Viewing affirmative mentions of localization of IL2 (H. sapiens) in lymphocytes

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Conradt et al. (1988)IL-2lymphocytesHuman peripheral blood lymphocytes secrete high titers of interleukin-2 (IL-2) after stimulation by Ca2+-ionophore A23187/phorbol 12-myristate-13-acetate.
Kalashnikova and Pukhal'ski? (1993)interleukin-2lymphocytesDose-dependent modifying of mitogen-induced interleukin-2 (IL-2) release by human peripheral blood lymphocytes (PBL) treated with dexamethasone (Dx) was demonstrated.
Kalashnikova and Pukhal'ski? (1993)IL-2PBLIn four independent experiments with PBL of 10 human subjects the effect of Dx administration on IL-2 release in serum-free culture medium could vary from appreciable enhancing to complete suppression.
Froelich et al. (1988)interleukin-2lymphocytesPhytohemagglutinin induced proliferation by aged lymphocytes: reduced expression of high affinity interleukin-2 receptors and interleukin-2 secretion.
Goebel et al. (2002)IL-2lymphocyteIn the next week, re-exposure to the conditioned stimulus (drink), but now paired with placebo capsules, induced a suppression of immune functions as analyzed by the IL-2 and IFN-gamma mRNA expression, intracellular production, and in vitro release of IL-2 and IFN-gamma, as well as lymphocyte proliferation.
Borysiewicz et al. (1985)IL-2lymphocytesSimilarly, IL-2 release was not affected by Herpes simplex virus infection of such cultures, although lymphocytes infected with Sendai or respiratory syncytial viruses produced considerably less IL-2.
Voss et al. (1989)IL-2lymphocytesWe have used an enzyme-linked immunosorbent assay (ELISA) to quantify the role of released and cell-bound IL-2 receptor following in vitro or in vivo activation of human lymphocytes with IL-2.
Voss et al. (1989)IL-2lymphocytesIn vitro experiments, culturing fresh peripheral blood lymphocytes in 30 U/ml IL-2 (corresponding to the steady-state IL-2 concentration achieved in patients receiving IL-2 in our clinical trials), showed that the levels of IL-2 receptor released into the culture media exceeded the levels of cell-associated receptor, with both rising in parallel to the cytotoxic activity of the peripheral blood lymphocytes (PBL) against cultured tumor cells.
Sabbaj et al. (1992)interleukin-2lymphocyteThe response to tetanus toxoid was examined in 45 HIV-infected individuals and 11 controls using conventional lymphocyte proliferative assays concurrently with limiting dilution analysis utilizing the secretion of interleukin-2 as the measure of a response.
Okai et al. (1984)IL 2lymphocytesMT 1 cells release significant interleukin 2 (IL 2) activity into the culture medium, which showed the same elution pattern of gel filtration and isoelectric focusing of IL 2 from lectin-stimulated normal human lymphocytes.
Kubbies et al. (1990)IL-2lymphocyteImprovement of human lymphocyte proliferation and alteration of IL-2 secretion kinetics by alpha-thioglycerol.
Li et al. (1990)interleukin-2lymphocytesImmunological abnormalities in HTLV-I-associated myelopathy: spontaneous release of interleukin-2 and interleukin-2 receptor by peripheral blood lymphocytes.
Li et al. (1990)IL-2lymphocytesTen patients with human T lymphotropic virus type I-associated myelopathy (HAM), 5 asymptomatic HTLV-I carriers and 11 healthy normal volunteers were studied to determine if peripheral blood lymphocytes spontaneously release IL-2 and soluble IL-2 receptors.
Bowlin et al. (1989)IL-2lymphocytesInterleukin 2 (IL-2) is a secreted glycoprotein which acts as an activation and proliferative signal for lymphocytes expressing membrane-bound glycoprotein IL-2 receptors.
Ruschen et al. (1988)Interleukin-2lymphocytesInterleukin-2 secretion by synovial fluid lymphocytes in rheumatoid arthritis.
Ruschen et al. (1988)IL-2SFLOn the other hand, higher levels of secreted IL-2 were found in SFL cultures compared to corresponding PBL cultures of RA patients and normal donors.
Hauser et al. (1987)Interleukin-2lymphocyteInterleukin-2(IL-2) is a lymphokine release from OKT4+ lymphocyte.
