Viewing affirmative mentions of negative regulation of CD4 (H. sapiens) in T cells

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Etemad-Moghadam et al. (2002)CD4T lymphocytesWe investigated the basis for the depletion of CD4(+) T lymphocytes in a SHIV-macaque model.
Clerici (1995)CD4T lymphocytesThe reduction in CD4 T lymphocyte counts is the hallmark of HIV infection nevertheless, long before the reduction of CD4 counts reaches critical levels, a series of profound and complex defects that impair the function of CD4 T lymphocytes can be observed.
Roger et al. (2002)CD4T cellSixty-nine patients completed the protocol, 22 of whom met our definition of a satisfactory immune reconstitution, showing a significantly more pronounced reduction in spontaneous CD4(+) T cell apoptosis at month 1 as well as month 3, compared with the other patients.
Roger et al. (2002)CD4T cellDown-regulation of CD4(+) T cell apoptosis by antiretroviral treatment is the main mechanism associated with early CD4(+) T cell increase.
Byrd and Sergent (1996)CD4T lymphocytesHe was subsequently found to be infected with the human immunodeficiency virus (HIV-1) and had marked depletion of peripheral CD4 positive T lymphocytes.
Douek (2003)CD4T-cellIn the context of virus-induced damage to the lymphoid tissues and cells that maintain these T-cell pools, and physiological limitations in peripheral CD4+ T-cell renewal, this homeostatic strain leads to the progressive depletion of the more vulnerable CD4+ T-cell pools.
Lane et al. (2008)CD4T cellsWe speculate that their human equivalents could be potential targets for HIV infection and their destruction explains the pattern of loss of CD4 T cells.
Brenchley et al. (2008)CD4T cellsThe major findings to emerge were as follows: (i) depletion of gastrointestinal CD4 T cells is associated with high frequencies of infected CD4 T cells; (ii) HIV-specific T cells are present at low frequencies in the gastrointestinal tract compared to blood; (iii) BAL CD4 T cells are not massively depleted during the chronic phase; (iv) infection frequencies of BAL CD4 T cells are similar to those in blood; (v) significantly higher frequencies and increased functionality of HIV-specific T cells were observed in BAL compared to blood.
Brenchley et al. (2008)CD4T-cellTaken together, these data suggest mechanisms for mucosal CD4 T-cell depletion and interventions that might circumvent global depletion of mucosal CD4 T cells.
Schnittman et al. (1989)CD4T cellsPrevious studies have demonstrated that in vitro infection of CD4+ T cells with HIV-1 results in downregulation of CD4 expression such that CD4 protein is no longer detectable on the surface of the infected cells.
Schneider et al. (1995)CD4T cellsThese findings show an early and preferential loss of duodenal CD4 T cells in HIV infection.
Lusso et al. (1994)CD4T cellsA selective and progressive downregulation of the surface membrane expression of CD4 was observed in human CD4+ T cells in the course of HHV-7 infection.
Grivel et al. (2003)CD4T cellsHIV infection is associated with depletion of CD4(+) T cells.
Mehandru et al. (2004)CD4T cellsWe undertook this study to assess whether a preferential depletion of mucosal CD4(+) T cells would be observed in HIV-1-infected subjects during the primary infection period, to examine the anatomic subcompartment from which these cells are depleted, and to examine whether suppressive highly active antiretroviral therapy could result in complete immune reconstitution in the mucosal compartment.
Cafaro et al. (2000)CD4T cellHere, we show that a vaccine based on the Tat protein of HIV blocks primary infection with the simian/human immunodeficiency virus (SHIV)89.6P and prevents the CD4 T cell decline and disease onset in cynomolgus monkeys.
Malkevich et al. (2001)CD4T lymphocytesOur data show that all R5 HIV-1 infections resulted in mild depletion of CD4(+) T lymphocytes, whereas all X4 HIV-1 infections caused severe depletion of CD4(+) T lymphocytes regardless of their subtype origin.
Chaves and Kallas (2004)CD4T lymphocytesBACKGROUND: Apoptosis is one of the possible explanations for the progressive loss of CD4(+) T lymphocytes in infection with the human immunodeficiency virus (HIV), which may interfere with cell cycle distribution.
Kirschner (1999)CD4T cellIt is known that infection with TB can decrease the CD4(+) T cell counts-a key marker of AIDS progression; thus, it shortens survival in HIV infected individuals.
