Viewing affirmative mentions of negative regulation of CD8A (H. sapiens) in T cells

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Casazza et al. (2001)CD8T-cellAfter an undetectable viral load was achieved, a slower decrease in HIV-specific CD8(+) T-cell response was observed that was well described by first-order kinetics.
Casazza et al. (2001)CD8T-cellThese data suggest that HAART quickly starts to restore CD8(+) T-cell responses to other chronic viral infections and leads to a slow decrease in HIV-specific CD8(+) T-cell response in HIV-infected patients.
Casazza et al. (2001)CD8T-cellThe slow decrease in the rate of CD8(+) T-cell response and rapid increase in response to recurrent viral replication suggest that the decrease in CD8(+) T-cell response observed represents a normal memory response to withdrawal of antigen.
Carton et al. (2004)CD8T cellsCD4+CD8+ human small intestinal T cells are decreased in coeliac patients, with CD8 expression downregulated on intra-epithelial T cells in the active disease.
Carton et al. (2004)CD8T cellsLevels of CD8 expression by CD4CD8 T cells in the epithelial layer were decreased significantly in patients with active coeliac disease.
Lascar et al. (2005)CD8T cellA cross-sectional study showed a reduction in HBV-specific CD8(+) T cell responses in HIV-positive, HBV-immune patients, compared with those in HIV-negative, HBV-immune patients.
Hambor et al. (1988)CD8T cellFunctional consequences of anti-sense RNA-mediated inhibition of CD8 surface expression in a human T cell clone.
Hambor et al. (1988)CD8T cellExpression of CD8 on this T cell clone, JH.ARL.1, was selectively and efficiently inhibited.
Terry et al. (1990)CD8T-cellWe also demonstrate the down-regulation of the CD8 alpha/beta heterodimers from the surface of a CD8+ T-cell clone following treatment with phorbol myristate acetate (PMA) while CD8 alpha/alpha homodimers remain on the cell surface.
Sheu et al. (2008)CD8T cellsIncreased percentages of tumor-infiltrating CD8(+) T cells with decreased CD4/CD8 percentages are of prognostic importance for cancer progression in human breast cancer.
de Quiros et al. (2000)CD8T cellsResistance was abrogated by depletion of CD8(+) T cells in vivo and was observed only in LTNPs with proliferative responses to p24.
Zheng et al. (2010)CD8T cellsIn vitro deprivation of CD8(+)CD57(+)T cells promotes the malignant growth of bone marrow colony cells in patients with lower-risk myelodysplastic syndrome.
Zheng et al. (2010)CD8T cellsRESULTS: After deprivation of CD8(+)CD57(+)T cells, BMNCs from 33 MDS patients formed colonies in the culture media.
Zheng et al. (2010)CD8T cellsIn 15 MDS patients with abnormal karyotypes, deprivation of CD8(+)CD57(+)T cells significantly increased the proportion of abnormal cells from 43.8% to 56.3% in BMNC culture (p < 0.001).
Genescŕ et al. (2009)CD8T cellsDepletion of CD8(+) T cells at the time of SIV challenge completely abrogates the protection mediated by prior infection with attenuated SHIV.
Taylor et al. (2006)CD8T lymphocyteActive therapy was associated with an unexplained decrease in CD8 and non-T lymphocyte counts.
Maimone and Reder (1991)CD8 moleculeT lymphocytesIn multiple sclerosis (MS), T lymphocytes exhibit decreased membrane expression of the CD8 molecule and defective suppressor function.
Denney et al. (2010)CD8T lymphocytesReduction of natural killer but not effector CD8 T lymphocytes in three consecutive cases of severe/lethal H1N1/09 influenza A virus infection.
Donia et al. (2009)CD8T cellsThe milder course of the disease was associated with a reduction of the histopathological signs associated to EAE: increased percentage of splenic CD4+CD25 + Foxp3+ Tregs and concomitant reduction of splenic CD8+T cells.
