Viewing affirmative mentions of binding of Trav6-3 (M. musculus) in T cells

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Takase et al. (2007)TCRT cellsInteractions between TCR and self-peptide/MHC complex play an important role in homeostasis and Ag reactivity of mature peripheral T cells.
Santori et al. (2004)TCRT cellThe affinity/avidity of the TCR ligand and the maturational stage of the T cell are thought to be principal determinants of the outcome of TCR engagement.
Unsinger et al. (2006)TCRT cellThe role of TCR engagement and activation-induced cell death in sepsis-induced T cell apoptosis.
Penninger et al. (1991)TCRT cellT lymphocytes recognize antigens via transmembrane heterodimers, their T cell receptors (TCR).
Lyons et al. (1996)TCRT lymphocyteT lymphocyte activation is mediated by the interaction of specific TCR with antigenic peptides bound to MHC molecules.
Schmid et al. (2006)TCRT cellsAccording to this concept, even chemically inert drugs can stimulate T cells because certain drugs interact in a direct way with T-cell receptors (TCR) and possibly major histocompatibility complex molecules without the need for metabolism and covalent binding to a carrier.
Itoh et al. (1999)TCRT cellIn the present study, we examined the relationships among quantitative aspects of TCR engagement as measured by receptor down-modulation, functional responses, and biochemical signaling events using both mouse and human T cell clones.
Gronski et al. (2004)TCRT-cellHere we have developed a model to investigate how the affinity of the T-cell receptor (TCR) for the activating agent influences autoimmunity.
Zhong et al. (2003)TCRT cellsDiacylglycerol, generated after TCR ligation, is essential in T cells.
Kersh et al. (1998)TCRT cellThe T cell receptor (TCR) alphabeta heterodimer interacts with its ligands with high specificity, but surprisingly low affinity.
Miller et al. (2010)TcRT cellsFurthermore, the TcR transgenic T cells that were infused in that model recognize a self antigen that would be expected to be present throughout the host, not only at the site of tumor growth or the tDLN.
Cole et al. (2007)TCRT cellIn contrast, the off-rates for all human TCR/pMHC interactions fall within a narrow window regardless of class restriction, thereby providing experimental support for the notion that binding half-life is the principal kinetic feature controlling T cell activation.
Aguado et al. (2006)TCRT cellsThe adapter molecule LAT (Linker for the Activation of T cells) is a membrane protein that becomes phosphorylated on conserved tyrosine residues upon TCR/CD3 complex engagement in T lymphocytes.
Ragin et al. (2005)TcRT cellsIn T cells, it is rapidly activated following TcR crosslinking in vitro [14,15].
Ragin et al. (2005)TcRT cellsWhile activation of the JNK pathway leading to phosphorylation and activation of c-jun has been demonstrated in T cells following TcR and CD28 crosslinking in vitro, as well as by peptide antigen stimulation in vivo, it is not clear whether the SAG SEB activates this pathway in vivo [29,30].
Reed-Loisel et al. (2005)TCRT cellsOur results provide a clear example of a Qa-1-specific TCR that can cross-react with a class Ia molecule and evidence supporting the idea that this may be a common property of T cells selected by class Ib molecules.
Castillo et al. (2004)TCRT-cellSuch high sequence homology was reflected in the identical structural conservation of how pockets A', C' and F' and tunnel T' conforming the antigen's binding site are organized, the similar arrangement of those amino-acids interacting with the T-cell receptor (TCR) during antigen presentation, and the conservation of YQNI-motif sequence in the cytoplasmatic tail (responsible for the molecule's intracellular trafficking in humans).
Leite-De-Moraes et al. (1998)TCRT cellsIt is noteworthy that whatever cytokines are used for their expansion, IL-12 stimulation, in the absence of TCR/CD3 cross-linking, promotes consistent IFN-gamma secretion by NK T cells without detectable IL-4 production.
Arsov and Vukmanovi? (1997)TCRT cellWe hypothesize that altered effector functions in H-Y-specific CD8+ cells are due to the low affinity of TCR-antigen-MHC interaction and/or the elevated threshold of CD8+ T cell activation.
Coyle et al. (1995)TCRT cellsCross-linking of the CD3/TCR complex of FACS-sorted lung T cells revealed that only when anti-IL-4 was administered during immunization was there an inhibition of T cell-derived IL-5 and IgE production.
