Viewing affirmative mentions of positive regulation of IL2 (H. sapiens) in blood

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Lyte (1988)IL-2bloodThe addition of 2-mercaptoethanol (2-ME) resulted in enhanced extracellular production of IL-2 in whole blood and Ficoll-Hypaque cultures.
Venkataraman (1992)interleukin-2bloodCryopreservation-induced enhancement of interleukin-2 production in human peripheral blood mononuclear cells.
Vint et al. (1993)interleukin-2bloodAuranofin, 30-300 nM causes a concentration-dependent potentiation of phytohaemagglutinin (PHA)-induced interleukin-2 (IL-2) release from human peripheral blood mononuclear cells in culture.
Tamori et al. (1989)IL-2bloodThe effect of 1 alpha, 25-dihydroxyvitamin D3 (1 alpha, 25(OH)2D3) on the expression of interleukin-2 (IL-2) receptor in activated T lymphocytes was examined. 1 alpha, 25(OH)2D3 enhanced the expression of IL-2 receptor (p55, Tac peptide) in phytohemagglutinin (PHA)-stimulated (3 days) human peripheral blood mononuclear cells (PBM) only in the presence of IL-2 without affecting the proliferation of the cells.
Kabuki et al. (1990)IL2bloodSaibokuto suppressed the induction of IL2 responsiveness induced by Dermatophagoides farinae (Df) antigen in peripheral blood mononuclear cells from patients with bronchial asthma.
Baxevanis et al. (1990)interleukin-2bloodEnhancement of human T lymphocyte function by prothymosin alpha: increased production of interleukin-2 and expression of interleukin-2 receptors in normal human peripheral blood T lymphocytes.
Baxevanis et al. (1990)interleukin-2bloodThe in vitro incubation of phytohemagglutinin (PHA)- or alloantigen-stimulated peripheral blood T cells with prothymosin alpha (ProT alpha) resulted in a marked and reproducible increase in the production of interleukin-2 (IL-2).
Komorowski (1992)IL-2bloodThe possible role of thyroid hormones and of an autoimmune mechanism in the link with increased IL-2 blood level in hypothyroidism in man have been discussed.
Stein et al. (1999)interleukin-2bloodInhibition of stimulated interleukin-2 production in whole blood: a practical measure of cyclosporine effect.
Stolc and Krause (1987)Interleukin-2bloodInterleukin-2 receptor levels are increased in blood of heart transplant patients during infections.
Rogers et al. (1998)IL-2bloodCirculating blood levels of sIL-2R were significantly elevated in all individuals that had experienced unilateral brain damage.
Beuth et al. (1995)interleukin-2bloodMoreover, administration of either ML-1 concentration resulted in enhanced expression of activation markers such as interleukin-2 receptors and HLA/DR-antigens on peripheral blood T-lymphocytes.
Xu et al. (1996)interleukin-2bloodOccupational levels of radiation exposure induce surface expression of interleukin-2 receptors in stimulated human peripheral blood lymphocytes.
Yamaoka et al. (1991)interleukin-2bloodResults are the following: improvement of leukocytosis and arterial oxygen tension was observed; peripheral blood cell analysis showed a decrease in natural killer cell counts and in helper/suppressor T cell ratio; superoxide production by peripheral blood white cells was decreased after treatment; interleukin-2 production was rather increased.
Geiselhart et al. (1997)IL-2bloodWe have shown that 10 microM p-benzoquinone (p-BQ), a thiol-reactive benzene derivative found in cigarette tar, inhibits mitogen-induced IL-2 production by human peripheral blood mononuclear cells by 76 +/- 7% without affecting lymphocyte/macrophage agglutination or blast transformation.
Ma et al. (1995)IL-2bloodTo study the effect of polysaccharides of Ginseng (PSG) on cellular-immunity from healthy subjects and patients of kidney disease, the peripheral blood mononuclear cell (PBMC) induced interleukin-2 (IL-2) were assayed in vitro.
Orvieto et al. (2003)IL-2bloodRESULTS: Whole blood culture IL-2 levels increased significantly during COH until peak E2, and then decreased significantly after hCG administration.
Hartung et al. (1998)interleukin-2bloodFilgrastim restores interleukin-2 production in blood from patients with advanced human immunodeficiency virus infection.
Lesniewski et al. (2008)IL-2UCBKnockdown experiments of BACH2 by transient transfection of UCB CD4(+) T cells with BACH2 siRNA resulted in significant reductions in stimulated IL-2 production.
Lorenz et al. (1996)interleukin 2bloodThe only systemic biological effect detectable in peripheral blood was a marked increase of soluble interleukin 2 receptor serum levels.
