Viewing affirmative mentions of localization of IFNG (H. sapiens) in T cells

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Palacios et al. (1983)IFN-gammaT cellStimulation of these cells with concanavalin A, phytohemagglutinin, or the UCHT1 monoclonal anti-human T cell antibody significantly increased the number of IFN-gamma-secreting cells.
Palacios et al. (1983)IFN-gammaT cellsFinally, cyclosporin A, a potent and selective immunosuppressive drug for T cells, strongly inhibited the secretion of IFN-gamma as assayed at the cell level.
Matsumoto et al. (1989)IFN-gammaT-lymphocytesIFN-gamma, also called immune interferon, is regarded as an important immunoregulator secreted by T-lymphocytes.
Tennenberg and Weller (1996)IFN-gammaT cellsT lymphocytes (T cells) and their secreted lymphokine interferon-gamma (IFN-gamma) play important mediator roles in endotoxin-induced inflammation.
Tennenberg and Weller (1996)IFN-gammaT cellWe sought to explore the necessary conditions for and degree of LPS-induced T cell activation for IFN-gamma secretion in a human syngeneic microvascular endothelial-T cell coculture system.
Tennenberg and Weller (1996)IFN-gammaT cellIn the absence of HAMVEC, LPS-induced T cell activation for IFN-gamma secretion was only minimally demonstrated in the presence of monocytes.
Kelleher et al. (2006)interferon-gammaT-cellIn two patients with semi-invasive Aspergillus-induced lung disease, significantly reduced levels of interferon-gamma secretion by peripheral blood mononuclear cells were found after in vitro stimulation with the T-cell mitogen phytohaemagglutinin.
Jaureguiberry et al. (1988)interferon gammaT-lymphocytesSupernatants from several plasmodial strains stimulated both CD+4 and CD+8 T-lymphocytes to proliferate and secrete interferon gamma in vitro.
Sareneva et al. (1996)IFN-gammaT cellsAs analyzed by pulse/chase experiments, the secretion of IFN-gamma from T cells was very rapid, the secretion half-time being approximately 20-25 min.
Meng et al. (2006)IFN-gammaT cellsIFN-gamma secreting T cells were enriched by means of magnetic sorting system and expanded with OKT(3), anti-CD(3)mAb and IL-2 combination.
Meng et al. (2006)IFN-gammaT lymphocytesRESULTS: A sizable proportion of IFN-gamma secreting T lymphocytes could be detected [(1.12 +/-0.13)% compared with (0.23 +/-0.07)%] and be further enriched to (67.3 +/-10.5)%, or (93.8 +/-22.1) fold.
Meng et al. (2006)IFN-gammaT lymphocytesCONCLUSION: It is feasible to detect significantly increased IFN-gamma secreting T lymphocytes after allogeneic PBMNCs stimulation based on the CKSA technique at single cell level and these cells can be efficiently enriched and expanded for further research.
Madan et al. (2008)IFN-gammaT cellsAn increase in the number of T cells secreting IFN-gamma was considered to be a positive enzyme-linked immunosorbent spot response.
Missale et al. (2004)IFN-gammaT cellCirculating HIV-specific CD8 cells were detected by tetramer staining and a high frequency of T cells were able to release IFN-gamma upon stimulation with HIV peptides, showing in vivo T cell priming by HIV.
Liu et al. (2000)IFN-gammaT cellThe conclusion is drawn that NK cells mediate two important functions in the liver: they induce cell death in the infected organ and concomitantly stimulate the induction of T cell-mediated immunity by release of IFN-gamma.
Andersson et al. (1985)IFN-gammaT cellsSince human gamma interferon (Hu IFN-gamma) is synthesized by T cells and has a controlling role in regulation of Epstein-Barr virus (EBV) infection, we have studied the effects of CsA on EBV-induced cellular Hu IFN-gamma release.
Feuchtinger et al. (2004)IFN-gammaT cellsIsolation and expansion of human adenovirus-specific CD4+ and CD8+ T cells according to IFN-gamma secretion for adjuvant immunotherapy.