Schlegel et al. (1995)TCRT cellsActivation of T cells leading to graft-vs-host disease (GVHD) requires two signaling events: the Ag-specific signal generated through the engagement of the TCR/CD3 complex with antigenic peptide fragments presented by MHC molecules on APCs and the second signal provided through additional costimulatory ligands.
Nakata et al. (1995)TCRT cellsWhen rhIL-1 was administered within 24 h after SEB inoculation, the cytokine interfered with tolerance induction; V beta 8+CD4 T cells from mice that had been treated with both SEB and IL-1 proliferated in response to SEB and produced IL-2, IL-4, and IFN-gamma upon TCR/CD28 cross-linking.
Nakata et al. (1995)TCRT cellsDelayed administration of rhIL-1 by 48 h failed to do this; T cells did not proliferate in response to SEB, but they retained an ability to produce IL-4 upon TCR/CD28 cross-linking.
Chu and Littman (1994)TCRT cellEngagement of ligand by the T cell antigen receptor (TCR) is followed by rapid tyrosine phosphorylation of several cellular proteins, including phospholipase C gamma 1 (PLC) and the TCR-associated CD3 zeta polypeptides.
Held et al. (1993)TCRT cellEndogenous and infectious mouse mammary tumor viruses (MMTVs) encode in their 3' long terminal repeat a protein that exerts superantigen activity; that is, it is able to interact with T cells via the variable domain of the T cell receptor (TCR) beta chain.
Presky et al. (1990)TCRT cellsIn contrast, the ability to stimulate T cells by direct cross-linking of TCR/CD3 complex is not dependent on the presence of these PI-anchored proteins.
Kupfer et al. (1987)TCRT cellThis coclustering of L3T4 with TCR occurs only when the relevant antigen and appropriate major histocompatibility class II molecules are presented to the T cell, and it therefore requires the specific interaction of the TCR with its complex ligand on the antigen-presenting cell.
Gross and Eshhar (1992)TCRT cellThe elaborate requirements for the T cell receptor (TCR)-antigen interaction stand in contrast to the simple and defined nature of the antigenic determinants recognized by antibodies.
Feng et al. (1998)TCRT-cellT-cell receptor (TCR) interacts with an antigenic peptide deeply buried in the major histocompatibility complex (MHC) molecule.
Feng et al. (1998)TCR-classT-cellThe identical TCR-I-Ek interaction in a heterogeneous T-cell population suggested the dominance of invariant TCR-class II MHC interaction.
Kersh and Allen (1996)TCRT cellTo address this issue, we have made amino acid substitutions at the primary T cell receptor (TCR) contact residue of the murine hemoglobin determinant, Hb(64-76)/I-Ek and produced 12 peptides that interact with the TCR of the T cell clone 3.L2.
Jorgensen et al. (1992)TCRT-cellStudies using synthetic peptide analogs for T-cell antigens have identified peptide residues that appear to interact with the MHC molecule and/or the TCR.
Seibel et al. (1997)TCRT cellAlthough cross-linking of this TCR with an antibody to the TCR idiotype elicited vigorous T cell hybridoma activation, stimulation with its natural MHC + peptide ligand did not.
PMC1262630TCRT cellThe immune system can rally against billions of pathogens, in part because every T cell expresses a unique receptor (TCR), acquired during development, that recognizes specific pMHCs.
Slansky and Jordan (2010)TCRT cellOccam's razor presumes that the stronger the TCR–peptide–MHC interaction, the stronger the T cell response.
Slansky and Jordan (2010)TCRT cellsThese two papers use different model systems; Corse et al. used CD4+ T cells and the TCR–peptide–MHC interaction had an affinity range from 42.4 to 165 µM.
Slansky and Jordan (2010)TCRT cellsZehn et al. used CD8+ T cells and the affinity of the TCR–peptide–MHC interaction was greater than 5.9 µM [21].
Wilson et al. (1999)TCRT cellsUsing Dk/MT389-397 tetramers, we directly visualized MT236-244 peptide-induced TCR down-modulation of virtually all MT389-397-specific CD8+ T cells freshly explanted from polyoma-infected mice, suggesting that a single TCR recognizes both Dk-restricted epitopes.
Williams et al. (1996)TCRT cellThe T cell receptor (TCR) recognizes antigenic peptide presented by major histocompatibility complex (MHC) molecules.
