Viewing affirmative mentions of gene expression of IL2 (H. sapiens) in accessory cells

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Roosnek et al. (1985)interleukin 2accessory cellRequirements for interleukin 2 production; lectin concentration determines the accessory cell dependency.
Roosnek et al. (1985)IL2accessory cellsAddition of accessory cells caused a shift in the dose-response curve, resulting in strongly enhanced IL2 production at low concentrations.
Roosnek et al. (1985)IL2accessory cellsOnly at lectin concentrations that were found to be optimal in the presence of accessory cells, removal of these cells abrogates IL2 production.
Sidell et al. (1984)IL-2accessory cellsRA-induced enhancement appears to induce increased sensitivity of T3+T6-Fc mu- thymocytes to PHA activation, but does not alter either IL-2-dependent proliferation or the accessory cells involved in IL-2 production.
Scheurich et al. (1985)IL2accessory cellsIn the absence of accessory cells, T cells activated with matrix-bound OKT3 express high levels of the Tac antigen within 15 h and produce interleukin 2 (IL2).
Hünig et al. (1983)interleukin 2accessory cellBoth induction of interleukin 2 production and of interleukin 2 responsiveness by concanavalin A are accessory cell dependent.
Hünig et al. (1983)IL2accessory cellIt was concluded that both IL2 production and induction of reactivity to IL2 are accessory cell-dependent events.
Konaka et al. (1981)IL2accessory cellIL2 production, on the other hand, is accessory cell-dependent, and this help is mediated via Fc receptors on the accessory cell.
Roosnek et al. (1985)IL2accessory cellsIn the presence of IL2, the same cooperative effect of lectin and accessory cells was found that we have previously described for IL2 production.
Roosnek et al. (1985)IL2accessory cellFurthermore, two stimuli (IL 1 and phorbol myristate acetate), which are able to replace monocytes at the level of IL2 production, also induce responsiveness to IL2 under accessory cell-dependent conditions.
Roosnek et al. (1985)IL2accessory cellsHowever, after addition of thiols to the medium, which enhances the IL2 production, a very narrow range of lectin concentration can be found which is just below toxic values and still high enough to induce IL2 production in the absence of accessory cells.
Lipkowitz et al. (1984)IL 2accessory cellsAlthough the production of IL 2 is strictly dependent upon accessory cell function, the expression of receptors for IL 2 seems to be relatively independent of accessory cells.
Lipkowitz et al. (1984)IL 2Accessory cellsAccessory cells are strictly required for IL 2 production during this activation phase, but they may not be necessary for expression of IL 2 receptors.
Santoli and Zurier (1989)IL-2accessory cellsMoreover, DGLA and AA inhibited IL-2 production by the human leukemia T cell line Jurkat which, when appropriately induced, is able to release high levels of IL-2 in the absence of accessory cells and measurable PGE production.
Jordan et al. (1989)IL-2accessory cellsCD4+ cells stimulated with mitogen and HLA-DR positive accessory cells produced measurable levels of IL-2 that were completely inhibited by 1,25-D3.
Schmid et al. (1981)TCGFaccessory cellsThe results are interpreted to indicate that accessory cells are essentially required for the presentation of virus to specific helper cells with such cells responding by the production of TCGF.
Van Lier et al. (1988)IL2accessory cellsFurthermore, we demonstrate that proliferation induced through the synergistic action of anti-CD28 mAb with anti-CD2 antibodies can be induced in the absence of accessory cells and is accompanied by the production of IL2 and the expression of IL2 receptors.
Rock (1982)IL 2accessory cellThe activation of an IL 1-dependent IL 2-producing T cell hybridoma by Con A requires an interaction, which is not H-2-restricted, with an Ia-bearing accessory cell.
Kern et al. (1986)IL 2accessory cellsTo further dissect the function of the accessory cell in allowing T cell proliferation, we compared mitogen-induced c-myc, interleukin 2 (IL 2), and IL 2 receptor gene expression in peripheral blood mononuclear cells (PBMC) and in T cells rigorously depleted of accessory cells through differential adherence and anti-Dr (anti-class II major histocompatibility antigen) monoclonal antibody complement-directed cytotoxicity.
Kern et al. (1986)IL 2accessory cellThese genes varied in their accessory cell dependence, with IL 2 expression most dependent, c-myc expression least dependent, and IL 2 receptor expression intermediate in dependency.
