Viewing affirmative mentions of positive regulation of IL2 (H. sapiens) in thymocytes

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Vives et al. (1987)interleukin 2thymocytesUnfractionated human thymocytes have a lower proliferative capacity than CD3-4-8- ones but have a similar capacity for expression of interleukin 2 receptors and production of interleukin 2.
Yeh et al. (1984)TCGF receptorthymocytesHuman thymocytes could be induced to express Tac antigen (TCGF receptor) on their cell surface by Concanavalin A.
Sidell and Ramsdell (1988)IL-2thymocyteThus, RA enhancement of thymocyte responses appears to be mediated by an increase in IL-2-receptor expression on thymocyte blasts, resulting in augmented IL-2-dependent growth.
Reem et al. (1986)interleukin 2thymocytesInduction of interleukin 2 receptors on immature human thymocytes and co-expression of T3 and T6 antigens.
Reem et al. (1986)interleukin 2thymocytesWe have recently demonstrated that human thymocytes can be induced to express interleukin 2 (IL-2) receptors and to synthesize IL-2.
Kees et al. (1994)IL-2thymocytesPER-117 cells produce substantial levels of IL-2 and thus provide a model to study stage-specific signal transduction and transcriptional activation of the IL-2 gene in IL-1 responsive immature thymocytes.
Moroi et al. (1993)interleukin 2thymocytesInduction of interleukin 2-responsiveness in thymocytes of the transgenic mice carrying lck-transgene.
Sidell and Ramsdell (1988)interleukin-2thymocytesRetinoic acid upregulates interleukin-2 receptors on activated human thymocytes.
Fox et al. (1985)interleukin 2thymocytesActivation of human thymocytes via the 50KD T11 sheep erythrocyte binding protein induces the expression of interleukin 2 receptors on both T3+ and T3- populations.
Blue et al. (1986)interleukin-2thymocytesUsing an in vitro culture system, light scatter analyses, and two-color flow cytometry, we provide evidence that the interleukin-2 (IL-2) and transferrin receptors can be induced within 48 hr on nonproliferating immature thymocytes.
Simi? et al. (1986)IL2thymocytesOn the other side, HCS also enhances the lectin-induced production of IL2 by thymocytes.
Roffman et al. (1985)interleukin 2thymocytesCellular and growth factor requirements for the direct and indirect oxidative induction of interleukin 2 responsiveness in human thymocytes.
Takatsu et al. (1986)interleukin 2thymocytesRequirement of both killer-helper factor(s) and interleukin 2 for CTL generation from a subpopulation of thymocytes.
Vives et al. (1987)IL-2thymocyteSurprisingly, however, the stimulation of these populations with either phorbol ester plus IL-2 or phorbol ester plus ionophore induced a high and similar level of IL-2 receptor expression in both thymocyte populations.
De la Hera et al. (1987)IL2thymocytesInterestingly, their proliferation in the absence of any exogenous stimulating agent was related to an autonomous use of the IL2 system (IL2 secretion and binding to its specific receptor, whose constitutive, functional expression in human early thymocytes was recently shown).
Reem et al. (1984)IL-2thymocytesStimulation with con A in combination with PMA or Bl cells resulted in secretion of IL-2 by dense, immature thymocytes, low-density, mature thymocytes, and unfractionated thymocytes, and in an increase in [3H]thymidine incorporation.
Reem et al. (1987)interleukin 2 genethymocytesLess mature, T3- thymocytes, isolated by negative selection are activated to a lesser extent than are unfractionated thymocytes; activation by the CD 2 pathway, induces proliferation, the expression of the interleukin 2 gene and interferon-gamma synthesis. 12-O-Tetradecanoyl phorbol 13-acetate in combination with the anti-CD 2 antibodies T11(2) + T11(3) increases the response of both unfractionated and T3- thymocytes.
Musiani et al. (1982)IL-2thymocytesThe addition of exogenous interleukin 1, a macrophage product, strongly augmented the blastic transformation of cultured thymocytes from both normal and neoplastic glands by influencing the production of interleukin 2 (IL-2) by a well-defined T-cell subset.
Reem and Yeh (1985)interleukin 2thymocytesInterleukin 2 augmented the expression of interleukin 2 receptors and interferon-gamma synthesis by thymocytes activated with concanavalin A, and it was required to maintain the growth of thymocytes in vitro and the expression of interleukin 2 receptors.
Kees et al. (1990)IL-2thymocytesPER-315 cells express the surface markers present on immature thymocytes, express cytoplasmic CD3, and their growth is dependent on interleukin-2 (IL-2).