Boulter et al. (2007)TCRT cellStronger TCR/pMHC interactions generally give better T cell responses [5].
Boulter et al. (2007)TCRT cellThe kinetic proofreading model of T cell activation postulates that the off-rates of TCR/pMHC interactions correlate with their activation potencies.
Boulter et al. (2007)TCRT cellFourthly, it is possible that TCR/pMHC interactions may be differentially affected by the mechanical stress induced by T cell-APC interaction [23].
Davis and Littman (1995)TCRT cellCD4 assists in T cell recognition of peptides bound to MHC class II molecules by binding to a non-polymorphic region on class II and stabilizing TCR recognition of the peptide-class II complex.
Biasi et al. (1994)TCRT cellsTCR ligation by mAbs also produced cell death of the relevant targets in in vitro IL-2 activated T cells.
Depta et al. (2004)TCRT-cellGlutaraldehyde-fixed APCs, however, were sufficient to elicit T-cell stimulation, indicating a processing-independent direct interaction of the drug with the TCR and MHC molecule.
Lee and Kranz (2003)TCRT cellsAllogeneic and syngeneic class I MHC complexes drive the association of CD8 and TCR on 2C T cells.
Fernández-Miguel et al. (1999)TCRT cellT cell activation is thought by many, but not all, to require TCR cross-linking by its antigen/major histocompatibility complex ligand.
Baus et al. (1996)TCRT cellsThese findings indicate that in addition to their previously described inhibitory effects on cytokine gene transcription, glucocorticoids block IL-2 production in activated T cells by interfering with an early step of the signal transduction cascade initiated by TCR/CD3 cross-linking.
Li and Green (2007)TCRT cellsTo block TCR engagement, Tg mouse strains with monoclonal TCR of irrelevant peptide/MHC specificities, all on MAIDS-susceptible genetic backgrounds, were tested: the study of a panel of TCR Tg CD4 T cells controlled for the possibility of serendipitous crossreactive recognition of virus-associated or induced-self peptide, or superantigen, MHC complexes by a given TCR.
Sugawa et al. (2002)TCRT cellMany murine T cell clones grow continuously in culture despite weekly ligation of their TCR by antigen.
Romero et al. (1993)TCRT cellUsing a direct binding assay based on photoaffinity labeling, we studied the interaction of T cell receptor (TCR) with a Kd-bound photoreactive peptide derivative on living cells.
van Oers et al. (1994)TCRT cellStudies with T cell lines and clones have shown that engagement of the TCR results in the tyrosine phosphorylation of the TCR subunits.
Ratcliffe et al. (1992)TCRT cellConversely, binding of anti-TCR/CD3 antibodies to the T cell under conditions that did not induce increased [Ca2+]i also failed to induce surface TCR/CD3 redistribution.
Ratcliffe et al. (1992)TCRT cellAggregation of TCR/CD3 and subsequent second messenger formation was achieved by combinations of mAb to distinct determinants within the complex due to the stable association of these determinants within the T cell membrane.
Shi et al. (2002)TCRT cellsIn the present study, we report that solid-phase TR6-Fc costimulated proliferation, lymphokine production, and cytotoxicity of mouse T cells upon T-cell receptor (TCR) ligation.
Shi et al. (2002)TCRT cellsA monoclonal antibody against LIGHT similarly costimulated mouse T cells in their proliferation response to TCR ligation.
Apasov et al. (1997)TCRT cellsOnly ATP(ext), but not the ATP catabolites, adenosine, dexamethasone, or TCR cross-linking, was efficient in triggering rapid protein synthesis independent lysis of CD4+8- thymocytes and peripheral CD4+ T cells.
Jost et al. (2007)TCRT cellsIn peripheral T cells, TCR ligation activates NF-kappaB through a selective pathway that involves protein kinase Ctheta, Bcl10, and Malt1.
DeBell et al. (1990)TCRT cellsStable binding of anti-TCR Ab-coated beads to T cells was temperature and energy dependent.
Labrecque et al. (1994)TCRT cellTCR-MHC class II interactions are thus required for T cell recognition of SAG.
Mingueneau et al. (2009)TCRLATHere we show that equipping postthymic CD4(+) T cells with LATY136F molecules or rendering them deficient in LAT molecules triggers a lymphoproliferative disorder dependent on prior TCR engagement.
