ethanol extracts) significantly increased proliferation and the production of IL-2 and TNF-alpha.
Brooks et al. (1992)IL-2PBMCRecombinant human interleukin-4 (IL-4) and transforming growth factor-beta (TGF-beta) reduce recombinant interleukin-2 (IL-2) induction of lymphokine-activated killer (LAK) cell activity from human peripheral blood mononuclear cells (PBMC).
Brooks et al. (1992)IL-2PBMCThis suggests that, although isolated CD3+ cells are not susceptible to IL-4 suppression of IL-2 activation, they are sensitive to inhibition when part of a mixed PBMC population.
Wu et al. (1994)interleukin-2mononuclear cellsIn vitro glutathione supplementation enhances interleukin-2 production and mitogenic response of peripheral blood mononuclear cells from young and old subjects.
Jackson and Scott (1996)interleukin 2PBMCStimulation of PBMC induced low levels of interleukin 2 (IL-2), interferon gamma (IFN-gamma), IL-4, and IL-10 production.
Zorn et al. (1994)IL-2mononuclear cellsSoluble interleukin 2 receptors abrogate IL-2 induced activation of peripheral mononuclear cells.
Shirasaka et al. (1989)IL-2PBMCN-CWS increased the number of PBMC expressing IL-2 receptor on their surfaces, and the presence of N-CWS at the early stage of the culture period was essential for the exertion of its augmentative activity on the LAK induction.
Colˇn et al. (1998)IL-2PBMCHowever, even prior to IL-2 activation, PBMC isolated from some normal subjects and those from almost all individuals who are infected by human immunodeficiency virus type 1 (HIV-1) exhibited significant levels of anti-fungal activity.
Yoshizawa et al. (1989)IL2mononuclear cellsPretreatment of the mononuclear cells with the monoclonal antibody to the HLA-DQ framework (Leu 10), but not the HLA-DR framework (OKIal), blocked the induction of IL2 responsiveness.
McElhaney et al. (1996)IL-2PBMCInitial analysis of the data showed increased IL-2 production in post-vaccination PBMC cultures from the diabetic group compared to the healthy group.
Anderson and Teuber (2010)IL-2PBMCParadoxically, EA and the walnut polyphenolics all significantly and dose-dependently inhibited stimulated [phytohemagglutin (PHA), alpha-CD3, and phorbol myristate acetate (PMA)/ionomycin] PBMC proliferation while simultaneously increasing IL-2 production.
Nakanishi et al. (1999)interleukin-2mononuclear cellsConcanavalin A stimulation significantly (p<0.05 and p<0.01) increased soluble interleukin-2 receptor alpha chain production when mononuclear cells were cultured with triiodothyronine (1-100 nmol/l) for 3 days.
Havas et al. (1993)IL-2mononuclear cellsMost patients' peripheral blood mononuclear cells continued to produce baseline to elevated levels of IL-2, in spite of age and disease status.
Shannon et al. (1997)IL-2mononuclear cellHydrolysis of thalidomide abrogates its ability to enhance mononuclear cell synthesis of IL-2 as well as its ability to suppress the synthesis of TNF-alpha.
Penttila et al. (1990)Interleukin-2mononuclear cellsInterleukin-2 receptor expression increased from 0 to 5.4% of cultured mononuclear cells after 7 days incubation with gluten fraction III.
Saxena et al. (1985)IL-2MNCIn vitro preincubation of MNC with alpha-IFN before stimulation with PHA, led to a significant increase in IL-2 activity in all subjects (P less than 0.01).
Lakhanpal and Handwerger (1986)interleukin-2mononuclear cellsNormal adult human peripheral blood mononuclear cells which are negative for interleukin-2 (IL-2) receptors as assessed by flow cytofluorometry, acquire IL-2 receptors and IL-2 responsiveness after culture in media supplemented with fetal calf sera.
