Viewing negative mentions of positive regulation of IL2 (H. sapiens)

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Clevers et al. (1985)IL-2It is concluded that A23187 induces the expression of IL-2 receptors without concurrent stimulation of IL-2 production, thus allowing only low levels of proliferation.
Ythier et al. (1985)IL2In fact, there was no measurable interleukin 2 (IL2) secretion and no significant increase in IL2 susceptibility following incubation with either PHA or anti-T11(2) plus anti-T11(3).
Wiranowska-Stewart and Hadden (1986)IL-2Alone they were unable to consistently induce IL-2 activity.
Rossi et al. (1988)IL2The irradiation or the addition of indomethacin did not enhance the IL2 production in PB from B-CLL patients.
Philip et al. (1996)IL-2Transfections with the non-AAV plasmid containing the identical expression cassette as the AAV plasmid induced IL-2 expression in the tumor cell line but failed to produce IL-2 in primary tumor cells.
Silva et al. (1981)IL-2The release of IL-2 by TG cells did not require DNA synthesis or functional Rc gamma receptors, since positively selected TH cells produced IL-2, even though they lacked lymphoproliferative responses to PHA and antibody-dependent cell-mediated cytotoxicity.
Teodorczyk-Injeyan et al. (1988)IL2Bypassing the requirements for mitogen-induced increases in [Ca++]i, using the cation ionophore A23187, or activating PK-C with the phorbol ester 12-o-tetradecanoyl-phorbol-13-acetate (TPA), failed to significantly restore SPA-induced IL2 production in cell cultures from burned patients.
Kasahara et al. (1989)IL2The kinetics of IL2 and IFN-gamma production were essentially similar for both lymphokines except that there was a faster accumulation of IFN-gamma mRNA than IL2 mRNA.
Altomare et al. (1997)IL-2There was a slight but not significant increase in IL-2 concentrations after major operations.
Kees et al. (1994)IL-2Significantly, a signal provided by a low concentration of PMA (not leading to IL-2 induction by itself in the presence of calcium ionophore) was necessary.
Welte et al. (1987)IL-2In patients whose cells had ceased to produce IL-2 spontaneously or never produced this cytokine, neither coculture with host cells nor stimulation with OKT3 antibody thereafter induced IL-2 release through the first year posttransplant.
Song et al. (1993)IL-2PMA alone, which induced high levels of tyrosine phosphorylation of the ERK protein, neither induced any detectable IL-2 nor increased the level of tyrosine phosphorylation of the 100,000 MW protein.
Hara and Fu (1985)IL-2They failed to induce either interleukin 2 (IL-2) receptor expression or IL-2 secretion.
Yu et al. (1998)IL-2Although PHA stimulation increased IL-2 release, the expression of IL-2R alpha and beta chains and the release of sIL-2R were not proportionately increased in BD.
Yeh et al. (1984)TCGFB lymphoblastoid cells or 12-O-tetradecanoylphorbol 13-acetate alone did not induce TCGF receptors, but they did exert a very marked synergistic effect with Concanavalin A.
Nihlmark and Lindqvist (1989)IL-2These results indicate that intact microtubules are necessary for PHA/OKT3-induced proliferation and IL-2 production, but not for IL-2-induced proliferation.
Baine et al. (1995)IL-2Conversely, calcium-independent anti-CD28 Ab and PMA-induced IL-2 production was resistant.
Yukioka et al. (1987)interleukin-2Polyamine biosynthesis is necessary for interleukin-2-dependent proliferation but not for interleukin-2 production or high-affinity interleukin-2 receptor expression.
Yukioka et al. (1987)IL-2These results indicate that polyamine biosynthesis is necessary for IL-2-dependent proliferation, but not for IL-2 production or IL-2 receptor expression.
Kang et al. (1987)IL-2BGEF alone did not induce the production of IL-2.
Manié et al. (1993)IL-2Interestingly, the co-culture stimulated by (Fab')2 fragments of CD3 mAb displayed an enhanced IL-1 beta production without any increase of IL-2 secretion.
Wells et al. (1994)IL-2No significant increase in IL-6, IL-2, or hyaluronic acid was found in the sera.