Wang et al. (2009)CD8T cellFurthermore, in the selective absence of LC, UV light still caused suppression of both CD8 T cell expansion and contact hypersensitivity.
Liu et al. (2007)CD8T cellSuppression of memory CD8 T cell generation and function by tryptophan catabolism.
Lütjen et al. (2006)CD8T cellsDepletion of CD4 T cells prior to infection did not affect frequencies of beta-Gal(876-884)-specific (consisting of residues 876 to 884 of beta-Gal) CD8 T cells but resulted in a pronounced reduction of intracerebral beta-Gal-specific gamma interferon (IFN-gamma)-producing and cytolytic CD8 T cells.
Tang et al. (2004)CD8T-lymphocytesLongitudinal analysis showed a significant reduction of CD8 T-lymphocytes after treatment in responders (P < 0.001).
Tang et al. (2004)CD8T-lymphocytesResponse to therapy led to a significant reduction of intrahepatic CD8 T-lymphocytes.
McCurdy et al. (2004)CD8T-cellMice immunized with MVA were fully protected from a low-dose vSC8-mIL4 challenge despite a depletion of CD4+ cells, CD8+ cells, or both T-cell subsets or an antibody deficiency.
Streif et al. (2004)CD8T cellsAfter MV infection, CD8 T cells are reduced in their proliferative capacity whereas the CD4/CD8 ratio, the number and activation status of CD8 T cells is not affected.
Gorochov et al. (2001)CD8T-cellDown-regulation of CD8+ T-cell expansions in patients with human immunodeficiency virus infection receiving highly active combination therapy.
Brophy et al. (2001)CD8T-cellWhile no specific T-cell subset marker exists to measure the adequacy of immunosuppression with polyclonal induction, flow cytometric analysis has been used to evaluate the suppression of CD3, CD4, and CD8 cells.
González Rincón et al. (1998)CD8T-lymphocyteA significant decrease of the CD4 and CD8 T-lymphocyte subsets, along with decreased CD4-CD8 quotient, were found in the aplastic crisis group, and an impairment of the immune response to the viral challenge can be inferred form this.
Paillard et al. (1990)CD8T cellIn contrast, activation signals such as anti-CD3 + PMA, which lead to lymphokine mRNA expression and T cell proliferation, promote a decrease of the TcR, CD4 and CD8 mRNA levels within 4 h post-activation, followed by their gradual re-expression.
Unzeitig et al. (1984)Leu 2T cellsHealthy hemophiliacs who had received more than 250 CFC infusions had a decreased number of Leu 3+ "helper" T cells, a decreased Leu 3-Leu 2 ratio, and decreased pokeweed mitogen responses.
Unzeitig et al. (1984)Leu 2T cellsHemophiliacs who had received greater than 250 CFC infusions and who had persistent lymphadenopathy had decreased Leu 3+ cells, increased Leu 2+ "suppressor" T cells, a decreased Leu 3-Leu 2 ratio, and decreased phytohemagglutinin responses.
Xiao et al. (2007)CD8T cellsDetuning CD8 T cells: down-regulation of CD8 expression, tetramer binding, and response during CTL activation.
Xiao et al. (2007)CD8T cellWe report that loss of CD8 expression early during in vivo responses to vaccinia virus or Listeria monocytogenes (LM) correlates with decreased T cell staining with specific class I/peptide tetramers and reduced CD8 T cell sensitivity for antigen.
Xiao et al. (2007)CD8T cellsWe determined that during response to LM, CD8 down-regulation is regulated by T cell reactivity to type I interferon (IFN-I) because CD8 loss was averted on IFN-I receptor-deficient T cells.
Maraninchi et al. (1988)CD8T-cellIn conclusion, when compared to the data in the literature, CD8 depletion was shown to be less efficient than pan-T-cell depletion in the prevention of GVHD after allogeneic BMT and was still associated with a major complication associated with this procedure, i.e., graft failure.
