Viewing affirmative mentions of positive regulation of IL2 (H. sapiens)

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Ott et al. (1997)IL-2IL-2 superinduction by Tat occurred at the transcriptional level, was mediated by the CD28-responsive element in the IL-2 promoter, and was exclusively dependent on the 29 amino acids encoded by the second exon of Tat.
Duchateau et al. (1985)IL2On the contrary, preincubation with different concentrations of thymopentin influenced PHA-induced IL2 production.
Duchateau et al. (1985)IL2A significant increase in the IL2 level was observed in the supernatant of the cultures if 1,000 ng/ml of thymopentin was used in the preculture period.
Bartlett et al. (1998)IL-2A dose-response relationship favored increasing IL-2 doses, and subcutaneous delivery offered greater increases than intravenous administration.
Bauer et al. (1995)IL-2RESULTS: Interleukin-2 dose modifications were based on tolerance and toxicity, such that 46% of these patients received a 50% increase in IL-2 dose during the second week, and 81% of those receiving the elevated dose continued receiving this dose level during the third week of treatment.
Uchiyama et al. (1993)interleukin 2Transfection of interleukin 2 gene into human melanoma cells augments cellular immune response.
Uchiyama et al. (1993)IL-2IL-2 gene was transfected into three human melanoma cell lines; secretion of IL-2 from stable transfected cells was confirmed by enzyme-linked immunosorbent assay.
Warrington (1988)IL-2At high cell densities, IL-2 production was decreased in SLE but remained enhanced in RA.
Warrington (1988)IL-2The possibility is discussed that a local hyper-production of IL-2 could induce disturbances of the immune response, resulting in the breaking of normal tolerance.
Bruserud and Moen (1984)IL-2One thousand rads. irradiation of the cells was found to alter the kinetics and to increase the production of IL-2.
Yamamoto et al. (1985)IL2 mRNAA remarkable increase of IL2 mRNA was induced by stimulation with phytohemagglutinin (PHA) in the presence of 12-O-tetradecanoyl-phorbol-13-acetate (TPA).
Yamamoto et al. (1985)IL2 mRNADNA synthesis and cell division were not necessary for the induction of IL2 mRNA production but the induction was inhibited by dexamethasone, showing that the production was mainly associated with the G1 phase of the cell cycle.
McElhaney et al. (1990)IL2This study provides evidence that defective IL2 production may also occur in response to physiologic antigenic stimulation and may be one explanation for the reduced efficacy of influenza vaccination in elderly persons.
Paetkau (1985)IL2The induction of IL2 and other lymphokines is apparently specific, in that only a small subset of proteins shows altered expression in the response.
Wang et al. (1984)IL-2Transcription and translation dependent induction of interleukin 2 (IL-2) and IL-2 receptors.
Wang et al. (1984)IL-2Therefore, we studied whether the induction of IL-2 receptors were transcription- or translation-dependent.
Kumar et al. (2004)IL-2Whereas all the three molecules showed enhanced proliferation and interleukin-2 (IL-2) induction in HPBLs.
Russell and Vindelov (1998)interleukin 2The assay requires reliable detection of the amount of interleukin 2 (IL-2) produced by one cell.
Durrant et al. (1997)interleukin-2The helper responses were exemplified by induction of interleukin-2 (IL-2), antigen-specific blastogenesis, and enhanced natural killer (NK) activity.
Durrant et al. (1997)IL-2Enhanced IL-2 production was observed following 15/19 injections of 100 micrograms of 105AD7 whereas only 4/11 injections of 200 micrograms of 105AD7 induced responses (p < 0.02).
Alcocer-Varela et al. (1989)IL-2AS-101 was found to be non-toxic to cells from both patient and control groups; it increased the production of IL-2, elevated the percentage of Tac-positive cells even among cells that had been pre-treated with pronase, and ameliorated the absorption of IL-2.
Welte et al. (1984)IL-2The addition of exogenous IL-2 then leads to expression of the IL-2 receptor, as recognized by Tac antibody, and to subsequent proliferation.
Efrat et al. (1984)interleukin-2Superinduction of human interleukin-2 messenger RNA by inhibitors of translation.
