Viewing affirmative mentions of regulation of CD8A (H. sapiens) in T cells

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Sanchez-Merino et al. (2005)CD8T cellMother-to-child transmission of CD8+ T cell escape variants may particularly affect CD8+ T cell recognition of infant HIV-1 epitopes.
Wirth et al. (2010)CD8T cellHowever, genome-wide microarray analyses revealed that each additional antigen challenge resulted in the differential regulation of several hundred new genes in the ensuing memory CD8(+) T cell populations and, therefore, in stepwise diversification of CD8(+) T cell transcriptomes.
Wirth et al. (2010)CD8T cellThese results reveal the complex regulation of memory CD8(+) T cell differentiation and identify potential new molecular targets to dissect the function of memory cells generated by repeated antigen stimulation.
Webster et al. (2004)CD8T cellsFurthermore, CD8(+) T cells with different specificities are differentially regulated during chronic infections.
Hong et al. (2009)CD8T cellsRegulation of secondary antigen-specific CD8(+) T-cell responses by natural killer T cells.
Cruz et al. (2004)CD8T-cellInvolvement of the major histocompatibility complex region in the genetic regulation of circulating CD8 T-cell numbers in humans.
Cruz et al. (2004)CD8T-cellThese results show that the MHC region is involved in the genetic regulation of CD8(+) T-cell numbers in humans.
Gao et al. (1996)CD8AT cellsPost-transcriptional regulation associated with control of human CD8A expression of CD4+ T cells.
Gao et al. (1996)CD8AT cellsExpression of the CD8A gene has been shown to be regulated by post-transcriptional mechanisms when 1) CD4(-)CD8(lo) thymocytes are blocked from differentiating into CD4(+)CD8(+) cells by TCR crosslinking and 2) upon activation of mature CD8(+) T cells.
Gao et al. (1996)CD8AT-cellWe demonstrate in this paper that there is also post-transcriptional regulation of CD8A expression in a CD4(+)CD8(-) T-cell line Jurkat.
Gao et al. (1996)CD8AT cellsIn addition, we provide evidence that post-transcriptional mechanisms also contribute to the regulation of CD8A expression in mature CD4(+)CD8(-) T cells, challenging the assumption that the regulation is due solely to transcriptional mechanisms.
Câmara et al. (2003)CD8T cellsIn this study we have examined the ability of CD4(+)CD25(+) T cells to regulate human CD8(+) T cells, and the behavior of CD8(+) T cells following activation in the presence of regulatory CD4(+)CD25(+) T cells.
Câmara et al. (2003)CD8T cellThe regulated CD8(+) T cell population showed sustained hyporesponsiveness and refractoriness to exogenous IL-2.
Fourcade et al. (2009)CD8T cellCollectively, our findings support the role of PD-1 as a regulator of NY-ESO-1-specific CD8(+) T cell expansion in the context of chronic Ag stimulation.
Lang et al. (2009)CD8T cellThese results strongly suggest that periodic, subclinical reactivations of a latent persistent virus cause dysregulation of memory CD8 T cell homeostasis, similar to the one in humans.
Rollman et al. (2008)CD8T cellsWe also successfully studied the release of perforin and granzyme B from deregulating SIV-specific CD8 T cells by flow cytometry.
Tewari et al. (2004)CD8T cellRegulation of CD8 T cell responses in chronic viral infections is not well understood.
Bourboulia et al. (2004)CD8T cellOBJECTIVE: To investigate the effect of highly active antiretroviral therapy (HAART) on Kaposi sarcoma-associated herpesvirus (KSHV) DNA load, anti-KSHV antibody responses and KSHV-specific CD8 T cell responses in HIV-infected individuals over a 2 year period.
Delaire et al. (2004)CD8T cellTherefore, information about the nuclear position of CD4 and CD8 genes during T cell development could provide insights into both the mechanism of regulation of CD4 and CD8 genes, and the process of lineage commitment.
Jaakkola et al. (2003)CD8T cellsIt is involved in target cell killing by CTLs, augments TCR-mediated activation of IL-2 and IFN-gamma production in CD8 T cells, and regulates CD8 T cell homing in vivo.
Esslinger et al. (1997)CD8T lymphocytesThis defect in maturation resulted in a transgene dose-dependent reduction in peripheral T lymphocytes, with the CD8 lineage being more severely affected.
DiSanto et al. (1993)CD8T lymphocyteThe regulated expression of multiple CD8 beta cytoplasmic isoforms and their potential role in T lymphocyte signal transduction is discussed.
Iancu et al. (2009)CD8T cellProtection from reactivation of persistent herpes virus infection is mediated by Ag-specific CD8 T cell responses, which are highly regulated by still poorly understood mechanisms.
