Viewing affirmative mentions of localization of IL2 (H. sapiens) in T cells

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Martin et al. (1989)IL-2T cellNone of the generated T cell hybridomas exhibited antigen-specific IL-2 secretion when stimulated with autologous thyrocytes, although 60% of the hybridomas expressed CD3 antigen and the T cell receptor alpha/beta heterodimer.
Kaplan et al. (1988)IL-2T cellSurface IL-2 epitopes were also detected on the Jurkat tumor cell line which secretes IL-2 upon stimulation and on another T cell tumor line MOLT 4.
Kaplan et al. (1988)IL-2T cellsAlthough it is possible that the epitopes seen were present on a distinct molecule independent of secreted IL-2, the distribution on a variety of T cells and regulation via cellular activation suggest that the surface expression of IL-2 epitopes is in some way related to the soluble lymphokine.
Meuer et al. (1982)IL 2T cellMitogen stimulation led to secretion of equivalent amounts of IL 2 from both the major T cell subsets; in contrast, after allogeneic activation, IL 2 was produced predominantly from the T4+ subset.
Solbach et al. (1982)Il-2T cellIn order to release Il-2, the OKT4 positive T cell requires a stimulus, such as allogeneic cells or the lectin phytohaemagglutinin A (PHA).
Vie and Miller (1986)IL 2T cellsEstimation by limiting dilution analysis of human IL 2-secreting T cells: detection of IL 2 produced by single lymphokine-secreting T cells.
Pinkston et al. (1987)interleukin 2T lymphocytesCorticosteroid therapy suppresses spontaneous interleukin 2 release and spontaneous proliferation of lung T lymphocytes of patients with active pulmonary sarcoidosis.
Pinkston et al. (1987)IL 2T cellIn contrast, over the same period, the treated group had marked reduction of spontaneous lung T cell release of IL 2 and proliferation (p less than 0.01, all comparisons before therapy).
Duc Dodon and Gazzolo (1987)IL2T cellsThe results also suggest that viral attachment to T cells possibly supplies an accessory function triggering autocrine secretion of IL2 by these cells.
Dautry-Varsat et al. (1988)interleukin-2T-cellThe effect of cyclosporin A (CsA), a potent immunosuppressive agent, on a human T-cell line, IARC 301, which constitutively secretes interleukin-2 (IL-2) and expresses high-affinity IL-2 receptors, was investigated.
Dautry-Varsat et al. (1988)IL-2T-cellCsA also prevents the constitutive secretion of IL-2 in this T-cell line by blocking transcription of the IL-2 gene.
Wee and Bach (1984)Interleukin-2T cellVarious functionally distinct human T cell clones derived from in vitro mixed leukocyte cultures are found to secrete lymphokines with detectable Interleukin-2 (IL-2)-like activity upon antigenic stimulation.
Weiss et al. (1984)IL 2T cellThese studies demonstrated that antibodies reactive with the T cell-specific T3 antigen were insufficient to result in the activation of Jurkat cells, determined by the secretion of IL 2.
Ruscetti and Gallo (1981)TCGFT cellsThus, release of TCGF and development of receptors for it appear to be obligatory for the clonal expansion of all activated T cells.
Cech et al. (2006)IL-2T cellsEchinacea alkylamides suppressed IL-2 secretion by stimulated T cells, and this effect was significantly lessened upon oxidation of the alkylamides to carboxylic acids and hydroxylated metabolites.
Hunninghake et al. (1983)IL-2T-cellsThese studies suggest that the release of IL-2 by lung T-cells may explain in part the local proliferation of T-cells and hypergammaglobulinemia that are characteristic of pulmonary sarcoidosis.
Manger et al. (1986)interleukin 2T cellDifferent T cell lines, which can be induced to secrete interleukin 2 (IL-2) in vitro, were used to dissect the effect of cyclosporin A (CsA).
