| Document |
Target |
Regulator |
Anatomy |
Sentence |
| Bruserud and Moen (1984) | IL-2 | | B lymphocytes | Addition of indomethacin or irradiated EBV-transformed B lymphocytes to the cultures, removal of adherent cells, and 18 h preincubation of the cells before PHA stimulation had an additive enhancing effect on the IL-2 production. |
| Antonaci et al. (1989) | interleukin 2 | | B cell | The suppressive factors are also responsible for a decreased interleukin 2 (IL-2) synthesis since a similar pretreatment of cell suspensions or exogenous human IL-1 and/or IL-2 supplementation of aged cell cultures leads to a recovery of T regulatory effects on B cell differentiation. |
| Lagoo et al. (1990) | IL-2 | | B cell | Interestingly, IL-2 production by the PBL cultures was also three to four times higher than in B cell cultures, suggesting an involvement of IL-2 in inducing DNA synthesis in these cells. |
| Vazquez et al. (1987) | IL-2 | | B cells | To determine the respective targets of the 50,000 BCGF and of IL-2, B cells were activated with anti-mu Ab and separated according to the expression of the IL-2 receptor (cluster designation (CD)25 antigen). |
| Mouzaki et al. (1995) | IL-2 | | B cells | These results demonstrate that the IL-2 NF-chi B site is indispensable for the activity of the IL-2 promoter in EBV-transformed B cells, whereas other transcription factors appear to be less important for IL-2 expression in these cells.
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| Oudrhiri et al. (1985) | IL 2 | | B cell | Using recombinant IL 2 and anti-Tac monoclonal antibody as a probe for the IL 2 receptor, we demonstrate that the requirement of accessory cells (here an irradiated B cell line) in inducing IL 2 responsiveness relies on their enhancing effect in functional IL 2 receptor expression by the T colony progenitors. |
| Armerding and Hren (1993) | IL2 | | B cell | The data presented suggest that IL2- and IL4-mediated B cell activation can be differentially modulated. |
| Kuhara et al. (1985) | IL2 | | B cell | IL2 stimulated the appearance of Thy-1+ cells in unprimed "B cell" populations which could substitute for the function of IL2, implicating an indirect role, at least in part, for IL2 in the TRF assay. |
| Nakagawa et al. (1988) | IL-2 | | B cells | Finally, the effects of IL-2 and BCGF on the DNA and RNA content of the various fractions of B cells was examined. |
| Kolb et al. (1993) | IL-2 | | B lymphocytes | In attempts to detect associations between early signaling events triggered by interleukins and the induction of DNA synthesis, inhibitors of various second messenger pathways were tested for their effects on IL-2- and IL-4-elicited mitogenesis in preactivated human B lymphocytes. |
| Kolb et al. (1993) | IL-2 | | B cell | Taken together, these observations indicate that IL-2 and IL-4 use different signaling pathways to induce the G1-->S transition in these cells and suggest that the IL-4 inhibition of the B cell response to IL-2 may result from its effect on cAMP generation.
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| Carosella et al. (1989) | IL-2 | | B lymphocytes | Effect of IL-1 and IL-2 on differentiation of human B lymphocytes induced by Fc fragments of human IgG.
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| Itoh et al. (1994) | interleukin-2 | | B cells | The role of the interplay of interleukin-2 (IL-2) and interleukin-10 (IL-10) in responses of human peripheral blood B cells stimulated by ligation of antigen receptors was examined in detail. |
| Perri and Kay (1987) | interleukin 2 | | B cell | The functional importance of interleukin 2 (IL-2) receptors in the regulation of malignant B cell proliferation still remains to be clarified. |
| Garrone and Banchereau (1993) | IL2 | | B cells | In our attempts to elucidate the mechanisms regulating the IL2- and IL4-induced proliferation of human B lymphocytes, we studied the effects of cholera toxin (CT) and other agents increasing adenosine 3', 5'-cyclic monophosphate (cAMP) levels on tonsil B cells activated through their antigen receptors. |
| Tomic et al. (2006) | IL-2 | | B cells | Because signals from both the innate and adaptive immune systems direct the acquisition of strong immunogenicity by professional APCs, the effects of IL-2 and the TLR-7 agonist, S28690, on the immunogenic properties of chronic lymphocytic leukemia (CLL) B cells were studied. |
| Blanchard et al. (1994) | IL-2 | | B cells | This contrasts with the CD40 system where B cells are essentially responsive to IL-4 and IL-10 but not to IL-2 alone. |
| Wagner et al. (1998) | IL-2 | | B cell | A pivotal role of cyclin D3 and cyclin-dependent kinase inhibitor p27 in the regulation of IL-2-, IL-4-, or IL-10-mediated human B cell proliferation.