Hartigan-O'Connor et al. (2007)CD8T cellIn the case of both the infant and the adult macaque, T reg cells were not able to directly suppress SIV-specific CD8(+) T cell responses and had no apparent effect on T cell activation.
van Baarle et al. (2001)CD8T cellsOur data indicate that functional loss of EBV-specific CD8(+) T cells with a concomitant increase in EBV load may play a role in the pathogenesis of AIDS-NHL.
Bratke et al. (2007)CD8T cellsActivated CD8(+) T cells are significantly reduced in CMV(+) patients with allergic asthma.
Hambor et al. (1990)CD8T cellBy antisense-mediated inhibition of CD8 expression in T cell clones and expression of CD8 in non-T cell lines, we have produced several sets of CD8+/CD8- paired cell lines.
Robertson et al. (2008)CD8T cellIn chronic Friend virus infections CD4(+) T regulatory (Treg) cells suppress CD8(+) T cell effector functions critical for virus clearance.
Lewis et al. (2007)CD8T cellAnother study has shown that the amount of CD4+ T cell apoptosis was reduced after four weeks with or without IL-2 therapy, but reduction of CD8+ T cell apoptosis levels took 24 weeks to develop [19].
Hart et al. (2006)CD8T-cellA threshold level of blood cobalt and chromium ions was associated with reduced CD8(+) T-cell counts.
Eggena et al. (2005)CD8T cellVirus suppression by ART was associated with a reduction in T cell activation, with a stronger observed effect on reducing CD8(+) compared with CD4(+) T cell activation.
Strowig et al. (2009)CD8T cellsBoth loss of CD4(+) and CD8(+) T cells abolished immune control.
DiSanto et al. (1989)CD8T cellThese studies demonstrate a significant differential property of the CD4 and CD8 antigens and suggest that down-regulation of the CD8 antigen may require its expression in a T-cell environment and/or the association of CD8 with the T-cell receptor or other T cell-specific molecules.
Grivel et al. (2003)CD8T cellsAccordingly, HHV-6A infection resulted in the depletion of both CD4(+) and CD8(+) T cells, whereas in HHV-6B-infected tissue CD4(+) T cells were predominantly depleted.
van Seters et al. (2008)CD8T cellsIn summary, high-risk HPV-related usual-type VIN lesions are characterized by an immunosuppressive state in the epidermis, showing a reduction of immature myeloid DCs (mDC) and CD8(+) T cells.
Wang et al. (2008)CD8AT-cellWe also observed the downregulation of CD8B and CD8A in CD8+ T-cell, possibly as a part of the CD8+ T-cell activation machinery.
Kolli et al. (2008)CD8T cellsConcurrent depletion of CD4(+) and CD8(+) T cells completely blocked airway obstruction as well as AHR.
Arosa et al. (1994)CD8T cellsIn addition to an occasional decrease in the amount of CD8-associated lck, HH patient-derived T cells showed a consistent decrease in the relative CD8-p56lck specific activity.
Gaufin et al. (2010)CD8T cellsTwo recent studies that combined CD8 and CD20 cell depletion in two different species of AGMs reported a trend toward a prolongation in peak viremia that was controlled with the rebound of the CD8+ T cells, and had no impact on the course of SIVagm infection [44,45].
Soudeyns et al. (2000)CD8T-cellThis indicates that ART leads to a global reduction of CD8(+) T-cell oligoclonality and significantly modulates the mobilization of HIV-specific CTL during primary infection.
Stohl et al. (1998)CD8T cellSuperantigen-driven, CD8+ T cell-mediated down-regulation: CD95 (Fas)-dependent down-regulation of human Ig responses despite CD95-independent killing of activated B cells.
Hel et al. (2001)CD8T-cellThe data obtained in this pilot study lead to the hypothesis that disease progression may be associated with loss of virus-specific CD8(+) T-cell function.
Markiewski et al. (2008)CD8T cellHere we show that the generation of complement C5a in a tumor microenvironment enhanced tumor growth by suppressing the antitumor CD8(+) T cell-mediated response.
