Viewing affirmative mentions of regulation of IL2 (H. sapiens) in mononuclear cells

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Venkataraman and Westerman (1990)IL-2MNCsThe effects of radiation on the kinetics of Interleukin-2 (IL-2) production and utilization by mononuclear cells (MNCs) were studied.
Tsang et al. (1986)interleukin-2PBMCThe effects of Isoprinosine (ISO) on interleukin-2 (IL-2) production by human peripheral blood mononuclear cells (PBMC) were investigated.
Briggs et al. (1999)interleukin-2mononuclear cellsTo evaluate molecular mechanisms that might account for the heterogeneity in the in vitro responsiveness of individual subjects' peripheral blood mononuclear cells (PBMC) to immunosuppressive drugs, the authors quantitated in normal human cells the suppressive effects of the glucocorticoids prednisolone and methylprednisolone and of cyclosporine on interleukin-2 (IL-2) mRNA expression and IL-2 production, as well as the stimulatory effect of these drugs on IkappaBalpha mRNA expression.
Donnelly et al. (1986)interleukin-2PBMCIn order to account at least partially for this immunopotentiation by NPT-15392, we examined the effects of this compound on interleukin-2 (IL-2) production by cultures of mitogen-activated human peripheral blood mononuclear cells (PBMC).
Venkataraman (1992)IL-2MNCsSimilar to freezing, L-leucine methyl ester (Leu-OMe) treatment (to eliminate IL-1 and prostaglandin E-2 (PGE-2)-secreting cells) also increased the IL-2-producing activities of fresh cells, but freezing no longer enhanced the production of IL-2 by Leu-OMe-treated cells, suggesting that (1) both the freezing process and Leu-OMe treatment have similar effects on IL-2 production, (2) the increased IL-2 secretion by frozen MNCs is independent of IL-1, and (3) inactivation of PGE-2-secreting cells during the freezing procedure is responsible for increased IL-2 secretion.
Ellner et al. (1990)interleukin-2mononuclear cellsRegulation of antigen-induced blastogenesis and interleukin-2 expression by adherent mononuclear cells in humans infected with Schistosoma mansoni.
Iwaz et al. (1986)interleukin 2mononuclear cellsWe used the cholera toxin (CT), a cAMP elevating agent, to study the influence of this nucleotide on the production of interleukin 2 (IL-2) by human peripheral blood mononuclear cells stimulated by phytohemagglutinin and phorbol myristate acetate.
Sirota et al. (1997)IL-2mononuclear cellsEffect of lipid emulsion on IL-2 production by mononuclear cells of newborn infants and adults.
Sirota et al. (1997)interleukin-2mononuclear cellsThe in vitro effect of a lipid emulsion (intralipid) on interleukin-2 (IL-2) production by cord blood mononuclear cells (CBMC) of preterm and term newborn infants was examined and compared to that of peripheral blood mononuclear cells (PBMC) of adults.
Jira et al. (1987)IL-2mononuclear cellsEffect of recombinant interleukin-2 (IL-2) on peripheral blood mononuclear cells (PBMCs) by tritiated thymidine uptake method was investigated.
Flescher et al. (1992)IL-2mononuclear cellsRegulation of IL-2 production by mononuclear cells from rheumatoid arthritis synovial fluids.
Alhomsi and Laposata (2006)interleukin-2mononuclear cellsFatty acid ethyl ester effects on interleukin-2 production, cyclic AMP synthesis, and calcium influx in human mononuclear cells.
Garcia-Mauriño et al. (1998)IL-2mononuclear cellsInvolvement of nuclear binding sites for melatonin in the regulation of IL-2 and IL-6 production by human blood mononuclear cells.
Garcia-Mauriño et al. (1998)IL-2mononuclear cellsIn this paper, we have extended our studies on the influence of melatonin on IL-2 and IL-6 production by human peripheral blood mononuclear cells (PBMCs) by comparing the effects of the specific membrane receptor agonist S 20098, the RZR/ROR(alpha) receptor agonist CGP 52608, and structurally related thiazolidinediones.
Mantovani et al. (1987)interleukin 2PBMCThe aims of the investigation were: 1) to determine if there are defects in interleukin 2 (IL 2) regulation either on phytohemagluttinin (PHA)-activated or non PHA-activated peripheral blood mononuclear cells (PBMC) in cancer patients, in order to ascertain the role of IL 2 in this disease, and 2) to carry out preliminary experiments for a direct quantitative evaluation of endogenous IL 2 production by PBMC cultures of cancer patients.
