Viewing affirmative mentions of regulation of IL2 (H. sapiens) in B cells

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Bruserud and Moen (1984)IL-2B lymphocytesAddition of indomethacin or irradiated EBV-transformed B lymphocytes to the cultures, removal of adherent cells, and 18 h preincubation of the cells before PHA stimulation had an additive enhancing effect on the IL-2 production.
Antonaci et al. (1989)interleukin 2B cellThe suppressive factors are also responsible for a decreased interleukin 2 (IL-2) synthesis since a similar pretreatment of cell suspensions or exogenous human IL-1 and/or IL-2 supplementation of aged cell cultures leads to a recovery of T regulatory effects on B cell differentiation.
Lagoo et al. (1990)IL-2B cellInterestingly, IL-2 production by the PBL cultures was also three to four times higher than in B cell cultures, suggesting an involvement of IL-2 in inducing DNA synthesis in these cells.
Vazquez et al. (1987)IL-2B cellsTo determine the respective targets of the 50,000 BCGF and of IL-2, B cells were activated with anti-mu Ab and separated according to the expression of the IL-2 receptor (cluster designation (CD)25 antigen).
Mouzaki et al. (1995)IL-2B cellsThese results demonstrate that the IL-2 NF-chi B site is indispensable for the activity of the IL-2 promoter in EBV-transformed B cells, whereas other transcription factors appear to be less important for IL-2 expression in these cells.
Oudrhiri et al. (1985)IL 2B cellUsing recombinant IL 2 and anti-Tac monoclonal antibody as a probe for the IL 2 receptor, we demonstrate that the requirement of accessory cells (here an irradiated B cell line) in inducing IL 2 responsiveness relies on their enhancing effect in functional IL 2 receptor expression by the T colony progenitors.
Armerding and Hren (1993)IL2B cellThe data presented suggest that IL2- and IL4-mediated B cell activation can be differentially modulated.
Kuhara et al. (1985)IL2B cellIL2 stimulated the appearance of Thy-1+ cells in unprimed "B cell" populations which could substitute for the function of IL2, implicating an indirect role, at least in part, for IL2 in the TRF assay.
Nakagawa et al. (1988)IL-2B cellsFinally, the effects of IL-2 and BCGF on the DNA and RNA content of the various fractions of B cells was examined.
Kolb et al. (1993)IL-2B lymphocytesIn attempts to detect associations between early signaling events triggered by interleukins and the induction of DNA synthesis, inhibitors of various second messenger pathways were tested for their effects on IL-2- and IL-4-elicited mitogenesis in preactivated human B lymphocytes.
Kolb et al. (1993)IL-2B cellTaken together, these observations indicate that IL-2 and IL-4 use different signaling pathways to induce the G1-->S transition in these cells and suggest that the IL-4 inhibition of the B cell response to IL-2 may result from its effect on cAMP generation.
Carosella et al. (1989)IL-2B lymphocytesEffect of IL-1 and IL-2 on differentiation of human B lymphocytes induced by Fc fragments of human IgG.
Itoh et al. (1994)interleukin-2B cellsThe role of the interplay of interleukin-2 (IL-2) and interleukin-10 (IL-10) in responses of human peripheral blood B cells stimulated by ligation of antigen receptors was examined in detail.
Perri and Kay (1987)interleukin 2B cellThe functional importance of interleukin 2 (IL-2) receptors in the regulation of malignant B cell proliferation still remains to be clarified.
Garrone and Banchereau (1993)IL2B cellsIn our attempts to elucidate the mechanisms regulating the IL2- and IL4-induced proliferation of human B lymphocytes, we studied the effects of cholera toxin (CT) and other agents increasing adenosine 3', 5'-cyclic monophosphate (cAMP) levels on tonsil B cells activated through their antigen receptors.
Tomic et al. (2006)IL-2B cellsBecause signals from both the innate and adaptive immune systems direct the acquisition of strong immunogenicity by professional APCs, the effects of IL-2 and the TLR-7 agonist, S28690, on the immunogenic properties of chronic lymphocytic leukemia (CLL) B cells were studied.
Wagner et al. (1998)IL-2B cellA pivotal role of cyclin D3 and cyclin-dependent kinase inhibitor p27 in the regulation of IL-2-, IL-4-, or IL-10-mediated human B cell proliferation.
Bumgardner et al. (1993)IL-2B-cellIn vitro cell culture studies were used to analyze the effects of three copper-based dental alloys on a T-cell and B-cell line and their secretion of soluble immune mediators (IL-2) and effectors (IgG), respectively.
Kosmas et al. (1992)IL-2B lymphocytesIn the present study we determined the effects of three different cytokines, interleukin-2 (IL-2), interleukin-4 (IL-4) and interleukin-6 (IL-6), and the tumour promoting phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on EBV-immortalised B lymphocytes.