Pack et al. (2002)interleukin-2HPBLFurthermore, LA had different effects on the secretion of interleukin-2 (IL-2) and steady-state levels of IL-2 mRNA in mitogen-stimulated HPBL depending on the mitogens used.
Pack et al. (2002)IL-2HPBLLA dramatically increased the induction of IL-2 mRNA and IL-2 protein secretion in PMA/IoM-stimulated HPBL, whereas it inhibited these in HPBL stimulated with PHA.
Hussein et al. (1987)IL-2lymphocyteThe inhibitor, which could be absorbed by activated but not resting lymphocyte cultures, appeared to act by inhibition of an early event preceding the release of IL-2.
Chopra et al. (1989)interleukin 2lymphocytesSoluble interleukin 2 receptors released from mitogen stimulated human peripheral blood lymphocytes bind interleukin 2 and inhibit IL2 dependent cell proliferation.
Vega et al. (1999)IL-2lymphocytesProliferative inhibition was due to a suboptimal levels of IL-2 secreted by lymphocytes, since the addition of recombinant IL-2 to the cultures reversed in a dose-dependent fashion the inhibitory effect of As.
Rocha and Bandeira (1988)Interleukin 2lymphocytesInterleukin 2 secretion is an exclusive property of L3T4+ lymphocytes.
Romano et al. (2004)IL-2TILsMoreover, tumor infiltrating lymphocytes (TILs), activated by endogenous IL-2 release, are linked to prognosis in cancer patients.
Zhang et al. (1998)interleukin-2lymphocyte[Alteration of peritoneal lymphocyte transformation and its interleukin-2 release in patients with infertility and endometriosis].
Zhang et al. (1998)IL-2lymphocyteOBJECTIVE: To study the relationship between alteration of peritoneal lymphocyte transformation activity, its interleukin-2 (IL-2) release and infertility associated with endometriosis.
Müller-Quernheim et al. (1996)IL-2lymphocytesA cohort of 89 sarcoidosis patients was allocated to four groups according to the following criteria: stage A, a low number of bronchoalveolar lavage (BAL) lymphocytes (< 20%) without IL-2 release (< 1 unit/ml in BAL cell culture supernatant); stage B, BAL lymphocytes < 20%, with IL-2 release (> or = 1 unit/ml); stage C, BAL lymphocytes > or = 20% with IL-2 release; and stage D, > or = 20% BAL lymphocytes without IL-2 release.
Opremcak et al. (1991)IL-2lymphocytesThese data show that patients with certain forms of uveitis have a measurable frequency of lymphocytes in the peripheral immunologic compartment capable of secreting IL-2 in response to autologous presentation of ocular autoantigen (S-antigen).
Mori et al. (1989)IL-2lymphocytesIn 21 untreated sarcoidosis patients, 7 treated patients and 13 control subjects, the mean IL-2 activity of fluid released from cultured alveolar lymphocytes was 9.8 +/- 15.7 u/ml (M +/- SD), 1.9 +/- 4.7 u/ml and 0.2 +/- 0.8 u/ml respectively.
Conradt et al. (1986)IL-2 proteinlymphocytesBased on their behavior in reversed-phase l.c. and their sodium dodecyl sulfate-gel-electrophoresis pattern, human IL-2 protein secreted by L cells showed a similar distribution of glycosylated (Mr 16 500) and nonglycosylated (Mr 14 500) forms as the natural protein secreted by human peripheral lymphocytes, whereas the hamster cell line secreted preponderantly the glycosylated forms.
Beltz et al. (2001)IL-2lymphocyteAlthough TNT concentrations decreased in both P1 and P2 eluates relative to untreated baseline soil (BL) eluates, a recovery in lymphocyte growth/viability and IL-2 secretion was seen with P2 but not P1 eluates relative to BL eluates.
Valtorta et al. (1991)interleukin-2lymphocyteLow concentrations of GHRH 1-29 increased phytoemoagglutinin (PHA)-induced lymphoproliferation, while high concentrations inhibited lymphocyte response, interleukin-2 (IL-2) secretion and IL-2 receptor expression on activated cells.