Petrova et al. (2009)IL2mononuclear cellsRegulation of IL2 and NUCB1 in mononuclear cells treated with acyl glucuronide of mycophenolic acid reveals effects independent of inosine monophosphate dehydrogenase inhibition.
Smith et al. (1990)interleukin-2mononuclear cellsThe influence of calciotrophic hormones on lymphocyte transformation and interleukin-2 production in human mononuclear cells.
Mauz-Körholz et al. (2004)interleukin-2mononuclear cellsRegulation of interleukin-2 induced soluble Fas ligand release from human peripheral blood mononuclear cells.
Siejka et al. (2005)interleukin-2mononuclear cells[Evaluation of the effect of GHRH(1-44)NH2 on the secretion of interleukin-2 (IL-2) and soluble IL-2 receptor alpha (sIL-2Ralpha) from human peripheral blood mononuclear cells in vitro].
He et al. (2004)interleukin-2mononuclear cellEffects of selenium on peripheral blood mononuclear cell membrane fluidity, interleukin-2 production and interleukin-2 receptor expression in patients with chronic hepatitis.
Hofmann et al. (1987)TCGFPBMCTo investigate the role of the inhibitor of TCGF production, PGE2, in AIDS, indomethacine was added to cultures of mitogen-stimulated PBMC from controls and patients.
Commes et al. (1986)IL-2PBMCThe role of suppressor factors/cells on IL-2 production was evaluated using indomethacin and irradiation of PBMC.
Nakanishi et al. (1999)interleukin-2mononuclear cellsThe influence of L-triiodothyronine on expression of the interleukin-2 receptor alpha chain by peripheral blood mononuclear cells from healthy volunteers and YT cells (an interleukin-2 independent natural killer-like cell line) was examined.
Faist et al. (1993)IL-2mononuclear cellThe major regulatory level of interleukin-2 (IL-2) release under stressful conditions was determined via parallel analysis of IL-2 messenger RNA (mRNA) expression and IL-2 protein synthesis in mitogen-stimulated peripheral blood mononuclear cell (PBMCs) cultures on consecutive days postinjury.
Huang et al. (2002)interleukin-2mononuclear cells[Effects of sterigmatocystin on interleukin-2 secretion of human peripheral blood mononuclear cells in vitro].
Sia and Chou (1987)IL-2PBMCLimiting dilution analysis showed that IL-2 responsive IVALC through expansion markedly affected the cloning efficiency of antigen-proliferating T cells of autologous PPD-stimulated PBMC cultures.
Wu and Yang (1991)interleukin 2PBMCThe effect of trace elements lithium, selenium, and zinc on interleukin 2 (IL-2) production by peripheral blood mononuclear cells (PBMC), MLA144, and Jurkat cell lines has been studied.
Gougerot-Pocidalo et al. (1988)IL-2PBMCOn the other hand, IL-2 recovery in the supernatants of O2-treated PBMC was always enhanced compared to the IL-2 control recovery after DNA synthesis was blocked in G1/S by mitomycin c, and the G0/G1 transition was protected by 2-ME.
Chakrabarti and Sinha (1997)IL-2PBMCTo evaluate the role of a 57 kD major antigenic outer membrane protein of S. dysenteriae 1 in the proliferation of PBMC and the production of IL-2, the in vitro blastogenic transformation assay was employed.
Haregewoin et al. (1983)IL-2mononuclear cellsHere we have studied the effect of IL-2 rich T-cell conditioned medium on lepromatous peripheral blood mononuclear cells.
Sakagami et al. (1988)interleukin 2mononuclear cellsEffects of an anti-tumor polysaccharide, schizophyllan, on interferon-gamma and interleukin 2 production by peripheral blood mononuclear cells.
Sakagami et al. (1988)interleukin 2mononuclear cellsWe examined the effect of schizophyllan, a neutral glucan isolated from the culture filtrate of Schizophyllum commune Fries, on the production of interferon-gamma (IFN-gamma) and interleukin 2 (IL 2) from the mitogen-stimulated human peripheral blood mononuclear cells (PBMC).
Iho et al. (1985)IL 2MNCThus, the reduction of proliferative response of MNC to PHA by 1,25(OH)2D3 appeared to have resulted from the inhibitory effects of the agent on both IL 2 and IL 1 production.