Kasprzak et al. (2010)IL-2B-cellNo significant relationships could be detected between expression of IL-2 and/or IL-22R(alpha) on one hand and histopathologic diagnosis, tumor location, age, or sex in B-cell NHLs on the other.
Mouzaki et al. (1995)IL-2 promoterB cellIn the present study we analyzed the control of IL-2 promoter activity in Epstein-Barr virus (EBV)-transformed B cell clones which are capable of secreting IL-2 at a low level after stimulation with phorbol 12-myristate 13-acetate and the Ca2+ ionophore ionomycin.
Kabelitz et al. (1985)interleukin 2B cellsSynergistic action of phorbol ester and interleukin 2 in the induction of Tac antigen expression and interleukin 2 responsiveness in leukemic B cells.
Brooks et al. (1990)lymphokineB cellSince B cell cloning techniques have not yet been developed to obtain a homogenous B cell population for studies of activation requirements, regulation of lymphokine receptors, and regulation of gene expression, we must utilize lymphokine-responsive neoplastic B cells.
Weetman (1986)interleukin-2B-cellThis study has examined the effect of methimazole on four important soluble mediators of the immune response, interleukin-1 (IL-1), interleukin-2 (IL-2), gamma-interferon (gamma-IFN) and B-cell differentiation factor (BCDF).
De Groot et al. (1990)IL-2B cellsThe susceptibility to the inhibitory action of IL-4 emerges at late time points after in vitro activation of the B cells, whereas IL-4 shows its growth promoting action during early stages of culture, indicating that activated IL-2 responsive B cells are the targets for IL-4 dependent inhibition.
Mitsui et al. (1991)interleukin 2B-cellThe role of phorbol myristate acetate (PMA: a protein kinase-C (PKC) activator) and calcium ionophore A23187 in the induction mechanism of the interleukin 2 receptor (IL2R) on B-cell chronic lymphocytic leukemia (B-CLL) cells was studied.
Matthews et al. (1995)interleukin-2B cellsFunction of the interleukin-2 (IL-2) receptor gamma-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-15.
Kehrl et al. (1984)interleukin-2B lymphocytesThe effects of interleukin-1, interleukin-2, alpha-interferon, and gamma-interferon on human B lymphocytes.
Aleksandrovski? and Chekhonin (1999)lymphokineB-cellTherapy with tranquilizers indicated that they produced an inhibitory effect on T- and B-cell immunity, antibody formation and lymphokine production.
Vasil'eva et al. (2005)IL-2B lymphocytesAs revealed in this study, neutrophilokines regulate the synthesis of IL-2 by T helpers of type 1, IL-4 and IL-5 by T helpers of type 2, IL-1 by B lymphocytes, as well as the expression of receptors IL-2 by immunocompetent cells.
Isacson et al. (1992)IL-2B cellsNone of the following parameters, tested prior to initiation of the therapy and 1-2 days after termination of each course of IL-2, correlated with the clinical response: WBC counts (total and differential), levels of blood CD4 and CD8 T cells, NK cells, monocytes and B cells, production of IL-1 and IL-1 inhibitor by monocytes, responsiveness to 3 mitogens, NK/LAK cell activity, and serum levels of IL-1 alpha, IL-2, soluble IL-2 receptor, and TNF alpha.
Goldstein et al. (1990)IL-2B cellsLymphokines including IL-2, IL-4, and IL-6 are involved in the induction of Ig production by activated B cells.
Chen et al. (1987)IL-2B cellsThese data suggest that vitamin D3 inhibits Ig production by inhibiting IL-2 receptor expression on B cells and via its effect on adherent macrophages.
Bartlett et al. (1989)lymphokineB cellIn order to determine the involvement of T-B cell contact vs lymphokine production in mediating B cell cycle entry and progression, Th cell clones "defective" in lymphokine production were cloned.
Tortolani et al. (1995)IL-2B cellBecause of the importance of IL-2, IL-4, and IL-7 in B cell physiology, we sought to determine whether JAK3 was also present in B lymphocytes and whether it was involved in signaling via cytokines that are important for B cell development and function.
Trentin et al. (1994)IL-2B cellsTo investigate the functional properties of IL-2 and TNF alpha on leukemic B cells, we evaluated (1) the regulation of expression of TNF receptors (TNF-R) and IL-2 receptors on leukemic B cells after culture with TNF alpha and IL-2; (2) the effect of the combination of TNF alpha and IL-2 in a proliferative in vitro assay; and (3) the expression and regulation by these cytokines of receptors for hematopoietic factors, including IL-3, granulocyte colony-stimulating factor (G-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF).
Rinkenberger et al. (1996)IL-2B cellThus, IL-2 regulation of BSAP concentration may provide a mechanism for controlling both repressor and activator functions of BSAP during a B cell immune response.