Johnson et al. (1998)IL-2bloodVenous and arterial iliac endothelial cells (VIEC, AIEC) both costimulate interleukin-2 (IL-2) production by peripheral blood lymphocytes (PBL) or T cell clones stimulated with phytohemagglutinin (PHA).
Zhang et al. (2002)IL-2bloodThe results showed that blood CD4+ cells and mitogen-induced IL-2 secreting cells and IL-2 production were significantly lower in schizophrenic subjects than in the normal controls.
Matsumoto et al. (1990)IL-2bloodThere was a significant increase of IL-2 activity in the culture supernatants of peripheral blood mononuclear cells (PBMC) after 2-3 days cultivation.
Lissoni et al. (1998)IL-2bloodSince the pineal gland has been proven to stimulate IL-2 endogenous production, the nocturnal increase in IL-2 blood concentrations could depend at least in part on the promoting action of MLT, whose release increases during the dark period of the day.
Ben-Hur et al. (1990)IL-2UCBLThe effect of THF-gamma 2 on PHA-induced IL-2 secretion was also studied and found that a 3hr preincubation with THF-gamma 2, prior to suboptimal PHA stimulation caused an increase in the IL-2 activity of the treated UCBL cultures.
Fan et al. (2009)IL-2bloodThese results demonstrate SSG interactions with IL-2 in vitro to activate key antitumor immune cells in peripheral blood of healthy and melanoma donors, providing further evidence for proof of concept clinical trials for effecting augmentation of IL-2 through inhibiting negative regulatory protein tyrosine phosphatases.
Nowlin et al. (2002)IL-2bloodWe investigated the effects of several tyrosine kinase inhibitors on human peripheral blood T-cell adhesion and adhesion-induced costimulation of IL-2 expression and secretion.
Kunzendorf et al. (1991)interleukin-2 mRNAbloodConcentrations of diltiazem which blocked the proliferation of PHA-stimulated human peripheral blood mononuclear cells, or prevented activation-associated accumulation of interleukin-2 mRNA, or p50- and p70-IL-2 receptor mRNA exceeded pharmacological concentrations by more than 100-fold.
Luger et al. (1983)Interleukin 2bloodAlthough EC-ETAF or SCC-ETAF by themselves exhibited no T-cell growth factor activity, both ETAF preparations enhanced Interleukin 2 production by cultured human peripheral blood lymphocytes when stimulated with polyclonal T-cells stimulants (Concanavalin A and phorbol myristate acetate).
Nakanishi et al. (1999)interleukin-2bloodIn conclusion, triiodothyronine may have an immunomodulatory effect by enhancing expression of the interleukin-2 receptor alpha chain on peripheral blood mononuclear cells in the presence of interleukin-2.
Maraveyas et al. (1999)interleukin-2bloodPossible improved survival of patients with stage IV AJCC melanoma receiving SRL 172 immunotherapy: correlation with induction of increased levels of intracellular interleukin-2 in peripheral blood lymphocytes.
Bocci et al. (1998)IL-2bloodWe have shown here that there is a small but consistent induction of some cytokines (TNF-alpha, IFN-gamma and IL-2) when human blood is directly exposed to O3 concentrations up to 100 micrograms/ml per g of blood.
Duchateau et al. (1985)IL2bloodPeripheral human blood lymphocytes from healthy blood donors were investigated in vitro to observe the influence of different doses of thymopentin on nonstimulated proliferation, candidin-stimulated proliferation, and phytohemagglutinin (PHA)-induced interleukin 2 (IL2) production.
Maurer and Echarti (1991)IL-2bloodWhen nonadherent peripheral blood mononuclear effector cells were exposed to 1 x 10(-9) or 1 x 10(-8) M mafosfamid 1 h prior to activation with interleukin 2 (IL-2), LAK-cell activity increased, resulting in fewer colonies of human KB squamous carcinoma cells than without mafosfamid treatment.
Boyer et al. (1989)interleukin-2bloodThe presence of autologous serum during recombinant interleukin-2 activation with blood lymphocytes had an augmentative effect on the resulting lymphokine-activated killer cytotoxicity in two of 20 patients, a suppressive effect in four of 20, and no effect in the other 14 of 20 patients tested.
Lister et al. (1995)interleukin 2bloodOverall toxicity associated with early posttransplant transfer of A-NK cells and interleukin 2 did not differ from that observed with peripheral blood stem cell transplantation alone in comparable patients.