Junger et al. (1997)IL-2 mRNAPBMCThis effect of HTS was paralleled by enhanced IL-2 production of activated PBMC and Jurkat cells and IL-2 mRNA transcription of Jurkat cells.
Rakhmilevich et al. (1990)IL-2mononuclear cellsThe effect of lipopolysaccharide, muramyl dipeptide, and a combination of these agents in vitro on the production of tumour necrosis factor (TNF) by human peripheral blood mononuclear cells (PBMC; monocytes and lymphocytes) and on the sensitivity of these cells to recombinant interleukin-2 (IL-2) was studied.
Mantovani et al. (1988)IL-2PBMCThe aims of the investigation were 1) to determine if there are defects in interleukin-2 (IL-2) regulation on either phytohemagglutinin (PHA)-activated or non-PHA-activated peripheral blood mononuclear cells (PBMC) in cancer patients to ascertain the role of IL-2 in this disease; 2) to carry out preliminary experiments for a direct quantitative evaluation of endogenous IL-2 production by PBMC cultures; and 3) to evaluate the IL-2 receptor expression by PBMC of cancer patients.
Wu (1992)IL-2mononuclear cells[Modulation effect of lithium on IL-2 and IFNr production by human peripheral blood mononuclear cells].
Ceuppens and Stevens (1986)IL-2PBMCThe latter can be replaced by a crude supernatant of PWM-stimulated PBMC, a conditioned medium containing interleukin 2 (IL-2) and presumably other helper factors for B cells.
Munno et al. (1992)interleukin-2mononuclear cellsInfluence of ST 789 on interleukin-1, interleukin-2 and interferon-gamma production from normal human peripheral blood mononuclear cells.
Munno et al. (1992)IL-2PBMCIn this framework, here we have evaluated the influence of ST 789 on interleukin (IL)-1, IL-2 and interferon (IFN)-gamma production from normal human peripheral blood mononuclear cells (PBMC).
Mzoguchi et al. (1987)interleukin 2mononuclear cellsEffects of interleukin 2 on estradiol binding capacity of peripheral blood mononuclear cells in asymptomatic HBV carriers.
Linker-Israeli and Casteel (1988)IL-2PBMSF PBM appear to affect directly the IL-2 producer cell, since it suppressed IL-2 production by (1) mitogen stimulated PBM depleted of CD8+ suppressor cells and by (2) mitogen induced Jurkat cells.
Weng et al. (2002)interleukin-2HMNCThe action mechanisms of CC-1-2 and CC-2-1 may involve the regulation of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) production in HMNC.
Bertotto et al. (1990)IL 2PBMCFurthermore, when anti-CD3 and phorbol myristate acetate (PMA) were added together, they exerted a very marked synergistic effect on both the proliferation of, and IL 2 production by, cord PBMC.
Conti et al. (1992)IL-2PBMCThese studies have examined some biological properties of hrIL-1ra, such as its effects on the secretion of IL-1 alpha or IL-1 beta and IL-2, the surface expression of IL-2R and DNA synthesis by peripheral blood mononuclear cells (PBMC).
Komorowski et al. (1997)IL-2mononuclear cellsEffects of hCG and beta-hCG on IL-2 and sIL-2R secretion from human peripheral blood mononuclear cells: a dose-response study in vitro.
Komorowski et al. (1997)IL-2PBMCThe inhibitory effect of very high concentrations of hCG and beta-hCG on IL-2 secretion together with their stimulatory effect on sIL-2R release from PBMC may be an important event during the human pregnancy and various cancers.
Chen et al. (1994)IL-2mononuclear cellsThe aim of the present work was to study the regulatory effects of cytokines (TNF alpha, IL-1 beta and IL-2) on the production of the prostglandins (PGI2 and TXA2) from human mononuclear cells.
Becker et al. (1995)lymphokinemononuclear cellsIn order to investigate transcriptional regulation of lymphokine genes in rheumatic diseases, peripheral blood mononuclear cells from patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and systemic sclerosis (SSc) were analysed for expression of DNA-binding proteins.
Dogan et al. (2006)IL-2mononuclear cellSoluble IL-2 receptor (sIL-2R) levels reflect mononuclear cell
Hernández et al. (2002)IL-2mononuclear cellsPeripheral blood mononuclear cells from four species of Aotusmonkey were obtained and their mRNAs for interleukin-2 (IL-2), IL-4, IL-6, IL-10, interferon-gamma (IFN), and tumor necrosis factor (TNF)-alpha were characterized.
