Viewing affirmative mentions of gene expression of cd45 (S. salar) in T cells

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Hendrickx and Bossuyt (2001)CD45T cellsIn healthy adults (n = 15), CD45 expression on B lymphocytes was lower than that on T cells.
ten Dam et al. (2000)CD45T cellsIn T cells, the splicing pattern of CD45 isoforms changes after activation; naive cells express high m.w. isoforms of CD45 which predominantly express exon A (CD45RA), whereas activated cells lose expression of exon A to form low m.w. isoforms of CD45 including CD45RO.
Gordon et al. (1996)CD45T cellsThree-colour immunofluorescence was used to determine CD45 isoform expression by CD4+ T cells from 28 patients with SLE.
Gordon et al. (1996)CD45RBT cellsNewly recruited and highly differentiated primed T cells were distinguished by their CD45RB expression.
Suzuki et al. (1998)CD45ROT-cellsCD45RO is a very light weight isoform of CD45 expressed on activated T-cells.
Chheda et al. (1996)CD45ROT cellsDeficiencies in the quantitative expression of CD45RA and CD45RO on CD4+ and CD8+ T cells and in a population of CD45RA(low)CD45RO(low) T cells in blood from term newborn infants were found by flow cytometry.
Chheda et al. (1996)CD45ROT cellsHowever, in newborn infants greater than 70% of T cells expressing CD45RO also expressed CD45RA.
Chheda et al. (1996)CD45ROT cellsIn addition, the quantitative expression of CD45RA and CD45RO on newborn T cells was significantly less than that found on adult blood T cells.
Blackwell et al. (2003)CD45T cellsCD4 T cells have been classified according to the expression of the CD45 isoforms into 'naive-like' T cells (CD45RA) and 'memory-like' T cells (CD45RO).
Nakamura et al. (2001)CD45T-lymphocytesIn 122 cases, the fluorescence intensity of the CD45 expression was measured as a relative value; the ratio of average linear values (RALV) of CD45 on the blasts to that on CD3-positive T-lymphocytes from the same specimen.
Tezuka et al. (1998)CD45ROT lymphocytesTransient increase in CD45RO expression on T lymphocytes in infected newborns.
Tezuka et al. (1998)CD45T lymphocytesThese results indicate that not only viral but also bacterial infections trigger transient and reversible changes in CD45 isoform expression by neonatal CD4+ T lymphocytes.
McElhaney et al. (1993)CD45T lymphocytesIn this study, we report the changes in the isoforms of CD45 expressed on T lymphocytes after influenza vaccination.
Trowbridge and Thomas (1994)CD45T cellsAnalysis of CD45 isoform expression has revealed a hitherto unrecognized plasticity in isoform usage by T cells and other leukocytes, adding to the regulatory complexity of isoform expression.
Mahalingam et al. (1996)CD45T cellThe consistent reduction in surface expression of all CD45 isoforms observed in our study may be of relevance to the impaired T cell activation characteristic of HIV infection.
Carulli et al. (2008)CD45T-lymphocytesCD45 expression was measured also on autologous T-lymphocytes and a "CD45 index" was calculated as the ratio MFI of pathologic B-lymphocytes/MFI of T-lymphocytes, to normalize the results obtained.
Mizobe et al. (2004)CD45RAT lymphocytesTransient decrease in the CD45RA expression on T lymphocytes in neonates with fetal distress.
Mizobe et al. (2004)CD45RAT lymphocytesSensitivity and specificity of the CD45RA expression on CD4+ T lymphocytes for discrimination of group III were calculated as 0.79 and 1.0, respectively, when the cutoff value was 22.7%.
Mizobe et al. (2004)CD45RAT lymphocytesWe conclude that CD4+ T lymphocytes from neonates with fetal distress show a transient decrease in the CD45RA expression without an increase in the CD45RO expression, and, therefore, analysis of the CD45 isoform expression is useful for laboratory evaluation of fetal distress.
Warren and Skipsey (1991)CD45RAT cellsThe results of the present study show that activation-induced changes in CD45RA and CD45RO expression on T cells and natural killer (NK) cells are not unidirectional for all cells during a 5-week culture period.