Johnson et al. (1992)interleukin-2T-cellsConditioned media from interleukin-2 secreting Jurkat T-cells as well as the glucocorticoid-insensitive, but receptor positive clone, CEM-C1, failed to prevent lymphocytolysis; exogenous interleukin-2 also did not provide protection.
Westendorp et al. (1994)interleukin-2T cellsHuman immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells.
Westendorp et al. (1994)IL-2T cellsIL-2 secretion was increased more than twofold in both Jurkat T cells and primary T cells stimulated by extracellular HIV-1 Tat protein.
Simons and Reynolds (1990)interleukin-2T cellIn addition, the ability of the T cell to secrete interleukin-2 (a cytokine necessary for the recruitment of other T cells) declines with age.
Efrat and Kaempfer (1984)IL-2T-cellWhile both helper and cytotoxic mouse T-cell lines proliferate in response to the IL-2 present in medium conditioned by stimulated human lymphocytes, only helper-T-cell lines respond to human IL-2 secreted from oocytes.
Burns et al. (1983)IL-2T-cellIL-2 secretion by soluble antigen-reactive human T-cell clones.
Burns et al. (1983)IL-2T-cellT-cell clones which were demonstrated to secrete IL-2 activity could also partially deplete media of IL-2 if cultured in the absence of soluble antigen and irradiated adherent cells.
Park and Cheong (2002)Interleukin-2T lymphocytesInterleukin-2 is a pharmacologically important cytokine secreted by T lymphocytes.
Gelfand et al. (1987)IL2T cellsIn the presence of optimal concentrations of lectin and appropriately presented antigen, T cells increase [Ca2+]i, secrete IL2, express IL2 receptors and later divide.
Gelfand et al. (1987)IL2T cellsTreatment of T cells with TPA appears to bypass the requirement for an increase in [Ca2+]i for IL2 secretion and cell proliferation, indicating that various mitogens can trigger T cells through both [Ca2+]i-dependent and [Ca2+]i-independent pathways.
Shah et al. (1991)IL-2T cellsOur results demonstrate that large numbers of T cells, which after activation react by secreting IL-2, can be obtained from small numbers of PBL.
Hou et al. (1995)IL-2T lymphocytesIn turn, secreted IL-2 serves to stimulate the proliferation and differentiation of T lymphocytes.
Adams et al. (1991)IL-2T cellThis assay offers distinct advantages over proliferative LDA techniques in that it is rapid (requiring only 2 days), and defines an antigen-reactive T cell subset with defined function (IL-2 secretion).
Lai et al. (1989)interleukin 2T lymphocyteT lymphocyte activation in euthyroid Graves' ophthalmopathy: soluble interleukin 2 receptor release, cellular interleukin 2 receptor expression and interleukin 2 production.
Rossi et al. (1988)IL2T-cellIn normal controls, we demonstrated that IL2 secretion per T-cell from BM was 5.4-fold greater than that from normal PB, suggesting a very efficient role of accessory cells controlling IL2 production in normal BM.
Hu et al. (1999)IL-2T cellsInspect the effects of the supernatant on transforming function of T cells, killing activity of natural killer cells, the IgG secretion of B cells and the interleukin-2 (IL-2) secretion by lymphocytes of human peripheral blood by radioimmunological assay (RIA).
Hopkins and Failla (1999)IL-2T lymphocyteCopper deficiency reduces secretion of the cytokine interleukin-2 (IL-2) by activated rodent splenocytes, human peripheral blood mononuclear cells and Jurkat cells, a human T lymphocyte cell line.
Pawelec et al. (1984)IL 2T lymphocyteAlloreactive human T lymphocyte clones were found to lose antigen-stimulated proliferative capacity and their ability to secrete interleukin 2 (IL 2) after a critical period in tissue culture.
Steenblock and Fahmy (2008)IL-2T-cellWe demonstrate the utility of this system in efficient polyclonal and antigen-specific T-cell stimulation and expansion, showing that sustained release of IL-2 in the vicinity of T-cell contacts dramatically improves the stimulatory capacity of these acellular systems, as compared to the effect of exogenous addition of cytokine.