Donati et al. (1992)IL-2It was observed that a single session of in vitro dialysis did not induce production of interleukin-2 (IL-2) and did not alter the expression of IL-2 receptor (IL-2R) on the cytoplasmic membrane and the secretion of soluble IL-2R, whereas it induced transcription of mRNA for IL-2R.
Murakawa and Sakane (1988)IL-2PMA alone did not stimulate IL-2 production but, in concert with PHA, induced IL-2 synthesis.
Perrin et al. (1988)IL 2On the contrary, infection with a live rabies virus does not specifically induce the production of IL 2: splenocytes from ill mice previously infected with wild rabies virus cannot be specifically stimulated by rabies antigens, whereas they can be non-specifically stimulated by a mitogen (Concanavalin A (Con A].
Roth and Dröge (1991)IL 2In contrast to the DNA synthesis activity in these cell cultures, IL 2 production is not augmented but rather inhibited by exogenous glutathione (GSH).
Loertscher et al. (1987)IL-2Stimulation with heated cells triggered the release of IL-1- and an IL-3-like bioactivity but did not induce IL-2 synthesis and/or release, thus explaining the lack of proliferation in the HMLR.
Manger et al. (1986)IL 2This antibody, designated J64, induced IL 2 secretion by HUT 78 in combination with PHA, T3 antibodies, or calcium ionophores, however not by itself.
Teng et al. (1996)IL-2By contrast, receptors which contained single tyrosine 188, 191 or 200 to phenylalanine substitutions were unable to induce IL-2.
Teng et al. (1996)IL-2These results imply that in this system phosphorylation of tyrosine 173 and hence activation of PI3-kinase is not required for CD28 induced IL-2 secretion.
Teng et al. (1996)IL-2Despite an apparent requirement for phosphorylation of all three of these tyrosines, however, receptors which contain tyrosine only at positions 191 or 200 and a truncated receptor which does not contain tyrosine 200 induce normal IL-2.
Liang et al. (1992)IL-2Flow cytometric studies showed that the level of surface IL-2 receptors was not increased by GSH treatment.
Zubiaga et al. (1991)IL-2This is not due to posttranslational conversion of inactive NFkB into its active form by CHX, because a clustered mutation in the kB-like sequence in the IL-2 enhancer that abrogates NFkB binding does not affect the up-regulation of IL-2 transcription.
Mire-Sluis et al. (1987)IL-2These data strongly suggest that stimulation of IL-2 receptors by IL-2 was not required for the completion of the first round of mitosis.
Suzuki et al. (1986)interleukin 2Regardless of this specific DNA replication, the AMLR generated no production of interleukin 2 (IL-2) and interferon gamma (IFN-gamma), both of which could be found in the allogeneic (allo) MLR.
Gerosa et al. (1986)IL-2Although stimulation of modulated clones with different anti-T3 mAb did not lead to IL-2 production, 4/39 of these clones produced IL-2 after stimulation with phytohemagglutinin (PHA).
Yamamoto et al. (1993)IL-2In 3 patients, the IL-2 dose could not be increased to the planned level due to fever or jaundice.
Linker-Israeli et al. (1985)IL-2Removal of OKT8+ cells from normals did not significantly increase IL-2 activity.
Hess and Bright (1991)IL-2CsA effectively inhibited the proliferative response and IL-2 production induced with anti-CD3 and Bryo but did not inhibit the response of cells stimulated with anti-CD28 and Bryo.
Ayanlar-Batuman et al. (1986)IL 2Thus, these cells are unable to produce IL 2 or generate IL 2 receptors.
Gigout et al. (1998)IL2Contrary to what was previously evidenced during primary infection with an attenuated SIV clone, no increase in IL2 and IL4 mRNA was detected in PBMCs of the ddI-treated monkeys, although these monkeys exhibited virus loads similar to those evidenced in macaques infected by attenuated SIV.