Feuchtinger et al. (2004)IFN-gammaT cellsMATERIALS AND METHODS: A clinical-grade strategy to generate ADV-specific T cells using the interferon-gamma (IFN-gamma) secretion assay, followed by expansion to numbers sufficient for clinical application with interleukin-2 (IL-2) and feeder cell stimulation, is described.
Feuchtinger et al. (2004)IFN-gammaT cellsCONCLUSION: Generation of adenovirus-specific T cells in a simple and rapid clinical-grade protocol was established, using IFN-gamma secretion assay with short expansion times, leading to sufficient numbers of ADV-specific T cells that can be used for adoptive immunotherapy.
Toungouz et al. (1996)IFN-gammaT cellDuring mixed lymphocyte reaction (MLR), which constitutes an in vitro model of allograft rejection and GVHD, T cell recognition of HLA differences induces IFN-gamma release.
Werner et al. (1987)interferon-gammaT-cellsThus phytohemagglutinin acts by activating T-cells to release interferon-gamma which in turn induces macrophages to degrade tryptophan.
Horton et al. (2006)IFN-gammaT cellsLongitudinally, HIV-specific T cells in this individual were able to secrete IFN-gamma and tumor necrosis factor alpha, as well as proliferate and degranulate in response to their cognate antigenic peptides up to 5 years postinfection.
Maruyama et al. (1995)IFN-gammaT cellsIt has also been demonstrated that gamma-interferon (IFN-gamma) which is released from infiltrated T cells can be detected in inflamed lesional sites.
Assi-Roth et al. (2010)IFN-gammaCTLAbility of the expanded CTL to secrete IFN-gamma and to proliferate after restimulation with the ADV peptide pool was confirmed.
Martinez-Maza et al. (1984)IFN-gammaT cellsThese spontaneous IFN-gamma-secreting cells were predominantly T cells of the helper/inducer phenotype, as defined by treatment with monoclonal antibody and complement.
Xu et al. (2004)IFN-gammaT cellsThe proliferation of T cells mixed with dendritomas was significantly higher than that of the controls (P < 0.01); The IFN-gamma secretion in the supernatant of the T cell culture 24 hours after mixing with the dendritomas was significantly higher than that of the control (P < 0.01).
Castagliuolo et al. (2004)interferon gammaT-cellAs an indicator of HSV-1-induced lymphocyte activation, we determined T-cell proliferation by means of 3H-thymidine incorporation and interferon gamma release.
Kamma et al. (1991)IFN-gammaT-cellsIt was considered that MHC-II antigens could be induced in some tumor cells in the immunological environment where IFN-gamma was secreted from T-cells and concentrated locally.
Anderson et al. (2010)IFN-gammaT-cellT-cell immunoglobulin, mucin domain-3 (Tim-3) is a membrane protein expressed at late stages of IFN-gamma secreting CD4(+) Th1 cell differentiation and constitutively on DC.
Takada et al. (2010)IFN-gammaT cellsIn addition, T cells incubated with gammaC399tr secreted less IFN-gamma when stimulated with antigen and APC; however, cytokine secretion was unaltered when T cells were stimulated non-specifically with a mixture of anti-CD3 and anti-CD28 antibodies.
Brown et al. (2010)IFN-gammaT cellsOur data indicate that CD8(+) T cells capable of secreting interferon-gamma (IFN-gamma) in a CMV-specific enzyme-linked immunosorbent spot (ELISpot) assay are detectable at 8 weeks after transplantation, before reconstitution of thymopoiesis, but fail to clear CMV viremia.
Carbone et al. (2010)interferon-gammaT cellConversely, their addition to T cells in combination with recombinant hCG (r-hCG) induced a powerful down-modulation of T cell proliferation, decreased interferon-gamma (IFN-gamma) secretion and increased interleukin-10 (IL-10) production.
Grotzke et al. (2009)IFN-gammaT cellUsing human dendritic cells and IFN-gamma release by CD8(+) T cell clones, we examined the processing and presentation pathway for two Mtb-derived antigens, each presented by a distinct HLA-I allele (HLA-Ia versus HLA-Ib).