Bryl et al. (2001)CD4T cellsThe T cells of young and elderly donors with reduced expression of CD4 were examined to see whether these cells exhibit other phenotypic features suggesting their active state.
Liovat et al. (2009)CD4T cellsThere is a transient loss of CD4(+) T cells in the blood in SIVagm and SIVsm infections and an early dramatic and more persistent decrease in the gut.
Badley et al. (2000)CD4T-cellInfection with the human immunodeficiency virus (HIV) is associated with a progressive decrease in CD4 T-cell number and a consequent impairment in host immune defenses.
Clerici et al. (1995)CD4T lymphocytesThe reduction in CD4 T lymphocyte counts is the hallmark of HIV infection; nevertheless, long before the reduction in CD4 counts reaches critical levels, a series of profound and complex defects that impair the function of CD4 T lymphocytes can be detected.
Chen et al. (1996)CD4T cellsCD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef.
Hartigan-O'Connor et al. (2007)CD4T cellT reg cells in the infant but not in the adult directly suppressed SIV-specific CD4(+) T cell responses, which were detectable only after depletion of T reg cells.
Hunt et al. (2003)CD4T cellPersistent T cell activation was associated with decreased CD4(+) T cell gains during therapy.
Serpente et al. (1993)CD4 receptorT cellsOne possible mechanism is the production of infected T cells which are lacking in surface expression of the CD4 receptor protein.
Secchiero et al. (1997)CD4T cellsHuman herpesvirus 7 induces the down-regulation of CD4 antigen in lymphoid T cells without affecting p56lck levels.
Jin et al. (2004)CD4T cellsIn this study we show that the down-regulation of CD4 in human Jurkat T cells expressing Nef was nearly complete (approximately 95%), whereas that induced by PMA was partial (approximately 40%).
Villadsen et al. (2007)CD4T cellsThis reduction in inflammatory mononuclear cells in situ was primarily due to a significant reduction in the numbers of skin-infiltrating CD4(+), but not CD8(+) CD3(+) T cells.
Mattapallil et al. (2006)CD4T cellsImmune responses were associated with a decrease in cell associated viral loads, and a loss of fewer mucosal CD4 T cells.
Weyand et al. (1987)CD4T cellData presented in this paper have demonstrated, for the first time, that antigenic stimulation of human T cell clones caused a decrease in the expression of the CD4 marker (as well as to the CD3 marker) to about 50% of the constitutive level.
Weyand et al. (1987)CD4T cellThe parallel down-regulation of CD3 and CD4 after antigen stimulation suggested that both markers might be members of a multimolecular complex mediating T cell activation.
de Leòn et al. (2006)CD4T cellsThe present work demonstrates, for the first time, the capacity of NGcGM3 ganglioside to down-modulate CD4 expression in murine and human T lymphocytes, especially in non-activated T cells.
de Leòn et al. (2006)CD4T lymphocytesThirty and tenfold reductions in CD4 expression were induced by purified NGcGM3 ganglioside in murine and human T lymphocytes, respectively.
Schneider et al. (1996)CD4T cellCD4 T cells play a critical role in antigen-dependent B cell differentiation, thus the pronounced CD4 T cell depletion in the intestinal mucosa may be responsible for the observed decrease of IgA plasma cells and a reduced secretion of IgA2.
Mouly et al. (2007)CD4T-cellsWe speculated that the CD4 silencer, which operates in CD8+ T-cells to repress CD4 expression, could be responsible for CD4 repression in human lymphoid non-T-cells.
Marracci et al. (2006)CD4T cellWe now demonstrate that treatment of human PBMC and T cell lines with LA downmodulated CD4 expression in a concentration-dependent manner.
Price et al. (2003)CD4T lymphocyteIn most cases, virologic failure on ART is associated with a coincident decline in CD4(+) T lymphocyte levels.
Xiang et al. (2009)CD4T cellsInfection of CD4(+) T cells and macrophages with YFV (17D vaccine strain) also inhibited HIV replication and decreased CD4 gene expression.
Nakamura et al. (2003)CD4T cellInvolvement of CD4 D3-D4 membrane proximal extracellular domain for the inhibitory effect of oxidative stress on activation-induced CD4 down-regulation and its possible role for T cell activation.