Castejón et al. (1999)IL-2B cellsThus, we investigate interleukin-2 (IL-2), IL-4, IL-6 and IL-10 in vitro effects on apoptosis of B cells from 32 previously untreated patients with B-CLL in initial clinical stages.
Zola et al. (1991)IL-2B lymphocytesExpression of IL-2 receptor p55 and p75 chains by human B lymphocytes: effects of activation and differentiation.
Torigoe et al. (1992)IL-2B-cellIn contrast to IL-2's effects on p56-LCK in T-cells, studies of an IL-2-responsive cell line of the B-cell lineage that lacks p56-LCK revealed that IL-2 specifically regulates the activity of the p53/56-LYN kinase.
Krawczyk et al. (2005)interleukin 2B lymphocyteTheir influence on the mitotic division of the cells and on selected immunological parameters, e. g., T and B lymphocyte proliferation and synthesis of the cytokines: interleukin 2 (IL-2), tumour necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) was assessed in vitro.
Benjamin et al. (1992)lymphokineB-cellOur data suggest that the differences in glycosylation of B-cell-derived TNFs may account for the incomplete neutralization, and may influence the cytotoxic biological activity of this lymphokine.
David et al. (1998)IL-2B lymphocytesParadoxically, this modified IL-2R expression does not lead to increased IL-2 responsiveness, except for B lymphocytes.
Trentin et al. (1994)interleukin-2B-cellExpression and regulation of tumor necrosis factor, interleukin-2, and hematopoietic growth factor receptors in B-cell chronic lymphocytic leukemia.
Lebman et al. (1990)IL-2B cellMechanism for transforming growth factor beta and IL-2 enhancement of IgA expression in lipopolysaccharide-stimulated B cell cultures.
Hayama et al. (1983)IL-2B cellsThe results suggest a marked dependency of PFC responses to TI antigen on IL-2 in all strains examined, including SJL, LAF1, DBA/2Ha, and CBA/N, probably through a direct activation of B cells.
Mouzaki and Zubler (1995)interleukin-2B-lymphocytes[Regulation of transcription of the interleukin-2 gene in B-lymphocytes].
Leitenberg and Feldbush (1988)lymphokineB cellsThis report describes studies of lymphokine and mitogen regulation of class II expression on rat B cells.
Nordborg and Nordborg (1998)IL-2B-cellsThe immunopositivity for macrophages, B-cells, HLA-DR, ICAM-1 and IL-2 was significantly stronger in the outer than in the inner half of the intima.
Abraham (1991)IL-2B cellSimilarly, the depressed generation of systemic and mucosal antibodies to bacterial antigens following injury may be affected by alterations in the production of cytokines affecting B cell function, namely IL-1, IL-2, IL-3, IL-5 and IFN-gamma.
Leprince et al. (1988)interleukin 2B cellsThe anti-B8.7 monoclonal antibody induces a dose-related inhibition of the low molecular weight B cell growth factor-dependent proliferation of activated B cells, whereas it does not affect their response to interleukin 2.
DeKruyff et al. (1993)IL-2B cellsUsing Th1 and Th2 clones, we have also shown that the pathways for IgG1 synthesis are redundant, in that induction of IgG1 synthesis in secondary responses in which B cells have already switched from IgM to IgG1, can occur via several pathways, one involving IL-4 and IL-5, the other involving IL-2.
Kumar et al. (1999)IL-2B cellsThese observations showing an association of B7 dysregulation on monocytes and B cells with altered production of IL-2 may have implications in HIV immunopathogenesis.
Ogawa et al. (1992)B cell growth factorB cellAbnormal production of B cell growth factor in patients with systemic lupus erythematosus.
Karpus and Swanborg (1991)lymphokineB cellsBoth CD4+ T suppressor cells, known to regulate EAE effector cell lymphokine production, and myelin basic protein (MBP)-primed B cells are required to transfer protection against EAE to normal recipients.
Kljaic-Turkalj et al. (1996)lymphokineB cellThese findings suggest a change in the lymphokine profile of patients receiving specific immunotherapy, and that the inhibition of IL-4-induced B cell stimulation may be hypothesized as the most important mechanism.
Ju et al. (1999)lymphokineB cellWe have also discussed recent advances in the areas of FasL gene regulation, lymphokine regulation of AICD, and regulation of B cell susceptibility to FasL.
Duyn et al. (1999)B-cell growth factorB-cellEffects of interleukin 3, interleukin 7, and B-cell growth factor on proliferation and drug resistance in vitro in childhood acute lymphoblastic leukemia.
Barnes et al. (2009)IL-2B cellThe influence of JAK/STAT, ERK/MAPK, IL-2, and B cell receptor signaling pathways was evident in patients with persistent oligoarthritis.