Enose-Akahata et al. (2008)CD8T-cellThus, CD8(+) T-cell dysregulation was mediated by both virus infection and enhanced IL-15 on CD14(+) cells in HAM/TSP patients.
Blanco et al. (2001)CD8T-cellAn effect on CD8(+) T-cell viability was exclusively observed in infections by X4 viruses, including the NL4-3 strain, in both PBMC and tonsilar tissue.
Cruz et al. (2006)CD8T-cellThe only variable significantly affecting CD8+ T-cell numbers was the HLA-A genotype (F = 20.56 and p = 0.0001).
Braun et al. (2006)CD8T-cellThe ability to measure both CD8 and CD4 responses in unexpanded samples makes the assays described here sensitive measurements of the T-cell responses in HSV infected individuals.
Stanciu et al. (2001)CD8T cellHowever, there is little data on how these factors affect adult human CD8(+) T cell functions.
Cruz et al. (2006)CD8T-lymphocyteA study of 82 extended HLA haplotypes in HFE-C282Y homozygous hemochromatosis subjects: relationship to the genetic control of CD8+ T-lymphocyte numbers and severity of iron overload.
Gamberg et al. (2004)CD8T cellTherefore, we studied how effective therapy affected HIV-specific CD8(+) T cell responses in 4 individuals who had progressed to advanced infection.
Adam et al. (2002)T-cell receptorT-cellHere, we discuss the significance of ceramide in T-cell biology, with special emphasis on the regulation of T-cell receptor expression, growth arrest, costimulation and death.
Jordan et al. (1989)CD8T cellThe purpose of this investigation was to further assess ability of 1,25-D3 to regulate CD4+ and CD8+ T cell functions.
Kaveri et al. (1996)CD8T cellAntibodies to a conserved region of HLA class I molecules, capable of modulating CD8 T cell-mediated function, are present in pooled normal immunoglobulin for therapeutic use.
Effros et al. (2003)CD8T cellsAge-related changes in thymic function and involution, cellular homeostasis and lifespan, population shifts, T-cell activation, the process of replicative senescence, and oligoclonal expansions are discussed in terms of their effect on CD8 T cells.
Saunders et al. (2010)CD8T-lymphocyteEpigenetic regulation of CD8(+) T-lymphocyte mediated suppression of HIV-1 replication.
Rajasekaran et al. (2010)CD8T cellThese contradictory findings indicate that the role of NKG2D in regulating CD8+ T cell effector functions is not fully understood.
Enose-Akahata et al. (2009)CD8T cellsUpregulation of SAP may be related to dysregulation of chronically activated CD8+ T cells in patients with HAM/TSP.
Imamichi et al. (2008)CD8T cellsThis study has provided further insights into the pleiotropic nature of IL-15 beyond the regulation of CD8(+) T cells.
Takada and Jameson (2009)CD8T cellsSelf-class I MHC molecules support survival of naive CD8 T cells, but depress their functional sensitivity through regulation of CD8 expression levels.
Harrison et al. (2006)CD8T cell4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily, is emerging as an important costimulatory molecule, particularly in the regulation of CD8(+) T cell responses.
Weetman et al. (1997)CD8T-cellThey are crucial to the autoimmune response, and, in particular, regulation of CD4+ and CD8+ T-cell function depends on the balance of cytokines produced during an immune response.
McCoy et al. (1995)T-cell receptorT-cellAlterations of T-cell receptor variable region expression in human immunodeficiency virus disease.
Sandalova et al. (2010)CD8T cellsImportantly, IL-15 incubation has a modest effect on Influenza specific CD8 T cells (Figure 6 A–B).
Copeland (2001)CD8T cellThe identification of CD8+ T cell factors which exert these controls on HIV-1 may lead to promising new therapies for HIV infection.
Kaiser et al. (2003)CD8T cellsIn the present study, we used a model tumor Ag to show that the kinetics of human DC maturation drastically affect the induction of Ag-specific effector CD8(+) T cells.
Al-Shanti and Aldahoodi (2006)CD8T cellThe molecular mechanisms that control CD8(+) T cell proliferation and differentiations are poorly understood.
Obar and Lefrançois (2010)CD8T cellIn this review we will focus on the requirements for mounting an effective CD8+ T cell response and highlight the elements regulating the differentiation of effector and memory subsets.
Hinrichs et al. (2006)CD8T-cellUnderstanding the mechanisms that control CD8+ T-cell differentiation is important in the development of novel immunotherapy strategies.
Travaglio-Encinoza et al. (1994)CD8T-cellsThese findings suggest an important role for CD8+ T-cells in chronic RA, especially in this extraarticular manifestation of the disease.