Warren and Skipsey (1991)CD45ROT cellsIn different cultures, CD45RO expression was not stable on 28-80% of T cells and 10-55% of NK cells.
Warren and Skipsey (1991)CD45ROT cellsInstability of CD45RO expression on cultured T cells and NK cells occurred at a time following the period of rapid cell growth when the cells were entering a quiescent phase.
Warren and Skipsey (1991)CD45T-cellBoth the CD4+ and CD8+ T-cell subpopulation showed similar changes in CD45 isoform expression.
Warren and Skipsey (1991)CD45ROT cellsIn contrast to the results obtained with the CD45R(Abright)RO(dim/neg) resting T cells, the CD45RO(bright)RA(dim/neg) subpopulation of resting T cells when activated and cultured under identical conditions retained CD45RO expression and remained CD45RAdim/neg.
Gelain et al. (2008)CD45T-cellAmong T-cell lymphomas the prevalent unusual phenotype was the under-expression or absence of CD45 (25%).
Fernsten et al. (1998)CD45T cellsExpression of the sialosyl-Tn epitope on CD45 derived from activated peripheral blood T cells.
Holzinger et al. (1996)CD45RAT cellsPeripheral T cells showed a reverse pattern of CD45RA/CD45RO antigen expression.
Lazarovits et al. (1992)CD45RBT cellsMT3 (CD45RB) inhibits the allogeneic MLR and inhibits CD4+ T cells from expressing interleukin 2 receptors, and prevents CD4+ CD45RA- T cells from entering the proliferative phase of the cell cycle.
O'Brien and Kemeny (1998)CD45RAT cellsWith CD8+ T cells, reactivity was also present in both isoforms, but was significantly greater in the CD45RA subset, with mean proliferation 2.5-3-fold that of the CD45RO cells (P < 0.05).
Fortin et al. (2002)CD45T cellTo investigate the role of CD45 phosphatase activity in apoptosis induction, we expressed either wild-type or phosphatase-dead CD45 molecules in a CD45-deficient BW5147 T cell line.
Leitenberg et al. (1999)CD45T cellIn the present study, we demonstrate a basal biochemical association of CD45 with the T cell receptor complex that is regulated in part by CD45 isoform expression.
Faustman (1993)CD45RAT cellAutologously driven T cell developmental transitions also appear to be blocked in these individuals in vitro; the peripheral blood of lower-risk relatives contains an increased number of CD4+ cells abnormally coexpressing CD45RA and CD45RO (p = 0.01).
Qin et al. (1993)CD45ROT-cellDual expression of CD45RA and CD45RO isoforms on myelin basic protein-specific CD4+ T-cell lines in multiple sclerosis.
Qin et al. (1993)CD45T-cellMyelin basic protein (MBP)-specific T-cell lines from patients with multiple sclerosis (MS) and healthy controls were analyzed for the expression of CD45 isoforms and adhesion molecules.
Qin et al. (1993)CD45T-cellThe dual expression of CD45 isoform in T-cell lines from MS was stable, did not represent a transition stage from CD45RA to CD45RO, and was cell-cycle independent.
Fernsten et al. (1998)CD45T cellsThe autoreactive determinants on CD45 are O-linked glycans expressed on activated T cells and certain T cell lines, rather than linear or conformational polypeptide epitopes or N-linked glycans.
Novak et al. (1994)CD45T cellsCD45 is expressed on T cells as distinct isoforms and these isoforms are expressed differentially on subsets of CD4 T cells.
De Bleecker and Engel (1995)CD45T cellsTo assess the relative abundance of the CD8+ and the CD4+ T cells expressing the two CD45 isoforms in the major inflammatory myopathies, we immunophenotyped T cells in muscle specimens from patients with inclusion body myositis, polymyositis (PM), and dermatomyositis.
Weinberg et al. (1995)CD45ROT lymphocytesThe capacity of histocompatible BMT recipients to generate new CD4+ T lymphocytes was determined by FACS analysis with antibodies to the two isoforms of CD45: CD45RA, which is expressed on newly generated CD4 T lymphocytes, and CD45RO, which is expressed on antigen-specific memory CD4 T lymphocytes.