Clarke and Rudensky (2000)TCRT cellsOur examination of these processes revealed that, whereas self class II MHC molecules do have a modest effect on long-term survival of individual CD4+ T cells, interactions with specific TCR ligands are not required for peripheral naive CD4+ T cell maintenance.
Delon et al. (1998)TCRT cellThe critical involvement of the cytoskeleton in antigen recognition on B cells introduces a checkpoint in T cell activation: the initial TCR engagement triggers a Ca2+ response only after an amplification step corresponding to a cytoskeleton-controlled increase in the number of engaged TCR.
Peng et al. (2004)TCRT-cellEngagement of the TCR by its cognate peptide/MHC ligand, with appropriate co-stimulatory signals, leads to activation of T-cell effector functions.
Isomäki et al. (2001)TCRT cellsChronic TNF exposure induced profound, but reversible, T cell hyporesponsiveness, with TNF-treated T cells requiring TCR engagement with higher peptide concentrations for longer periods of time for commitment to IL-2 production.
Preckel et al. (1997)TCRT cellBased on a serial triggering model of T cell activation, our data favor a model in which antagonists block T cell functions by competitively engaging the specific TCR in unproductive interactions.
Kruisbeek (2001)TCRT cellA heterogeneous population of hybridomas can be cloned by limiting dilution to obtain hybridomas that express specificity to one T cell receptor (TCR).
Smiley and Grusby (1997)TCRT-cellDuring thymic development, T cells rearrange and express genes encoding clonotypic T-cell receptors (TCR), and undergo selective events involving interactions between TCR and thymic major histocompatibility complex (MHC) molecules.
Han et al. (2005)TCRT cellsEngagement of the T-cell receptor (TCR) triggers a series of signaling events that lead to the activation of T cells.
Mirshahidi et al. (2001)TCRT cellRecently, we demonstrated that low avidity engagement of T cell receptor (TCR) by low densities of agonist peptides induced anergy in T cell clones.
Carreño et al. (2007)TCRT-cellHowever, whether the half-life of the TCR/pMHC interaction can modulate T-cell activation in response to a pathogen challenge remains unknown.
Carreño et al. (2007)TCRT-cellConsidered together, our data suggest that the half-life of TCR/pMHC interaction can significantly modulate T-cell activation in vivo, as well as influence recognition of antigens expressed by bacteria.
Yamazaki et al. (1997)TCRT cellT cell selection is thought to be determined through the interaction between TCR and Ag/MHC.
Marquez et al. (2005)TCRT cellNormal TCR levels and cytokine production were restored by culturing cells in the absence of TCR/spMHC interaction, demonstrating dynamic tuning of peripheral T cell responses.
Feng et al. (1996)TCRT cellsTCR reactivity analysis clearly indicates a great variation in the interaction with cl 16-26 by T cells generated from different strains of I-Ek-bearing mice.
Feng et al. (1996)TCR-E-kT cellsDespite the diverse interactions with antigenic peptide by these T cells, most TCR-E-k contacts are limited to the central region of the I-Ek beta-chain.
Ashwell et al. (1996)TCRT cellThe fate of an immature thymocyte, life or death, is largely determined by the ligand-specificity of its T cell antigen receptor (TCR).
Zhong et al. (2003)TCRT cellMuch is known about how T cell receptor (TCR) engagement leads to T cell activation; however, the mechanisms terminating TCR signaling remain less clear.
Born et al. (2010)TCRT cellsFinally, they indicate that gammadelta T cell functions often segregate with TCR-defined subsets, in contrast to conventional T cells.
Hardy et al. (2008)TCRT cellTogether, these results indicate that nitrotyrosine formation can impact T cell recognition both directly, through alteration of TCR-contact residues, or indirectly, through alterations in MHC-contact positions.
Chistiakov (2005)TcRT cellThe two-signal theory for T cell activation requires TcR engagement of its cognate antigen-MHC complex and CD28 binding to B7 ligands (B7-1 and B7-2) on APC.
Chen and Kuo (2001)TCRT cellA highly conserved sequence block (CSB) located in the mouse and human T cell receptor (TCR) Jalpha loci is recognized by tissue-specific factors and up-regulates TCR alpha enhancer activity.