Nath et al. (1984)IL-2T cellSuppressive MoF did not interfere with (1) IL-2 release, (2) IL-2 utilization by Con A-induced T cell blasts or (3) constitutive proliferation of Jurkat cells.
Luchansky and Bailey (2010)IL-2T lymphocytesThis same sandwich assay is then used to monitor the temporal secretion profile of IL-2 from Jurkat T lymphocytes in serum-containing cell culture media in the presence of the entire Jurkat secretome.
Combaret et al. (1989)IL2T-cellSecond, patients presented with profound T-cell defect with undetectable IL2 secretion up to 1 year post-graft but they all had normal NK functions from the first month post-graft, these functions exceeding normal values on the second and third months post-graft.
Calder and Newsholme (1992)interleukin-2T-lymphocytesThe proliferation of T-lymphocytes is dependent upon their ability to synthesize and secrete the cytokine, interleukin-2.
Yi et al. (1992)IL2T cellsSingle activated T cells were identified by their secretion of IL2 and IFN gamma using a cell enzyme-linked-immunosorbent technique.
Haynes and Cohen (1993)TCGFT-cellSecretion of TCGF is detectable 1 day after stimulation of splenocytes with the T-cell mitogen phytohemagglutinin (PHA) and peaks following 2 to 3 days of stimulation.
Pawelec et al. (2004)cell growth factor interleukin-2T cellsUsing T cells from young donors to model the process of T cell clonal expansion in vitro under these conditions reveals age-associated increasing levels of oxidative DNA damage and microsatellite instability (MSI), coupled with decreasing DNA repair capacity, telomerase induction and telomere length, decreased levels of expression of the T cell costimulator CD28 and consequently reduced secretion of the T cell growth factor interleukin-2 (IL-2).
Valentine and Vaughan (1986)IL-2T cellAugmentation of mitogen-induced release of the T cell lymphokine interleukin-2 (IL-2) occurred using several cytochalasins in coculture with a T cell lymphoma line (JM) or with purified T cells.
Trifiletti et al. (1989)interleukin 2T cellsSince in other experimental systems the activation of T cells by CD2/LFA-3 interactions has resulted in increased secretion of interleukin 2 (IL2), we were interested in studying the role of IL2 in PBMC cultures stimulated with PWM and autologous E.
Venuta et al. (1983)IL-2T-cellA recently developed monoclonal antibody, Pan T2, binds to normal T cells, renders T cells responsive to IL-2, and induces the release of IL-2, which in turn provides the second signal for T-cell proliferation.
Teodorczyk-Injeyan et al. (1988)IL2T-cellIL2 secretion in response to the T-cell mitogen Staphylococcal protein A (SPA) is significantly decreased in patients with major burns (n = 10, greater than 20% total body surface area) up to 50 days postburn in comparison with normal control (greater than 2 to 10 U/ml and 16 to 36 U/ml, respectively).
Claret et al. (1992)IL2T-cellValid estimation of IL2 secretion by PHA-stimulated T-cell clones absolutely requires the use of anti-CD25 monoclonal antibody to prevent IL2 consumption.
Kumagai et al. (1987)IL-2T cellsThe level of IL-2 mRNA accumulation and resultant IL-2 secretion is one of the limiting factors for proliferation of T cells exposed to the drugs for less than 3 hr, but not for longer exposures.
Katzen et al. (1985)IL 2T cellsThe failure of IL 2 secretion was not caused by down-regulation of IL 2 production by IL 2 itself, because the addition of IL 2 to cultures of T cells stimulated with PHA in the presence of monocytes did not interfere with IL 2 production.
Foa et al. (1987)IL-2T-cellEvidence is provided that the IL-2 released by B-CLL T-lymphocytes may be utilized by the neoplastic B-cell clone that expresses the IL-2 receptor and that decreased availability of IL-2 may play a contributory role in some of the T-cell defects encountered in B-CLL.
