Viewing affirmative mentions of gene expression of IL2 (H. sapiens)

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Kahle et al. (1981)IL 2In addition, cloning efficiencies were acceptable (over 30%) when IL 2 produced spontaneously from the leukaemic cell Jurkat (M-N) was used.
Foa et al. (1992)IL2 geneThese considerations have led to the belief that more sophisticated technologies aimed at introducing the IL2 gene into the neoplastic cells may potentially overcome some of the limitations coupled to the in vivo infusion of high doses of IL2.
Azogui et al. (1983)IL 2The aim of the present work was to study the helper function by measuring the production of interleukin 2 (IL 2).
Azogui et al. (1983)IL 2A consecutive series of 34 patients was tested for IL 2 production after BMT.
Azogui et al. (1983)IL 2The mechanism of this low IL 2 production was investigated.
Azogui et al. (1983)IL 2The IL 2 production was not restored or was slightly affected by irradiation early after BMT.
Azogui et al. (1983)IL 2These results suggest that the lack of immune reconstitution after BMT may be caused by the lack of IL 2-producing cells and/or the increased activity of suppressor cells of the helper function.
Cheong et al. (2003)IL2Our model system is recombinant parvovirus MVM expressing human IL2, but the method should be adaptable to other vectors expressing transgenes that are secreted and for which antibodies are available.
Duchateau et al. (1985)IL2No IL2 production was observed in the unstimulated cultures, even in the presence of thymopentin.
Duchateau et al. (1985)IL2On the contrary, preincubation with different concentrations of thymopentin influenced PHA-induced IL2 production.
Kaplan et al. (1988)IL-2MLA-144 produces IL-2 constitutively; however, it did not possess membrane-associated epitopes.
Andersson and Sander (1989)IL-2Only 1% of the cells produced IL-2, but each IL-2 stained cell was very bright, indicating a low capacity of anti-CD3 antibody to induce IL-2 production rather than an insensitivity of our detection system.
Stern et al. (1984)IL-2The availability of homogeneous IL-2 will allow accurate biological studies of its activity free from the contamination of the numerous lymphokine species that are known to be co-produced with IL-2 during the induction procedure.
Altman et al. (1984)interleukin 2Antibodies of predetermined specificity against chemically synthesized peptides of human interleukin 2.
Chouaib and Fradelizi (1982)interleukin-2[Cellular regulation of human interleukin-2 production].
Chouaib and Fradelizi (1982)IL2Previous studies have also suggested that control of IL2 production is similar in the Human.
Chouaib and Fradelizi (1982)IL2A model for the cellular control of human IL2 production is proposed.
Ghoneum et al. (1987)Interleukin-2Interleukin-2 and lymphotoxin production were decreased by 64% and 38%, respectively.
Elfenbein et al. (1984)interleukin-2There appear to be defects in both interleukin-2 production and interleukin-2 responsiveness in this system early after marrow transplant.
Ryll et al. (1990)interleukin-2Production of recombinant human interleukin-2 with BHK cells in a hollow fibre and a stirred tank reactor with protein-free medium.
Ryll et al. (1990)IL-2For the production of recombinant human interleukin-2 (IL-2) two different culture processes, a 1-2 liter homogeneous stirred bubble-free aerated system and a dense cell hollow fibre bioreactor were compared.
Ryll et al. (1990)IL-2In the stirred culture 0.75 mg IL-2 were produced with 1 l of perfused medium at a maximum cell number of 3 X 10(10).
Zhao et al. (2008)IL-2Expression kinetics indicated that the expression level of IL-2 was already high at 24 h after infection and reached the highest level at 48 h after infection.
Petrov and Lijnen (2000)IL-2The normal expression of IL-2 receptors was preserved while the IL-2 production was blocked in the presence of nifedipine or mibefradil.
Frydecka et al. (1999)Interleukin 2Interleukin 2 (IL-2), a pleiotropic cytokine which plays a central role in immune response, has been introduced in several clinical trials in patients with hematological malignancies after BMT or PBSCT to increase immunocompetence of these patients and eradicate residual malignant cells.
Uchiyama et al. (1993)interleukin 2Transfection of interleukin 2 gene into human melanoma cells augments cellular immune response.
Uchiyama et al. (1993)IL-2IL-2 gene was transfected into three human melanoma cell lines; secretion of IL-2 from stable transfected cells was confirmed by enzyme-linked immunosorbent assay.
Uchiyama et al. (1993)IL-2These data suggest that IL-2 gene transfection may be an important strategic approach to enhancing specific immune responses induced by a polyvalent melanoma cell vaccine.
Schleuning et al. (1993)IL-2This cell line shows a highly proliferative activity in response to the autocrine produced IL-2.
Kalashnikova and Pukhal'ski? (1993)IL-2A transition from stimulation to suppression of IL-2 production by Dx was essentially observed in the dose range of 10(-9) to 10(-8) M.