Gulino et al. (1990)IL-2 geneThis suggests that the constitutive and inducible expression of the IL-2 gene can be dissociated and are presumably subjected to separate regulatory pathways.
Toossi et al. (1986)IL-2Mean PPD-induced IL-2 activity was 81.2% lower in patients as compared with healthy tuberculin reactors.
Venkataraman and Westerman (1990)IL-2-mRNAAn increase in IL-2-mRNA levels was also noticed in irradiated, PHA-stimulated cells.
Smith and Pruett (1989)IL-2Therefore, the recently reported circadian variations in T helper to T suppressor ratios do not seem to significantly affect mitogen-induced IL-2 production.
Pinkston et al. (1987)IL 2 geneIn this regard, sarcoidosis represents a "model" human disorder to test in vivo the known in vitro action of corticosteroids on suppressing the activated IL 2 gene.
Uchino et al. (2002)IL-2IL-2 release from the cells was enhanced by SQOOH and increased at a non-cytotoxic dose.
Duc Dodon and Gazzolo (1987)IL2These results taken together demonstrate that the loss of the exogenous IL2 (and other growth-helping factors) requirement defines an early event of HTLV-I infection.
Clevers et al. (1985)IL-2Combination of PMA and A23187 resulted in considerable IL-2 production.
Clevers et al. (1985)IL-2It is concluded that A23187 induces the expression of IL-2 receptors without concurrent stimulation of IL-2 production, thus allowing only low levels of proliferation.
Toossi et al. (1989)IL-2Upon addition in low ratios to Leu 11-depleted cells, Leu 11-enriched fractions increased antigen-induced IL-2 production three-fold (P less than 0.05), whereas at higher ratios IL-2 production was suppressed P less than 0.01.
Modiano et al. (1988)interleukin 2We studied the ability of a lectin mitogen (PHA) and a calcium ionophore (ionomycin) to induce interleukin 2 receptors, interleukin 2 (IL2) production, and proliferation over various concentrations of extracellular Ca++.
Itoyama et al. (1988)IL-2IL-2 activity increased in the supernatant of 3-day cultured cells from HAM patients, but not in cultured cells from the controls.
Baroja and Ceuppens (1987)IL-2Comparison of the kinetics of IL-2 accumulation in the presence and absence of anti-Tac revealed that IL-2 consumption by mitogen-stimulated cells occurred as early as 6 h after culture initiation.
Henics et al. (1994)IL-2 mRNAComparable transcriptional rates for these lymphokines suggested the involvement of post-transcriptional mechanisms in selective IL-2 mRNA accumulation.
Manger et al. (1986)IL-2The T leukemia cell Jurkat requires an increase in cytoplasmic calcium concentration ([Ca++]i) and phorbol myristate acetate (PMA) for the induction of IL-2 production, which is completely blocked by CsA.
Cignetti et al. (1994)IL2PURPOSE: The purpose of this study was to evaluate the possibility of inducing a productive transfer of the IL2 gene into human acute leukemia cells and to assess the phenotypic and proliferative changes generated in the engineered cells, as well as their tumorigenic potential in nude mice.
Gerez et al. (1995)IL-2 geneMitogenic induction of human IL-2 gene expression elicits a transient wave of unstable mRNA.
Gerez et al. (1995)IL-2 mRNAWhen translation is blocked (e.g. by cycloheximide), expression of IL-2 mRNA can be superinduced by 2 orders of magnitude.
Kiremidjian-Schumacher et al. (1994)interleukin-2This apparently was related to the ability of the nutrient to enhance the expression of receptors for the growth regulatory lymphokine interleukin-2, and consequently, the rate of cell proliferation and differentiation into cytotoxic cells.
Ketzinel and Kaempfer (1999)IL-2Depletion of CD8 cells elicits marked superinduction of IL-2 mRNA; reintroduction of CD8 cells causes severe inhibition.
Ketzinel and Kaempfer (1999)IL-2Moreover, during IL-2 gene induction, splicing of IL-2 precursor transcripts becomes inhibited, resulting in a transient mRNA wave.
Ketzinel and Kaempfer (1999)IL-2Response to CHX, manifested in superinduction of IL-2 mRNA, is enhanced 10-fold during suppression.