Gayá et al. (1991)IL-2accessory cellsIn the present work we have analyzed the effect of IL-4 on IL-2 and IFN-gamma synthesis by stimulating CD4+ human T cells (+10% accessory cells) with Con A in the presence of several doses (1 to 100 U/ml) of human rIL-4.
Palacios et al. (1982)interleukin 2accessory cellsIn addition, DxS stimulated OKT4+8- T cells to produce interleukin 2, a process that also occurred only in the presence of accessory cells.
Via et al. (1990)IL-2accessory cellsIn our study, we have measured in vitro proliferation and IL-2 production by human PBL to characterize the interactions between Th cells and accessory cells (AC) involved in responses to either conventional Ag or alloantigens.
Groux et al. (1993)IL-2 geneaccessory cellsAddition of IL-1, which induces IL-2 gene expression and secretion or addition of accessory cells, had the same preventive effect.
Roosnek et al. (1985)IL2accessory cellThus, the (absolute) accessory cell dependency for T cells to produce IL2 is defined by experimental conditions.
Rossi et al. (1988)IL2accessory cellsTo explore the role of accessory cells in controlling IL2 production, we added phorbol ester or indomethacin to the culture system or irradiated the cells before culture.
Konaka et al. (1981)IL2accessory cellIL2 receptors induction by this means occurs within a short time span, and independent of any demonstrable accessory cell.
O'Neill et al. (1987)TCGFaccessory cellsThe parameters investigated include medium, serum, amount of the mitogen phytohaemagglutinin, amount of T-cell growth factor (TCGF) and the number of irradiated feeder or accessory cells.
Oudrhiri et al. (1985)IL 2accessory cellsPHA-driven monoclonal colony formation by low concentrations of resting T4 lymphocytes in agar culture requires the presence of interleukin 2 (IL 2) and accessory cells.
Infante et al. (1982)IL-2accessory cellsProduction of IL-2 appeared independent of the involvement of accessory cells.
Infante et al. (1982)IL-2accessory cellsThese accessory cells may be unnecessary for IL-2 production in our assay, or their effect may be produced by anti-idiotype.
Yssel et al. (1987)interleukin 2accessory cellsHY837, which reacts with a series of mAb directed at different epitopes on the TcR, could be induced to proliferation and interleukin 2 (IL-2) production by soluble mAb directed at the CD3/TcR complex in the absence of accessory cells. mAb directed at the CD2 epitope T11-1 were shown to block the IL-2 production by HY837, as well as the expression of the IL-2 receptor, induced by anti-CD3 mAb, resulting in the inhibition of the proliferative response.
Kuhweide et al. (1990)interleukin 2Accessory cellAccessory cell-derived helper signals in human T-cell activation with phytohemagglutinin: induction of interleukin 2-responsiveness by interleukin 6, and production of interleukin 2 by interleukin 1 [corrected].
Hünig (1983)IL2accessory cellsFurthermore, irradiated, neuraminidase-treated T cells served as accessory cells (AC) in the induction of responsiveness to IL 2, but not for production of IL2, which depends on Ia+ AC.
Dröge et al. (1987)TCGFaccessory cellAfter stimulation with concanavalin A accessory cell-depleted splenic T-cell populations were found to produce only minute amounts of T-cell growth factor (TCGF); but substantial amounts of TCGF were produced if the cultures were supplemented either with splenic adherent cells or with lactate but not with interleukin-1 (IL-1).
Ulmer and Flad (1982)interleukin-2accessory cellDifferent accessory cell requirements of human T-lymphocyte subpopulations for generation of interleukin-2.
Schwinzer et al. (1994)IL-2accessory cellsIf accessory cells were used as the source of co-stimulatory signals, strong expression of the 55-kDa chain of the interleukin-2 (IL-2) receptor (CD25), significant IL-2 production and vigorous proliferation were observed in CD45R0+ cells, whereas CD45RA+ cells responded weakly.
Laderach et al. (2002)IL-2accessory cellsOne, the induction of IL-2 production, could be directly triggered by 4-1BB engagement on CD8(+) T cells in the absence of accessory cells.
Costello et al. (1993)IL-2accessory cellsThis potent activation does not require accessory cells, such as monocytes, but depends on persistent interleukin 2 (IL-2) secretion and receptivity, which is associated with high and prolonged expression of the inducible CD25/IL-2 receptor alpha (IL-2R alpha) chain gene.
Schwab et al. (1985)IL 2accessory cellsIn the presence of accessory cells, OKT3 induces loss of T3 molecules from the cell surface, production of IL 2, expression of IL 2 receptors, and proliferation.