Streeck et al. (2008)CD8T cellThese data in a single individual suggest that sequence variations within a targeted CD8+ T cell epitope that lead to lost or reduced recognition of the epitope can result in an increase in the functional profile of the respective epitope-specific CD8+ T cell population.
Franke et al. (1994)CD8T-cellThe ELISA detected changes in numbers of CD8 molecules on the cells earlier than flow cytometry recognized changes in CD8+ T-cell counts.
Harouse et al. (2003)CD8T cellIndeed, after depletion of CD8+ T cells in the coinfected animals, X4 virus emerged, supporting the concept that differential CD8+ T cell-mediated immune control of X4- and R5-SHIV replication is responsible for the selective outgrowth of R5 viruses.
Ratnofsky et al. (1987)CD8T cellThe resulting CD8+ hybridomas demonstrated a 10-fold increase in IL-2 production over the parent cell line when stimulated with JY, a human B lymphoblastoid cell line expressing both class I and II HLA antigens, demonstrating that expression of CD8 increases T cell activation. mAbs directed against the CD8 molecule inhibited the response of CD8+ hybridomas to JY, supporting the conclusion that the CD8 molecule was fractional.
Wiesel et al. (2009)CD8T cellIn the past years, it has become clear that multiple in vivo parameters are involved in shaping the composition of the memory CD8 T cell population, including antigen load, duration and strength of CD8 T cell stimulation, the level of inflammation, availability of CD4 T cell help and CD8 T cell precursor frequencies.
Grant et al. (2000)CD8T cellTherefore, modulation of CD8+ T cell numbers or of certain CD8+ CTL activated in HIV-infected individuals may be beneficial.
Korngold (1991)CD8T cellOur investigations related to GVHD over the last few years have established the role of CD8+ and CD4+ T cell subsets in the etiology of the disease across different genetic barriers and has raised several important questions about the nature of in vivo functions and mechanisms of pathogenesis of these subsets.
Akbar et al. (2000)CD8T cellAlthough similar mechanisms regulate apoptosis in both humans and rodents, the available data suggests that replicative senescence may be controlled differently in these species, suggesting the there may be different constraints in the regulation of CD8+ T cell memory between different species.
Akbar et al. (2000)CD8T cellDifferential regulation of CD8+ T cell senescence in mice and men.
Buseyne et al. (1996)CD8T cellsThis viral inhibition was observed in heterologous CD4+ T cells and when CD8+ and CD4+ populations were separated by a semipermeable membrane, demonstrating the involvement of a diffusible factor(s).
Neumann-Haefelin et al. (2007)CD8T cellHost and viral factors contributing to CD8+ T cell failure in hepatitis C virus infection.
Chen et al. (2009)CD8T cellsA critical role for CD8 T cells in a nonhuman primate model of tuberculosis.
Câmara et al. (2003)CD8T cellThe regulation of CD8(+) T cell activation was cell contact-dependent and included inhibition of perforin, granzyme B and IFN-gamma cytokine production at the transcriptional level and impaired cytotoxicity.
Cruz et al. (2008)CD8T-lymphocyteGlobal analysis of the conserved haplotypes on CD8+ T-lymphocyte numbers and the clinical expression of HH
Adamopoulou et al. (2007)CD8T cellThe contribution of viral epitope expressing T-APCs in the regulation of the herpes virus-specific CD8+ T cell memory response remains unclear.
Mao et al. (2004)CD8T cells[Regulation of CD3, CD4 and CD8 expressions on PMA-activated human peripheral T cells].
Czesnikiewicz-Guzik et al. (2008)CD8T cellsThe data show that CD8 T cells are age sensitive by at least two partially independent mechanisms: fragile homeostatic control and gene expression instability in a large set of regulatory cell surface molecules.
Pohling et al. (2010)CD8T cellEvolution of the magnitude and specificity of CD8+ anti-HIV T cell responses
O'Rourke et al. (2005)CD8T-cellsThese data suggest both CD4+ and CD8+ T-cell compartments, as well as the regulation of CD95 expression on CD8+ T-cells, as targets for further study into obesity's effects on the immune system.
Gulzar et al. (2010)CD8T-cellProductive infection resulted in a decrease in expression of CD8 and CXCR4 molecules on the surface of the CD8(+) T-cell clones and antibodies to these molecules abrogated viral binding and replication.
Neumann-Haefelin et al. (2008)CD8T-cellTherefore, we set out to perform a full-breadth analysis of the intrahepatic virus-specific CD8+ T-cell response, its relation to the peripheral T-cell response, and the overall influence of viral escape and the genetic restriction on intrahepatic CD8+ T-cell failure.
Pietersma et al. (2010)CD8T cellsMETHODS: In a prospective study, we monitored 40 patients during the first 3 months after transplantation and measured viral loads in combination with intracellular perforin expression in CD8(+) T cells.