Nakamura et al. (2003)CD4T cellThese activation signals cause CD4 down-regulation, presumably acting to optimize T cell activation.
Nakamura et al. (2003)CD4T cellIn this study, we have further investigated inhibition of CD4 down-regulation by oxidative stress and its role for T cell activation.
Nakamura et al. (2003)CD4T cellOur results demonstrate that Ag-induced T cell activation which is normally concomitant with CD4 down-regulation may be disturbed through the aberrant regulation of CD4 expression by oxidative stress.
Hu et al. (2008)CD4T cellRecently, CD4(+) regulatory T (Treg) cells were found to inhibit protective anti-HIV CD4(+) and CD8(+) T cell responses.
Caporossi et al. (1998)CD4T cellMoreover, we provide evidence that a CD4-specific T cell priming can occur in vivo, following a gp120 or anti-CD4 monoclonal antibody (mAb)-mediated CD4 molecule downregulation on antigen-presenting cells (APC).
George et al. (2006)CD4T lymphocytesGBV-C replicates in peripheral blood mononuclear cells (PBMCs) and CD4(+) T lymphocytes in vitro, and depletion of CD4(+) T lymphocytes has been proposed as the reason for clearance of GBV-C among persons positive for human immunodeficiency virus.
Molina-Pinelo et al. (2006)CD4T-cellOBJECTIVE: To analyze the predictive capacity of thymic volume in CD4 T-cell loss after treatment interruption in HIV-infected patients with high nadir CD4 count.
Molina-Pinelo et al. (2006)CD4T-cellAll variables with statistical association with CD4 T-cell loss were analyzed using multivariate Cox proportional hazards regression models.
Molina-Pinelo et al. (2006)CD4T-cellCONCLUSIONS: In this study, we demonstrate for the first time that thymic volume predicts CD4 T-cell loss in patients with nadir CD4 count greater than or equal to 250 cells/muL under treatment interruption.
Sung et al. (2005)CD4T cellsThe average KRG intake over 111.9 +/- 31.3 months was 4,082 +/- 3,928 g, and annual decrease in CD4 T cells was 35.0 +/- 28.7/microl.
Sung et al. (2005)CD4T cellsIn addition, KRG intake significantly slowed the decrease in CD4 T cells even when influence of HLA class I was statistically eliminated (repeated-measure analysis of variance; P < 0.05).
Barbour et al. (2004)CD4T cellThe pol RC value of 43% may represent a threshold below which HIV-1 has lowered virulence and is less able to deplete CD4(+) T cell counts.
Hara et al. (1991)CD4T-cellAutologous non-T-cell stimulation of the T-cell clones resulted in a decrease in cell surface expression of CD4, whereas the expression of CD2, CD3, and WT31 was unchanged.
Haczku et al. (1996)CD4T-lymphocytesInhibition of re-expression of surface CD4, but not CD8, on activated human T-lymphocytes by the immunosuppressive drugs dexamethasone and cyclosporine A: correlation with inhibition of proliferation.
Papasavvas et al. (2003)CD4T cellThe present study assessed antiviral T cell immune responses in 48 human immunodeficiency virus (HIV)-infected children with a stable or decreasing CD4(+) T cell counts and different levels of viral control, in the presence or absence of antiretroviral therapy.
Juszczak et al. (1991)CD4T lymphocytesLong term treatment (20 h) of human T lymphocytes with gp120 resulted in the down-regulation of cell surface CD4 molecules.
Juszczak et al. (1991)CD4T lymphocytesSuch mechanisms may account for the down-regulation of cell surface CD4 molecules and the depletion of functional CD4+ T lymphocytes which are characteristic of human immunodeficiency virus infections and acquired immune deficiency syndrome pathogenesis.
Peretz et al. (2005)CD4T-cellThe rate of CD4+-T-cell loss was calculated for all participants from monthly CD4 counts.
Evans et al. (1988)CD4T cellsHowever, unlike other HIV isolates, HIV-2UC1 does not cause cytopathic effects in susceptible T cells nor does it lead to loss of CD4 antigen expression on the cell surface.
