Viewing affirmative mentions of gene expression of IL2 (H. sapiens) in IL2R

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Mills et al. (1990)IL2IL2RIL2 induced tyrosine phosphorylation in YT 2C2 cells which express only the 75-kDa intermediate affinity IL2 binding molecule (IL2R beta) but not in cells which either express only the 55-kDa low affinity IL2 receptor molecule (IL2R alpha) or no IL2-binding sites.
Sahraoui et al. (1992)IL2IL2RIn order to determine the role of interleukin 2 (IL2) on the proliferation of leukemic cells from patients with T-cell acute lymphoblastic leukemia (T-ALL) we studied the production of IL2, the function of IL2 receptors (IL2R) expressed on T-ALL cells and their IL-2-dependent in vitro proliferation.
Kelley et al. (1998)interleukin 2IL2RAlso, additional DHA did not alter the number of T cells producing interleukin 2 (IL2), the ratio between the helper/suppressor T cells in circulation, or the serum concentrations of immunoglobulin G, C3, and interleukin 2 receptor (IL2R).
Alexander et al. (1993)IL2IL2RWhile T-TIL exhibit a poor proliferative response regardless of the form of stimulation these cells remain sensitive to both anti-CD3 and IL2 in terms of IL2 and gamma-interferon or IL2R alpha expression, respectively.
Alexander et al. (1993)IL2IL2RThe fact that proliferative unresponsiveness exists even though T-TIL can produce IL2 and express IL2R alpha/beta suggests that T-TIL have a selective loss of a common intracellular signaling pathway which is requisite to proliferation but not other aspects of response to antigenic stimulation.
Reed et al. (1986)interleukin 2IL2RThe proliferation of non-neoplastic T lymphocytes is regulated, in part, by the coordinated expression of genes encoding T-cell growth factor (interleukin 2, IL2), IL2 receptors (IL2R), and transferrin receptors (TFR).
Lai et al. (1991)IL2IL2RIt was also demonstrated that the release of soluble IL2R (sIL2R) and IL2 production in supernatant from cultured PBMC varied with different lectin stimulation.
Lai et al. (1991)IL2IL2RA significant correlation was demonstrated between the cellular and soluble IL2R but the production of IL2 from activated mononuclear cells bore no good correlation with either the cellular IL2R expression or the release of sIL2R.
Akbar et al. (1991)IL2IL2RAfter activation, both subsets up-regulate their IL2 receptor (IL2R) and IL4R expression, yet IL4 substantially enhanced the proliferation of the CD4+CD45RA+ but not of the CD4+CD45R0+ T cell subset, while IL2 increased the proliferation of CD4+CD45R0+ but not of the CD4+CD45RA+ T cells.
Prince and John (1986)IL2IL2RThese findings indicate that CsA inhibits mitogen-induced expression of IL2R and TR, and for some mitogen systems, this inhibition appears, at least in part, to be secondary to decreased IL2 production.
Shirakawa et al. (1989)interleukin 2IL2RIn a previous study, we reported that adult T-cell leukemia (ATL) cells produce interleukin 1 (IL1)-like factors that stimulate murine thymocyte proliferation, the production of interleukin 2 (IL2), and the expression of IL2 receptors (IL2R) on normal human T-cells in the presence of concanavalin A.
Shirakawa et al. (1989)IL2IL2RThe expression of IL2R on ATL cells was also enhanced by IL1, but the production of IL2 was not induced.
Smith (2006)IL2IL2RIndeed, crystals of IL2 bound to the IL2R ?
Perillo et al. (1993)IL2IL2RHowever, we have now observed that such restimulation induces an increase in the percentage of cells expressing the 55 kDa chain of the IL2 receptor (IL2R alpha, CD25) without any associated increase in cell number.
Yasumura et al. (1994)IL2IL2RIncubation of the gastric (HR) or renal cell carcinoma (RCC) cell lines, but not of other IL2R+ carcinoma cell lines or normal keratinocytes, in the presence of IL2 resulted in dose-dependent inhibition of tumor cell growth.
Kammer et al. (1993)IL2IL2RT cell activation, verified by IL2 mRNA, IL2 receptor-alpha (IL2R-alpha) mRNA, and IL2R-beta mRNA expression, did not diminish cAMP-inducible, PKA-dependent protein phosphorylation.
Hayward et al. (1989)IL2IL2RAfter 7 days of culture with live virus, IL2 receptors (IL2R) were found on CD4 and CD8 cells while cultures stimulated with fixed or extracted antigen had IL2R only on CD4 cells.
D’Alessandria et al. (2009)Interleukin-2IL2RInterleukin-2 is a small single-chain glycoprotein (15.5 kDa) of 133 amino acids that is synthesized and secreted in vivo by activated lymphocytes in several pathological conditions, such as autoimmune diseases, graft rejection, and tumors characterized by chronic infiltration of lymphomononuclear cells expressing the IL2R (interleukin-2 receptor) on their surface membrane.