Reem et al. (1986)IL-2thymocytesIn thymocytes activated in vitro the expression of IL-2 receptors, determined by dual colour cytofluorometry with the PE-conjugated monoclonal anti-human IL-2 receptor antibody (PE anti-IL-2 R), was detected by the second day of induction in both immature T6+ and mature T3+ thymocytes.
Reem et al. (1986)IL-2thymocytesThe present study shows that relatively immature T6+ human thymocytes as well as the more mature T3+ thymocytes could be induced to express functional IL-2 receptors when activated with either Concanavalin A (Con A), Con A and 12-O-tetradecanoylphorbol 13-acetate (TPA) or IL-2 in combination with Con A or TPA.
Reem et al. (1989)IL-2thymocytesWe have provided evidence that tumor necrosis factor alpha (TNF-alpha) enhances the proliferation and the state of activation of human thymocytes cultured with concanavalin A or interleukin 2 (IL-2), as evidenced by an increase in the expression of the c-myc gene and the gene of the IL-2 receptor (alpha-chain, Tac antigen) and by the expression of Tac antigen on the cell surface.
Reem et al. (1989)IL-2thymocytesBy contrast, anti-Tac inhibits the response to TNF-alpha of thymocytes induced with IL-2 completely.
de la Hera et al. (1989)IL2thymocytesHere we have analyzed the requirements of the induction of the IL2 pathway in early thymocytes, and their developmental potential.
de la Hera et al. (1989)IL2thymocytesWe show that: (i) thymic stromal cells, which are present in thymocyte suspensions, are necessary to induce the IL2 pathway and the development of alpha beta or gamma delta T cell lineages from early thymocytes in vitro; and (ii) when removed from the in vivo environment, early thymocytes can develop in vitro into TCR-CD3- cells of the natural killer (NK) lineage.
Reem and Yeh (1985)IL 2thymocytesThe results indicate that thymocytes cultured in complete medium do not express receptors for IL 2, nor did IL 2 by itself induce the expression of IL 2 receptors.
Caligiuri et al. (1989)IL2thymocytesIn addition, we were able to show that the NKH1+ fraction consistently displayed an increased proliferative response to similar concentrations of IL2 when compared to NKH1- cells, for both clonal and polyclonal populations of thymocytes.
Caligiuri et al. (1989)IL2thymocyteTaken together, these studies demonstrate that the initial appearance of the NKH1 antigen following thymocyte culture in the presence of IL2 results from the induction of NKH1 expression on NKH1- thymocytes, while the subsequent predominance of this cell type also results from an enhanced proliferative response to IL2 which coincides with NKH1 expression.
Biasi et al. (1987)IL-2thymocyteThe effect of a supernatant (SN-A) obtained from PMA-stimulated IL-2 producing EL-4 cells on cytotoxic cell induction in thymocyte and splenocyte cultures was evaluated.
Blue et al. (1986)IL-2thymocytesIncreases in antigen-receptor-associated T3-antigen expression followed transferrin and IL-2-receptor induction and occurred on maximally activated T4+T8+ thymocytes on Day 3 of culture.
Gray et al. (1983-1984)IL-2thymocytesIn contrast, the cytotoxic activity of IL-2 activated thymocytes can be augmented by subsequent exposure to IFN.
Musiani et al. (1982)IL-2thymocytesThe higher proliferative responses exhibited by thymocytes from thymoma were effectively sustained by a higher production of IL-2 in culture.
Zav'yalov et al. (1992)IL-2thymocyteNonapeptide corresponding to the sequence 27-35 of the mature human IL-2 efficiently competes with rIL-2 for binding to thymocyte receptors [corrected].
Siliciano et al. (1985)interleukin-2thymocytesIn addition, the majority of thymocytes that have not yet acquired the T3-Ti antigen/major histocompatibility complex (MHC) receptor can be activated to express interleukin-2 (IL-2) receptors through this T11 structure.
Toribio et al. (1983)IL 2thymocyteDifferent supernatants were compared for: (a) IL 2 activity, (b) thymocyte proliferation capacity and (c) induction of NK-like cytotoxicity.
Kasahara et al. (1987)IL 2thymocyteNot only IL 1 alpha activity in the thymocyte costimulator assay, but also IL 1-dependent IL 2 production by a human leukemic cell line, HSB.2 subclone, were blocked by these polyclonal or monoclonal Ab.
Simi? et al. (1986)IL2thymocytesThus, HCS enhances the lectin-induced expression of IL2-receptors as evidenced by both increased responsiveness to IL2 and increased capacity to absorb IL2 of HCS-treated thymocytes.