Vakkila and Hurme (1990)IL-2T cellsActivation of resting T cells to proliferate is usually accompanied by their expression of interleukin 2 receptors (IL-2R) and secretion of (IL-2).
Vakkila and Hurme (1990)IL-2T-cellThus, we concluded that the higher capacity of DC, as compared to monocytes, to stimulate T-cell proliferation is based primarily on the more efficient stimulation of IL-2 secretion.
Liberman et al. (2003)interleukin 2T cellThe secretion of interleukin 2 (IL-2) is a key event in T cell activation.
Holländer et al. (1998)IL-2T cellUncontrolled secretion of IL-2 results in adverse reactions ranging from anergy, to aberrant T cell activation, to autoimmunity.
Wustrow (1989)IL-2T cellThe IL-2 secretion is dose dependent after stimulation with the mitogens phytohaemagglutinin A (PHA), phorbolester (PMA) or the monoclonal T cell antibody OKT3.
Krowka et al. (1987)IL 2T cellThe results demonstrate that these T cell lines are able to react to soluble antigen by proliferation and IL 2 release.
Pawelec et al. (1991)T-cell growth factorT-cellThe secretion of cytokines without known T-cell growth factor activity (interferon-gamma, tumour necrosis factor-alpha) was also not significantly blocked by these agents.
Kimber et al. (1984)IL-2T cellSupernatants derived from MLA-144, a gibbon T cell line that constitutively releases interleukin-2 (IL-2) and which lack detectable interferon (IFN) had the capacity to enhance the natural killer (NK) cells function of human peripheral blood lymphocytes.
Lindauer et al. (1996)IL-2T cellIn contrast, IL-2 secreting SW480 cells strongly promoted primary T cell proliferation.
Lindauer et al. (1996)IL-2T lymphocytesWe conclude that endogenous IL-2 secretion by the colorectal carcinoma cell line SW480 does not result in the activation of MHC restricted specific T lymphocytes but predominantly induces lymphokine-activated killer cells.
Brajac et al. (2004)IL-2T-lymphocyteThe increase of IL-2R+ cells in early phase of the disease could suggest that T-lymphocyte activation with IL-2 secretion and IL-2R expression may initiate the immune inflammatory mechanism of alopecia areata.
Paliard et al. (1991)IL-2T cellInterleukin (IL)-4 has been shown to be secreted simultaneously with IL-2 and interferon (IFN)-gamma by the majority of CD4+ human T cell clones isolated and cultured using IL-2 as a growth factor.
Paliard et al. (1991)IL-2T cellMost of the CD4+ T cell clones isolated in IL-4 were found to have the ability to simultaneously secrete IL-2, IL-4, and IFN-gamma upon activation.
Spannaus-Martin et al. (1990)IL-2T-cellThe reduction in inflammation is noted in the animals administered a contra-interleukin-2 (IL-2) cytokine secreted by a cloned T-cell line.
Henderson et al. (1983)IL 2T cellInterleukin 2 (IL 2) was purified from the conditioned medium of a gibbon T cell line, MLA144, which releases IL 2 constitutively.
Zeevi and Duquesnoy (1985)IL-2T cellMonoclonal antibody (mAb) inhibition studies on alloreactive T cell clones showed similar inhibition profiles of PLT, CML and IL-2 release assays.
Zeevi and Duquesnoy (1985)IL-2T cellsThese findings suggest that cytolytic activity, secondary proliferation and IL-2 release by alloactivated T cells may be induced by the same HLA encoded determinant.
Minakuchi et al. (1990)IL-2T cellsAlthough PMA and 9.3 markedly increased the amount of IL-2 produced by mitogen-stimulated T cells, the percentage inhibition of IL-2 secretion caused by PGE2 and other cAMP elevating agents remained comparable in these costimulated cultures.