Toossi et al. (1986)IL-2mononuclear cellsPPD-induced expression of T cell IL-2 receptors was 5.9 times less in peripheral blood mononuclear cells of patients with tuberculosis as compared with healthy tuberculin reactors.
Venkataraman and Westerman (1990)IL-2mononuclear cellsRadiation causes increased production and decreased utilization of IL-2 in human mononuclear cells.
Welte et al. (1984)IL2PBMCThis study demonstrates that PBMC in patients after BMT have a defect of IL2 production but are able to express IL2 receptors in response to OKT3 antibody and to proliferate normally upon addition of hpIL2.
Kasid et al. (1990)IL-2PBMCIn particular, they reveal the previously unrecognized function of IL-4 in antagonizing the IL-2 induction of TNF, LT, and Tac mRNA in PBMC.
Baroja and Ceuppens (1987)IL-2mononuclear cellsAddition of anti-Tac to cultures of mitogen-stimulated peripheral blood mononuclear cells resulted in a 2-4-fold increase of maximal levels of IL-2 in the supernatants.
Fiocchi et al. (1984)interleukin 2mononuclear cellsTo investigate potential abnormalities of interleukin 2 in inflammatory bowel disease, we measured its activity in cultures of intestinal mucosa mononuclear cells derived from Crohn's disease and ulcerative colitis patients.
Romagnani et al. (1985)IL2mononuclear cellsHowever, crude supernatants from protein A-stimulated peripheral blood mononuclear cells, which were found to possess both IL2 and B cell growth factor (BCGF) activities, maintained the ability to promote proliferation of anti-mu-activated B cells after depletion of IL2.
Tsang et al. (1986)IL-2PBMCThese results suggest that the increase in IL-2 production following treatment of PBMC with ISO may be mediated through the activation of a distinct subset of IL-2 producing cells.
Rezai et al. (1990)IL-2PBMCStimulated PBMC from AIDS KS patients as a group, displayed a lower percentage of IL-2 receptor bearing cells, which was significantly increased by the addition of histamine even at concentrations as low as 10(-6) M and peaking at 10(-3) M.
Yamamoto et al. (1991)IL-2mononuclear cellsPeripheral blood mononuclear cells (PBM) from normal donors and patients with recurrent glioma were activated initially for 48-72 h with phytohemagglutinin-P (PHA) and recombinant human interleukin-2 (IL-2), and then proliferated in vitro for up to 5 months with IL-2.
Prasad et al. (2006)IL-2MNCsIt was further shown that either in vivo zinc supplementation or the addition of zinc in vitro to MNCs from zinc-deficient subjects results in correction of the gene expression of IL-2 and IL-2Ralpha.
Ellner et al. (1990)interleukin-2mononuclear cellsRegulation of antigen-induced blastogenesis and interleukin-2 expression by adherent mononuclear cells in humans infected with Schistosoma mansoni.
Suzuki et al. (1984)IL-2mononuclear cellsThis potentiation of IL-2 on NK enhancement was suppressed by PGE2, and was enhanced by indomethacin in the experiments using unfractionated mononuclear cells.
Cooley et al. (1989)IL2PBMCStatistical analysis of the clinical factors possibly affecting lymphokine synthesis showed that in vivo cyclosporin A did not affect the in vitro capacity of PBMC to produce cytokines, although steroid therapy had a negative effect on IL2 production.
Triozzi et al. (1993)IL-2PBMCAci-reductones completely suppressed the production of prostaglandin E2 from PBMC in response to IL-2 and partially suppressed superoxide anion production.
Vint et al. (1993)IL-2mononuclear cellsAuranofin, 30-300 nM causes a concentration-dependent potentiation of phytohaemagglutinin (PHA)-induced interleukin-2 (IL-2) release from human peripheral blood mononuclear cells in culture.
Nakarai et al. (1990)IL-2PBMCPBMC were incubated with human recombinant IL-2 (25 U/ml) for 72 h; during the last 24 h, various concentrations (10 pM-1 microM) of MTX were added to the culture.