Vire et al. (2009)IFNgammaT lymphocytesMS-275- and to a lesser extent Trichostatin A- and SAHA-treated Raji cells significantly up regulated T lymphocytes proliferation which was reduced by about 50% by a 4-1BB blocking recombinant protein, while MS-275- but neither Trichostatin A- nor SAHA-treated cells up-regulated IFNgamma secretion by T lymphocytes.
Schub et al. (2009)IFN-gammaT cellsThese CMV-TCR-transgenic T cells displayed a broad spectrum of important effector functions (secretion of IFN-gamma and IL-2, cytotoxicity, proliferation) in response to endogenously processed pp65 and could be enriched and expanded by strictly Ag-specific stimulation.
Roti et al. (2008)IFN-gammaT cellsH5N1-reactive T cells were also detected ex vivo, exhibited a memory phenotype, and were capable of secreting IFN-gamma, TNF-alpha, IL-5, and IL-13.
Duvall et al. (2008)IFN-gammaT cellHere, we report a detailed assessment of the HIV-2-specific CD4(+) and CD8(+) T cell response compared to HIV-1, using polychromatic flow cytometry to assess the quality of the HIV-specific T cell response by measuring IFN-gamma, IL-2, TNF-alpha, MIP-1beta, and CD107a mobilization (degranulation) simultaneously following Gag peptide stimulation.
Pereyra et al. (2008)interferon-gammaT cellsElite controllers represent a distinct group of individuals who have significantly more CD4 and CD8 T cells that secrete interferon-gamma and interleukin-2 and lower levels of HIV-neutralizing antibodies.
Khan et al. (2008)IFN-gammaT cellsOur data indicate that epigenetic modification can convert a tumor cell to an antigen presenting cell capable of activating IFN-gamma secreting T cells via the class I pathway.
Yang et al. (2008)IFN-gammaT cellBlocking TIM-3 during T cell stimulation significantly enhanced IFN-gamma secretion in control subjects but had no effect in untreated patients with MS, demonstrating a defect in TIM-3 immunoregulation.
Soysal et al. (2008)interferon-gammaT cellsUnlike TST, T-SPOT.TB is not confounded by BCG vaccination or exposure to most of the other non-tuberculous mycobacteria, because this assay is based on enumeration of interferon-gamma-secreting T cells in response to Mycobacterium tuberculosis-specific antigens.
Lee et al. (2008)interferon-gammaT cellsAutologous T cells primed by allogeneic mDCs displayed a larger number of interferon-gamma-secreting cells against leukemic cells than those primed by either leukemic DCs or autologous mDCs.
Spadaro et al. (2008)IFN-gammaT cellsThey also display a reduced ability to take up antigen and increased capacity to trigger proliferation and release IFN-gamma in the presence of allogeneic human T cells.
Standley et al. (2007)IFN-gammaT-cellMoreover, vaccination with particles containing both ovalbumin (OVA) and CpG DNA induced a superior OVA-specific CD8 T-cell response in vivo, as measured by increased OVA-specific CD8 T-cell proliferation, secretion of the proinflammatory cytokine IFN-gamma, and the induction of OVA-specific cytotoxicity.
Aerts-Toegaert et al. (2007)IFN-gammaT cellDown-regulation of CD83 expression on human DC through RNA interference (RNAi) results in a less potent induction of allogeneic T cell proliferation, reduced IFN-gamma secretion by established T cells and decreased capacity in the priming of functional tumor antigen-specific CD8+ T lymphocytes.
Scheinberg et al. (2007)interferon-gammaT cellsTo validate this method, CD8+ T cells from two HLA A()0201 individuals were sorted and compared clonotypically based upon their ability either to secrete interferon-gamma in response to a CMV pp65 epitope or to bind to the corresponding pMHC I tetramer.
Chen et al. (2007)IFN-gammaT-cellThe release of IFN-gamma and granzyme B by CD8+ T-lymphocytes specific for R3, a recently described T-cell epitope peptide derived from a leukemia-associated antigen designated RHAMM/CD168 (receptor for hyaluronic acid mediated motility), was inhibited by imatinib in a dose-dependent fashion (range: 1-25 microM).