Lotze et al. (1987)IL-2bloodHigh levels of IL-2 receptor-positive cells were found in the peripheral blood of patients receiving recombinant IL-2 in these Phase I clinical trials.
Lai et al. (1989)interleukin 2bloodMitogen-stimulated cellular interleukin 2 (IL2) receptor expression, soluble interleukin 2 receptor release, and interleukin 2 production, were studied in peripheral blood mononuclear cells cultured for 24 h.
Smith et al. (1989)IL-2bloodThis inhibitor inhibits the mitogenic response of normal peripheral blood mononuclear cells and seems to be primarily due to impaired IL-2 production.
Teodorczyk-Injeyan et al. (2008)IL-2bloodThe former were used for studies of the in vitro production of IL-2, while systemic (in vivo) levels of IL-2 production were determined in sera derived from non-heparinized blood samples.
Komorowski (1992)interleukin-2bloodEvaluations of interleukin-1 beta (IL-1 beta), interleukin-2 (IL-2), thyrotropin, thyroxine, and triiodothyronine were performed in seven patients with primary hypothyroidism and eight euthyroid healthy control subjects on the basis of venous blood samples collected after an overnight rest.
Whiteside (2001)IL-2bloodThis unit describes the preparation of natural killer (NK) cells from normal human peripheral blood and their incubation in vitro in the presence of interleukin 2 (IL-2) to yield lymphokine-activated killer (LAK) cells.
Alexander et al. (1993)IL2bloodIn contrast to the lack of proliferative activity, stimulation of T-TIL or peripheral blood lymphocytes with phytohemagglutinin or anti-CD3 resulted in comparable levels of both IL2 and gamma-interferon mRNA and protein expression.
Yoshii and Shinohara (2000)IL-2bloodWe studied the production of and response to interleukin-2 (IL-2) by cultured peripheral blood mononuclear cells (PBMC) and the soluble IL-2 receptor levels in 10 patients with GBS (eight men and two women) aged 23-67 years.
Stein et al. (1999)IL-2bloodMETHODS: CSA inhibition of phytohemagglutinin-P (PHA)-stimulated IL-2 production, measured by ELISA, was studied ex vivo in whole blood drawn before, and after subjects received 4 mg/kg oral CSA.
Sakane et al. (1989)interleukin-2bloodFamilial occurrence of impaired interleukin-2 activity and increased peripheral blood B cells actively secreting immunoglobulins in systemic lupus erythematosus.
Burns et al. (1985)IL-2bloodHuman thymocytes differed from peripheral blood T cells, in that they did not proliferate in response to mouse monoclonal antibodies specific for the T3 antigen complex (UCHT1 and OKT3), even in the presence of T-cell growth factor (IL-2) or with monocytes plus IL-2.
Rossi et al. (1988)IL2bloodWe have previously shown an increased and dysregulated secretion of IL2 in peripheral blood from patients with B-CLL.
Baeyens et al. (2004)IL-2bloodIn this study we therefore investigated whether the radiation-induced MN response in IL-2 cultures was the same as in concordant whole blood cultures.
Härtel et al. (2004)interleukin-2bloodPrevious investigations have demonstrated the occurrence of tacrolimus-resistant production of interleukin-2 (IL-2) in vitro, which may explain in part why rejection episodes are still a frequent problem despite attainment of therapeutic blood concentrations and HLA matching.
Chou et al. (2009)interleukin-2bloodA new synthetic compound, 2-OH, enhances interleukin-2 and interferon-gamma gene expression in human peripheral blood mononuclear cells.
Akiyoshi et al. (1987)IL 2bloodPerigastric lymph node cells (LNC) from patients with gastric carcinoma or benign lesions were tested for interleukin 2 (IL 2) production upon stimulation with phytohemagglutinin (PHA), in comparison with that of peripheral blood mononuclear cells (PBM) or spleen cells (SPC).
Kikuchi et al. (1988)IL-2bloodWe studied production of, absorption of and response to interleukin 2 (IL-2) by peripheral blood mononuclear cells (PBMC) from 66 patients with gynecologic malignancies, in addition to measurement of the OKT 4/OKT 8 cell ratio.
Johnson et al. (1998)IL-2 mRNAbloodDaily rhuIL-2 administration for 30 days induced increases in CD25+ and CD56+ cells in the blood. rhuIL-2 therapy also resulted in increased expression of gamma-interferon and IL-2 mRNA at the site of a delayed-type hypersensitivity (DTH) response to purified protein derivative of tuberculin.
van der Kuyl et al. (2010)IL-2bloodReplication competition assays were performed with selected virus pairs in PHA/IL-2 activated peripheral blood mononuclear cells (PBMC's) and analyzed with the Heteroduplex Tracking Assay (HTA) and isolate-specific PCR amplification.
