| Document |
Target |
Regulator |
Anatomy |
Sentence |
| Bogunia-Kubik et al. (2003) | IL-2 | | T cells | Stimulation of T cells in the presence of CB sera increased the frequency of IL-2 producing cells (p < 0.005) (but not the amount of IL-2 secreted) and resulted in a higher expression of CD25 (p < 0.05). |
| Pinkston et al. (1983) | interleukin-2 | | T cells | Blood T cells from the same patients did not release interleukin-2. |
| Umetsu et al. (1988) | IL-2 | | T cell | We identified human T cell clones which secrete IL-4 but not IL-2 or IFN-gamma, and which appeared to correspond to murine Th2 clones. |
| Yamada et al. (1991) | IL-2 | | T cell | It also revealed through the use of an in vitro assay utilizing the human IL-2 dependent cell line, Sez 627, that none of these T cell lines secrete IL-2 in detectable volumes. |
| Ndhlovu et al. (2010) | IL-2 | | T cells | That said, the failure of IL-2 to expand IL-17 producing CD4+ T cells while increasing T-reg populations may augur well for IL-2 use in auto-immunity, diseases characterized by depleted T-reg populations, and elevated IL-17 expression. |
| Blasco et al. (1995) | IL-2 | | T cell | CD3- Jurkat cell variants failed to secrete IL-2, suggesting the involvement of the T cell receptor/CD3 complex pathway in jacalin signaling. |
| Foa et al. (1985) | IL 2 | | T lymphocytes | The spontaneous release of IL 2 and IFN-gamma was practically absent both with B-CLL and normal T lymphocytes. |
| Tennenberg and Weller (1996) | IL-2 | | T cell | IL-2 was not secreted as part of the LPS-induced T cell activation response. |
| Paliard et al. (1988) | IL-2 | | T cell | Two alloantigen-specific and two tetanus toxoid-specific T cell clones secreted IL-2, IL-4, and IFN-gamma simultaneously, whereas one alloantigen-specific T cell clone secreted IL-2 and IFN-gamma, but not IL-4. |
| Hamann et al. (1997) | IL-2 | | T cells | These T cells do not secrete IL-2 or -4 but can produce IFN-gamma and TNF-alpha. |
| Cayeux et al. (1989) | IL-2 | | T cells | In contrast, when normal T cells were cultured with non-T cells derived from patients found between 20 and 330 days after ABMT, no IL-2 secretion and no proliferative responses could be seen. |
| Krusemeier and Snow (1988) | interleukin-2 | | T cells | The stimulation of CSA-treated T cells with specific antigen in the presence of low concentrations of CSA, demonstrated that the T cells did not release detectable levels of interleukin-2, interleukin-4, and interleukin-5. |
| Sell et al. (1992) | interleukin-2 | | T-cell | Analysis of cytokines secreted by these individual clones showed that the antiidiotype-reactive cloned T-cell lines that suppressed the response of idiotype-bearing cells appear to secrete predominantly interferon gamma, whereas those antiidiotype-reactive cloned T-cell lines that augmented the response do not secrete interferon gamma but secrete interleukin-2, -4, and -6. |
| Bosticardo et al. (2001) | IL-2 | | T lymphocytes | T lymphocytes stimulated with anti-CD3 mAb or PHA at low pH(e) were unable to secrete IL-2 and IFN-gamma and their ability to progress through the cell cycle was impaired. |
| Takahashi et al. (1995) | IL-2 | | T cells | These CD4+ T cells released IFN-gamma, IL-4, and TNF-alpha, but not IL-2, in response to HLA-DR15+ target cells. |
| Barcy et al. (1995) | IL-2 | | T cell | When cultures were prepared in 96-well plates coated with human IgG, stimulation of T cells with allogeneic monocytes resulted only in modest T cell proliferation and no detectable IL-2 secretion as compared with untreated culture plates or plates coated with Fab fragments of human IgG. |
| Geppert et al. (1992) | IL-2 | | T cells | CD4+ T cells did not secrete IL-2 when cultured alone, with control or CD8+ CHO cells. |
| Harari et al. (2004) | IL-2 | | T cells | However, a skewing toward IFN-gamma-secreting cells (70% of HIV-1-specific CD4 T cells) was observed in subjects with progressive disease, and IL-2- and IL-2/IFN-gamma-secreting cells were almost absent. |
| Ramirez et al. (1987) | B cell growth factor | | T cells | SLE serum or Ig fractions did not induce B cell growth factor release by T cells. |
| Katzen et al. (1985) | IL 2 | | T cells | In contrast to T cells stimulated with PHA in the presence of monocytes, T cells stimulated with PHA and IL 2 released no detectable IL 2. |
| Vukmanovi? et al. (1992) | IL-2 | | T-cells | We have identified a patient whose peripheral T-cells failed to proliferate and secrete IL-2 upon stimulation. |
| Auphan-Anezin et al. (2003) | IL-2 | | T cell | Indeed, we characterized a T cell population stimulated in response to the partial agonist that was committed to produce IFN-gamma, but failed to divide or secrete IL-2. |
| Camisaschi et al. (2010) | IL-2 | | T cells | Ex vivo analysis showed that CD4(+)CD25(high)Foxp3(+)LAG-3(+) T cells are functionally active cells that release the immunosuppressive cytokines IL-10 and TGF-beta1, but not IL-2. |
| Dai et al. (2005) | IL-2 | | T cells | Gal-9-treated DCs secreted IL-12 but not IL-10, and they elicited the production of Th1 cytokines (IFN-gamma and IL-2) but not that of the Th2 cytokines (IL-4 and IL-5) by allogeneic CD4+ T cells. |
| Infante and Currier (1989) | IL-2 | | T cell | Carrier (KLH)-specific type 1 T cell clones (Th1), which are defined by secretion of IL-2 and IFN-gamma but not IL-4, and type 2 (Th2) clones, which secrete IL-4, but not IL-2 or IFN-gamma, have been isolated and analyzed for their ability to collaborate in providing help for B cells to secrete phosphorylcholine-specific IgM antibodies. |
| Chedid et al. (1997) | IL-2 | | T cells | The present study demonstrated that: 1) there were no detectable (1 in < 20 x 10(4) HBsAg-precursor T cells in any of the nonresponders, while in responders the frequency of HBsAg-precursor T cells ranged from 1 in 3.2 x 10(3) to 1 in 40 x 10(3); 2) nonresponder cell cultures did not secrete IL-2 in response to HBsAg stimulation; 3) exogenous recombinant IL-2 did not restore the proliferative response of the T cells in HBsAg-pulsed cultures of nonresponders. |
| Kobata et al. (1994) | IL-2 | | T cell | CD27-mediated T cell proliferation did not seem to be dependent on the IL-2/IL-2R system because no detectable level of IL-2 was secreted, and only a partial inhibition was observed with anti-IL-2 and anti-IL-2R Abs. |
| Strober and Holoshitz (1990) | IL-2 | | T-cell | Interestingly, the CD4+ T-cell lymphokines, IL-2 and IFN-gamma, were not spontaneously secreted in detectable quantities by synovial biopsies. |
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