Wallays and Ceuppens (1993)IL-2accessory cellsIn conclusion, PWM directly stimulates human T cells and this results in production of several cytokines including IL-2, GM-CSF and TNF-alpha, and at least one of them (IL-2) is further upregulated by IL-1 beta/IL-6 from accessory cells.
Chouaib et al. (1988)IL-2accessory cellExogenous rIL-1 did not improve IL-2 production and the subsequent T cell proliferation indicating that these two events were not associated with a defective accessory cell function involving IL-1 release.
Groux et al. (1993)IL-2 geneaccessory cellsWe propose that co-signals provided by accessory cells allow a coupling of IL-2 gene and IFN-gamma gene expression, and that an essential role for IL-2 secretion in T cell activation involves the inhibition of a death program induced by IFN-gamma secretion.
Dohlsten et al. (1987)lymphokineaccessory cellsHistamine acts directly on human T cells to inhibit lymphokine production without the involvement of accessory cells.
Cooley et al. (1989)lymphokineaccessory cellTo investigate the mechanisms behind this apparently differential inhibition of lymphokine production, we stimulated PBMC from recipients of HLA-identical sibling bone marrow transplants with phytohaemagglutinin (PHA), PHA + phorbol ester (PMA) (to bypass accessory cell requirements) or Ca++ ionophore + PMA (to bypass both accessory cell and T cell surface receptor (CD2 and/or CD3/Ti interactions).
Eisenstein et al. (1993)IL-2accessory cellsFurthermore, we show that this IL-2 production defect is not due to an accessory cell abnormality, since it was seen in the presence of normal (allogeneic) accessory cells, and patient accessory cells supported normal amounts of IL-2 production by PHA-stimulated CD4+ T cells obtained from normal individuals.
Skansén-Saphir et al. (1998)lymphokineaccessory cellsDown-regulation of lymphokine synthesis by intravenous gammaglobulin is dependent upon accessory cells.
Davis and Lipsky (1993)IL2accessory cellsAnergy appeared to result from an inability to produce sufficient IL2 and proliferative responses could be restored by large numbers of accessory cells.
Laderach et al. (2002)IL-2accessory cellsThus, suboptimal accessory cells and 4-1BB co-stimulation combined their effects to enhance IL-2 production and proliferation.
Bruserud and Ulvestad (2003)IL-2accessory cellThe accessory cell function of ALL blasts showed no correlation with the release of immunomodulatory mediators (IL-2, IL-10, IL-15) or the expression of any single adhesion/costimulatory membrane molecule (CD54, CD58, CD80, CD86) by the blasts.
Volkman et al. (1985)lymphokineaccessory cellsCo-cultivation with any accessory cells regardless of histocompatibility resulted in increased proliferation and lymphokine production.
Rutenfranz et al. (1991)lymphokineaccessory cellsThe expression of IFN-gamma mRNA and production of the lymphokine was dependent on accessory cells.
Tada et al. (1990)Interleukin 2accessory cellsAlthough minimal Interleukin 2 (IL-2) receptor expression was apparent, T cells even from responders failed to proliferate in response to anti-Leu4, in the absence of accessory cells.
Tada et al. (1990)IL-2accessory cellsThus, in T cells from responders or nonresponders, anti-Leu4 stimulation induces early intracellular signal transduction and IL-2 receptor expression, but without accessory cells, proliferation does not occur.
Cayeux et al. (1989)IL-2accessory cellsTaken together, these new data provide additional evidence that T cells early in ontogeny possessed an intrinsic defect in IL-2 synthesis and that physical cell-to-cell contact between patients' T cells and allogeneic accessory cells induced functional responsiveness to exogeneous IL-2.
Beckman et al. (1988)IL-2accessory cellTriggering of the T-cell receptor by anti-CD3 monoclonal antibodies (mAb), for example OKT3, induces accessory cell (AC)-dependent interleukin-2 (IL-2) and IL-2 receptor synthesis, and ultimately, T-cell proliferation.
Caplan and Rothenberg (1984)IL 2accessory cellsIn the presence of TPA, IL 2 production by thymocytes is relatively independent of adherent accessory cells; this allows us to compare the abilities of different thymic subpopulations to make IL 2.
Geppert and Lipsky (1987)IL 2accessory cellThe data suggest that IFN-gamma-treated FB take up and process antigen effectively, but lack an accessory cell property necessary for antigen-induced T4 cell IL 2 production and proliferation.
