Viewing affirmative mentions of regulation of CD4 (H. sapiens) in T cells

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Clerici (1995)CD4T lymphocytesThus, HIV infection is characterised by quantitative and qualitative defects affecting CD4 T lymphocytes.
Kalish et al. (2000)CD4T cellSeveral studies of patients infected with human immunodeficiency virus (HIV) type 1 have suggested that women have lower plasma HIV-1 RNA levels than men, even when controlling for CD4 T cell levels.
Sorice et al. (1995)CD4T lymphocytesGangliosides modulate the expression of CD4 molecules on the cell surface of T lymphocytes.
Kawaguchi et al. (1989)CD4T lymphocytesCharacteristic mode of action of gangliosides in selective modulation of CD4 on human T lymphocytes.
Clerici et al. (1995)CD4T lymphocytesThus, HIV infection is characterized by quantitative and qualitative defects affecting CD4 T lymphocytes.
Bartholomew et al. (1995)CD4T cellsIn order to down-modulate CD4 on resting, normal CD4 T cells there was an absolute requirement for FcR-mediated cross-linking of the anti-CD4 antibody, and only CD4 levels were affected.
Cucchiarini et al. (1995)CD4T-cellBecause of the lack of vpu in HIV-2, we investigated the effects of two HIV-2 isolates (ROD 10 and EHO) on CD4 expression in the CEM T-cell line.
Theze (2008)CD4T lymphocytesUninfected CD4 T lymphocytes are also indirectly affected during this second phase: they are activated, become anergic, then disappear by apoptosis, ultimately contributing to CD4 lymphopenia.
de Leòn et al. (2006)CD4T cellsRole of tumour-associated N-glycolylated variant of GM3 ganglioside in cancer progression: effect over CD4 expression on T cells.
Mouly et al. (2007)CD4T-cellsCD4 regulation in human lymphoid non-T-cells: a role for the silencer element.
Nakamura et al. (2003)CD4T cellOur results demonstrate that Ag-induced T cell activation which is normally concomitant with CD4 down-regulation may be disturbed through the aberrant regulation of CD4 expression by oxidative stress.
Zhang et al. (1994)CD4T cellsThe regulatory effects of phorbol myristate acetate (PMA) on the expression of the CD4 molecule on horse T cells were investigated.
Zhang et al. (1994)CD4T cellsThese findings demonstrate that equine CD4+ T cells undergo alterations in CD4 expression in response to PMA, and suggest that the equine homolog of the CD4 molecule is regulated by PMA in a similar manner to the human CD4 molecule.
Kontny (1989)CD4T cellsIn order to estimate the dependence of CD4 and CD8 antigen expression upon the cell activation, their presence on resting and activated human T cells was investigated.
Wagner et al. (2004)CD4T cellOur results suggest a disturbed regulation of CD4(+) T cell homeostasis leading to the repertoire aberrations reported in RA.
Blum et al. (1993)CD4T cellThe human CD4 transgenic mice provide a useful system for the identification and characterization of additional sequence elements that participate in human CD4 gene regulation and for the elucidation of regulatory mechanisms governing the developmental program mediating the maturation of the CD4+ and CD8+ peripheral T cell subsets.
Boto et al. (1991)CD4T cellsDistinct modulatory effects of bryostatin 1 and staurosporine on the biosynthesis and expression of the HIV receptor protein (CD4) by T cells.
Paillard et al. (1990)CD4T lymphocytesTranscriptional and post-transcriptional regulation of TcR, CD4 and CD8 gene expression during activation of normal human T lymphocytes.
Pomer (1994)CD4T cellsNew approaches to successful prevention and management of transplant rejection include the use of biological immunosuppressants, such as monoclonal antibodies targeting the CD3 and CD4 molecules on native T cells, the interleukin 2 receptor on activated T cells, monocytes and B cells, and adhesion molecules.
Hultin et al. (1998)CD4T lymphocytesHere we describe a reproducible method for quantitative fluorescence cytometry (QFCM) that depends on the tightly regulated expression of CD4 antigen on human CD4+ T lymphocytes, which we estimated in a study of 57 normal donors to have an interperson coefficient of variation of 4.9%.
Braun et al. (2006)CD4T-cellThe ability to measure both CD8 and CD4 responses in unexpanded samples makes the assays described here sensitive measurements of the T-cell responses in HSV infected individuals.