Nishimura et al. (2005)CD4T lymphocytesUnlike HIV-1 and simian immunodeficiency virus (SIV), which induce a slow, unrelenting loss of immune function spanning several years, highly pathogenic simian-human immunodeficiency viruses (SHIVs) induce a rapid, complete, and irreversible depletion of CD4(+) T lymphocytes in rhesus monkeys within weeks of infection, leading to death from immunodeficiency.
Brambilla et al. (2000)CD4T lymphocytesBecause no difference in survival was observed after diagnosis according to AIDS-'87, the association of the SDF1-3'A/3'A genotype with the accelerated progression of late-stage HIV-1 disease appears to be explained for the most part by the loss of CD4(+) T lymphocytes.
Vermeire et al. (2009)CD4T lymphocytesContinuous specific downmodulation of CD4 receptor expression in T lymphocytes by the small molecule cyclotriazadisulfonamide (CADA) selected for the CADA-resistant human immunodeficiency virus type 1 (HIV-1) NL4.3 virus containing unique mutations in the C4 and V5 regions of gp120, likely stabilizing the CD4-binding conformation.
Bainbridge et al. (2000)CD4T-cellsThe suppressive effect of HLA-G on the mixed lymphocyte reaction persisted after depletion of phagocytes and CD8(+) T-cells from the responder population, but the mixed lymphocyte reaction was entirely abolished by depletion of CD4(+) T-cells.
Lusso et al. (1995)CD4T-cellGrowth of macrophage-tropic and primary human immunodeficiency virus type 1 (HIV-1) isolates in a unique CD4+ T-cell clone (PM1): failure to downregulate CD4 and to interfere with cell-line-tropic HIV-1.
Wagner et al. (2004)CD4T cellIn healthy individuals, blockade of TCR-pMHC class II contact resulted in decreased CD4(+) T cell division.
Kim et al. (1993)CD4T cellInfection of T cell lines by the type 1 human immunodeficiency virus (HIV-1) is associated with downregulation of the CD4 receptor and resistance to further HIV-1 infection, the phenomenon of viral interference.
Macchia et al. (2006)CD4hiT cellsCross-sectional studies of SIV-infected animals demonstrated that the frequency of CD4hi CD8alphalo T cells was lower in wild-type SIV-infected animals compared to uninfected controls, although prospective studies of SIV-infected animals demonstrated depletion of CD4hi CD8alphalo lymphocytes only in a subset of animals.
Cloke et al. (2010)CD4T cellsAlthough depletion of CD4(+) T cells is frequently used to explain immunosuppression, chronicity of infection and progressive loss of CD4(+) T cells are not sufficient to fully account for immune dysregulation.
Owen et al. (2007)CD4T cellLong-term cryopreservation, however, may lead to the loss of CD4(+) T cell responses and mild skewing of T cell phenotypic marker expression.
Garcia et al. (1993)CD4T cellsWe also determined that Nef is functional in murine T cells and induces downregulation of both murine CD4 and CD8 (Ly-2) from the cell surface.
Paillard et al. (1990)CD4T cellIn contrast, activation signals such as anti-CD3 + PMA, which lead to lymphokine mRNA expression and T cell proliferation, promote a decrease of the TcR, CD4 and CD8 mRNA levels within 4 h post-activation, followed by their gradual re-expression.
Rotoli et al. (1995)CD4T cellSerum IgE levels were elevated (1000 IU/ml), and T cell subsets showed an increase in CD8+ and a decrease in CD4+ with an inversion of CD4+/CD8+ ratio (= 0.78).
Grivel et al. (2003)CD4T cellsAccordingly, HHV-6A infection resulted in the depletion of both CD4(+) and CD8(+) T cells, whereas in HHV-6B-infected tissue CD4(+) T cells were predominantly depleted.
Smith et al. (2005)CD4T cellsCoincident with acquiring the new strain, the individual's viral load increased by about 10,000 copies/ml with a decrease of 150 x CD4 T cells/mul over the next 6 months.
Vavricka et al. (2004)CD4T-cellPneumocystis carinii pneumonia in patients with chronic lymphocytic leukaemia (CLL) who have not been treated with fludarabin are rare, although clinically relevant CD4 T-cell depletion can occur in longstanding CLL without prior treatment with purine analogues.
Dao Nguyen and Robinson (2004)CD4T cellsFluticasone propionate increases CD4CD25 T regulatory cell suppression of allergen-stimulated CD4CD25 T cells by an IL-10-dependent mechanism.