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| Bumgardner et al. (1993) | IL-2 | | B-cell | In vitro cell culture studies were used to analyze the effects of three copper-based dental alloys on a T-cell and B-cell line and their secretion of soluble immune mediators (IL-2) and effectors (IgG), respectively. |
| Kosmas et al. (1992) | IL-2 | | B lymphocytes | In the present study we determined the effects of three different cytokines, interleukin-2 (IL-2), interleukin-4 (IL-4) and interleukin-6 (IL-6), and the tumour promoting phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on EBV-immortalised B lymphocytes. |
| Kasprzak et al. (2010) | IL-2 | | B-cell | No significant relationships could be detected between expression of IL-2 and/or IL-22R(alpha) on one hand and histopathologic diagnosis, tumor location, age, or sex in B-cell NHLs on the other. |
| Mouzaki et al. (1995) | IL-2 promoter | | B cell | In the present study we analyzed the control of IL-2 promoter activity in Epstein-Barr virus (EBV)-transformed B cell clones which are capable of secreting IL-2 at a low level after stimulation with phorbol 12-myristate 13-acetate and the Ca2+ ionophore ionomycin. |
| Kabelitz et al. (1985) | interleukin 2 | | B cells | Synergistic action of phorbol ester and interleukin 2 in the induction of Tac antigen expression and interleukin 2 responsiveness in leukemic B cells.
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| Brooks et al. (1990) | lymphokine | | B cell | Since B cell cloning techniques have not yet been developed to obtain a homogenous B cell population for studies of activation requirements, regulation of lymphokine receptors, and regulation of gene expression, we must utilize lymphokine-responsive neoplastic B cells. |
| Weetman (1986) | interleukin-2 | | B-cell | This study has examined the effect of methimazole on four important soluble mediators of the immune response, interleukin-1 (IL-1), interleukin-2 (IL-2), gamma-interferon (gamma-IFN) and B-cell differentiation factor (BCDF). |
| De Groot et al. (1990) | IL-2 | | B cells | The susceptibility to the inhibitory action of IL-4 emerges at late time points after in vitro activation of the B cells, whereas IL-4 shows its growth promoting action during early stages of culture, indicating that activated IL-2 responsive B cells are the targets for IL-4 dependent inhibition. |
| Mitsui et al. (1991) | interleukin 2 | | B-cell | The role of phorbol myristate acetate (PMA: a protein kinase-C (PKC) activator) and calcium ionophore A23187 in the induction mechanism of the interleukin 2 receptor (IL2R) on B-cell chronic lymphocytic leukemia (B-CLL) cells was studied. |
| Matthews et al. (1995) | interleukin-2 | | B cells | Function of the interleukin-2 (IL-2) receptor gamma-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-15.
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| Kehrl et al. (1984) | interleukin-2 | | B lymphocytes | The effects of interleukin-1, interleukin-2, alpha-interferon, and gamma-interferon on human B lymphocytes.