Gandhi et al. (2010)CD4T cellBecause residual viremia might affect immune recovery, perhaps by triggering abnormal T cell activation and increasing activation-induced cell death, we assessed whether raltegravir intensification affected the CD4 cell count.
Jordan et al. (1989)CD4T cellThe purpose of this investigation was to further assess ability of 1,25-D3 to regulate CD4+ and CD8+ T cell functions.
Mao et al. (2004)CD4T cells[Regulation of CD3, CD4 and CD8 expressions on PMA-activated human peripheral T cells].
Chen et al. (2005)CD4T cellsFurthermore, we demonstrated that the CD4 expression level in primary T cells affects their susceptibility to CCR5-tropic HIV-1 infection but not VSV G-pseudotyped HIV-1 infection.
Pinchuk et al. (2008)CD4T-cellPD-1 ligand expression by human colonic myofibroblasts/fibroblasts regulates CD4+ T-cell activity.
Johansson-Lindbom et al. (2003)CD4T cellTaken together, these data suggest that GCs and B cells regulate CD4(+) T cell differentiation in a finely tuned fashion, either by promoting differentiation of Th2 cells, which apparently leave the lymphoid tissue before evolving a cytokine-producing phenotype, or by furnishing T cell unresponsiveness.
Sabahi et al. (1995)CD4T cellCONCLUSIONS: CD4 T helper (Th1) cell function is down regulated progressively during the three trimesters of pregnancy without changes in the quantity of T cell subsets.
Trzonkowski et al. (2002)CD4T-cellThe aim of the study was to examine changes in CD4(+) and CD8(+) T-cell subpopulations, the expression of the inhibitory molecule, CD152 on T lymphocytes and the levels of interleukins (IL) 2, 6, 10, 12 and tumour necrosis factor alpha (TNF alpha) in primary glomerulonephritis chronic haemodialysis (HD) patients before and under rHuEpo treatment.
Prowse et al. (2002)CD4T lymphocytesIn similar experiments with human T lymphocytes, ES and rFhCatL were shown to down regulate surface CD4 expression.
Lahn (2000)CD4T cellsFor instance, gammadelta T cells modulate CD4+alphabeta T cells in tuberculosis, and in allergic inflammation they support IgE production.
Mooij et al. (2000)CD4T-cellA secondary but beneficial effect of immunization on virus load and CD4(+) T-cell counts was observed despite failure to protect from infection.
Weetman et al. (1997)CD4T-cellThey are crucial to the autoimmune response, and, in particular, regulation of CD4+ and CD8+ T-cell function depends on the balance of cytokines produced during an immune response.
Onodera et al. (1998)CD4T cellsIn particular, a direct solution may be obtained by controlling the CD4+ cell function that controls the immune response of autoimmune T cells.
Vanhems et al. (1999)CD4T cellThe slope of the CD4+ T cell count within 2 years after seroconversion was significantly associated with the year of seroconversion, by sex and by use of injection drugs, when controlling for initial CD4+ cell count.
Connor et al. (1993)CD4T-cellOur results indicate that the pathogenic mechanisms responsible for CD4+ T-cell depletion may be related to both quantitative and qualitative changes in HIV-1.
Qu and Zhao (2007)CD4T-cellsRegulatory CD4(+)CD25(+) T-cells are controlled by multiple pathways at multiple levels.
Smith and Aggarwala (2009)CD4T cellsCan the viral reservoir of latently infected CD4(+) T cells be eradicated with antiretroviral HIV drugs?
Badri et al. (2001)CD4T-lymphocyteMETHODS: Age, race, risk status, CD4+ T-lymphocyte count, history of AIDS, prophylactic co-trimoxazole and antiretroviral therapy were controlled for in a time-dependent Cox proportional hazards regression model.
Taylor et al. (1995)CD4T-cellThis very high correlation is suggestive of biologic hypotheses concerning possible control of the circulating CD4+ T-cell number.
LaBonte et al. (2000)CD4T-cellFurthermore, changes in the HIV-1 envelope glycoproteins are responsible for the increased CD4(+) T-cell-depleting ability observed in infected monkeys upon in vivo passage of simian-human immunodeficiency virus (SHIV) chimeras.
Wang et al. (2009)CD4T cellsMonitoring alpha4beta7 integrin expression on circulating CD4+ T cells as a surrogate marker for tracking intestinal CD4+ T-cell loss in SIV infection.
Bartholomew et al. (1995)CD4T cellsA fully humanized anti-CD4 antibody was studied for its effects on resting and activated CD4 T cells.
