Viewing affirmative mentions of localization of IL2 (H. sapiens)

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Borysiewicz et al. (1985)IL-2cytotoxic T cellThe immunosuppressive effects of measles virus on T cell function--failure to affect IL-2 release or cytotoxic T cell activity in vitro.
Foa et al. (1994)IL-2cytotoxic T lymphocytesEvidence has also been provided that the IL-2 released constitutively by engineered tumor cells may induce the generation of specific cytotoxic T lymphocytes and of an antitumor memory response.
Kaufmann and Rosenberg (1984)interleukin-2CTLWe have investigated the effect of cyclosporin (Cys) on the maturation of cytotoxic T lymphocytes (CTL), and on the induction of interleukin-2 (IL-2) secretion using two bifunctional CTL hybridomas.
Norose and Yano (1996)IL-2CTLsIL-6 production and sIL-2R secretion of CTLs were enhanced when CTLs were stimulated with P-36.
Bunjes et al. (1995)IL-2-secretingcytotoxic T cellNo autoreactive IL-2-secreting T helper cell precursors or cytotoxic T cell precursors were detectable in either group.
Arienti et al. (1994)IL-2CTLIn a limiting dilution assay, transduced, but not parental melanoma lines unless added with an amount of IL-2 comparable to that released by the transduced cells, were able to expand both nonspecific and melanoma-specific CTL precursors from autologous peripheral blood lymphocytes (PBL).
Welte et al. (1982)IL-2cytotoxic T cellAll three molecular forms of IL-2 were biologically active at concentrations of 10(-11) - 10(-10) M, supporting the growth of human and murine cytotoxic T cell lines.
Krowka et al. (1987)interleukin 2cytotoxic T lymphocyteThe ability of T cells from these lines to induce cytotoxic T lymphocyte or antibody responses were compared with their ability to proliferate or release interleukin 2 (IL 2).
Zier and Salvadori (1999)IL-2CTLIn addition, the lack of a response could not be attributed to insufficient levels of IL-2 alone, since even tumor cells that secreted IL-2 failed to stimulate anti-(class I) CTL.
Kaufmann and Rosenberg (1984)lymphokinecytotoxic T lymphocyteBlocking by cyclosporine of antigen-induced maturation and lymphokine secretion by cytotoxic T lymphocyte hybridomas.
Belin et al. (1990)lymphokinecytotoxic T cellsCsA works via the inhibition of both lymphokine release and subsequent activation of cytotoxic T cells.
Czitrom and Liddell (1983)IL-2CTLSince IL-2 is a product of helper T (Th) cells secreted upon activation by antigen recognized in context of self H-2 and is known to stimulate antigen-activated cytotoxic T-lymphocyte precursors (CTL-P) non-specifically to effector CTL function, the results indicate that accessory cells interact in an H-2 restricted fashion with helper rather than cytotoxic T-lymphocyte precursors.
Ozery et al. (1989)IL2CTLThe independent triggering of specific killing and IL2 secretion in the monoclonal cytolytic hybridomas suggests that in CTL distinct signals stimulate killing activity and IL2 production.
Morisaki et al. (1994)IL-2CTLInterleukin-2 (IL-2) and IL-4 secretion was induced in both CD4+ and CD8+ CTL after stimulation by melanoma cells.
Yu et al. (2009)IL-2cytotoxic T-lymphocyteTo determine whether RNA interference (RNAi) could block cytotoxic T-lymphocyte antigen 4 (CTLA4) in human lymphocytes in vitro and promote IFN-gamma and IL-2 secretions, three small interfering RNAs (siRNAs) were selected based on target specificity sequences of human CTLA4 and transfected into human lymphocytes of chronic HBV patients.
Brignone et al. (2007)IL-2cytotoxic T lymphocytesA clinically effective therapeutic vaccine to fight viruses or tumour requires the generation and expansion of specific cytotoxic T lymphocytes (CTL) able to proliferate and/or secrete Th1-type cytokines such as IL-2, IFN?
Kaufmann and Berke (1983)IL 2CTLAnti-LFA-1 monoclonal antibody, a potent inhibitor of CTL and CTL hybridoma-mediated target cell lysis, abolishes antigen- or mitogen-induced IL 2 secretion by the CTL hybridomas.
Littaua et al. (1992)interleukin-2cytotoxic T-lymphocyteA CD4+ cytotoxic T-lymphocyte clone to a conserved epitope on human immunodeficiency virus type 1 p24: cytotoxic activity and secretion of interleukin-2 and interleukin-6.