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| Aleksandrovski? and Chekhonin (1999) | lymphokine | | B-cell | Therapy with tranquilizers indicated that they produced an inhibitory effect on T- and B-cell immunity, antibody formation and lymphokine production. |
| Mackler et al. (1974) | Lymphokine | | B cells | Lymphokine synthesis by B cells was not dependent on concomitant blastogenesis. |
| Vasil'eva et al. (2005) | IL-2 | | B lymphocytes | As revealed in this study, neutrophilokines regulate the synthesis of IL-2 by T helpers of type 1, IL-4 and IL-5 by T helpers of type 2, IL-1 by B lymphocytes, as well as the expression of receptors IL-2 by immunocompetent cells. |
| Isacson et al. (1992) | IL-2 | | B cells | None of the following parameters, tested prior to initiation of the therapy and 1-2 days after termination of each course of IL-2, correlated with the clinical response: WBC counts (total and differential), levels of blood CD4 and CD8 T cells, NK cells, monocytes and B cells, production of IL-1 and IL-1 inhibitor by monocytes, responsiveness to 3 mitogens, NK/LAK cell activity, and serum levels of IL-1 alpha, IL-2, soluble IL-2 receptor, and TNF alpha. |
| Goldstein et al. (1990) | IL-2 | | B cells | Lymphokines including IL-2, IL-4, and IL-6 are involved in the induction of Ig production by activated B cells. |
| Chen et al. (1987) | IL-2 | | B cells | These data suggest that vitamin D3 inhibits Ig production by inhibiting IL-2 receptor expression on B cells and via its effect on adherent macrophages. |
| Bartlett et al. (1989) | lymphokine | | B cell | In order to determine the involvement of T-B cell contact vs lymphokine production in mediating B cell cycle entry and progression, Th cell clones "defective" in lymphokine production were cloned. |
| Tortolani et al. (1995) | IL-2 | | B cell | Because of the importance of IL-2, IL-4, and IL-7 in B cell physiology, we sought to determine whether JAK3 was also present in B lymphocytes and whether it was involved in signaling via cytokines that are important for B cell development and function. |
| Trentin et al. (1994) | IL-2 | | B cells | To investigate the functional properties of IL-2 and TNF alpha on leukemic B cells, we evaluated (1) the regulation of expression of TNF receptors (TNF-R) and IL-2 receptors on leukemic B cells after culture with TNF alpha and IL-2; (2) the effect of the combination of TNF alpha and IL-2 in a proliferative in vitro assay; and (3) the expression and regulation by these cytokines of receptors for hematopoietic factors, including IL-3, granulocyte colony-stimulating factor (G-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF). |
| Itoh and Hirohata (1995) | IL-2 | | B cells | By contrast, IL-10 rather rescued SA-activated B cells from apoptosis and thus supported the differentiation of these B cells without any influences of IL-2, when it was added after 72 h of culture. |
| Abken et al. (1992) | IL-2 | | B cell | All B cell clones analyzed were found to secrete the cytokines IL-1 alpha, IL-6, TNF-alpha, and TNF-beta whereas no activity of IL-2, IL-4, low m. w. |
| Rinkenberger et al. (1996) | IL-2 | | B cell | Thus, IL-2 regulation of BSAP concentration may provide a mechanism for controlling both repressor and activator functions of BSAP during a B cell immune response.
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| Castejón et al. (1999) | IL-2 | | B cells | Thus, we investigate interleukin-2 (IL-2), IL-4, IL-6 and IL-10 in vitro effects on apoptosis of B cells from 32 previously untreated patients with B-CLL in initial clinical stages. |
| Creery et al. (1996) | IL-2 | | B cells | The expression of B7-1 and B7-2 on purified B cells were not altered by any of the cytokines tested, including IL-1 alpha, IL-1 beta, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IFN-gamma, TNF-alpha, TGF-alpha and GM-CSF. |
| Klyushnenkova et al. (1996) | IL-2 | | B cells | Accessory signal provided through CD48 required the presence of IL-4 and/or IL-10, whereas responses of B cells to IL-2 was not affected. |
| Zola et al. (1991) | IL-2 | | B lymphocytes | Expression of IL-2 receptor p55 and p75 chains by human B lymphocytes: effects of activation and differentiation.
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| Torigoe et al. (1992) | IL-2 | | B-cell | In contrast to IL-2's effects on p56-LCK in T-cells, studies of an IL-2-responsive cell line of the B-cell lineage that lacks p56-LCK revealed that IL-2 specifically regulates the activity of the p53/56-LYN kinase. |
| Krawczyk et al. (2005) | interleukin 2 | | B lymphocyte | Their influence on the mitotic division of the cells and on selected immunological parameters, e. g., T and B lymphocyte proliferation and synthesis of the cytokines: interleukin 2 (IL-2), tumour necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) was assessed in vitro. |
| Benjamin et al. (1992) | lymphokine | | B-cell | Our data suggest that the differences in glycosylation of B-cell-derived TNFs may account for the incomplete neutralization, and may influence the cytotoxic biological activity of this lymphokine.