Plana et al. (1991)IL2T cellsAn increased IL2 secretion in T cells cultured with PMA plus 134-2C2 mAb was observed and Northern blot analysis showed that the mAb 134-2C2 acts synergistically with PMA favoring the induction of both IL2 and interferon-gamma mRNA synthesis, as well as the enhancement of IL2 receptor and transferrin receptor mRNA expression.
Aihara et al. (1999)IL-2T cellsBeta agonists have been found to inhibit secretion of IL-2 from T cells through intracellular cAMP elevation.
Ulrich et al. (1985)IL-2T cellCutaneous delayed hypersensitivity, T cell subsets, and IL-2 secretion in patients with peripheral vascular disease.
Ulrich et al. (1985)IL-2T cellsIn vitro secretion of IL-2 by purified T cells was similar in anergic patients and in patients with normal delayed hypersensitivity responses.
Kees et al. (1994)IL-2T cellAn immature human T cell line, PER-117, can be induced to secrete interleukin-2 (IL-2).
Eylar et al. (1993)IL-2T cellsIL-2 secreted by T cells was also enhanced by NAC, approximately 1.5-fold, but IL-2 secreted by cells from old donors was enhanced by 3-fold.
Palacios (1984)IL 2T cellsThe results show that Tac+ T cells secreted IL 2 and IFN-gamma but not IL 3.
Fehniger et al. (2003)IL-2T cellHere, we demonstrate that CD56(bright) NK cells are present in human lymph nodes and that endogenous T cell-derived IL-2, acting through the NK high-affinity IL-2 receptor, costimulates CD56(bright) NK cells to secrete IFN-gamma.
Roosnek et al. (1987)IL-2T cellsAlso during this period, the proliferative response of the T cells can be restored by the addition of irradiated "feeder cells" obtained from the bone-marrow donors, as these cells secrete IL-2 without consuming it.
Kouttab et al. (1984)interleukin 2T cellInterleukin 1 is typically assayed by its effect on thymocytes or by its ability to promote the T cell-dependent release of interleukin 2.
Kroemer et al. (1991)IL-2T cellIL-2 has a short half-life and is secreted in apposition to the cell with which the T cell interacts.
Upham et al. (1997)IL-2T cellDespite inhibiting proliferation, alveolar macrophages had little or no effect on T cell calcium flux, the characteristic changes in CD3, CD2, CD28 and interleukin-2 (IL-2) receptor expression which accompany normal T cell activation, and IL-2 and interferon gamma secretion.
Dakhama et al. (1998)IL-2T-lymphocytesBAL T-lymphocytes from acute and ex-FL patients released considerable amounts of IL-2 after stimulation with concanavalin A and showed dose-dependent proliferative responses to IL-2.
Shimomura et al. (1991)IL-2T cellsInterleukin-2 (IL-2) is a polypeptide secreted by antigen or mitogen-actuated T lymphocytes that functions as a growth factor for T cells.
Matsuzaki et al. (1986)IL-2T-cellTo analyze the mechanism of induction of IL-2 secretion of persistently infected T-cell hybridomas, we exposed T-cell hybridomas specific for UV-treated virus to replicating type 3 reovirus.
Matsuzaki et al. (1986)IL-2T-cellThis process was not a consequence of nonspecific IL-2 gene activation, which occurs in cells persistently infected with reovirus, because reovirus infection did not activate IL-2 secretion in T-cell hybridomas with other antigenic specificities.
Kelleher et al. (1988)IL-2T-cellIn Jurkat E6.1, a phenotypically non-activated human T-cell line, IL-2 secretion in response to a combination of PMA and the calcium ionophore, ionomycin, or to the mitogen phytohaemagglutinin (PHA) was completely inhibited by H-7.
Kelleher et al. (1988)IL-2T-cellIn contrast, HUT-78, a phenotypically activated T-cell line, secreted IL-2 in response to PMA alone, and IL-2 secretion was not inhibited by doses of H-7 that completely blocked PKC activity.