Viewing negative mentions of binding of IL2 (H. sapiens)

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Document Target Regulator Anatomy Sentence
Smith et al. (1989)IL-2The inhibitor does not appear to bind to IL-2 or the IL-2 receptor.
Najjam et al. (1998)IL-2Human IL-2 analogs with single amino acid substitutions at positions Lys43, Thr51, and Gln126 analogs no longer bind to heparin.
Kamio et al. (1992)IL-2No IL-2 binding was detectable in the presence of anti-Tac antibody in these cells.
Ogura et al. (1988)IL-2The ternary complex with human IL-2 was formed on EL/Tac 3 cells expressing human L and murine H chains, although human IL-2 was unable to bind to the parental EL-4 cell, which does not express human L chain.
Emerson et al. (2003)IL-2NMR characterization of interleukin-2 in complexes with the IL-2Ralpha receptor component, and with low molecular weight compounds that inhibit the IL-2/IL-Ralpha interaction.
Ide et al. (1987)IL-2All the four MAbs were specific to human IL-2: they did not cross-react with mouse or rat IL-2.
Lee et al. (1990)IL-2IL-4-mediated inhibition of IL-2-induced IL-2R expression does not seem to be due to the direct interaction between IL-4 and cell surface receptors, inasmuch as preincubation of cells with IL-4 for 60 min at 37 degrees C did not alter the binding of 125I-IL-2 to cells previously cultured for 3 days with SAC plus IL-2.
Najjam et al. (1998)IL-2In addition soluble IL-2 receptor alpha and beta polypeptides do not compete with heparin for the binding of IL-2.
Leonard et al. (1984)interleukin-2We have isolated an additional cDNA that may correspond to an alternatively spliced mRNA that lacks a 216 base segment and appears to encode an altered membrane protein which cannot bind interleukin-2.
Kikuchi et al. (2002)IL-2 geneFurthermore, no association was observed between IL-2 gene polymorphisms and clinical characteristics, such as clinical course and age at disease onset.
Fenton et al. (1996)IL-2A third patient who was DTH(+) after vaccination with no IL-2 had a dramatic PR after receiving IL-2 subcutaneously in a subsequent protocol.
Clark et al. (2000)IL-2Intratumoral granzyme A activity was significantly increased in tumors injected with IL-2 plasmid:DMRIE/DOPE complexes, but not by an irrelevant plasmid DNA:DMRIE/DOPE control.
Sperandio et al. (2008)IL-2In this macromolecular complex, the presence of an equilibrium between several conformations has been observed and small molecules have been determined that prevent the interaction between IL-2 and its receptor IL-2R?
De Groot et al. (1990)IL-2High-density fractions contain cells with a "resting" phenotype which after in vitro activation proliferate with IL-4 but not with IL-2.
Aszalos et al. (1987)IL-2The cell population that did not effectively bind dans-CsA lacked IL-2 receptors and did not respond to CsA or IL-2 with immediate membrane potential changes.
Karmann et al. (1996)IL-2However, increased IL-2 secretion in the presence of EC can not fully account for endothelial-induced CD40 ligand up-regulation as (1) the effect of exogenous IL-2 is greater at 24 h than at 6 h, whereas the opposite is true for EC; (2) the effect of saturating levels of IL-2 is considerably smaller than that of EC; and (3) blocking of IL-2 receptors does not fully inhibit endothelial effects on CD40 ligand expression.
Heaton and Grimm (1995)IL-2We assessed the roles of the various receptor complexes in these responses to IL-2 using antibodies that block the interaction of IL-2 with the intermediate-affinity IL-2R (humanized Mik beta 1) and high- and low-affinity interactions (HTac).
Piscitelli et al. (1996)Interleukin-2Interleukin-2 and alpha interferon do not alter the pharmacokinetics of zidovudine and didanosine, respectively.
Jacques et al. (1987)IL-2Whereas 2.5% of cell-surface IL-2R expressed 2 days after antigenic stimulation of 2B11 cells were of high affinity for IL-2 (KD = 25 pM), no (less than 0.07%) high affinity binding sites could be detected on the purified soluble IL-2R.
Deane et al. (2000)IL-2GIF did not bind human GM-CSF or IL-2 in spite of the fact that orf virus is a human pathogen.
Recchia et al. (2002)IL-2Interleukin-2 (IL-2) which has no cross-resistance with chemotherapy, has given responses in tumors resistant to chemotherapy, and shown to be more effective when tumor burden is low. 13-cis retinoic acid (RA) has immunomodulatory properties, potentially synergistic with IL-2.
Collins et al. (1988)interleukin 2Substitution of Asp20 or deletion of Phe124 resulted in inactive analog proteins that were unable to interact with the high-affinity p55/p70 complex or the intermediate-affinity p70 subunit of the interleukin 2 receptor.
Zorn et al. (1994)IL-2These last findings indicate that there is at least no functional interaction between sIL-2R and free IL-2, whereas an interaction of sIL-2R with the membrane-bound receptor for IL-2 seems possible.
Rickert et al. (2004)IL-2We find an entropically favorable high affinity interaction between IL-2 and its alpha receptor, a moderately entropically favorable low affinity interaction between IL-2 and its beta receptor, and no interaction between IL-2 and the shared receptor, gamma(c).
Recchia et al. (2001)IL-2IL-2 has no cross-resistance with chemotherapy and improves cancer-related lymphocytopenia, a factor that determines poor prognosis, whereas RA has immunomodulatory properties, potentially synergistic with IL-2.