Littaua et al. (1992)interleukin-2CTLProduction and secretion of lymphokines such as interleukin-2 and interleukin-6 after specific antigenic stimulation were demonstrated by this gag-specific CD4+ CTL clone.
Lone et al. (1998)interleukin-2CTLThey specifically bound HLA-A2-restricted peptides and induced a peptide-specific cytotoxic T lymphocyte (CTL) clone to proliferate and secrete interleukin-2.
Bunjes et al. (1981)interleukin 2cytotoxic T cellCyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2.
Harding and Allison (1993)IL-2CTLCD28-mediated signaling provokes the release of interleukin 2 (IL-2) from the CD8+ CTL precursors, as anti-CD28 mAb could be substituted for by the addition of IL-2, and an anti-IL-2 mAb can block the generation of anti-CD28-induced CTL.
Mizobata et al. (1996)IL-2CTLsThus, CTLs generated by FN might have both killer and helper functions, since they could lyse autologous tumour cells and secrete various cytokines, including IL-2.
Juhn et al. (2008)IL-2cytotoxic T-cellsThere are many biological effects including: chemotaxis of cytotoxic T-cells and B-lymphocytes, cytokine synthesis of IL-2 and IL-8 and TNF, neutrophil chemotaxis and degranulation, fibroblast and epithelial proliferation, and histamine release (13, 14).
Klarnet et al. (1989)IL-2cytotoxic T lymphocytesHelper-independent CD8+ cytotoxic T lymphocytes express IL-1 receptors and require IL-1 for secretion of IL-2.
Li and Fu (2001)IL-2CTLA significant increase of IL-2 secretions was detected during IL-4 mTC inducing CTL responses.
Li and Fu (2001)IL-2CTLIL-2 secretion and CTL response were inhibited by anti-IL-4 or anti-surface molecule McAbs.
Li and Fu (2001)IL-2CTLCONCLUSION: IL-4 gene modification might enhance the tumor cell-specific CTL killing activities by inducing cell surface molecules expression and IL-2 secretion.
Chao and Lin (2010)IL-2cytotoxic T lymphocytesSheeja et al. showed that the A. paniculata ethanol extract and andrographolide stimulated the cytotoxic T lymphocytes (CTL) activity through enhanced release of IL-2 and IFN?
Foss (2002)IL-2cytotoxic T lymphocytesThe presence of costimulatory molecules, such as B7-1 and B7-2, on antigen-presenting cells and the secretion of IL-2 promote the differentiation of recruited CD8+ lymphocytes into cytotoxic T lymphocytes.
Vassilev et al. (1996)lymphokinecytotoxic T-cellsCONCLUSION: The effect of increasing the cytolysis shows that these drugs are active, probably by increasing the lymphokine secretion and the generation of cytotoxic T-cells.
Golden-Mason et al. (2007)interleukin-2CTLsIn vitro blockade of PD-1 by monoclonal antibodies specific to its ligands (PD-L1 and PD-L2) results in restoration of functional competence (proliferation and gamma interferon and interleukin-2 secretion) of HCV-specific CTLs, including those residing in the liver.
Veldman et al. (2009)IL-2cytotoxic T-lymphocyteIn contrast, the larger subpopulation showed a Th-like phenotype, lacking Foxp3, cytotoxic T-lymphocyte antigen 4 (CTLA4) and glucocorticoid-induced tumour necrosis factor receptor (GITR) expression and IL-2 secretion, and did not mount a proliferative response to Dsg3 and mitogenic stimuli.
Van Emmerik et al. (1997)IL-2CTLIn the present study, we analyse whether both CTL subsets were distinct with respect to their IL-2, IL-4, IL-6 and interferon-gamma (IFN-gamma) secretion pattern.
Rogy et al. (2000)interleukin 2cytotoxic T lymphocytesThe release of interleukin 2 (IL-2) and Interferon-gamma (IFN-gamma) by naive T lymphocytes predominantly stimulates cytotoxic T lymphocytes, macrophages, and natural killer (NK) cells and increases the antigen-presenting potential of all these cell types.
Mizuochi et al. (1985)interleukin 2CTLOne of the necessary functions performed by both L3T4+ and Lyt-2+ Th cell populations in allospecific CTL responses was found to be the secretion of interleukin 2.