Viewing affirmative mentions of gene expression of IL2 (H. sapiens)

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Hurez et al. (2003)IL-2naive T cellsRestricted clonal expression of IL-2 by naive T cells reflects differential dynamic interactions with dendritic cells.
Goldrath et al. (2000)interleukin 2Naive T cellsNaive T cells dividing in a lymphopenic host upregulate CD44, CD122 (interleukin 2 receptor beta) and Ly6C expression, acquire the ability to rapidly secrete interferon gamma, and become cytotoxic effectors when stimulated with cognate antigen.
Hartig et al. (2000)IL-2naive T cellsBecause naive T cells produce only IL-2 in short term culture, IFN-gamma production by this approach is a measure of a memory immune response.
Sagerström et al. (1993)IL-2naive T cellsTaken together with the above results, this suggests that the activation of primary T cells requires at least two signals and that IL-2 produced by naive T cells in vivo may act in an autocrine fashion to allow them to proliferate and differentiate.
Avice et al. (2001)IL-2naive T cellsMoreover, CD47 mAb strongly suppressed IL-2 production and IL-2Ralpha expression in primary cultures and IL-2 response of activated naive T cells.
Demeure et al. (1997)IL-2naive T cellsPGE2 primes naive T cells in a dose-dependent fashion for production of high levels of IL-4, IL-10 and IL-13, and very low levels of IL-2, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and TNF-beta.
Buckle and Hogg (1990)interleukin 2naive T cellsThese cells appear to be in a state of marginal activation in that they also express low levels of the interleukin 2 receptor (Tac antigen) and have increased cell size as compared to the naive T cells.
Duthoit et al. (2005)IL-2naive T cellPrior reports have shown that CD4(+)CD25(+) regulatory T cells suppress naive T cell responses by inhibiting IL-2 production.
Andris et al. (1996)IL-2naive T cellsWe demonstrate in this report that antibodies to the B7.2 molecule inhibit IL-2 production in vivo caused by anti-CD3 administration, suggesting that anti-CD3 monoclonal antibodies (mAb) stimulate naive T cells in vivo in a co-stimulation-dependent fashion.
Cusick et al. (2009)IL-2naive T cellDifferences were observed in the cytokine responses to H1, H3, and H5, whereas both IL-2 and IFN-gamma production characteristic of memory responses were observed for H1 and H3, and H5-specific responses elicited primarily IL-2 and little or no IFN-gamma, consistent with a naive T cell phenotype.
Katamura et al. (1995)IL-2naive T cellsPGE2 added at priming of naive T cells inhibited the production of IL-2 and IFN-gamma, but not of IL-4 and IL-5, in a dose-dependent manner.
Katamura et al. (1995)IL-2naive T cellsThese results indicate that PGE2 inhibits the acquisition of the ability to produce IL-2 and IFN-gamma by acting directly on naive T cells.
Geginat et al. (2001)IL-2naive T cellsDendritic cells (DCs) and DC-derived cytokines allowed naive T cells to proliferate selectively in response to IL-4, and potently boosted the response of T(CM) to IL-7 and IL-15 by increasing the expression of the IL-2/IL-15Rbeta and the common gamma chain (gamma(c)).
Kohlmeier et al. (2006)interleukin-2naive T cellsCostimulation of naive T cells through ICAM-1 resulted in expansive cell division, high interleukin-2 production, and protection from apoptosis.
Hathcock et al. (1989)IL-2naive T cellsSoluble F23.1 antibody-induced proliferation in naive T cells only in the presence of both AC and exogenous IL-2, and these responses were confined to Lyt-2+ T cells.
Kimachi et al. (1997)IL-2naive T cellsPrimed T cells were as sensitive as the previously reported T cell hybridomas, requiring about 100 Ag-MHC complexes to synthesize readily detectable quantities of IL-2, whereas naive T cells required 15 times more ligand to produce equivalent quantities of IL-2.
Kimachi et al. (1997)IL-2naive T cellsA further analysis of IL-2 and IL-2R expression indicated: 1) The first synthesis of IL-2 was detected at the same ligand concentration in both primed and naive T cells, but primed T cells made much more IL-2 as the ligand concentrations increased; 2) primed T cells expressed about fivefold more IL-2 receptor (R) than naive T cells, despite the fact that the antigen dose-response curves with respect to the percentage of cells expressing IL-2R were identical.