Yates et al. (2007)CD4T cellsThese processes could be distinguished by assessing whether virus in patients in the chronic phase of infection shows an increasing capacity to infect host CD4+ T cells ex vivo over time.
Zhao et al. (2006)CD4T cell[Effects of traditional Chinese medicine on CD4 + T cell counts and HIV viral loads during structured treatment interruption in highly active antiretroviral therapy].
Kovacs et al. (2001)CD4T lymphocytesWe examined the effects of human immunodeficiency virus infection on the turnover of CD4 and CD8 T lymphocytes in 17 HIV-infected patients by 30 min in vivo pulse labeling with bromodeoxyuridine (BrdU).
Morrison et al. (1994)CD4T cellSelective CD4 modulations have independently redefined the specific contributions of CD4 surface expression during T cell activation and may establish a role for CD4 receptor subtypes during HIV-1 infection of CD4+ cells.
Gómez et al. (2009)CD4T cellsOur results and other authors' have not proved a SLE causative role for CD4+CD25+ T cells.
Gómez et al. (2009)CD4T cellsA role of natural regulatory CD4+CD25+ T cells in peripheral tolerance has been established, but a causative role of these cells has not been proved in human autoimmune diseases.
Yoo et al. (2010)CD4T cellThe viral load, which is used to predict changes in CD4+ T cell count in the near future, is associated with the prognosis.
Buseyne et al. (1996)CD4T cellsThis viral inhibition was observed in heterologous CD4+ T cells and when CD8+ and CD4+ populations were separated by a semipermeable membrane, demonstrating the involvement of a diffusible factor(s).
Ssewanyana et al. (2007)CD4T cellInterestingly, no correlation between plasma HIV RNA level and T cell activation was observed after controlling for CD4+ T cell count.
Whitby et al. (2002)CD4T-lymphocyteQuality control of CD4+ T-lymphocyte enumeration: results from the last 9 years of the United Kingdom National External Quality Assessment Scheme for Immune Monitoring (1993-2001).
Schapiro et al. (1996)CD4T-cellThe effect of high-dose saquinavir on viral load and CD4+ T-cell counts in HIV-infected patients.
Puaux et al. (2004)CD4T-cellAfter intrarectal challenge with SHIV 89.6P, immunised animals demonstrated early control of SHIV 89.6P replication and stable CD4+ T-cell counts.
Mirano-Bascos et al. (2010)CD4T-cellPrevious studies indicated that CD4(+) T-cell epitope dominance is controlled by antigen three-dimensional structure through its influence on antigen processing and presentation.
Blanco et al. (2001)CD4T cellsOur results suggest that X4 and R5 HIV isolates depleted CD4(+) T cells to a different extent and that CD8(+) T-cell viability may also be affected by mechanisms other than those acting in CD4(+) T cells.
Mehandru et al. (2006)CD4T cellsIn addition, there is a persistent increase in proliferating CD4+ and CD8+ T cells in the GI tract during antiretroviral therapy.
Sung et al. (2005)CD4T cellsIn conclusion, these data show that KRG intake independently and significantly affected the slow depletion of CD4 T cells irrespective of HLA class I.
Wang et al. (2007)CD4T cellsThe results in dicate that "activated" central memory CD4+ T cells are the major target for early SIV infection and CD4+ T cell depletion in neonatal macaques.
Korngold (1991)CD4T cellOur investigations related to GVHD over the last few years have established the role of CD8+ and CD4+ T cell subsets in the etiology of the disease across different genetic barriers and has raised several important questions about the nature of in vivo functions and mechanisms of pathogenesis of these subsets.
Camara et al. (2010)CD4T cellsESN subjects showed lower levels of CD38 expression on CD4(+) T cells than did control subjects.
Stahl et al. (2005)CD4T cellA longitudinal analysis of self-reactive antibody repertoires of progressor and non-progressor patients suggested an influence of CD4(+) T cell counts on immunoglobulin reactivity toward self-antigens.
Khanna et al. (2009)CD4T cellCONCLUSIONS: cART reduced the incidence and PML-attributable 1-year mortality, regardless of baseline CD4+ T cell count, whereas overall mortality was dependent on cART use and baseline CD4+ T cell count.
Gao et al. (2008)CD4T-lymphocyteBoth Cox-2 expression and the number of CD4+ TIL and CD4+ infiltrating T-lymphocyte were detected by immunohistochemistry, and data were analyzed closely with patients' clinical figures so as to investigate the correlation between the 3 elements.