Warrington (1988)IL-2It was found that in both RA and SLE there was a significant overproduction of IL-2 demonstrable at low cell densities.
Warrington (1988)IL-2At high cell densities, IL-2 production was decreased in SLE but remained enhanced in RA.
Warrington (1988)IL-2The possibility is discussed that a local hyper-production of IL-2 could induce disturbances of the immune response, resulting in the breaking of normal tolerance.
Grote et al. (1987)IL-2Using TPA/A23187 induction, up to 500 micrograms of IL-2 per liter were produced.
Goeken and Eckerle (1986)Interleukin 2On culture day 10, neither pellet nor interface cells displayed significant spontaneous proliferation but exogenous Interleukin 2 (IL-2) produced up to five times as much proliferation in interface cells as in pellet cells.
Nunn et al. (1986)interleukin-2Cell proliferation was assessed by measuring the incorporation of 125iododeoxyuridine; interleukin-2 (IL-2) production was measured using an IL-2-dependent cell line, and the number of 1,25(OH)2D3 receptors was measured by whole-cell nuclear association assay.
Nunn et al. (1986)IL-2This effect was more pronounced in the cells from the intermediate and high density layers and was reflected both in cell proliferative responses and in relative IL-2 synthesis.
Goodman and Weigle (1985)IL 2That IL 2 itself was in fact responsible for both the specific response to antigen and the synergistic interaction with 7m8oGuo was confirmed in experiments with purified IL 2 produced by recombinant DNA technology.
Reem et al. (1984)IL-2IL-2 synthesis preceded the proliferative response and required the continuous presence of con A.
Lomnitzer et al. (1984)interleukin-2Suppression of interleukin-2 production by human concanavalin A-induced suppressor cells.
Lomnitzer et al. (1984)IL-2Glutaraldehyde-treated S cells (which retained the ability to absorb IL-2) did not affect the proliferative response or IL-2 production by the R cells, indicating that passive absorption of IL-2 was not entirely responsible for suppression induced by S cells.
Lomnitzer et al. (1984)IL-2These results show that Con A-treated MN cells suppressed or prevented [3H]thymidine incorporation by actively inhibiting IL-2 production.
Bruserud and Moen (1984)IL-2One thousand rads. irradiation of the cells was found to alter the kinetics and to increase the production of IL-2.
Faist et al. (1993)interleukin-2Inadequate interleukin-2 synthesis and interleukin-2 messenger expression following thermal and mechanical trauma in humans is caused by defective transmembrane signalling.
Faist et al. (1993)IL-2 proteinThe IL-2 protein synthesis generated in PHA-stimulated PBMC cultures following trauma, compared with that in controls (0.62 +/- 0.04 U/mL) was persistently and significantly depressed during the observation time with a 57% inhibition on day 10-identical with that on day 1.
Yamamoto et al. (1985)IL2 mRNADNA synthesis and cell division were not necessary for the induction of IL2 mRNA production but the induction was inhibited by dexamethasone, showing that the production was mainly associated with the G1 phase of the cell cycle.
Yamamoto et al. (1985)IL2 geneThis suggests that TPA induces certain changes in the biochemical pathway of signal transduction so that the cells can be triggered to express IL2 gene by subsequent stimulation with mitogen.
Numazaki et al. (1988)IL-2CMV-infected cultures became deficient in terms of ability both to produce interleukin-2 (IL-2) activity as well as to respond to purified, recombinant IL-2 which was added exogenously.
McElhaney et al. (1990)interleukin 2Age-related decline in interleukin 2 production in response to influenza vaccine.
McElhaney et al. (1990)IL2Previous experiments that have shown defective IL2 production related to aging have used potent mitogens such as concanavalin A and phytohemagglutinin to stimulate TH.
McElhaney et al. (1990)IL2This study provides evidence that defective IL2 production may also occur in response to physiologic antigenic stimulation and may be one explanation for the reduced efficacy of influenza vaccination in elderly persons.
Wang et al. (1984)IL-2Actinomycin D and puromycin inhibited the appearance of IL-2 receptors as well as the production of IL-2.
Wang et al. (1984)IL-2Thus, these data suggested that both IL-2 production and the appearance of IL-2 receptors were dependent on transcription and translation in non-resting cells.
Stott et al. (1986)IL-2The recent cloning of the human gene encoding interleukin 2 (IL-2) has provided the means for economical production of large quantities of the pure lymphokine for clinical studies.
Russell et al. (2001)IL-2Methodological problems in LDA include autoreactivity in the responder or stimulator cell populations and interleukin 2 (IL-2) production by the stimulator cells as a response to the responder cells (backstimulation).
Stopeck et al. (1998)IL-2Established tumor cell lines produced 10- to 100-fold more IL-2 than did fresh or short-term tumor cultures as measured by enzyme-linked immunoabsorbent analysis.