Via (2010)CD8T cellsFinally, the review considers the evidence that supports a potential role for CD8 T cells, both cytotoxic and memory cells, in mediating disease remission.
Nakagawa et al. (2010)CD8T-cellOBJECTIVE: The goal of this study was to examine the role of CD8 T-cell responses to human papillomavirus type 16 (HPV-16) in a favorable clinical trend in women being studied for abnormal Pap smear results.
Fourcade et al. (2009)CD8T cellsPD-1 up-regulation on spontaneous NY-ESO-1-specific CD8(+) T cells occurs along with T cell activation and is not directly associated with an inability to produce cytokines.
Fourcade et al. (2009)CD8T cellsTo investigate the role of PD-1 in impairing spontaneous tumor Ag-specific CD8(+) T cells in melanoma patients, we have examined the effect of PD-1 expression on ex vivo detectable CD8(+) T cells specific to the tumor Ag NY-ESO-1.
Lozanoska-Ochser and Peakman (2009)CD8T cellWe therefore tested the hypothesis that the level of endothelial MHC class I molecule expression in diabetes-prone mice directly influences autoreactive CD8 T cell migration.
Lozanoska-Ochser and Peakman (2009)CD8T cellLevel of major histocompatibility complex class I expression on endothelium in non-obese diabetic mice influences CD8 T cell adhesion and migration.
Deb et al. (2009)CD8T cellsTo test the role of CD8 T cells in axon injury, we established a perforin-deficient mouse model on the H-2 major histocompatibility complex background thereby removing confounding factors related to viral biology in this Theiler murine encephalomyelitis virus-susceptible strain.
Deb et al. (2009)CD8T cellsThese results suggest that perforin is a key mediator of axon injury and lend additional support to the hypothesis that CD8 T cells are primarily responsible for axon damage in multiple sclerosis.
Zhang et al. (2009)CD8T-cellWe found that CD127 expression on total CD8 T cells was significantly down-regulated, which was correlated with the increased CD8 T-cell apoptosis and disease progression of chronic HIV-1 infection.
Grosso et al. (2009)CD8T cellsFrom a mechanistic perspective, both Ag concentration and proinflammatory signals control the expression of LAG-3 and PD-1 phenotypes on CD8 T cells under activating and tolerizing conditions.
van der Heiden et al. (2009)CD8T cellsTo study the role of CD8 T cells in the control of varicella-zoster virus (VZV) reactivation, we developed multimeric major histocompatibility complexes to identify VZV-specific CD8 T cells.
Gutermuth et al. (2009)CD8T cellsTo evaluate the role of CD8 T cells in autoimmunity and its modulation using self-peptides, we used mice expressing soluble OVA (sOVA) under control of the keratin-14 promoter.
Li et al. (2009)CD8T cellsTo define the mechanisms that underlie the age-associated preferential KIR expression in CD8 T cells, we examined KIR2DL3 promoter methylation patterns.
Linker and Lee (2009)CD8T cellA limitation of the classical EAE model is a neglect of CD8 T cell mediated immune mechanisms.
Bandyopadhyay et al. (2008)CD8T cellSelf-antigen prevents CD8 T cell effector differentiation by CD134 and CD137 dual costimulation.
Araki et al. (2008)CD8T cellsThus, epigenetic changes mediated via histone acetylation may provide a chromatin "memory" for the rapid and robust transcriptional response of memory CD8 T cells.
Longhi et al. (2007)CD8T cellCD8 T cell targets on CYP2D6-in particular CYP2D6(245-254)-may be the focus of novel immune intervention in AIH-2.
Lee et al. (2007)CD8T cellPhenotypic changes induced by IL-12 priming regulate effector and memory CD8 T cell differentiation.
Johnson et al. (2007)CD8T cellsOver the last decade, several new observations in MS research imply an emerging role for CD8 T cells in neuropathogenesis.
Verhaagh et al. (2006)CD8T-cellFinally, a significant dose-sparing effect in MYII mice as compared with wild-type littermates on anti-SIVgag CD8+ T-cell induction following intramuscular vaccination with an rA35.SIVgag vaccine was observed.
Viallard et al. (2006)CD8T lymphocytesMB0 classified patients, characterized by fewer CD27+ B cells, had higher percentages of CD8+DR+ T lymphocytes expressing perforin and/or granzyme with a differentiated effector (CCR7- and CD45RA+) phenotype.
Watkins et al. (2006)CD8T cellsFive on seven Tat Oyi vaccinated macaques showed a better control of viremia compared to control macaques and an increase of CD8 T cells was observed only on Tat Oyi vaccinated macaques.