Yang et al. (1999)TCRT cellsHere, we demonstrate that Tec, expressed in T cells, is activated following TCR/CD3 or CD28 ligation and interacts with CD28 receptor in an activation-dependent manner.
Minoguchi et al. (1999)TCRT cellT cell clones were stimulated with anti-CD3 Abs and further treated with goat antimouse immunoglobulin Abs for cross-linking of TCR/CD3 complex.
Stack et al. (1998)TCRT cellsTo determine the role of CD28 in the generation of polarized T cells, clones were derived using cells from CD28-deficient (CD28-/- mice, which had been bred with mice that express the DO11.10 transgene, a CD4+ TCR-alphabeta receptor that recognizes OVA peptide 323-339 bound to I-Ad.
Jacobs et al. (1997)TcRT cellT cell triggering can be achieved by monoclonal antibodies (mAbs) specific for the CD3/TcR complex.
Duan et al. (1996)TCRT cellsTyrosine phosphorylation was similar among MRL and normal CD4+ T cells after cross-linking with either anti-TCR antibody or anti-CD3 antibody, and following co-culture with Con A.
Baliga et al. (1994)TCRT cellT cell activation is the result of antigen-specific interactions with the TCR/CD3 complex and costimulation via other T cell surface receptors.
Ishigami et al. (1992)TCRT cellsWe investigated the mechanisms of anti-IgM antibody-induced cell death in a recently established human surface IgM+ IgD+ B lymphoma cell line, B104, the growth of which is irreversibly inhibited by anti-IgM antibody but not by anti-IgD antibody, and compared it with the cell death of T cells via TCR/CD3 complex and with the cell death of a murine anti-IgM antibody-sensitive B lymphoma cell line, WEHI-231.
Gur et al. (1992)TCRT cellsThe role of cross-linking the TCR/CD3 complex in the induction of T cell activation was examined using human peripheral blood T cells and the Jurkat leukemic T cell line.
Murakawa et al. (1992)TCRT cellIn further studies, we immunoprecipitated surface radioiodinated T cell lysates with OKT3 and Leu 8 mAb to determine if molecules in the TCR/CD3 complex associate with Leu 8 molecules.
Robey et al. (1992)TCRT cellOne model to explain this paradox proposes that thymocytes whose T cell antigen receptors (TCRs) recognize MHC with high affinity are eliminated by negative selection, whereas low affinity TCR-MHC interactions are sufficient to mediate positive selection.
Robey et al. (1992)TCRT cellThis observation indicates that quantitative differences in TCR-MHC recognition are a critical determinant of T cell fate, a finding predicted by the affinity model for thymic selection.
Foo-Phillips et al. (1992)TCRT cellsGiven the significant sequence homology in the C-terminal portion of the open reading frame (ORF) region among these three MMTV and the almost equivalent effect of these three MMTV provirus upon the V beta 12 repertoire, their apparent hierarchic effect upon the V beta 5 and V beta 11 repertoires suggests that affinity differences in recognition of the same determinant by different TCR V beta may play a significant role in the clonal deletion of self-reactive T cells.
Rellahan et al. (1991)TCRT cellTo examine the role of V(D)J junctional sequences in antigen recognition by TCR-gamma/delta, we derived an alloreactive murine TCR-gamma/delta+ T cell line, LKD1, specific for the I-Ad class II major histocompatibility complex (MHC) molecule, and compared its receptor with that expressed by a previously characterized class II MHC alloreactive T cell line, LBK5, specific for I-Ek,b,s Ia molecules.
Nelson et al. (1991)TCRT lymphocyteCross-linking an anti-tumor antibody, specific for tumor cell surface antigens, and an anti-lymphocyte antibody, specific for the T lymphocyte receptor complex (TCR/CD3), produces a heteroconjugate that can direct T cells to lyse tumor cells.
Finn et al. (1991)TCRT cellConstitutive PKC-gamma expression may therefore mimic physiologic PKC activation, thereby abrogating the requirement for TCR-Ag interaction in T cell activation.
Dupuy et al. (1990)TCRT lymphocytesTaken together, these results strongly suggest that normal human epidermis occasionally harbors TCR-gamma/delta complex bearing lymphocytes, which constitute a small fraction of the CD3+ cutaneous T lymphocytes.
González et al. (2008)TCRT cellsAs a result of exposure to RSV-infected DCs, T cells became unresponsive to subsequent TCR engagement.