Shifera and Horwitz (2008)IL-2Cells expressing either mutation failed to induce IL-2 following stimulation with PMA/ionomycin while the induction of IL-2 was restored in cells reconstituted with the wild type IKK gamma.
de Totero et al. (1994)IL2Since in variant HCL the IL2 receptor alpha chain could not be induced by different stimuli, it appears that the CD25 antigen may not be essential in the process of IL2-promoted growth, while p75 and p64 play a primary role in IL2 activation.
Kuhns et al. (1992)IL-2There was little accumulation of IL-4 and no accumulation of IL-1 alpha or IL-2 during the 24-h period.
O'Shea et al. (1992)IL-2In combination, these agents induced tyrosine phosphorylation of cellular substrates, elevated cytosolic free calcium, and induced interleukin 2 receptor (IL-2R) alpha chain expression but not IL-2 secretion.
Fan et al. (1993)IL-2 geneIL-2 gene expression was not increased significantly.
Grady et al. (1998)IL-2OBJECTIVES: To describe the extent and severity of perceived fatigue in a cohort of HIV-infected men (N= 50) who, as participants in a randomized clinical trial, were randomized to receive or not to receive investigational interleukin-2 (IL-2).
Ruscetti and Gallo (1981)TCGFIn some cases, these cells become independent of exogenous TCGF by producing their own growth factor, implying a role for TCGF in the continuous proliferation of these cells.
Zu et al. (1990)IL 2After cell conversion from an IL 2 dependent state to an IL 2 independent state, one of the five phosphoproteins, the 65-kDa protein, became constitutively phosphorylated even without addition of IL 2.
Fernandez et al. (1995)IL-2These results do not support the possibility of a modulatory effect on the immune response by thalidomide via IL-2 production and IL-2 response.
Okai et al. (1984)IL 2In contrast, MT 2 cell line did not produce IL 2 activity, but non-IL 2 type growth factor was observed.
Tartour et al. (2000)IL-2 mRNAIn addition, we did not find any expression of exogenous IL-2 mRNA in post-therapeutic lesions removed 29 days after the start of therapy.
Cantrell and Smith (1983)IL-2The decay of IL-2 receptors could not be attributed to IL-2-mediated down-regulation.
Donnelly et al. (1986)IL-2NPT-15392 alone did not induce IL-2 synthesis at any of the doses employed and did not induce proliferation of the IL-2-dependent target cells used to quantitate IL-2 activity.
Povlsen et al. (1989)IL-2CsA, added during antigen activation, reduced the number of Tac antigen presenting cells, but anti-Tac was unable to detect variations in the expression of high affinity IL-2 receptors.
Nagy and Rosztóczy (1988)IL-2Enterotoxin production, coagulase production, pigment formation and the phage type of the staphylococci showed no strict correlation of any of these properties with the IL-2 inducer activity.
Tamori et al. (1989)IL-2The addition of interleukin-1 (IL-1, 0-100 U/ml), did not enhance the expression of IL-2 receptor in these cells in the presence of IL-2.
Fiocchi et al. (1988)interleukin 2This cytotoxic function was critically dependent on the continuous availability of interleukin 2, but not on the expression of the Tac antigen, since Tac-negative cells were also cytotoxic.
Konaka et al. (1981)IL2IL2 production in this model is demonstrable at 4-6 h, or earlier, and is proliferation-independent.
Kasahara et al. (1989)IL2 geneTaken collectively, these experiments support the notion that IL1 does not trigger IL2 gene activation per se, but amplifies the preactivated lymphokine genes initiated by PMA and ionomycin, whereas IL1 can activate the IL2 receptor gene without any other known signal requirements.
Hirano et al. (1984)IL 2 mRNAIn these ways, it was shown that TPA alone did not induce any significant IL 2 mRNA synthesis, but when added together with PHA it increased the level of IL 2 mRNA by at least 10-fold, as compared with that induced by PHA alone.
Dohlsten et al. (1988)IL2This discrepancy in kinetics was not due to an increased absorption of IL2 by the CD4+45R+ cells during the first day of culture.
Miller et al. (1986)IL 2Although these cells have been activated to an IL 2R+ stage, most of them are unable to produce detectable IL 2 unless they are cultured together with the original, activating antigen.