Walker et al. (2007)interferon-gammaT-cellWe have developed a novel diagnostic technology to monitor the human cytomegalovirus (HCMV)-specific CD8+ T-cell responses that is based on the detection of secreted interferon-gamma (IFN-gamma) in the whole blood (referred to as QuantiFERON -CMV).
Malmassari et al. (2007)IFN-gammaT cellsHBx-specific IFN-gamma-secreting T cells were found in 36 of 52 patients (69%), and 78% (28/36) of responding patients had T cells targeting epitopes in the carboxy-terminal part of HBx.
Malmassari et al. (2007)IFN-gammaT cellIFN-gamma-secreting T cells recognized a previously unknown immunodominant CD4+ T cell epitope, HBx 126-140 (EIRLKVFVLGGCRHK), in 86% (24 of 28) of patients.
Dotan et al. (2007)interferon-gammaT cellsIntestinal epithelial cells from inflammatory bowel disease patients preferentially stimulate CD4+ T cells to proliferate and secrete interferon-gamma.
Ahmed et al. (2007)IFN-gammaT-cellEx vivo, stimulation of HER2-specific T cells with HER2-positive medulloblastomas resulted in T-cell proliferation and secretion of IFN-gamma and interleukin 2 (IL-2) in a HER2-dependent manner.
Yan et al. (2007)IFN-gammaT cellsCD84 is a homophilic family member that enhances IFN-gamma secretion in activated T cells.
Buttari et al. (2007)IFN-gammaT lymphocytesWe demonstrated that an oxidized Hb preparation enriched in hemichromes expands IFN-gamma-secreting T lymphocytes in patients with advanced carotid atherosclerosis and enhances the phenotypical and functional maturation of human monocyte-derived dendritic cells induced by lipopolysaccharide (LPS).
Malhotra et al. (2007)IFN-gammaT cellsT cells were evaluated for gamma interferon (IFN-gamma) secretion using two peptide panels: subtype B consensus (CON) peptides and a novel peptide panel providing 70% coverage of PTE in subtype B HIV-1 Nef.
Curti et al. (2007)interferon-gammaT cellsEight of 15 patients developed an Id-specific T-cell proliferative response, 8/15 increased interferon-gamma-secreting T cells and 4/15 showed an Id-positive delayed-type hypersensitivity test.
Fleming et al. (2006)Interferon-gammaT cellsQFT is an in-vitro diagnostic test that measures a cell mediated immune response in a sample of human whole blood, and is based on the measurement of Interferon-gamma secreted from stimulated T cells previously exposed to TB [7].
McWhirter et al. (2006)IFN-gammaT cellsAddition of primary CLL but not normal B cells to macrophages and T cells downregulated the Th1 response, as seen by a 50-95% reduction in secreted IL-2 and IFN-gamma.
Higashide et al. (2006)IFN-gammaT cellsIn ELISPOT assay, IFN-gamma-secreting T cells, but not IL-4, against several insulin peptides were observed in 77.8% of patients with recent-onset T1D, 50.0% of patients with established T1D, and 0% of healthy control subjects.
Karges et al. (2006)interferon-gammaT lymphocytesIn contrast to a cohort of patients with permanent type 1 DM, interferon-gamma secretion was low in PBMC and CD45(+)RA(+), but not in CD45(+)RA(-) insulin-reactive T lymphocytes.
Feuchtinger et al. (2006)IFN-gammaT cellsIsolation was based on gamma-interferon (IFN-gamma) secretion after short in vitro stimulation with viral antigen, resulting in a combination of CD4(+) and CD8(+) T cells. 1.2-50 x 10(3)/kg T cells were infused for adoptive transfer.
Gianfrani et al. (2006)IFN-gammaT cellThe majority of gliadin-specific T cell clones had a Th0 cytokine production profile with secretion of IL-2, IL-4, IFN-gamma, and IL-10 and proliferated in response to gliadin.
Ballet et al. (2006)IFNgammaT cellsHemagglutination inhibition titers and frequency of IFNgamma-secreting T cells were measured before 1 and 3 months after vaccination.
Popovic et al. (2006)IFN-gammaT cellsIn addition, HMGB1 prevented the CpG induced up-regulation of costimulatory molecules on the surface of PDC and potently suppressed their ability to drive generation of IFN-gamma-secreting T cells.