Carding et al. (1989)IL-2thymocytesA second phase of lymphokine gene expression occurs in the majority of 15-day thymocytes, and a population of cells constitutively produces both IL-2 and IL-4 mRNAs.
Chang (1995)IL-2thymocyteHowever, at doses of amiprilose HCl previously found to stimulate thymocyte proliferation (1-10 micrograms/ml), increased levels of culture supernatant IL-2 were observed.
Dudich et al. (1995)IL2thymocyteSoluble class I antigens were shown to costimulate IL2 production by thymocytes in response to submitogenic doses of exogenous IL2 and to increase PHA-induced thymocyte proliferation.
Saha et al. (1995)IL-2thymocyteIntraperitoneal treatment of hydrocortisone treated aged mice with zinc-thymulin (100 ng/day x 5) resulted in mild augmentation of splenocyte but not thymocyte responses in vitro to IL-1, IL-2, and natural cytokine mixture (NCM) and to PHA and concanavalin A (Con A) (average increase 40%).
Lotz et al. (1988)IL-2thymocytesAnalysis of the mechanism of the IL-6 effect on thymocytes and T lymphocytes showed that IL-6 did not lead to an increase in IL-2-R expression.
Reem et al. (1987)LymphokinethymocytesLymphokine synthesis is induced in human thymocytes by activation of the CD 2 (T11) pathway.
Mossalayi et al. (1990)IL2thymocytesCD7+CD2- precursors differed from more mature CD7+CD2+ thymocytes because they were not sensitive to PHA, IL2, or CD2 triggering.
De Felice et al. (1990)IL-2thymocytesOn the other hand, MoAb CLB-CD28/1 induces response to IL-2 in thymocytes in the absence of accessory cells.
Kang et al. (2003)IL-2thymocytesThese data suggest that FeTMPyP downregulates the proliferative activity by inhibition of p38 MAPK activation, NF-kappaB activation, and IL-2 secretion during mitogenic stimulation of thymocytes.
Kang et al. (2003)interleukin-2thymocytesIron tetrakis (N-methyl-4'-pyridyl) porphyrinato inhibits proliferative activity of thymocytes by blocking activation of p38 mitogen-activated protein kinase, nuclear factor-kappaB, and interleukin-2 secretion.
Pilarski and Deans (1993)interleukin-2thymocytesUpon culture, MN thymocytes proliferate in response to interleukin-2 (IL-2) or anti-CD2/28 and differentiate as defined by acquisition of CD3 as well as CD4 and/or CD8.
Caplan and Rothenberg (1984)interleukin 2thymocytesWe have characterized the thymocytes that can be induced to secrete interleukin 2 (IL 2) after polyclonal stimulation with Con A.
Le et al. (1988)IL-2thymocytesIncubation of thymocytes with IL-6 in the presence of PHA resulted in an increased expression of the IL-2 receptor (IL-2R) as demonstrated by flow cytometry.
Deans et al. (1989)IL-2 mRNAthymocytesPostulating that the CD45R glycoprotein might represent an important signal delivery molecule, we analyzed the ability of mAb specific for CD45 epitopes to synergize with suboptimal amounts of PHA and PMA in the stimulation of IL-2 mRNA production by multinegative thymocytes.
Todd et al. (1994)IL-2thymocytesOnce stimulated, the thymocytes failed to respond to additional SEB; however, they could be induced to proliferative with IL-2, which suggests that these expanded populations had become anergic.
Ramsdell and Golub (1987)IL-2ThymocytesThymocytes require slightly more IL-2 than do peripheral blood lymphocytes to generate LAK activity.
Fabbi et al. (1992)IL-2thymocyteFurthermore, the proliferation of these thymocyte precursors in the presence of rIL-7, although accompanied by a significant increase of IL-2 receptor (IL-2R) p55 expression, appeared independent of that mediated by the autocrine IL-2 pathway, since mAbs to IL-2 and IL-2R p55 did not eliminate responsiveness to rIL-7.
Chang et al. (1991)IL-2thymocytesIntrathymic transfer of CD4-8- thymocytes revealed that the most recent thymic emigrant CD4+8- T cells contained few IL-2-producing cells and were not functionally mature with respect to high level IL-2 inducibility.
Deans et al. (1989)IL-2thymocytesCD45R as a primary signal transducer stimulating IL-2 and IL-2R mRNA synthesis by CD3-4-8- thymocytes.