Stopeck et al. (1998)IL-2Enzyme-linked immunoabsorbent analysis of the amount of IL-2 secreted into the medium by transfected tumor cells correlated with the percentage of tumor cells expressing intracellular IL-2 as measured by flow cytometry.
Russell and Vindelov (1998)interleukin 2The assay requires reliable detection of the amount of interleukin 2 (IL-2) produced by one cell.
Durrant et al. (1997)IL-2Enhanced IL-2 production was observed following 15/19 injections of 100 micrograms of 105AD7 whereas only 4/11 injections of 200 micrograms of 105AD7 induced responses (p < 0.02).
Pahlavani and Richardson (1996)interleukin-2The effect of age on the expression of interleukin-2.
Pahlavani and Richardson (1996)IL-2The expression of IL-2 has been found to decrease with age in humans and rodents.
Pahlavani and Richardson (1996)IL-2The decline in IL-2 production has been shown to parallel the age-related decrease in immunologic function.
Su et al. (1991)interleukin 2[Effect of diethyldithiocarbamate on interleukin 2 production of patients with oral lichen planus and its clinical therapeutic efficacy].
Goretski? et al. (1989)IL-2Moreover serum-inhibitors of production acted as IL-2 activity stimulators, while serum-stimulators of IL-2 production inhibited the mediator effects.
Alcocer-Varela et al. (1989)IL-2AS-101 was found to be non-toxic to cells from both patient and control groups; it increased the production of IL-2, elevated the percentage of Tac-positive cells even among cells that had been pre-treated with pronase, and ameliorated the absorption of IL-2.
Walker et al. (1987)Interleukin 2Interleukin 2 synthesis in the presence of steroids: a model of steroid resistance.
Prochazka et al. (1987)IL-2These data collectively suggest that, in addition to impaired IL-2 production, there is an endogenous defect in IL-2 responsiveness.
Romagnani et al. (1986)interleukin-2Frequent occurrence of unusual T4-positive cells which co-express cytolytic activity and production of interleukin-2.
Welte et al. (1984)IL-2The addition of exogenous IL-2 then leads to expression of the IL-2 receptor, as recognized by Tac antibody, and to subsequent proliferation.
Lamb et al. (1983)interleukin-2The dissociation of interleukin-2 production and antigen-specific helper activity by clonal analysis.
Charley et al. (1985)interleukin-2Production of porcine interleukin-2 and its biological and antigenic relationships with human interleukin-2.
Charley et al. (1985)IL2Preculture of porcine PBL or addition of indomethacin enhanced IL2 production, suggesting the existence of a prostaglandin-mediated inhibition of IL2 production in fresh PBL cultures.
Efrat et al. (1984)IL-2 geneThese findings suggested the involvement of a labile protein repressor in the regulation of human IL-2 gene expression.
Gulino et al. (1990)IL-2 geneThis suggests that the constitutive and inducible expression of the IL-2 gene can be dissociated and are presumably subjected to separate regulatory pathways.
Bryan et al. (2006)IL-2We analysed human milk from 52 mothers (15-357 days postpartum) by ELISA to determine levels of aqueous IL-2, as well as production by human milk cells.
Bryan et al. (2006)IL-2IL-2 was produced constitutively at detectable levels by 57% of milk cell samples and production was significantly increased by stimulation with Con A (380%).
Toossi et al. (1986)interleukin 2Defective interleukin 2 production and responsiveness in human pulmonary tuberculosis.
Toossi et al. (1986)IL-2Patients with newly diagnosed, pulmonary tuberculosis had a tuberculin-specific defect in IL-2 production.
Toossi et al. (1986)IL-2The basis for low IL-2 production in such individuals is unknown.
Venkataraman and Westerman (1990)IL-2A radiation dose of 800 rad and higher had a marked effect on both IL-2 production and consumption.
Venkataraman and Westerman (1990)IL-2Despite a difference in both the production and consumption of IL-2 between the irradiated and non-irradiated cells, there was no difference in their ability to generate IL-2 receptors.
Smith and Pruett (1989)IL-2Efforts to correlate various immunological disorders with alterations in IL-2 production in vitro have led to highly variable and often contradictory results.
Smith and Pruett (1989)IL-2Therefore, the recently reported circadian variations in T helper to T suppressor ratios do not seem to significantly affect mitogen-induced IL-2 production.
Wainberg et al. (1983)TCGFWe have also shown that virus co-incubated cultures are deficient with respect to their ability to synthesize detectable levels of TCGF activity in the presence of phytohemagglutinin.
Niu et al. (1996)IL2[The effect of IL2 gene transfection on the growth and metastatic characteristics of muous B16 melanoma cells].
Niu et al. (1996)IL2Northern blot also showed the expression of IL2 gene in mRNA level.
Niu et al. (1996)IL2No obvious influence was observed on the morphology and growth of the tumor cells in vitro after the transfection of IL2-cDNA.