Choi et al. (2006)IFN-gammaT cellsStimulation of autologous CD3(+) T cells with leukemic DCs grown in the presence of various concentrations of autologous serum resulted in induction of more IFN-gamma-secreting cells than was the case for unprimed CD3(+) T cells.
Choi et al. (2006)IFN-gammaT cellsLeukemic DCs cultured with 10% autologous serum induced the highest numbers of IFN-gamma-secreting cells and CD8(+)CD56(+) T cells from autologous T cells.
Abd El-Maged et al. (2006)IFN-gammaT cellHuman T cell responses and gamma interferon (IFN-gamma) secretion by peripheral blood mononuclear cells (PBMCs) in response to M. tuberculosis Early Secretory Antigen Target-6 (ESAT-6) eight synthetic overlapping peptides, were investigated in Egyptian tuberculosis patients as well as a control group.
Abd El-Maged et al. (2006)IFN-gammaT-cellThree cell mediated immunoassays (lymphoproliferative, ELISPOT and intracellular flowcytometry) have been employed in this study to determine the ability of ESAT-6 to induce T-cell responses and IFN-gamma secretion, which play a critical role in protective cell-mediated immunity against tuberculosis (TB).
Toussirot et al. (2006)IFN-gammaT cellWe evaluated the immunological changes induced by oral administration of OM-89 in 12 RA patients (polyclonal T cell reactivity to PHA, T cell precursor frequencies specific for OM-89 and Tetanus toxoid (TT), a control antigen and the release of Th1 (IFN-gamma, TNF-alpha), Th2 (IL-4) and T regulatory 1 cell (Tr1) (IL-10) cytokines in the supernatants of PBMC cultures.
Morse et al. (2005)interferon-gammaT cellsThe number of spots (interferon-gamma-secreting T cells) per 20,000 responding PBMC was reported.
Takato-Kaji et al. (2005)interferon-gammaT cellsIn the presence of a TCR antagonist peptide, proliferation of naive CD4+ T cells and antigen dose-dependent secretion of interferon-gamma, a typical Th1-type cytokine, by these cells was down-regulated.
Smith et al. (2005)IFN-gammaT cellsWe used an in vitro stimulation step prior to enzyme-linked immunospot assays to identify IFN-gamma-secreting T cells specific for HPV16 and 18 E6/E7 peptides.
Feuchtinger et al. (2005)interferon-gammaT cellsAfter stimulation ex vivo with ADV-lysate, interferon-gamma-secreting T cells were analysed by flow cytometry.
D'Elios et al. (2005)IFN-gammaT cellThe majority of the autoreactive T cell clones secreted IFN-gamma and showed a T helper 1 (Th1) profile.
Kronfeld et al. (2005)IFN-gammaT cellIn a HLA Class I-mismatched co-culture, T cell proliferation, IFN-gamma and GM-CSF secretion equally depend on the levels of B7-1 and B7-2 on tumor cells.
Kronfeld et al. (2005)IFN-gammaT cellIn contrast, in a HLA Class I-matched situation, B7-2 is more effective in the induction of IFN-gamma and GM-CSF secretion than B7-1, but both B7 molecules induce T cell proliferation equally efficient.
Batchu et al. (2005)IFN-gammaT lymphocytesNY-ESO-1-specific T lymphocytes generated with PTD-NY-ESO-1 secreted IFN-gamma indicative of a Tc1-type cytokine response.
Cox et al. (2005)interferon-gammaT cellsIn 19 of 23 subjects, interferon-gamma-secreting T cells specific for 1 or more peptides spanning the entire HCV polyprotein were detected 1 to 3 months after infection.
Morishita et al. (2004)IFN-gammaT cellsAlthough freshly isolated T cells responded poorly to mDCs, hTg-primed T cells responded much more strongly to hTg pulsed mDCs, which selectively induced IFN-gamma-secreting T cells.
Bergstrom et al. (2004)IFN-gammaT cellsRESULTS: Anti-CD40 mAb induced upregulation of APC cell surface activation markers that promoted generation of T cells that demonstrated an increase in tumor-specific IFN-gamma secretion and a statistically significant reduction in the number of pulmonary tumors (p< 0.01) after adoptive transfer.