Kitasato et al. (2003)CD4T cellsBronchoalveolar lavage fluid analysis showed an increase of lymphocytes and CD8+ T cells (93.3% of lymphocytes), and a decrease of the CD4/8 ratio of the T cell subset (0.04).
Lai et al. (2002)CD4T cellLymphocyte subset quantitation showed a T cell deficiency and a decreased CD4/CD8 ratio.
Magro et al. (2001)CD4T-cellCONCLUSION: Lymphoid atypia, erythrophagocytosis, loss of certain pan T-cell markers, a reduced CD4/8 ratio and TCR rearrangement define subcuticular T-cell lymphoid dyscrasia, including a subset of LEP and ILLP.
Haynes et al. (2000)CD4T cellsThe defect in IL-2 production may be the only critical deficiency of aged naive CD4 T cells.
Van Lier and Baars (1999)CD4T-cellApart from fundamental issues addressing lineage relationships between naive, memory and effector T cells and the cellular basis for long-term T-cell memory, these types of studies have proved to be valuable in understanding T-cell reconstitution in situations of severe T-cell depletion, i.e., after chemotherapy, treatment with depleting CD4 monoclonal antibodies or during HIV infection.
Vella et al. (1997)CD4T-cellThe down-regulation of surface CD4 molecules was delayed and virus yields significantly exceeded those obtained in T-cell lines.
Hernichel-Gorbach et al. (1994)CD4T-cellIn refractory periodontitis patients the T-cell CD4/CD8 ratio was decreased.
Effros et al. (1994)CD4T cellsThe decline in the percentage of CD28+ T cells correlates with a reduction in the CD4/CD8 ratio (r2 = 0.695, p < 0.0001).
Brummer et al. (1993)CD4T-cellT-cell subsets in patients' tissues were characterized by means of monoclonal antibodies, and a reduced CD4/CD8 ratio was demonstrated.
Scudeletti et al. (1993)CD4T lymphocyteNevertheless, certain immunological modifications, including a significant reduction of the circulating T lymphocyte level and of the CD4/CD8 ratio, which was between 1 and 1,5 during the DFC treatment and between 1 and 2 during the PDN treatment, are more pronounced and more stable with DFZ than with PDN.
Idezuka et al. (1991)CD4T lymphocytesA sample of bronchoalveolar lavage fluid showed increased T lymphocytes and a decreased CD4/8 ratio.
Ayabe et al. (1989)CD4T lymphocyteFurthermore, gangliosides purified from plasma of patients with HAM significantly inhibited the expression of CD4 antigen on human T lymphocyte membrane.
Sipka et al. (1988)CD4T cellsAdenosine reduced the expression of CD4 antigen both in HIV infected and uninfected H9 T cells.
Nagy et al. (2006)CD4T cellsMoreover, overexpression of HRES-1/Rab4 reduced CD4 expression on peripheral blood CD4+ T cells.
McCormick-Davis et al. (2000)CD4T cellThese results indicate that a membrane-bound Vpu is not required for the CD4(+) T cell loss and neurological disease in SHIV-inoculated pig-tailed macaques.
Veazey et al. (2003)CD4T cellsIn macaques intravenously infected with SIV, rapid depletion of CD4(+) T cells was observed in the vagina, particularly among the CCR5(+)CD4(+) subset.
Klippstein et al. (2003)CD4T-lymphocyteCONCLUSION: Bendamustine is capable of inducing a reduction in CD4(+) lymphocyte counts causing a severe T-lymphocyte-mediated immunosuppression.
Hamamoto et al. (1989)CD4T cellComparison of effects of protein kinase C inhibitors on phorbol ester-induced CD4 down-regulation and augmentation of human immunodeficiency virus replication in human T cell lines.
Ciurea et al. (2001)CD4T cellWe present evidence that the failure of the infected host to mount effective humoral responses against emerging neutralization-escape mutants correlates with the rapid loss of CD4(+) T cell responsiveness during the establishment of viral persistence.
Fan et al. (1993)CD4T cellThus, the low IL-2 mRNA expression seen in PBMC is primarily due to the reduced CD4 T cell numbers.
Parolini et al. (1999)CD4T lymphocytesHuman T lymphocytes have become a well established model system for studying the process of phorbol ester-induced down-regulation of CD4.