Lansigan et al. (2010)IL2IL2RWe know now that the IL2R is a complex comprised by three parts: the alpha chain (CD25) which is required for high affinity binding, the beta chain (CD122) which participates in IL2 and IL15 signal transduction, and the common gamma chain (CD132) which participates in downstream signal transduction of IL2 and other cytokines.11–14
Teodorczyk-Injeyan et al. (1991)IL2IL2RIn this period in vitro IL2 production and IL2R alpha secretion in patient's cultures were significantly reduced compared to control.
Lansigan et al. (2010)DAB486-IL2IL2RThe IL2R-diphtheria toxin fusion protein: DAB486-IL2
Zhu et al. (1995)interleukin 2IL2RHowever, the surface expression of interleukin 2 receptor alpha (IL2R alpha) chain, as measured by flow cytometry, was increased rather than decreased by THC treatment.
Lai et al. (1989)IL2IL2RMitogen-stimulated cellular interleukin 2 receptor (IL2R) expression, sIL2R release, and interleukin 2 (IL2) production were also examined in peripheral blood mononuclear cells (PBMC) cultured for 24-48 hr in 21 patients with IgA nephropathy, 17 patients with chronic glomerulonephritides, and 17 healthy controls.
Teodorczyk-Injeyan et al. (1991)IL-2IL2RIn the same patients, however, high serum concentrations of the low-affinity IL-2 receptor (IL2R alpha), a product of an IL-2-activated gene, have been observed.
Smith (2005)IL2IL2RHe suggested that his data point to a defect in IL2-responsiveness, which could be attributable to changes in the IL2 receptor chains, the IL2R signaling pathways, or in the expression of IL2-regulated genes, in particular the IL2-reguated genes that promote cell cycle progression.
Stohl and Linker-Israeli (1989)IL2IL2RThe effects of anti-CD2 monoclonal antibodies (mAb) on anti-CD3-driven interleukin 2 (IL2) production and IL2 receptor (IL2R) expression were investigated.
Leclercq et al. (1990)IL-2IL2RAnalysis of the DNA content and the IL-2 receptor (IL-2R) p55 expression showed that during the first days of culture the TCR-V gamma 3+ cells had a much higher proliferation rate than the TCR-V gamma 3- cells, although TCR-V gamma 3+ IL2R p55+ cells could not be detected.
Sparkes (1993)IL2IL2RThe TAC portion of the IL2 receptor (IL2R alpha), expressed on the T-cell surface, appears to be responsible for this difference, as the number of lymphocytes able to express IL2R alpha falls post-burn.
Eichhorn and Dobbelaere (1995)IL2IL2RA T. parva-infected T-cell line, TpM(803), known to express the IL2 and IL2R genes in a constitutive way, was permanently transfected with one of the two constructs, and the effect of antisense IL2R alpha-chain RNA expression upon proliferation of TpM(803) cells was tested.
Fagiolo et al. (1994)IL2IL2RWhile the stimulation index of PBL was strongly reduced in 10 cases (64 +/- 56 vs 138 +/- 45 in the control group), IL1 alpha, IL2 and IL2R were greatly increased in all the patients, and IL4 in 5 (IL1 alpha :199 +/- 268 pg/ml in patients vs 0.30 +/- 0.2 in controls; IL2:716 +/- 311 pg/ml vs 16 +/- 4; IL4:29 +/- 13 pg/ml vs 13 +/- 7; IL2R:1233 +/- 471 U/ml vs 256 +/- 114).
Malabarba et al. (1996)IL2IL2RThe lymphocyte growth factors interleukin-2 (IL2), IL4, IL7, IL9 and IL15 use the common IL2 receptor-gamma (IL2R gamma) and activate the IL2R gamma-associated tyrosine kinase JAK3 (Janus kinase 3).
Carreño et al. (2005)IL2IL2RFurthermore, IL2 rescues the blockade of T-cell development in FTOC treated with anti-PRL antiserum but PRL does not recover cultures treated with an anti-IL2R alpha chain mAb, which drastically blocks the T-cell development.
Noronha et al. (1993)IL2IL2RCon A activated cultures treated with IFN-beta showed decreased IL2R expression and accumulation of IL2.
Fagiolo et al. (1994)IL2IL2RIn 14 patients with autoimmune hemolytic anemia (AIHA), idiopathic or in the course of: lymphoma, B hepatitis, carcinoma, drug therapy (alpha-methyldopa), systemic lupus erythematosus (SLE), and not yet submitted to immunosuppressive therapy, the PBL proliferative response to PHA and the IL1 alpha, IL2, IL4 and IL2R serum levels have been valued.
Lobo-Yeo et al. (1990)interleukin 2IL2RChildren with uncontrolled autoimmune chronic active hepatitis have increased numbers of activated T lymphocytes expressing interleukin 2 receptors (IL2R).