Schmidt et al. (1985)IL 2Before activation, the IL 2 receptor expression of NK clones was confined to cells in the G2 - M phase, but after T11 activation the more pronounced IL 2 receptor expression became independent of the cell cycle.
Praditpornsilpa et al. (2003)IL-2In conclusion, experiments in the MLC model suggest that allorecognition upregulates IL-2 but not IL-15 expression.
Lundin et al. (1989)IL-2This may be due, not to a defect in the recognition of the antigen, but to an inability to produce sufficient amounts of interleukin 2 (IL-2) for autocrine growth, since specific HLA-restricted proliferative responses could be induced in 'non-proliferative' clones by the addition of exogenous IL-2 or phorbol myristate acetate (PMA).
Härtel et al. (2004)IL-2 mRNAOur approach is potentially valuable for identifying transplant patients in whom IL-2 mRNA expression is unaffected or even enhanced after initiation of immunosuppressive therapy.
Gullberg and Smith (1986)IL-2Accordingly, T4+ cell autocrine IL-2 responsiveness is restricted by a mechanism that is independent of IL-2-R, and which ultimately results in cessation of both T4+ and T8+ cell IL-2-dependent clonal expansion.
Fenton et al. (1996)IL-2Patients were randomized to one of three groups: no adjuvant IL-2, low-dose IL-2 (1.2 x 10(6) IU/m2), or high-dose IL-2 (1.2 x 10(7) IU/m2).
Grabstein et al. (1986)IL 2This early peak of IFN-gamma mRNA, therefore, is likely to be independent of IL 2 action.
Malnati et al. (2002)IL-2Thus, IL-2 therapy seems safe in most patients infected with both HIV and HHV-8, except for those with detectable HHV-8 viremia, who may not be eligible for IL-2 treatment.
Fujino et al. (1997)IL-2Cytometric analysis showed Oxo-M treatment did not up-regulate expression of cell surface molecules such as CD3, CD2, CD4, CD8, and IL-2 receptors.
Aladdin et al. (2000)IL-2The HIV RNA level did not change during IL-2 therapy; however, after 8 weeks of follow-up a significant increase (P<0.001) in viral load was observed.
Beltz and Kierszenbaum (1987)IL-2T. cruzi neither absorbed nor inactivated IL-2.
Nagler et al. (1997)IL-2Significant reductions in both the resting and stimulated parotid and submandibular salivary flow rates were observed during IL-2/IFN-alpha immunotherapy compared with the pre- and post-therapy values (P < 0.01), while no hyposalivation was observed in the control patients who underwent ABSCT and did not received IL-2.
Evans et al. (1994)IL-2Pervanadate does not, however, induce the activity of tyrosine kinases associated with the IL-2 receptor or the phosphorylation of a major IL-2 responsive protein of 116 kDa (Jak-3).
Matesanz et al. (2001)IL-2Expression level differences of the IL-2 alleles (between one- and three-fold) were not attributable to the -384 promoter polymorphism.
Clayman et al. (1992)IL-2No significant alteration of the IL-2Rp55 subunit occurred with therapy.
Croll et al. (1987)interleukin-2The presence of cyclohexamide, which inhibits protein synthesis by greater than 99%, had no effect on the induction by A23187 plus mezerein of mRNA from either gene, indicating that synthesis of proteins such as interleukin-2 is not required for activation of either gene.
Menéndez et al. (1992)interleukin-2These alterations could not be ascribed either to a decreased synthesis of interleukin-2 or to a defective expression of interleukin-2 receptor after cellular activation.
Li (1991)IL-2At IL-2 concentration of 100 U/ml no increase in IP3 was observed.
Mastro et al. (1991)IL-2In this study, we present evidence that protein kinase C activation is directed to production of IL-2 but not to IL-2 receptors.
Szamel et al. (1990)interleukin 2Incubation of cells with synthetic diacylglycerols and calcium ionophores proved to be effective in expression of high affinity interleukin receptors, no detectable amounts of interleukin 2 were, however, synthetized.
Kawano et al. (1992)IL2The pre-existing IL2 responsiveness in the patients was not increased by the CD45RA antibody pretreatment.