Ketzinel and Kaempfer (1999)IL-2The near-complete absence of IL-2 mRNA superinduction by CHX in Jurkat Th cells, lacking cells with suppressive capacity, supports this interpretation.
Wilkinson and Euhus (2003)interleukin-2Adenoviral-mediated gene transfer of interleukin-2 in a human breast cancer cell line and a fresh primary breast cancer culture.
Mekori et al. (1989)IL-2Reserpine also interfered with the mitogen-induced IL-2 production by these cells, but the IL-2 receptor expression, as measured by immunofluorescence, was unaffected.
Meuer et al. (1984)IL-2Soluble or Sepharose-bound anti-Ti monoclonal antibodies, like physiologic ligand, enhanced proliferative responses to purified IL-2 by inducing a 6-fold increase in surface IL-2 receptor expression.
Meuer et al. (1984)IL-2These results suggest that induction of IL-2 receptor expression but not IL-2 release occurs in the absence of T3-Ti receptor cross-linking.
Gillis and Watson (1980)IL-2Addition of the fatty acid derivative phorbol myristate acetate to mitogen-stimulated cultures increased Jurkat-FHCRC IL-2 production to concentrations > 400 U/ml.
Tsoukas et al. (1984)interleukin-2Other metabolites of vitamin D3 were less effective than 1,25(OH)2D3 in suppressing interleukin-2; their order of potency corresponded to their respective affinity for the 1,25(OH)2D3 receptor, suggesting that the effect on interleukin-2 was mediated by this specific receptor.
Fernandez et al. (1995)IL-2We investigated the effect of thalidomide on the production of IL-2 by the human leukemia cell line Jurkat through induction of IL-2 gene enhancer activity and through the presence of IL-2 in supernatants. beta-galactosidase activity, encoded by a reporter lac z construct and controlled by a transcription factor in thalidomide-treated PMA- and ionomycin-stimulated Jurkat cells, was similar (97 +/- 1.33%; p > 0.1) to non-thalidomide-treated controls at all drug concentrations tested.
Mills et al. (1984)IL-2Acid treatment enhances IL-2 activity of conditioned medium.
Wacholtz et al. (1991)IL2The effect of cyclic AMP-elevating agents on mitogen-stimulated IL2 production was examined.
Wacholtz et al. (1991)IL2Although phorbol myristate acetate (PMA) greatly enhanced PHA-stimulated IL2 production by Jurkat cells.
Wacholtz et al. (1991)IL2The combination of PMA and the calcium ionophore, ionomycin, also induced IL2 production by Jurkat cells, and this was similarly suppressed by CT, suggesting that a step after initial second messenger generation was inhibited.
Ketzinel et al. (1991)IL-2Induction of IL-2 and IFN-gamma genes largely precedes appearance of suppressor cell activity, allowing expression of both genes to occur before strong down-regulation is exerted by activated suppressor cells.
Roifman et al. (1986)interleukin 2The lack of proliferative response was secondary to the failure of the mitogens to induce interleukin 2 (IL-2) production.
Efrat and Kaempfer (1984)IL-2 mRNAMitogenic stimulation results in the appearance of greatly increased levels of IL-2 mRNA activity.
Efrat and Kaempfer (1984)IL-2 mRNAThe accumulated active IL-2 mRNA decays with a half-life of about 20 hr.
Cantrell and Smith (1983)IL-2Instead, renewed IL-2 receptor expression was dependent upon the reintroduction of the initial activating signal.
Noma et al. (1984)IL2Bestatin therefore increases both IL2 sensitivity and IL2 production.
Weiss et al. (1987)interleukin 2Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene.
Patel et al. (1994)IL-2Multiple infections increased the level of IL-2 secretion to 5,000 units/10(6) cells.48 hr.
Horst and Flad (1985)IL-2The changes in the concentration of the high affinity binding sites are considered as being the result of: receptor stimulation by PHA and/or IL-2 (days 1-2); receptor down regulation by extensive IL-2 production (day 3); increase of unoccupied IL-2 receptor after disappearance of IL-2 from the medium (days 4-6) and cessation of receptor synthesis and receptor breakdown (days 7-10).
Hemler et al. (1984)IL-2The transient elevation in IL-2 receptor level was antigen specific because it occurred in response to specific allogeneic stimulator cells but not after exposure to cells expressing irrelevant HLA allotypes.