McDouall et al. (1994)IL-2lymphocytesHere we have compared the effects of cyclosporine on the phytohaemagglutinin (PHA) response of immature (cord) and mature (adult) lymphocytes using the following parameters of activation: (i) proliferation, measured by 3H-thymidine uptake; (ii) expression of cell surface IL-2 receptor; (iii) release of IL-2 into the supernatant.
Robinson et al. (1984)IL-2lymphocytesConsistent with this observation, lung lymphocytes from patients with active sarcoidosis, a disease in which lung lymphocytes are spontaneously releasing IL-2, did express NK cell activity (P less than 0.01).
Suo (1996)IL-2lymphocytesThe underlying mechanisms of this tumor suppressive effect may be related with the activation of macrophages, followed by the indirect priming of lymphocytes to release effector molecules such as IL-2, to express IL-2 receptors, and to selectively suppress the synthesis of macromolecules in tumor cells.
Baba et al. (2006)interleukin-2lymphocytesThe aim of this work was to study the in vitro effects of different concentrations of three novel aziridines, 2-hydroxy-methyl-1-(N-phtaloylglycyl) aziridine (aziridine 1), 2-hydroxy-methyl-1-(N-phtaloylalanyl) aziridine (aziridine 2) and 2-hydroxy-methyl-1-(N-phtaloylphenylalanyl) aziridine (aziridine 3), on the proliferative responses of human lymphocytes stimulated by mitogens (concanavalin A (Con A) and lipopolysaccharide (LPS)), and interleukin-2 (IL-2), interleukin-6 (IL-6) secretion.
Filaci et al. (1997)interleukin 2lymphocyteChenodeoxycholic acid inhibited phytohemagglutinin-induced lymphocyte proliferation and interferon-gamma secretion, and phytohemagglutinin and pokeweed-mediated interleukin 2 secretion.
Filaci et al. (1997)interleukin 2lymphocyteS-adenosil-L-methionine did not affect lymphocyte proliferation while it reduced interleukin 2 secretion upon phytohemagglutinin and pokeweed stimulation and interferon-gamma secretion upon all stimuli tested.
Filaci et al. (1997)interleukin 2lymphocyteMoreover, S-adenosil-L-methionine counteracted chenodeoxycholic acid-mediated inhibition of lymphocyte proliferation and interleukin 2 secretion.
Filaci et al. (1997)interleukin 2lymphocyteThe results of our study confirm the immunosuppressive role of chenodeoxycholic acid on both secretive and proliferative lymphocyte functions and provide evidence of immunomodulatory activities of S-adenosil-L-methionine and its capacity to antagonize chenodeoxycholic acid-mediated inhibition of lymphocyte proliferation and interleukin 2 secretion.
Dong et al. (1991)IL-2lymphocytesCI-959 (5-methoxy-3-(1-methylethoxy)-N-1H-tetrazol-5-yl-benzo [b]-thiophene-2-carboxamide), an antiallergy compound, blocked release of IL-2 from Con A stimulated rat splenocytes and human lymphocytes with respective IC50s of 19.1 and 23.1 microM.
Ruscetti et al. (1980)TCGFlymphocyteRemoval of PHA 12 h after incubation had no effect on lymphocyte transformation but decreased TCGF release by 90%.
Bub et al. (2003)Interleukin-2lymphocytesInterleukin-2 secretion by activated lymphocytes and the lytic activity of natural killer cells were significantly increased by both juices.
Heemskerk et al. (2008)interleukin-2lymphocytesAdoptive cell therapy for patients with melanoma, using tumor-infiltrating lymphocytes genetically engineered to secrete interleukin-2.
Yamaguchi et al. (2001)interleukin-2lymphocytesGeneration of cytotoxic effector lymphocytes by MLTC using tumor cells genetically modified to secrete interleukin-2.
Conry et al. (1994)interleukin 2LymphocytesLymphocytes from 2 of 5 mice had interleukin 2/interleukin 4 release in response to CEA.
Mandreoli et al. (1992)IL-2LymphocyteLymphocyte release of soluble IL-2 receptors in patients with minimal change nephropathy.
Wustrow (1989)Interleukin 2lymphocytes[Interleukin 2 secretion by lymphocytes of patients with squamous cell cancer of the oropharynx or larynx].