Lauta (2003)IL-2bloodSerum levels of IL-6, sIL-6R, sIL-2R, and the expression of membrane-bound IL-2 receptors, both on bone marrow plasma cells and on peripheral blood mononuclear cells, are correlated with disease activity and disease stage.
Pellegrini et al. (1997)IL-2bloodWe evaluated the interleukin (IL)-2, interferon (IFN) gamma, IL-4, sIL-2R and IL-10 levels in the serum and the release of IFN gamma, IL-4 and IL-10 from peripheral blood mononuclear cells (PBMC); the PBMC expression of CD3, CD16 and CD19 phenotypic antigens; the PBMC proliferative responses to IL-2, IL-2 + anti-CD3 monoclonal antibody (mCD3) and mCD3.
Weinstein et al. (1993)IL-2bloodThe finding of an increased IL-2 activity in the CRF group suggests that factors other than membrane blood interactions are involved in its production.
Rosztóczy et al. (1986)Interleukin-2bloodInterleukin-2 (IL-2) production was stimulated with staphylococcus enterotoxin A, heat-killed Staphylococcus aureus, or concanavalin A (ConA) in cultures of human peripheral blood mononuclear cells (PBMC).
Xu et al. (1996)IL-2bloodWe show that low doses of radiation, in the range commonly received by atomic radiation workers or as a result of minor medical diagnostic procedures (0.25 to 10 mGy), stimulate the expression of IL-2 receptors (IL-2R) on the surface of peripheral blood lymphocytes (PBL) taken from normal human donors.
Hsia et al. (1990)interleukin-2bloodTo determine whether rhinovirus infection induced a systemic cellular immune response in humans, specific antigen-stimulated blastogenesis, natural killer cell activity, and mitogen-stimulated production of interleukin-2 and interferon-gamma by peripheral blood mononuclear cells (PBMC) were quantified during experimental rhinovirus infection of normal volunteers.
Chin et al. (1991)IL-2bloodSignificant lymphokine-activated killer (LAK) cell activity has been described in cord blood, suggesting a possible role for LAK and/or interleukin-2 (IL-2) therapy in newborns with serious viral infections.
Kawano et al. (1992)IL2bloodPeripheral blood lymphocytes from nonallergic individuals acquired responsiveness to interleukin 2 (IL2) after stimulation with ovalbumin (OVA) or Dermatophagoides farinae (Df) antigens when they were pretreated with the CD45RA antibody, which has been shown to define the suppressor inducer subset of CD4+ cells and also to block its suppressor activity.
Martinez et al. (1993)IL-2bloodAn in vitro system consisting of irradiated, allogeneic stimulator cells and normal peripheral blood mononuclear cells as responders was established to further investigate alloantigen-driven IL-2 and IL-5 production.
DeCesare et al. (1995)IL-2bloodLymphocytes were obtained from the peripheral blood or ascites of ovarian cancer patients and activated with IL-12 alone or concomitantly with interleukin 2 (IL-2) for 2 to 3 days.
Hank et al. (1990)IL-2bloodWhile continuous infusion of IL-2 induces a greater cytotoxic potential per milliliter of blood obtained from patients, the peak serum IL-2 levels attained are greater with bolus IL-2 infusions.
Remick et al. (1987)IL-2bloodRecent reports have demonstrated the IL-2 dependent activation of human peripheral blood lymphocytes into lymphokine activated killer cells capable of lysing tumor cells both in vitro and in vivo.
Müller-Quernheim et al. (1986)IL 2bloodIn contrast, no IL 2 mRNA transcripts could be detected in fresh autologous blood T cells or in purified autologous blood Leu-3+ T cells, although IL 2 mRNA transcripts were inducible in these cells by phytohemaglutinin/phorbol myristic acetate.
Heaton et al. (1993)IL-2bloodCharacterization of lymphokine-activated killing by human peripheral blood mononuclear cells stimulated with interleukin 2 (IL-2) analogs specific for the intermediate affinity IL-2 receptor.
Fleischer (1981)cell growth factorbloodInduction of T cell growth factor synthesis in human peripheral blood lymphocytes by staphylococcal protein A.
Lardone et al. (2009)IL-2bloodAntagonism of membrane melatonin receptors using luzindole exacerbates the drop of the IL-2 production induced by PGE(2) in peripheral blood mononuclear and Jurkat cells.
Spain et al. (1995)IL-2bloodLung and blood lymphocytes proliferated in response to IL-2 but not IL-4.