Bessler et al. (1996)IL-2mononuclear cellsEffect of dexamethasone on IL-2 and IL-3 production by mononuclear cells in neonates and adults.
Bessler et al. (1996)interleukin 2mononuclear cellsThe effect of dexamethasone on interleukin 2 (IL-2) and interleukin 3 (IL-3) production by mononuclear cells in preterm and term infants and adults was evaluated.
Gobec et al. (2001)IL-2mononuclear cellsWhile MDP and LK 415 are relatively ineffective in modulation of IL-2, IL-4 and IL-10 production in vitro, the synthesis of all three cytokines is considerably up-regulated when peripheral blood mononuclear cells are co-incubated with LK 517.
Weichenthal et al. (2000)IL-2PBMCUVB irradiation did not lead to significant changes on IL-1 and IL-2 expression by PBMC.
Krause et al. (1995)interleukin 2PBMCThe present study aimed at evaluating the influence of interleukin 1 beta (IL-1 beta) and interleukin 2 (IL-2) on the number and on the dissociation constant (KD) of beta 2R on PBMC in vitro.
Weir et al. (1991)IL-2mononuclear cellThe 5-LO does not inhibit mononuclear cell responses simply by shunting the formation of arachidonic acid precursors to form inhibitory prostaglandins, since it does not impair IL-2 responsiveness in a manner similar to ENO.
Rueda et al. (1989)IL2MNCIn a dose-response curve carried out with increasing PLT number per MNC, progressive inhibition was found, reaching to 62.6% and 49.5%, respectively, to phytohemagglutinin and IL2 lymphoproliferative response and 87.8% in IL2 production, at 80 PLTs/MNC.
Lin et al. (2002)IL-2PBMCThe inhibitory mechanisms may involve the blocking of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) production, since compound 3 attenuated IL-2 and IFN-gamma production of PBMC in a dose-dependent manner.
Vint et al. (1993)interleukin-2mononuclear cellsThe effects of auranofin on activation and interleukin-2 release from human peripheral blood mononuclear cells.
Todoroki et al. (1990)IL-2mononuclear cellsAzelastine suppressed the induction of IL-2 responsiveness induced by Df antigen in peripheral blood mononuclear cells from patients with bronchial asthma in a dose dependent manner.
Chou et al. (2009)IL-2PBMCIn addition, effects of 2-OH on interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) production in PBMC were determined by enzyme immunoassay.
Leclerc et al. (1984)IL 2mononuclear cellsIn the present study, well-defined immunomodulatory synthetic glycopeptides were used to investigate putative regulatory mechanisms of in vitro IL 2 production by normal human peripheral blood mononuclear cells.
Atluru et al. (1993)IL-2mononuclear cellsHuman peripheral blood mononuclear cells (PBMCs) were cultured in vitro with various stimuli and in the presence or absence of a 5-lipoxygenase (5-LO) inhibitor, A-63162, to measure its effects on PBMC proliferation, interleukin-2 receptor (IL-2R) expression, interleukin-2 (IL-2) synthesis, interleukin-6 (IL-6) synthesis, and accumulation of messenger RNA for IL-2 or IL-6.
Van Oosterhout and Nijkamp (1990)interleukin-2PBMCThe effect of recombinant human interleukin-2 (rh IL-2, Genzyme, yeast derived) on the beta-adrenoceptor function of human peripheral blood mononuclear cells (PBMC), guinea pig splenic lymphocytes and isolated guinea pig tracheal spirals was investigated.
Funk et al. (1993)IL-2PBMCPrevious experiments revealed an influence of He-Ne laser irradiation on concentrations of interleukin-1 alpha (IL-1 alpha), tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), and interferon-gamma (IFN-gamma) in supernatants of cultures of human peripheral blood mononuclear cells (PBMC) with increased cytokine concentrations after irradiation of 18.9 J/cm2 and decreased concentrations after irradiation of 37.8 J/cm2.
Funk et al. (1993)IL-2PBMCAnalysis of the IL-2 receptor (IL-2R) and intercellular adhesion molecule-1 (ICAM-1) expression in PBMC showed partial down-regulation of both receptors at 37.8 J/cm2, but only after stimulation with PHA.
Tsai et al. (2008)IL-2PBMCThe action mechanisms of seselin may involve the regulation of cell cycle progression, interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) production in PBMC.