Roffman et al. (1984)IL-2The induction of IL-2 receptors by the oxidized cells was not inhibited by subsequent reduction with borohydride, since the cells could still be stimulated with IL-2.
Roffman et al. (1984)IL-2The conditioned medium derived from the borohydride-reduced cells cannot support the growth of the IL-2-dependent line, indicating that borohydride inhibits the oxidation-induced IL-2 production.
Pizzato et al. (1998)IL-2Accordingly, human glioma cells were used as targets for gene transfer after selecting a packaging cell clone that produced a reasonable titer of recombinant virus and expressed high levels of IL-2 and tk transcripts.
Visani et al. (1987)IL2Thus, IL2 receptor inducibility is a characteristic feature of CML clonogenic cells, which they share with AML, but not with normal marrow progenitors.
Wiranowska-Stewart and Hadden (1986)IL-2NPT 15392 was able to enhance PHA-induced IL-2 production at 10-100 times lower concentrations than isoprinosine.
Takimura et al. (1997)IL-2When the signal peptide was more basic near its amino terminal and more hydrophobic in the middle region, IL-2 production increased 20 fold.
Dornand et al. (1987)IL 2We have studied the mechanism whereby amiloride inhibits the blastogenesis by measuring their effect on: 1) IL 2 production, 2) acquisition of IL 2 responsiveness and induction of IL 2 receptors, 3) IL 2-induced proliferation.
Dornand et al. (1987)IL 2Moreover under these conditions, an enhanced accumulation of IL 2 was observed in the supernatants of stimulated cells.
Gelfand et al. (1987)IL2An increase in [Ca2+]i is critical for IL2 secretion in contrast to the requirements for IL2 receptor expression and IL2-IL2 receptor interaction.
Rossi et al. (1988)IL2Phorbol ester significantly increased the IL2 secretion in both the PB and the BM of B-CLL patients.
Rossi et al. (1988)IL2However, IL2 secretion increased in the BM cells from B-CLL patients after addition of indomethacin or prior irradiation, in a similar way to that observed in PB and BM of normal controls, suggesting an apparent normal control of the IL2 production in BM from B-CLL patients.
Forsgren et al. (1989)interleukin 2Ciprofloxacin at 5 mg/l inhibits immunoglobulin production but the growth factor interleukin 2 (IL-2) is increased by 4-quinolones at the same concentration and hyperinduced at higher concentrations.
Forsgren et al. (1989)IL-2Increased IL-2 may contribute to CNS side effects.
Palladino et al. (1984)IL-2Transfer of resistance to allografts and tumor grafts requires exogenous IL-2.
Li et al. (1990)IL-2Furthermore, soluble IL-2 receptors in the cell-free supernatants from HAM patients were markedly increased compared to those from asymptomatic carriers.
Valentine et al. (1985)IL-2In contrast, stimulator cells with no shared HLA-DR or without evidence of EBV infection never induced IL-2 release.
Nomura et al. (2003)IL-2Pretreatment with oxotremorine-M (Oxo-M) caused the increase in phytohemagglutinin-induced IL-2 production.
Prasad et al. (2006)IL-2In this study, it has been reported for the first time that zinc is also required for gene expression of IL-2 and IL-2Ralpha in primary cells.
Shaw et al. (1988)IL-2 mRNAHuman Jurkat cells show a rapid increase of IL-2 mRNA on induction of IL-2 synthesis, followed by an equally rapid decline 4 to 6 h later.
Shaw et al. (1988)IL-2 mRNAThe decline occurs despite a high rate of synthesis, and appears to be due to an enhanced rate of IL-2 mRNA degradation.
Bessler et al. (1986)IL-2On the other hand, a higher stimulatory activity for IL-2 production was observed in cord serum as compared with adult normal serum.
Krönke et al. (1984)TCGFTo define further both the specificity of CsA and the level at which it interferes with lymphokine gene expression, we have studied its effects on TCGF mRNA accumulation as well as TCGF gene transcription.
Krönke et al. (1984)TCGFCsA completely inhibited induced TCGF mRNA accumulation at concentrations of 0.3-1.0 microgram/ml, whereas low levels of appropriately sized TCGF mRNA were present at 0.01 microgram/ml.