Kaur et al. (2003)CD8T lymphocytesReduction in CMV-specific CD8(+) T lymphocytes and anti-CMV neutralizing Abs was significantly correlated with a decline in CMV-specific CD4(+) T lymphocytes.
Brooks et al. (1993)CD8T cellsMost human T cells express the TCR alpha/beta and either CD4 or CD8 molecules (single positive, SP); however, small numbers lack CD4 and CD8.
Rubinstein et al. (2009)T-cell receptorT-cellLoss of T cell-mediated antitumor immunity after construct-specific downregulation of retrovirally encoded T-cell receptor expression in vivo.
Lee et al. (2010)CD8T cellsTransfection of CD8(+) T cells with dominant-negative PKC diminished the prosurvival effect of PEP005 significantly.
Lusso et al. (2007)CD8T cellsRapid disease development in dually infected animals was heralded by an early depletion of both CD4(+) and CD8(+) T cells.
Palena et al. (2003)T-cell receptorT cellsA T-cell receptor agonist epitope of CAP-1 (designated CAP1-6D) has been shown to enhance the stimulation of T cells over levels obtained using CAP-1.
Maecker et al. (2003)CD8T-cellViral antigen-specific CD8+ T-cell responses are impaired in multiple myeloma.
Peinado et al. (1999)CD8T-cellThe CD8(+) T-cell subset was increased in both smokers and COPD compared with nonsmokers, yielding a reduction of the CD4(+)/CD8(+) ratio.
Shearer et al. (2000)CD8T-cellThe same children exhibited the anticipated significantly increased 5-year cumulative mortality, increased serum HIV-1 RNA load, and decreased CD8(+) (cytotoxic) T-cell counts.
Spentzou et al. (2010)CD8T cellWe have characterized an assay measuring CD8 T cell-mediated inhibition of human immunodeficiency virus (HIV) type 1 replication, demonstrating specificity and reproducibility and employing a panel of primary HIV-1 isolates.
Fischer et al. (2007)CD8T-cellOne such obstacle is immunodominance, where the CD8(+) T-cell response to a vector can suppress the desired CD8(+) T-cell response to a recombinantly encoded antigen.
Sanchez et al. (2004)CD8T cellsInfected patients who died had reduced numbers of T cells, CD8(+) T cells, and activated (HLA-DR(+)) CD8(+) T cells, while the opposite was noted for patients who survived the disease.
Singer and Theofilopoulos (1990)CD8T-cellWe further speculate that downregulation of CD4 and CD8 accessory molecules on thymocytes with moderately autoreactive T-cell receptors is involved in selecting cells, including lpr/gld precursors for this pathway.
Sánchez-Ramón et al. (2003)CD8T-lymphocytesThus, a decrease of CD8(+) T-lymphocytes would diminish the host capacity to control viral infection, as reported in animal models, enabling infected macrophages to cross the blood-brain barrier.
Kostense et al. (2002)CD8T cellsPersistent numbers of tetramer+ CD8(+) T cells, but loss of interferon-gamma+ HIV-specific T cells during progression to AIDS.
Kostense et al. (2002)CD8T-cellThese data indicate that the loss of HIV-specific CD8(+) T-cell activity is not due to physical depletion, but is mainly due to progressively impaired function of HIV-specific CD8(+) T cells.
Verjans et al. (2007)CD8T cellsHigh numbers of activated CD8(+) T cells expressing a late effector memory phenotype were found to reside in latently infected TG.
Avanzini et al. (2006)CD8T cellsRESULTS: We found a significantly higher absolute number of CD8(+) and a significantly lower percentage of CD8(+)CD45RA(+)beta7(+) T cells in patients with intestinal a-GVHD than in patients with a-GVHD without intestinal involvement (p = 0.003 and p = 0.003, respectively) or not experiencing a-GVHD (p = 0.02 and p = 0.002, respectively).