Berzins et al. (1988)IL-2accessory cellThe results suggest that the LFA-1 antibodies block an early step in the reactions necessary for IL-2 production, and that the LFA-1 molecule participates not only in T cell-accessory cell interaction but also in T-T interaction during the early phases of the activation process.
Lombardi et al. (1996)IL-2accessory cellsThe results obtained suggest that 1) lack of costimulation is not responsible for the inhibitory effects of T cell Ag presentation on IL-2 production; the provision of costimulation by immobilized anti-CD28 Ab or by the addition of accessory cells failed to reverse the effects of T cell Ag presentation, but restored the response to immobilized anti-CD3; 2) T cell Ag presentation induced a minimal increase in intracellular Ca2+ compared with that induced by antigen-pulsed B cells; this difference in the calcium response is not explained by quantitative differences in ligand density between B cells and T cells; and 3) despite the weak calcium signal, T cell presentation supported IL-4 release in the absence of IL-2 production.
Hashimoto et al. (1993)IL-2accessory cellsOur results are consistent with an ongoing role for class I antigens in the cellular interactions between lymphocytes and accessory cells required for the production of IL-2.
Nakamura et al. (1989)IL-2accessory cellsThis effect was independent of monocytes and other accessory cells. mAb G38 augmented PMA-induced IL-2-R expression.
Jenkins et al. (1988)IL-2accessory cellsOur results suggest that IL-2 production by normal T cell clones is dependent not only on T cell receptor occupancy, but also on short range costimulatory signals that are provided to different degrees by various non-T accessory cells.
Bagnasco et al. (1990)IL-2accessory cellsIn addition, IL-2 and gamma-IFN productions were substantially unaffected by the drug, as well as IL-1 production by accessory cells.
Halvorsen et al. (1988)IL-2accessory cellsThe activation of resting T cells to interleukin 2 (IL-2) production and DNA synthesis via Ti-CD3 is dependent on accessory cells (AC).
Sékaly et al. (1991)interleukin 2accessory cellsThree CD4- murine T cell hybridomas were transfected with the human CD4 molecule and assayed for interleukin 2 production in the presence of accessory cells bearing human MHC class II molecules and of the appropriate enterotoxin.
Kern et al. (1987)IL-2accessory cellsThe role of accessory cells in Lyt-2+ Con A-induced proliferation and IL-2 production was also investigated.
Takeuchi et al. (1987)IL 2Accessory cellAccessory cell (AC) function of B cells was examined in Con A response of a cloned T cell line, 22-9D, which is Thy 1+,L3T4+,Lyt2-,H-2KbDb+ and I-Ab-.22-9D cells produced IL 2 in the presence of Con A without participation of AC.
Shimizu et al. (1982)TCGFaccessory cellsLarge amounts of TCGF were produced when these cells were cultured with Fc-receptor positive (FcR+) accessory cells.
Shimizu et al. (1982)TCGFaccessory cellsAnti-T-200 monoclonal antibody inhibited anti-Thy-1-induced TCGF production by EL-4 G12 and accessory cells.
Shimizu et al. (1982)TCGFaccessory cellThe data suggest there are at least 2 different accessory cell help mechanisms in anti-Thy-1-induced TCGF production, anti-Thy-1-bound membrane aggregation either by GaRIG, Protein A or FcR, and a LAF-dependent mechanism.
Wu et al. (1993)IL-2accessory cellsThese BA elicited IL-2 production or proliferation from Ag-specific T cell hybridoma cells or splenic T cells, respectively, in the presence, but not the absence, of accessory cells expressing the appropriate MHC class II molecule.
Halvorsen et al. (1987)IL-2accessory cellsHowever, DNA synthesis was observed when recombinant interleukin 2 (IL-2) or other secondary signals, such as those provided by phorbol myristate acetate (PMA) or autologous accessory cells (AC), were also added.
Cogoli (1997)IL-2accessory cellsThe data at 0g support the notion that the expression of IL-2 receptor is inhibited at 0g, while mitogen binding and the transmission of IL-1 by accessory cells occur normally.
Fischer et al. (1989)IL-2accessory cellsBoth the G8 mAb and an anti-HLA-DR mAb 9-49 inhibited SEA binding to accessory cells and also inhibited SEA-induced, but not PHA-induced, T cell proliferation and production of IL-2.
Green et al. (1992)IL-2accessory cellsIn this manuscript we have demonstrated that both SEA and SEB can directly activate purified T cells in the absence of accessory cells as determined by a transition from G0 to G1 and induction of IL-2 receptor expression.