| Document |
Target |
Regulator |
Anatomy |
Sentence |
| Papasavvas et al. (2000) | CD4 | | T cell | After a median interruption of 55 days of therapy accompanied by rebound of virus, reinitiated therapy in 4 of 5 subjects resulted in suppression of 98.86% of plasma virus load by 21-33 days and no significant decrease in CD4 T cell percentage from baseline. |
| Willey et al. (2003) | CD4 | | T cells | Although all of the vaccinated monkeys became infected, they displayed reduced postpeak viremia, had no significant loss of CD4(+) T cells, and have remained healthy for more than 15 months postinfection. |
| Marracci et al. (2006) | CD4 | | T-cell | LA treatment of Con A stimulated PBMC specifically removed CD4 from the T-cell surface, but not CD3. |
| Lori et al. (1999) | CD4 | | T lymphocytes | No loss of naive CD4 T lymphocytes was observed, and recovery of up to 35% of naive CD8 T lymphocytes occurred in several weeks. |
| Vignali et al. (1996) | CD4 | | T cell | Thus, neither colocalization of CD4 and the TCR nor signal transduction via CD4 was solely responsible for the functional restoration of these T cell hybridomas by wild-type CD4. |
| Hofmann-Lehmann et al. (2001) | CD4 | | T-cell | One of the four infants remained uninfected after oral challenge with SHIV89.6P, and two infants had no or a delayed CD4(+) T-cell decline. |
| Singh et al. (2001) | CD4 | | T cells | In this study, we have analyzed the tissue-specific changes in the env and nef in one macaque that developed neuroAIDS (macaque 50 O) and in three macaques that developed only a moderate or no significant loss of CD4(+) T cells and no neurological disease (macaques 50 Y, 20220, 20228) following inoculation with DeltavpuSHIV(KU-1bMC33). |
| Weiss et al. (2010) | CD4 | | T-cell | Our results indicate that the level of HIV-DNA in PBMCs reflecting, at least in part, the size of the HIV reservoir and the number of CD4+ T cells, preferential targets of the virus, were independent predictors of CD4 T-cell decline. |
| Kakimoto et al. (2002) | CD4 | | T lymphocytes | In contrast, there appeared to be no reduction in the capacity for presentation of an HLA class II-binding peptide to the peptide-specific CD4(+) T lymphocytes. |
| Heath et al. (2009) | CD4 | | T cells | Furthermore, CD4+ T cells in BAL are infected at similar frequencies to CD4+ T cells found in blood in subjects with chronic infection, and are not massively depleted, as has been found in the GI tract [8]. |
| Wing et al. (2003) | CD4 | | T cells | CD4 T cell activation by myelin oligodendrocyte glycoprotein is suppressed by adult but not cord blood CD25+ T cells.
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| Doria-Rose et al. (2003) | CD4 | | T cells | In contrast, DNA priming/vaccinia virus boosting and vaccinia virus priming/DNA boosting vaccines both protected animals from disease: 11 of 12 macaques had no loss of CD4(+) T cells or moderate declines. |
| Newman et al. (2001) | CD4 | | T cells | Modification of the Fc region of a primatized IgG antibody to human CD4 retains its ability to modulate CD4 receptors but does not deplete CD4(+) T cells in chimpanzees.
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| Sung and Rice (2006) | CD4 | | T cells | These observations indicate that a large increase in the association of 7SK/HEXIM1 with P-TEFb does not generally repress gene expression in CD4+ T cells, consistent with our previous studies in PBLs [14]. |
| Brooks et al. (2005) | CD4 | | T cells | Herein, we illustrate that virus-specific CD4 T cells are functionally inactivated early during the transition into viral persistence and fail to produce effector cytokines (i.e., interleukin-2 and tumor necrosis factor alpha), thereby compromising an efficient and effective antiviral immune response. |
| Hirohata et al. (2002) | CD4 | | T cells | By contrast, any of sulfasalazine, SP, 5-ASA and 4-acethyl SP did not suppress the IFN-gamma production of immobilized anti-CD3 stimulated CD4+ T cells. |
| Todd et al. (1994) | CD4 | | T cell | We show here that introducing cells expressing the endogenous superantigen Mls 1a into an Mls 1b environment results in the induction of an anergic state with little or no depletion of V beta 6/CD4+ T cell from the peripheral T cell repertoire. |
| Rezvany et al. (2006) | CD4 | | T cells | The clonally restricted pattern was significantly reduced in CD4 (P < 0.01) but not in CD8 T cells. |
| Rout et al. (2010) | CD4 | | T lymphocyte | The frequency of NKT lymphocytes within the CD8+ and DN T lymphocyte subsets were also similar between SIV-negative and naturally SIV-infected sooty mangabeys (Figure 8B–C), indicating that there was no depletion of CD4? |
| Basch et al. (1996) | CD4 | | T cells | CD4 expression is not limited to T cells and monocytes. |
| Pahwa (2007) | CD4 | | T cells | A subset of patients, however, fail to recover CD4 T cells despite virologic suppression. |
| Ergin et al. (2007) | CD4 | | T cells | In contrast, treatment of protein 253 with LPS removal beads did not reduce the frequency of stimulated CD4+ T cells. |
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