Weinberg et al. (1995)CD45RAT lymphocytesImmediately following BMT, all patients had low levels of CD45RA-expressing CD4 T lymphocytes, which increased during the first year and then stabilized.
Volarevi? et al. (1992)CD45T cellIn T cell variants expressing progressively lower levels of CD45 (from normal to undetectable), CD45 expression was inversely related to spontaneous tyrosine phosphorylation of multiple proteins, including the TCR zeta chain, and was directly correlated with TCR-driven phosphoinositide hydrolysis.
Niklinska et al. (1994)CD45T-cellT cells that lack the CD45 transmembrane tyrosine phosphatase have a variety of T-cell receptor (TCR) signaling defects that are corrected by reexpression of wild-type CD45 or its intracytoplasmic domains.
Pulido and Sánchez-Madrid (1990)CD45T cellEpitopes defining the T cell maturation related CD45R0 and CD45RB antigen specificities were present on the mature 180- and 190-kDa K-562 CD45 proteins, respectively.
Pingel et al. (1994)CD45T cellWe have developed CD4+ and CD8+ T cell clones that are deficient in the expression of CD45 and have previously shown that these cells fail to proliferate in response to antigen or cross-linked CD3.
Rajasekar and Augustin (1994)CD45RBT cellsThe accumulation of cells that display this ability parallels the progressive proliferative enrichment of Ag-specific T cells and correlates with the surface expression of the CD45RB(low) isoform.
Ishiyama et al. (1996)CD45ROT cellsIn the present study, we investigated CD45RO and Fas antigen expression and apoptosis by T cells in three patients with this disease.
Ishiyama et al. (1996)CD45ROT cellsApoptosis of T cells from the two patients with increased CD45RO and Fas antigen expression occurred after overnight culture in the presence of pokeweed mitogen.
Shabtai et al. (2002-2003)CD45T cellsDown regulation of CD45 expression on CD4 T cells during acute renal allograft rejection: evidence of a decline in T suppressor/inducer activity.
Shabtai et al. (2002-2003)CD45T cellsWe examined the kinetics of CD45 expression on CD4+ T cells in renal allograft recipients from pretransplant values to acute rejection and after reversal of rejection, searching for a shift in balance between helper/inducer and suppressor/inducer cell subsets.
Lemieux et al. (2008)CD45RAT cellsThe percent of T cells expressing CD45RA, an early activation marker, was higher in the PTSD diagnosed women, and the levels correlated positively with intrusive symptoms and negatively with avoidant symptoms.
Kudlacek et al. (1995)CD45T cellsThe number of CD4+ T cells expressing CD45 RO isoform (memory cells) was increased in aged people; CD45 RA+ CD4+ cells (naive cells) were decreased.
Lemaire et al. (1999)CD45T cellsActivation of CD45RA+ T cells shifted CD45 expression from CD45RA to CD45RO, and induced a large increase in expression of both SF2 and SRp55.
Lemaire et al. (1999)CD45ROT cellsThe different SR proteins expressed by memory and activated T cells emphasize the different phenotypes of these cell types that both express CD45RO.
Oberdoerffer et al. (2008)CD45RAT cellsDepletion or overexpression of hnRNPLL in B and T cell lines and primary T cells resulted in reciprocal alteration of CD45RA and RO expression.
Rachmilewitz et al. (2003)CD45T cellALL mutant T cell line that differ in CD45 expression, we established that the inhibitory effects of PP14 are dependent upon the expression of intact CD45 on T cell surfaces.
Weinberg et al. (1995)CD45RAT lymphocytesSince thymic function decreases with age in normal individuals, the impact of recipient age on the generation of new CD45RA,CD4 T lymphocytes was determined in BMT recipients with and without chronic graft-vs.
Harris et al. (1996)CD45T cellsCD45 is a transmembrane protein tyrosine phosphatase expressed by all lymphoid cells including T cells.
Holada et al. (1995)CD45RAT cellsCD45RA monoclonal antibodies recognize the higher molecular weight isoforms (220 and 205 kDa) of leukocyte common antigen family (CD45), which are typically expressed on B cells and unstimulated T cells.