Chandok and Farber (2004)IL-2naive T cellsMemory T cells exhibit low activation thresholds and mediate rapid effector responses when recalled by antigen; contrasting the higher activation threshold, slower responses and predominant IL-2 production by naive T cells.
Muraille et al. (1995)IL-2naive T cellsThus, naive T cells are sensitive to CD28-mediated co-stimulation during superantigen-mediated responses but IL-2 production can be induced by high doses of superantigens in the presence of APC expressing weak co-stimulatory activity.
Kumaraguru et al. (2000)IL-2naive T cellsIn the present study, we demonstrate that exposure of macrophages to plasmid DNA encoding viral proteins or OVA generates Ag-specific material that, when presented in vitro by dendritic cells to naive T cells, induces primary CTL response or elicits IL-2 production from an OVA peptide-specific T-T hybridoma.
Dodeller and Schulze-Koops (2006)IL-2naive T cellsIn CaMKIV-deficient mice, whereas naive T cells did not express any apparent defect in cytokine expression, the expression of IL-2, IL-4, and IFN-?
Rothoeft et al. (2003)IL-2naive T cellsLikewise, DCs were found to be more potent inducers of interleukin-2 (IL-2) production and proliferation of naive T cells than Mphi.
Cho et al. (2007)IL-2naive T cellsIn contrast, we describe a novel form of homeostatic proliferation that occurs when naive T cells encounter raised levels of IL-2 and IL-15 in vivo.
Nanki and Lipsky (2001)IL-2naive T cellsCXCL12 also induced enhancement of IL-2 production and proliferation by anti-CD3 stimulated CD4+ memory T cells, but not by CD4+ naive T cells.
Joseph et al. (1998)IL-2naive T cellEnhanced naive T cell responses were only observed with anti-CD3 and anti-CD28, suggesting that co-signaling through surface-bound receptors was required to initiate IL-2 production.
Abbate et al. (2001)IL-2naive T cellsAfter a cycle of HAART + IL-2, followed by therapy interruption, CD45RA and CD62L are detected on virions rarely, indicating that even during virus rebound, expanded naive T cells do not become a major target of virus replication.
Tai et al. (1997)IL-2naive T cellsThese data indicate that CD9-mediated costimulation of TCR-triggered naive T cells leads to activation followed by apoptosis as the result of failure to generate a positive signal for sufficient levels of IL-2 production.
Lambot et al. (2001)IL-2naive T lymphocytesNo change was detected in the level of IL-2, IL-10 and IL-12 synthesis, whereas the pro-inflammatory cytokine tumour necrosis factor-alpha seemed involved in the activation of naive T lymphocytes.
Bullens et al. (1999)IL-2-dependentnaive T cellsIL-4 production by naive T cells is strictly IL-2-dependent.
Jin et al. (2005)IL-2naive T cellsIFN-gamma production was lower in MSCs + naive T cells group than that in naive T cells alone group: (1.147 +/- 0.181) pg/ml versus (4.897 +/- 0.189) pg/ml (P < 0.05), but IL-2 production was higher in the co-culture group: (16.141 +/- 2.729) pg/ml versus (2.551 +/- 0.460) pg/ml (P < 0.05).
Trebilcock and Ponnappan (1998)IL-2naive T cellsIn addition, this age-related decrease in induction of nuclear NFkappaB correlated with decrease in intracellular IL-2 receptor expression and anti-CD3-induced proliferation of both memory and naive T cells subsets.
Lederer et al. (1996)IL-2naive T cellsQuantitative reverse transcriptase-polymerase chain reaction analysis of cytokine transcripts indicates that interferon (IFN) gamma, IL-4, and IL-2 mRNA are expressed with distinct kinetics after naive T cells are stimulated with antigen and either IL-4 or IL-12.
Vanhecke et al. (1995)IL-2naive T cellsAfter completion of functional differentiation, at stage 5, in vivo IL-2 mRNA transcription and CD69 expression are down-regulated, and the cells become functionally resting naive T cells expressing CD45RA+.