Chaperot et al. (2004)IFN-gammaT cellsWhereas IL-3 + CD40L-activated LPDC prime naive CD4(+) T cells towards a Th2 pathway (IL-4-secreting T cells), virus-activated LPDC drive a Th1 profile (IFN-gamma-secreting T cells).
Klyushnenkova et al. (2004)IFN-gammaT-cellSeveral CD4+ and CD8+ TcR alpha/beta+ T-cell lines were selected for PSA reactivity as measured by at least a threefold increase in IFN-gamma secretion in response to PSA presented by irradiated autologous PBMC.
Gamadia et al. (2004)IFN-gammaT cellsBased on the expression of the TNFR SFP CD27, two Ag-primed CD8(+) T cell subsets can be discerned in the circulation of healthy individuals: CD27(+) T cells that produce a variety of cytokines but do not display immediate cytolytic activity; and cytotoxic CD27(-) T cells, which secrete only IFN-gamma and TNF-alpha.
Messmer et al. (2004)IFN-gammaT cellsFurthermore, B box induced secretion of IL-12 from DCs as well as IL-2 and IFN-gamma secretion from allogeneic T cells, suggesting a Th1 bias.
Raez et al. (2004)interferon-gammaT-cellsImmune response was assessed by a change between pre-study and postvaccination enzyme-linked immunospot frequency of purified CD8 T-cells secreting interferon-gamma in response to in vitro challenge with AD100.
McShane et al. (2004)IFN-gammaT cellsProtective immunity against Mycobacterium tuberculosis depends on the generation of a T(H)1-type cellular immune response, characterized by the secretion of interferon-gamma (IFN-gamma) from antigen-specific T cells.
McShane et al. (2004)IFN-gammaT cellsIn the first phase 1 study of any candidate subunit vaccine against tuberculosis, recombinant modified vaccinia virus Ankara (MVA) expressing antigen 85A (MVA85A) was found to induce high levels of antigen-specific IFN-gamma-secreting T cells when used alone in bacille Calmette-Guerin (BCG)-naive healthy volunteers.
McShane et al. (2004)IFN-gammaT cellsIn volunteers who had been vaccinated 0.5-38 years previously with BCG, substantially higher levels of antigen-specific IFN-gamma-secreting T cells were induced, and at 24 weeks after vaccination these levels were 5-30 times greater than in vaccinees administered a single BCG vaccination.
Kamath et al. (2003)IFN-gammaT cellSuch priming results also in a nonmemory response to whole bacteria and to lipopolysaccharide, characterized by IL-12-dependent secretion of IFN-gamma by gammadelta T cells and by gammadelta T cell proliferation.
Kamath et al. (2003)IFN-gammaT cellsDrinking tea, which contains l-theanine, a precursor of the nonpeptide antigen ethylamine, primed peripheral blood gammadelta T cells to mediate a memory response on reexposure to ethylamine and to secrete IFN-gamma in response to bacteria.
Harzheim et al. (2003)IFN-gammaT lymphocytesBy contrast, IFN-beta1a, an established treatment for relapsing-remitting MS, increases the expression of N-cadherin and vinculin and partly inhibits the downregulation of these adhesion molecules by phytohemagglutinin (PHA)-stimulated IFN-gamma-secreting human T lymphocytes in coculture experiments.
Hhn et al. (2003)IFN-gammaT cellT cell clones directed against this epitope recognized not only the nominal peptide ligand, but also a closely related peptide (VPTDPNPPEV) from the HIV envelope gp120 (HIV(env) gp120) protein characterized by IFN-gamma release.
Hladik et al. (2003)IFN-gammaT cellsMost highly exposed seronegative men lack HIV-1-specific, IFN-gamma-secreting T cells.
Hladik et al. (2003)IFN-gammaT cellsTo determine the presence and nature of such an HIV-1-specific immune response, we evaluated the quantity and fine specificity of HIV-1-reactive IFN-gamma-secreting T cells in a group of highly exposed seronegative men having sex with men.