Hodge et al. (2004)CD45RAT cellsMeasurement of CD69 expression on NK cells with CD45RA, CD45RO, CD25 and CD69 expression on T cells resulted in a significant increase in at least two leucocyte activation markers from infected patients.
Hodge et al. (2004)CD45ROT cellsA combination of this marker with CD45RA, CD45RO, CD25 and CD69 expression on peripheral blood derived T cells is the most sensitive and specific for neonatal infection.
Gabriel et al. (1998)CD45ROT cellsThe cell-surface expression of CD45RO (P < 0.001) on T cells, but not cell concentrations of CD45RO+ T cells, were higher during OT.
Robson et al. (1996)CD45T cellsVarious isoforms of CD45 (Mr 180-240 kDa) regulate sets of intermolecular associations between different surface receptors, and appear to be differentially expressed on B and T cells (namely CD45RA, B or CD45RO).
Wang et al. (2000)CD45T cellTransient transfection of the CD45- T cell line, J45.01, with CD45 cDNA incorporating four Ser to Ala (S/A) mutations in the 19-aa insert did not affect the magnitude of NF-AT activation resulting from TCR ligation.
Adamthwaite and Cooley (1994)CD45T-cellCD8+ T-cell subsets defined by expression of CD45 isoforms differ in their capacity to produce IL-2, IFN-gamma and TNF-beta.
Adamthwaite and Cooley (1994)CD45T-cellExpression of different isoforms of CD45, the leucocyte common antigen (LCA), on T-cell subsets has permitted distinctions between the functional activities of subpopulations within the major CD4+ T-cell subset.
Wang and Johnson (2005)CD45T cellExpression of CD45 lacking the catalytic protein tyrosine phosphatase domain modulates Lck phosphorylation and T cell activation.
Wang and Johnson (2005)CD45T cellsTo further explore the function of D2 in T cells, a full-length construct of CD45 lacking the D1 catalytic domain (CD45RABC-D2) was expressed in CD45+ and CD45- Jurkat T cells.
Wang and Johnson (2005)CD45RABCT cellExpression of CD45RABC-D2 in CD45+ Jurkat T cells resulted in its association with Lck, increased the phosphorylation state of Lck, and reduced T cell activation.
Cahir McFarland et al. (1993)CD45T-cellT-cell clones deficient in expression of CD45, a transmembrane protein-tyrosine-phosphatase (protein-tyrosine-phosphate phosphohydrolase, EC, are impaired in their ability to respond to either antigen or T-cell receptor cross-linking.
Brugnoni et al. (1995)CD45ROT cellHowever, the percentage of CD4+ CD45RO+ peripheral blood mononuclear cells (PBMC) progressively increased with age in controls (r = 0.69; P = 0.03), but not in HIV-infected children, showing that while vertical transmission of HIV does not prevent CD45RO expression early in life, it is associated with a disturbance of the physiological process of antigen priming, contributing to poor immunological memory to T cell-dependent antigens.
Rudd et al. (1987)CD45T lymphocytesThe T4 (CD4) subset of T lymphocytes has been subdivided into two major subsets, a suppressor/inducer subset (T4+,2H4+) and a helper subset (T4+,2H4-) on the basis of the differential expression of the L-C/T200 (CD45) antigens.
Czyzyk et al. (1996)CD45T cellsOBJECTIVE: To determine the specificity of anti-CD45 autoantibodies in systemic lupus erythematosus (SLE) for native CD45 and for CD45 expressed by T cells and B cells, and at different stages of cellular activation.
Neidhart et al. (1996)CD45T-lymphocytesCD45 isoforms expression on CD4+ and CD8+ peripheral blood T-lymphocytes is related to auto-immune processes and hematological manifestations in systemic lupus erythematosus.
Neidhart et al. (1996)CD45T-lymphocytesWe investigated whether, in systemic lupus erythematosus (SLE), the CD45 isoforms expression on peripheral blood T-lymphocytes (T-PBL) is related to the auto-immune processes and hematological manifestations.
Adamthwaite and Cooley (1994)CD45RAT cellsThe results showed that CD8+ CD45RA- and CD8+ CD45RO+ T lymphocytes produce significantly more of all three cytokines than do CD8+ CD45RA+ or CD8+ CD45RO- T cells.