Konikoff et al. (2006)CD8T lymphocytesEffective treatment with FP decreased the number of CD8(+) T lymphocytes and mast cells in both the proximal and distal esophagus (P < .05).
Casazza et al. (2001)CD8T-cellA rapid decline in HIV-specific CD8(+) T-cell response was observed at initiation of therapy.
Lichterfeld et al. (2007)CD8T-cellThese data suggest that high-avidity HIV-1-specific CD8+ T-cell clones are recruited during early infection but are subsequently lost in the presence of persistent high-level viral replication.
Accapezzato et al. (2005)CD8T cellAlthough all individuals showed a boost in antibody titers to HBV, six of nine individuals who were administered chloroquine showed a substantial CD8+ T cell response to HBV antigen, whereas zero of eight without chloroquine lacked a CD8 response.
Carton et al. (2004)CD4CD8T cellIn active coeliac patients, CD4CD8 T cell percentages were significantly decreased in both the epithelial layer and lamina propria.
Kannagi et al. (1997)CD8T cellsSuch tapering consequences of in vitro HIV-1 infection in the PBMC of ACs were abrogated by depletion of CD8+ T cells from the culture.
Allen et al. (2005)CD8T cellsFourteen optimal HIV-1 T-cell epitopes were targeted by CD8(+) T cells, four of which underwent mutation associated with dramatic loss of the original CD8(+) response.
Cella et al. (2010)CD8T cellsThus, DNAX-activating molecule-1 downregulation on CD8(+) T cells aggravates the impairment of CTL effector function in chronic HIV-1 infection.
Woodahl et al. (2009)CD8T-lymphocyteAn individual's response to fludarabine may be influenced by the amount of CD4(+) and CD8(+) T-lymphocyte suppression.
Alter et al. (2008)CD8T-cellKIR-associated suppression of CD8(+) T-cell function was independent of ligand engagement, suggesting that these regulatory receptors may constitutively repress TCR activation.
Cruz et al. (2008)CD8T-lymphocyteRemarkably, the two conserved haplotypes defined in Portuguese patients were also observed in the geographically different population of Canadian patients, also predicting CD8+ T-lymphocyte numbers and the severity of disease.
Schmitz et al. (1998)CD8T lymphocyteThe MF of anti-CD8alpha beta staining was significantly reduced on CD8(+) T lymphocyte subsets that showed immunophenotypic evidence of activation.
Slavik et al. (2001)CD8T cellMoreover, rapamycin-resistant proliferation of the CD8(+) T cell clones was blocked by anti-IL-2 Abs, suggesting that while some of the parallel pathways triggered by IL-2R signaling are sensitive to the effects of rapamycin, others account for the Ag-driven rapamycin resistance.
Sheu et al. (2008)CD8T cellsThe tumor-infiltrating CD8(+) T cells significantly increased with stage progression, reflected in a more strongly decreased CD4/CD8 percentage (P=0.003).
Lukens et al. (2010)CD8T-cellA systemic neutrophil response precedes robust CD8(+) T-cell activation during natural respiratory syncytial virus infection in infants.
Radcliffe et al. (2007)CD8T cellProlonged antigen expression following DNA vaccination impairs effector CD8+ T cell function and memory development.
Elling et al. (1990)CD8T lymphocytesMedian percentage and number of circulating CD8+ T lymphocytes (suppressor/cytotoxic T lymphocytes) are markedly decreased in patients with giant cell arteritis (GCA).
Vestey et al. (1989)CD8T cellsIn 2 of them, depletion of CD8+ T cells by panning restored the lymphoproliferative response to HSV.
Vestey et al. (1989)CD8T cellsDepletion of CD8+ T cells did not affect lymphoproliferation to HSV outwith recrudescence (four patients), nor lymphoproliferative responses to another antigen (PPD; five patients) during recrudescence.
Streeck et al. (2008)CD8T cellSome of the patients began antiretroviral therapy during the study, and the researchers found that this treatment, which reduced the viral load, reversed CD8+ T cell exhaustion.