Friedman et al. (1999)CD4T-cellsA critical role for human CD4+ T-cells in rejection of porcine islet cell xenografts.
Jacobson et al. (2009)CD4T cellSecond, we selected our cases and controls based on more than one factor (i.e., the groups differed based on both CD8+ T cell activation and absolute CD4+ T cell counts).
Gao et al. (1996)CD4T cellsPost-transcriptional regulation associated with control of human CD8A expression of CD4+ T cells.
Gao et al. (1996)CD4T-cellWe demonstrate in this paper that there is also post-transcriptional regulation of CD8A expression in a CD4(+)CD8(-) T-cell line Jurkat.
Smith et al. (2006)CD4T-cellMutations within the FOXP3 gene result in dysregulated CD4+ T-cell function and elevated cytokine production, leading to lymphoproliferative disease.
van der Lubbe et al. (1997)CD4T cellsWithin the CD4+ subset there was a selective depletion of CD45RA+ T cells, HLA-DR+, and CD25+ cells, providing evidence that activated/memory CD4+ cells resist the effect of CD4 monoclonal antibodies.
Höhn et al. (1999)CD4T lymphocytesHuman papillomavirus (HPV)-encoded proteins may provide targets for CD8+ or CD4+ T lymphocytes infiltrating into cervical cancer.
Jana et al. (2010)CD4T cellsCD4+CD25-, CD4+CD25low and CD4+CD25high T cells were isolated from human PBMC by flow sorting (Figure 1A).
Jana et al. (2010)CD4T cellsControl of CD4+CD25low T cells proliferation was, therefore, decreased in all three groups, but, seriously compromised only in RO T1D subjects (Kruskal-Wallis test, p?
McAleer and Vella (2008)CD4T-cellLipopolysaccharide (LPS) is a natural adjuvant synthesized by gram-negative bacteria that has profound effects on CD4 T-cell responses.
Furukawa et al. (1994)CD4T cellsDistinct effects of human herpesvirus 6 and human herpesvirus 7 on surface molecule expression and function of CD4+ T cells.
Hauss et al. (1995)CD4T cellsCD4-mediated regulation of CD4+ T/DC adhesion was suggested by the observation that preincubation of CD4+ T cells and DC individually with anti-CD4 antibodies inhibited adhesion.
Andrieu and Lu (2004)CD4T cellCD4 T cell counts and viral load levels before and under prednisolone
Vignali et al. (1996)CD4T cellThus, neither colocalization of CD4 and the TCR nor signal transduction via CD4 was solely responsible for the functional restoration of these T cell hybridomas by wild-type CD4.
Pugach et al. (2010)CD4T cellAs in blood, the entire CD4+ T cell population in the lymph nodes bound the DARPins.
Barbour et al. (2007)CD4T cellIncident HSV-2 infection – that is seroconversion or acquisition of HSV-2 after infection HIV-1 – was observed in our cohort, and analyzed separately for its effect on viral load and CD4+ T cell count.
Barbour et al. (2007)CD4T cellThat an incident HSV-2 infection did not modulate the relationship of HIV-1 to viral load or CD4+ T cell count suggests that the effect of HSV-2 infection on CD4+ T cell counts manifests prior to acquisition of HIV-1.
Barbour et al. (2007)CD4T cellThe manner by which HSV-2 co-infection may confer a protective effect on CD4+ T cell populations is not clear.
Londei (2005)CD4T celltreatment the 'hibernated' peripheral blood CD4+CD25+ Treg pool recovered and powerfully inhibited, as in healthy controls, not only T cell proliferation but also the production of TNF-?
Boto et al. (1991)CD4T lymphocytesTo extend the analyses of the biological activities of these highly unusual biosynthetic animal products, we have examined the effect of bryostatin 1 (bryo-1) on the steady-state expression of the human immunodeficiency virus receptor, CD4, by normal peripheral blood T lymphocytes.
Hill et al. (2008)CD4T-cellModulation of the severe CD4+ T-cell loss caused by a pathogenic simian-human immunodeficiency virus by replacement of the subtype B vpu with the vpu from a subtype C HIV-1 clinical isolate.
Litjens et al. (2011)CD4T cellCMV-seropositivity has a large effect on CD4+ and CD8+ T cell subsets at all ages in healthy individuals.
Apetrei et al. (2010)CD4T cellsregulation of CD4 and CCR5 expression on CD4+ T cells may effectively control human immunodeficiency virus acquisition and result in SIV extinction.