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| David et al. (1998) | IL-2 | | B lymphocytes | Paradoxically, this modified IL-2R expression does not lead to increased IL-2 responsiveness, except for B lymphocytes. |
| Hu et al. (1999) | IL-2 | | B cells | RESULTS: The supernatant of the cultured non-immunological cells of decidua can inhibit the immunological function of T cells, natural killer cells and B cells to different extents, their maximum inhibiting ratio were 22.7%, 52.3% and 14.8% respectively, but there is no significant effect on the IL-2 secretion by lymphocytes.
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| Trentin et al. (1994) | interleukin-2 | | B-cell | Expression and regulation of tumor necrosis factor, interleukin-2, and hematopoietic growth factor receptors in B-cell chronic lymphocytic leukemia.
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| de la Calle-Martín et al. (1992) | IL-2 | | B lymphocytes | In the presence of Mo, PWM stimulation of T lymphocytes (highly depleted of B lymphocytes) induces as much IL-2 mRNA as phytohemagglutinin (PHA), but results in higher and persistent IL-2 levels in culture supernatants despite the concomitant T cell mitogenesis, suggesting that PWM-activated T cells do not utilize the IL-2 they produce. |
| Lebman et al. (1990) | IL-2 | | B cell | Mechanism for transforming growth factor beta and IL-2 enhancement of IgA expression in lipopolysaccharide-stimulated B cell cultures.
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| Hayama et al. (1983) | IL-2 | | B cells | The results suggest a marked dependency of PFC responses to TI antigen on IL-2 in all strains examined, including SJL, LAF1, DBA/2Ha, and CBA/N, probably through a direct activation of B cells. |
| Mouzaki and Zubler (1995) | interleukin-2 | | B-lymphocytes | [Regulation of transcription of the interleukin-2 gene in B-lymphocytes].
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| Leitenberg and Feldbush (1988) | lymphokine | | B cells | This report describes studies of lymphokine and mitogen regulation of class II expression on rat B cells. |
| Nordborg and Nordborg (1998) | IL-2 | | B-cells | The immunopositivity for macrophages, B-cells, HLA-DR, ICAM-1 and IL-2 was significantly stronger in the outer than in the inner half of the intima.
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| Abraham (1991) | IL-2 | | B cell | Similarly, the depressed generation of systemic and mucosal antibodies to bacterial antigens following injury may be affected by alterations in the production of cytokines affecting B cell function, namely IL-1, IL-2, IL-3, IL-5 and IFN-gamma. |
| Leprince et al. (1988) | interleukin 2 | | B cells | The anti-B8.7 monoclonal antibody induces a dose-related inhibition of the low molecular weight B cell growth factor-dependent proliferation of activated B cells, whereas it does not affect their response to interleukin 2. |
| DeKruyff et al. (1993) | IL-2 | | B cells | Using Th1 and Th2 clones, we have also shown that the pathways for IgG1 synthesis are redundant, in that induction of IgG1 synthesis in secondary responses in which B cells have already switched from IgM to IgG1, can occur via several pathways, one involving IL-4 and IL-5, the other involving IL-2. |
| Kumar et al. (1999) | IL-2 | | B cells | These observations showing an association of B7 dysregulation on monocytes and B cells with altered production of IL-2 may have implications in HIV immunopathogenesis.
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| Ogawa et al. (1992) | B cell growth factor | | B cell | Abnormal production of B cell growth factor in patients with systemic lupus erythematosus.
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| Karpus and Swanborg (1991) | lymphokine | | B cells | Both CD4+ T suppressor cells, known to regulate EAE effector cell lymphokine production, and myelin basic protein (MBP)-primed B cells are required to transfer protection against EAE to normal recipients. |
| Kljaic-Turkalj et al. (1996) | lymphokine | | B cell | These findings suggest a change in the lymphokine profile of patients receiving specific immunotherapy, and that the inhibition of IL-4-induced B cell stimulation may be hypothesized as the most important mechanism.
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| Ju et al. (1999) | lymphokine | | B cell | We have also discussed recent advances in the areas of FasL gene regulation, lymphokine regulation of AICD, and regulation of B cell susceptibility to FasL. |
| Duyn et al. (1999) | B-cell growth factor | | B-cell | Effects of interleukin 3, interleukin 7, and B-cell growth factor on proliferation and drug resistance in vitro in childhood acute lymphoblastic leukemia.
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| Barnes et al. (2009) | IL-2 | | B cell | The influence of JAK/STAT, ERK/MAPK, IL-2, and B cell receptor signaling pathways was evident in patients with persistent oligoarthritis. |
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