Abolhassani and Chiao (1991)IL-2In ELISA assay antibodies against IL-1, IL-2, IL-3 and IL-6 did not recognize the LGEF preparation.
Marrack et al. (1983)interleukin 2It was found that subclones of the hybridoma that no longer secreted interleukin 2 in response to Ag/H-2, even though they continued to secrete interleukin 2 in response to concanavalin A, also no longer bound specifically to Ag-pulsed monolayers of the appropriate H-2 type.
Eicher et al. (2002)IL-2-inducibleSingly or co-transfected IL-2Rbeta and gamma(c) chimeras showed no spontaneous or IL-2-inducible oligomerization.
Chu and Sharom (1993)IL-2The glycolipids also prevented chemical cross-linking of [125I]IL-2 to the p55/p75 complex, as well as to both IL-2R alpha (p55) and IL-2R beta (p75) independently.
Neeper et al. (1987)IL 2Tac protein missing amino acids 102 to 173 (exon 4) is unable to bind IL 2: detection of spliced protein after L cell transfection.
Chen and Rothenberg (1994)IL-2This result, and similar results in cyclosporin A-treated cells, imply that individual IL-2 transcription factors cannot stably bind their target sequences in vivo without coengagement of all other distinct factors at neighboring sites.
de Jong et al. (1996)IL-2Proliferation of anti-CD3 (OKT3)-stimulated human PBL was compared for responsiveness to IL-2, IL-15, and F42K, and IL-2 mutant that does not bind the IL-2R alpha chain.
Lilleby and Fosså (2005)IL-2At the end of the 1990s, no single chemotherapeutic drug, alone or in combination with interleukin-2 (IL-2) or interferon-alfa (IFN), had shown activity beyond the one expected by immunotherapy alone.
Saragovi et al. (1998)IL-2The association is specific, because the 90.60.3 phospholipid is not found in association with other domains of IL-2 receptor alpha subunits, or near IL-2 receptor beta or gamma subunits.
Duggan et al. (1992)IL-2We conclude that IL-2 with or without IFN-beta is not effective therapy for NHL in the doses and schedule used in this study.
Watkins and Cohen (1987)mammalian interleukin-2No functional cross-reactivity among different mammalian interleukin-2 (IL-2) and Xenopus TCGF preparations was detected.
Ahmed et al. (1992)recombinant interleukin 2Theileria annulata-infected cells were cultured in the presence or absence of human recombinant interleukin 2 (hrIL-2).
Manchanda et al. (2008)IL-2The reason behind no association of IL-2 could be that patients are given high therapeutic doses of CsA during the early period of transplantation.
Morrone et al. (1988)interleukin 2Furthermore the Fr line does not produce or respond to interleukin 2.
Svenson et al. (1990)IL-2The antibodies did not cross-bind human recombinant IL-1 beta, IL-2, IL-6, or tumour necrosis factor alpha (TNF-alpha).
Sunahara et al. (1989)IL-2The two EIA systems with an assay range of 1.5-100 ng/ml do not recognize IL-1 beta, IL-2, rHu-TNF alpha, IFN-alpha and IFN-gamma of human origin.
Nomura et al. (2006)IL-2But we also observed no significant differences in the ratio of IL-2+/IFN?
Carracedo et al. (1995)IL-2Apoptosis of natural killer (NK) cells can be induced by non-specific physical damage (UV irradiation, heat shock) or by simultaneous ligation of the CD16 and the interleukin-2 receptor (IL-2R) molecules, but not with either anti-CD16 or IL-2 alone.
Wang and Smith (1987)IL-2High-affinity IL-2-R binding results from an exceptional type of cooperative interaction between two IL-2-binding proteins termed alpha and beta.
Roessler et al. (1994)IL-2We demonstrated that IL-2 F42A, an analog that fails to bind to the isolated IL-2R alpha subunit and would be predicted by the hierarchical affinity-conversion model to have impaired binding to cells expressing both chains, instead readily binds to the IL-2R alpha/beta heterodimer in COS cells.
Arima et al. (1992)IL-2However, ED515-I and 3T3-alpha beta 11, which expressed the IL-2R beta chain, did not bind IL-2 at all when IL-2 binding to their IL-2R alpha chain was blocked with anti-Tac monoclonal antibody, whereas the intermediate affinity binding in ED515-D, Kit225, and Hut102 cells remained.
Sugamura et al. (1992)IL-2The gamma chain was detected in lymphoid transfectants of IL-2R beta cDNA, which showed the intermediate-affinity IL-2R, but not in nonlymphoid transfectants of IL-2R beta cDNA, which showed no IL-2 binding activity.
Kierszenbaum et al. (1993)IL-2We report herein that TIF does not compete with IL-2 for binding to IL-2R and that shedding of IL-2R is decreased in the presence of T. cruzi.
Sospedra et al. (1995)IL-2There was no association with a particular HLA class II allele or with the presence of IFN-gamma and IL-2 in the tissue, as assessed by reverse transcription-PCR.
Donn et al. (2001)IL-2No significant association with IL-1alpha, IL-2, IL-4, IL-6, IL-10, IFNA1, or IFNG was observed.
Schlaak et al. (1994)hIL-2Our data show that this assay is not crossreactive with hIL-1 beta, hIL-2, hIL-3, hIL-4, hIL-5, hIL-6, hIL-9, hIL-12, hGM-CSF and hTNF-alpha and that it can be completely blocked by an antibody against human IL-10.