Viewing affirmative mentions of transcription of IL2 (H. sapiens) in blood

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Müller-Quernheim et al. (1986)IL 2bloodIn contrast, no IL 2 mRNA transcripts could be detected in fresh autologous blood T cells or in purified autologous blood Leu-3+ T cells, although IL 2 mRNA transcripts were inducible in these cells by phytohemaglutinin/phorbol myristic acetate.
Falsafi-Amin et al. (2008)interleukin-2bloodThe aim pf the present study was to characterize the time course of the synthesis of mRNA encoding interleukin-2 (IL-2) by peripheral blood mononuclear cells (PBMCs) isolated from nickel-allergic women and subsequently exposed to nickel sulphate in vitro.
Kotasek et al. (1987)IL-2bloodLevels of IL-2 that are 3-5 times greater than peak blood IL-2 levels, transiently present in patients following bolus IL-2 injections, fail completely to produce HEC cytotoxicity even during prolonged incubation.
Hughes and Pober (1996)interleukin-2bloodTranscriptional regulation of the interleukin-2 gene in normal human peripheral blood T cells.
Feron et al. (1992)IL-2bloodFor this reason, 3-colour immunofluorescent staining was performed to assess the distribution of IL-2 receptors (IL-2R) and the CD45RO-antigen on CD4+ and CD8+ subsets of peripheral blood lymphocytes (PBLs) from patients with posterior uveitis (n = 29).
McIntyre et al. (1994)interleukin-2bloodThe detection of intracytoplasmic interleukin-2 in Jurkat E6.1 and human peripheral blood mononuclear cells using direct conjugate, two-colour, immunofluorescent flow cytometry.
Yao et al. (2004)IL-2bloodRESULTS: Striking differences in the biodistribution of IL-2 and Albuleukin were noted. (111)In-IL-2 cleared from blood rapidly, with less than 1% ID/g (percentage of injected dose per gram of tissue) at 20 min after injection.
Lesniewski et al. (2008)IL-2 geneUCBDecreased IL-2 gene transcription in UCB CD4(+) T cells transfected with BACH2 siRNA was confirmed by a human IL-2 luciferase assay.
Briggs et al. (1999)IL-2bloodEffects of glucocorticoids and cyclosporine on IL-2 and I kappa B alpha mRNA expression in human peripheral blood mononuclear cells.
Brod et al. (1991)IL-2bloodWe found that most clones from both the peripheral blood and CSF express IL-1, IL-2, IL-4, IFN-gamma, or TNF-alpha cytokine mRNA after activation with ionomycin and PMA.
Roy et al. (1995)IL-2bloodIn the current study, we used reverse transcription (RT) polymerase chain reaction (PCR) to explore the mRNA expression of candidate inflammatory cytokines IL-1 alpha, IL-2, IL-4, IL-6, TNF-alpha, and interferon-gamma (IFN-gamma) in peripheral blood mononuclear cells (PBMC) and skin biopsies of allogeneic BMT patients with GVHD and controls.
Owen-Schaub et al. (1991)IL-2bloodIL-2 dose regulates TNF-alpha mRNA transcription and protein secretion in human peripheral blood lymphocytes.
Koutouby et al. (1993)IL-2bloodHowever, some correlation was found between CsA blood levels and IL-2 mRNA levels.
Kuzuya et al. (2009)IL-2bloodWe measured the suppression of IL-2 mRNA expression in whole blood following the addition of a range of CsA concentrations by a real-time reverse transcription-polymerase chain reaction (RT-PCR) method.
Kuzuya et al. (2009)IL-2bloodOur data imply that measurement of IL-2 mRNA levels in whole blood could be valuable in monitoring CsA PD in transplant patients.
Conlon et al. (1995)lymphokinebloodComparison of lymphokine secretion and mRNA expression in the CD45RA+ and CD45RO+ subsets of human peripheral blood CD4+ and CD8+ lymphocytes.
Kuzuya et al. (2009)interleukin-2bloodEvaluation of interleukin-2 mRNA in whole blood as a parameter for monitoring cyclosporine pharmacodynamics.
Secrist et al. (1990-1991)IL-2bloodAfter PHA stimulation of peripheral blood, IL-2, IL-4, and IL-6 mRNA were expressed with similar kinetics: peak expression occurred after four hours and subsequently declined over 48 hr.
Carcelain et al. (2003)IL-2bloodRESULTS: At initiation of IL-2, TREC copies/microl of blood were correlated with naive T cell numbers and age.
Couzi et al. (2008)interleukin-2bloodMETHODS: Forty-one KTR given cyclosporine (n=18) or tacrolimus (n=23) were followed up every week during 1 month, then every month during 11 months, by measuring the patient's whole blood ability to inhibit interleukin-2 (IL-2) gene transcription and by measuring the patient's intracellular T-cell IL-2, interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) production in response to polyclonal activation.