Chen et al. (1988)IL-2thymocytesEarly (Ly2-L3T4-) thymocytes responded with a cloning efficiency of 60%; their efficient growth was dependent on both IL-1 and IL-2.
Ticchioni et al. (1995)IL-2thymocyteVLA-4, VLA-5, and VLA-6 activated with either mAbs or their natural ligands (fibronectin, laminin, and vascular cell adhesion molecule-1) are able to transduce costimulatory signals in thymocytes activated via the CD3 pathway, i.e., enhancement of thymocyte proliferation, CD25 and CD69 expression, and IL-2 secretion.
Skinner et al. (1987)IL-2thymocytesWhile the events that lead to the expression of the IL-2 receptor on 14-d fetal thymocytes are unknown, IL-2 in fetal thymus organ cultures inhibits the normal maturation of fetal thymocytes and raises the question of whether the cytotoxic cells that appear reflect selection through an alternative pathway of development.
Lowenthal et al. (1986)IL 2thymocytesA subpopulation of phenotypically immature (Lyt-2-/L3T4-) thymocytes express receptors for the polypeptide hormone interleukin 2 (IL 2); however, these cells do not proliferate in vitro in response to IL 2.
Touw et al. (1986)IL 2thymocyteIn contrast, colony formation stimulated by PHA and the induction of IL 2 receptors by PHA were limited to the one case of T-NHL with the mature thymocyte immunophenotype.
Vatteroni and Papiernik (1984)interleukin 2thymocytesPhenotypic modifications of thymocytes after concanavalin A stimulation in the presence of interleukin 2: early modifications of Lyt 1+2+ subset and later proliferation of cells with more mature phenotypes.
Shams et al. (1989)IL-2thymocyteBoth E and FLE cells constitutively produced an IL-1-like factor as determined by thymocyte proliferation assay and IL-2 induction in EL-4 lymphoma cells.
Reem et al. (1985)IL-2thymocytesThese results document that IL-2 acts as a hormone that induces the activation of thymocytes and T cells, as evidenced by the de novo induction of biologically active, high-affinity IL-2 receptors.
Vatteroni and Papiernik (1984)IL-2thymocyteIn an attempt to study the participation of the different thymocyte subsets and especially that of the cortical type, phenotypic modifications were examined during concanavalin A activation in the presence of IL-2.
CarreƱo et al. (2005)IL2thymocytesThese results support IL2/IL2R mediation of PRL effects on developing thymocytes.
Leclercq et al. (1990)IL-2thymocytesThroughout the IL-2 culture, one-fourth of the TCR-V gamma 3+ thymocytes was positive for CD8.
Chang et al. (1991)IL-2thymocytesFor TCR-alpha beta-bearing CD4+8+ and CD4+8low thymocytes that are actively engaged in positive and negative selection processes, negligible to low levels of IL-2 production and cell proliferation were observed in response to TCR:CD3 triggering or to the combined activation of protein kinase C and calcium mobilization mediated by PMA and ionomycin, respectively.
Okada et al. (1988)IL-2thymocytesrIL-6/B cell stimulatory factor 2 was found to augment CTL generation from mature as well as immature human T cells stimulated with UV-treated allogeneic cells. rIL-6 also acted on peanut agglutinin-positive murine thymocytes and Lyt-2-positive splenic T cells to give rise to CTL. rIL-6 alone could not induce CTL generation, the presence of IL-2 during the early phase of culture period was found to be essential for the IL-6 activity in the induction of CTL.
Groh et al. (1990)interleukin 2thymocytesWhen cultured in the presence of interleukin 7 or interleukin 2, these thymocytes gave rise to 30-60% CD3/TCR gamma delta medium and high cells (60-70% expressing V delta 1) seen as discrete populations.
Novogrodsky et al. (1984)interleukin-2thymocytesThe indole alkaloid tumor promoters were all comitogenic for murine thymocytes and induced production of interleukin-2.
Charon et al. (1982)interleukin 2thymocyteIn this study, human gingival fluid from normal subjects was shown to contain a low-molecular-weight factor (molecular weight, 10,000 to 25,000) which augmented murine thymocyte proliferation, enhanced the production of interleukin 2 by T lymphocytes, and augmented the proliferation of fibroblasts.
Sanchez-Madrid et al. (1985)IL 2-containingthymocytesAfter activation with IL 2-containing supernatants, mature T3+, T6- thymocytes proliferate and are able to nonspecifically kill different target cells.
Tentori et al. (1988)IL-2thymocytesProliferation and production of IL-2 and B cell stimulatory factor 1/IL-4 in early fetal thymocytes by activation through Thy-1 and CD3.