Wolf and Brelsford (1988)interleukin-2lymphocytesWe studied levels of soluble interleukin-2 receptors (IL-2R), which are released by activated lymphocytes, in 139 serum samples from 12 patients with systemic lupus erythematosus (SLE).
Sriwanthana and Chavalittumrong (2001)IL-2lymphocyteWe investigated the effect of Derris scandens hydroalcoholic extract on lymphocyte proliferation, natural killer (NK) cell activity and secretion of IL-2 and IL-4.
Schnorr et al. (1997)IL-2PBLsLess IL-2 was released from PBLs after contact with MV-infected presenter cells when compared with that released after contact with uninfected cells.
Takahashi et al. (1997)IL-2lymphocytesPBMC and lymphocytes were isolated from the subjects and their cells were stimulated with an anti-CD3 monoclonal antibody (anti-CD3 MoAb) and the secreted IL-2 levels in the culture were bioassayed.
Nagaraj et al. (2004)IL-2lymphocytesThere are several reports introducing IL-2 producing genes into pancreatic cancer, but there are no reports about IL-2 secreting lymphocytes functioning as immune enhancer cells.
Wiseman et al. (1991)IL-2lymphocytesStimulation with PND-MN induced proliferation of lymphocytes from 2 of the children and IL-2 secretion by lymphocytes from 5 of the children.
Amirghofran et al. (2007)IL-2lymphocyteCONCLUSION: The decline of antibody titer and DTH response indicates that H. elymatica, by acting on the lymphocyte proliferation and IL-2 secretion, inhibits both humoral and cell-mediated immune responses.
Sauer et al. (1995)IL-2lymphocytesIn patients with HPA pathologies, cortisol-induced inhibition of lymphocyte interleukin-2 (IL-2) secretion in vitro positively correlated (p < .005) with IL-2 synthesis, such that lymphocytes secreting less IL-2 were less cortisol sensitive.
Cossarizza et al. (1989)interleukin-2lymphocytesExtremely low frequency pulsed electromagnetic fields increase interleukin-2 (IL-2) utilization and IL-2 receptor expression in mitogen-stimulated human lymphocytes from old subjects.
Cossarizza et al. (1989)IL-2lymphocyteTaken together, these data suggest that PEMFs were able to modulate mitogen-induced lymphocyte proliferation by provoking an increase in utilization of IL-2, most likely acting on the expression of its receptor on the plasma membrane.
Glauser et al. (1988)IL-2lymphocytesThese abnormalities do not seem to be caused by IL-2 directly; the causes may be mediated by IL-2 activated lymphocytes or other IL-2 activated cellular mediators.
Owen-Schaub et al. (1988)IL-2lymphocyteUsing TNF-alpha as a model, we demonstrate that (a) the cytotoxic synergy occurs with both fresh human tumors and cell lines; (b) the degree of IL-2/TNF-alpha synergy, for most peripheral blood lymphocyte donors, is dependent upon the IL-2 concentration used for activation with the most striking synergy observed at lower IL-2 doses; (c) synergy is specific for TNF-alpha and can be abrogated by neutralizing antibody against this cytokine; (d) addition of high-dose neutralizing antibody to IL-2 alone-stimulated peripheral blood lymphocytes can reduce the cytotoxicity capacity of these effectors suggesting an immunoregulatory role for endogenous TNF-alpha; and (e) TNF-alpha addition to IL-2-stimulated peripheral blood lymphocytes does not increase proliferation or cell recovery but does result in enhanced IL-2 receptor expression.
Gluckman et al. (1983)IL-2lymphocytesHowever, MLR suppressor cells did not inhibit the release of IL-2 from autologous pre-BT lymphocytes.
el Ridi et al. (1987)IL 2lymphocytesThe findings suggest that Con A activation of snake lymphocytes in optimal seasonal conditions is associated with the secretion of a lymphokine analogous to the interleukin 2 (IL 2) of endothermic vertebrates.
Pockley and Bolton (1989)interleukin-2lymphocytesPlacental protein 14 (PP14) inhibits the synthesis of interleukin-2 and the release of soluble interleukin-2 receptors from phytohaemagglutinin-stimulated lymphocytes.
Pockley and Bolton (1989)interleukin-2lymphocytesCrude human decidual extracts containing up to 15.0 mg/l PP14 were investigated for their effects on the release of interleukin-2 (IL-2) and of IL-2 receptor (IL-2R) from phytohaemagglutinin (PHA) stimulated lymphocytes.
Müller-Quernheim et al. (1996)IL-2-releasinglymphocytesAlthough patients of stages C and D (n = 49) exhibited lymphocytic inflammation, only 20/49 of these patients had activated IL-2-releasing alveolar lymphocytes.
Spain et al. (1995)IL-2lymphocytesEnhanced proliferation and IL-2 secretion by lung lymphocytes from HIV-infected subjects.
Garraud (1993)IL-2lymphocytesThese lymphocytes did not incorporate tritiated thymidine (neither they did proliferate) although they expressed IL-2 alpha and beta binding chains and secreted IL-2 (or at least TCGF).
Pawelec et al. (1986)IL 2-secretinglymphocytesThis modulation of function from specific alloproliferative, IL 2-secreting nonsuppressive status to strong nonspecific suppressive and NK-like cytotoxic status represents a novel functional activity of human T helper lymphocytes under conditions of clonal propagation.
Sekine (1992)IL-2lymphocytes[Expansion of peripheral blood lymphocytes by culture with immobilized anti-CD3 antibody and IL-2].
Guarini et al. (1997)IL-2lymphocytesWhen PBMC were cultured up to 3 weeks with IL-2 releasing LC89 cells (LC89/IL-2), the number of viable CD3+ and CD56+ lymphocytes was much greater than in cultures with parental cells or with LC89 cells transduced with the other cytokine genes.
Murakami (2004)IL-2lymphocytesLevels of serum sIL-2R (soluble interleukin-2 receptor) reflect the total amount of activated T lymphocytes in tumor infiltrating lymphocytes of cancer tissues and metastatic organs, because a part of alpha-chain of IL-2R is released into the bloodstream on the attachment of IL-2 (interleukin-2) to its specific IL-2R membrane.
Nagaraj et al. (2004)IL-2lymphocytesThe reproducible observation that virtually all malignant cells can be lysed by IL-2 stimulated lymphocytes in a manner directly related to the intensity of IL-2 administration encouraged the pursuit of aggressive, intensive clinical trials, especially in renal cell carcinoma and melanoma.
Thibault et al. (1991)IL-2lymphocyteIn the case of PHA stimulation, STPM strongly inhibited IL-2 (but not IL-1) secretion and IL-2R P55 expression at a concentration where lymphocyte proliferation was also blocked.
Thibault et al. (1991)IL-2lymphocyteThese results suggest that STPM inhibit lymphocyte proliferation by affecting one or several events occurring in the synthesis and/or expression of IL-2R P55 by a mechanism which is at least partially independent of its inhibitory effect on IL-2 secretion.
Viret et al. (1995)IL-2lymphocyteWe further show that defective IL-2 secretion in response to melanoma antigens was not due to a T cell clone refractoriness induced by the culture, since one of these clones could be induced to secrete IL-2 by an antigen-expressing melanoma line, upon increased lymphocyte function associated antigen-3 expression induced by gene transfection.
Viret et al. (1995)IL-2lymphocytesTogether these data suggest that defective IL-2 secretion by many tumour-infiltrating lymphocytes clones in response to antigen presentation by melanoma cells in vitro is not exclusively due to the inability of these cells to provide an appropriate co-stimulation through the B7-1 molecule.
Loertscher et al. (1987)interleukin-2lymphocyteDifferential effect of gamma-irradiated and heat-treated lymphocytes on T cell activation, and interleukin-2 and interleukin-3 release in the human mixed lymphocyte reaction.
Ghoneum et al. (1987)interleukin-2lymphocytesWe have developed a simple culture assay system for measuring the in vitro effects of a chemical carcinogen, 3-methylcholanthrene (MCA), on certain activities of human peripheral blood lymphocytes: blastogenesis, cell-mediated cytotoxicity by natural killer cells, interleukin-2 production, lymphotoxin release and percent T-cell subpopulations.
Goeken and Eckerle (1986)Il-2lymphocyteIf a mechanism of suppression in the mixed lymphocyte reaction is to reduce the synthesis/release of Il-2, memory cells may acquire their relative resistance to this suppression by virtue of the increased IL-2 sensitivity of this discrete subpopulation.