Uçeyler et al. (2007)IL-2bloodMETHODS: In this prospective study, we analyzed blood mRNA and protein levels of the pro-inflammatory cytokines interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF) and the anti-inflammatory cytokines IL-4 and IL-10 in 32 patients with painful neuropathy, 20 patients with painless neuropathy, and 38 healthy control subjects, using quantitative real-time PCR and ELISA.
Grünig and Antczak (1995)interleukin 2bloodMessenger RNA for interleukin 2 (IL-2), interleukin 4 (IL-4), and interferon gamma (IFN gamma) was detected in endometrial tissues, unstimulated peripheral blood lymphocytes, and control kidney tissue, but not in trophoblasts. leukocytes resident in the endometrium or traversing the uterus via blood vessels might be the source of these cytokines.
Freudenreich et al. (2010)IL-2bloodIn a cross-sectional study, we used quantitative reverse-transcription polymerase chain reaction (RT-PCR) to compare the mRNA levels of IFN-gamma, TNF-alpha, IL-2, and IL-10 in peripheral blood mononuclear cells (PBMCs) between 15 schizophrenia patients and 15 matched healthy controls.
Afzelius and Nielsen (1997)IL-2bloodWe found no difference in levels of intracellular cAMP, IL-2 mRNA expression, IL-2R mRNA expression, or proliferative responses of PBMC from colon cancer patients compared to healthy blood donors.
Flores et al. (2004)IL-2BloodBlood was then either stained for CD3, IFN-gamma, IL-2, IL-4, and TNF-alpha and analyzed on a flow cytometer with various gating strategies, or submitted to RNA extraction for analysis of the above mentioned cytokines mRNA transcripts using TaqMan RT-PCR.
Uçeyler et al. (2007)interleukin-2bloodWe studied blood cytokine mRNA and protein levels of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF), interleukin-2 (IL-2) and IL-8 and the anti-inflammatory cytokines IL-4, IL-10, and transforming growth factor-beta1 (TGF beta 1) in 40 prospectively recruited patients with CRPS I, two patients with CRPS II, and 34 controls.
Uçeyler et al. (2007)IL-2bloodPatients with CRPS had higher blood TNF and IL-2 mRNA levels (p=0.005; p=0.04) and lower IL-8 mRNA levels (p<0.001) than controls.
Hassan and Reen (1994)IL-2bloodExpression of IL-2 mRNA by unstimulated and stimulated purified T cells and mononuclear cells from adult and cord blood was investigated in an attempt to better understand the underlying defective neonatal host immune defense system.
Lahat et al. (1999)IL-2bloodThe expression of IL-2 and IL-4 mRNA was not observed in peripheral blood samples from inactive CD patients associating them with disease activity.
Guillaume et al. (1994)IL-2bloodThese findings are consistent with the conclusion that: (a) multiple dysregulations exist in the production of cytokines important in immune homeostasis; (b) a defect occurs at or prior to the level of transcription of IL-2 mRNA; (c) IL-10 does not play a direct role in the pathogenesis of posttransplantation immunosuppression; and (d) there is no evidence that peripheral blood stem cells may be superior to bone marrow-derived stem cells in accelerating immune reconstitution.
Posadas et al. (2002)IL-2bloodIL-2, IL-4, IFN, TNF, perforin, granzyme B (GrB), and FasL mRNA expression levels were determined in peripheral blood mononuclear cells by competitive RT-PCR.
Esnault et al. (1996)IL-2bloodDifferential spontaneous expression of mRNA for IL-4, IL-10, IL-13, IL-2 and interferon-gamma (IFN-gamma) in peripheral blood mononuclear cells (PBMC) from atopic patients.
Saito et al. (1999)IL-2bloodSignificant positive correlations were observed between mean blood pressure and concentrations of the Th-1 type cytokines IL-2, IFN-gamma, and TNF-alpha.
Taubert et al. (2008)IL-2bloodPrimary infection was accompanied by an increase of IFN-gamma and IL-2 gene transcription in whole blood samples, peaking during prepatency (8-12 days p.i.) and declining thereafter, whereas IL-4 gene transcription was induced predominantly in patency.
Corrigan and Loke (2007)IL-2bloodFor example, elevated percentages of peripheral blood CD4, but not CD8 T cells from patients with exacerbation of asthma expressed mRNA encoding IL-3, IL-5 and GM-CSF but not IL-2 and IFN-?
Dheda et al. (2005)IL-4delta2bloodOBJECTIVE: To study levels of mRNA encoding IL-4 and IL-4delta2, and their relationship to treatment and clinical parameters, in cells from lung lavage and blood from patients with pulmonary tuberculosis.
Dheda et al. (2005)IL-4delta2bloodRESULTS: mRNA levels for IL-4 and IL-4delta2 were elevated in unstimulated cells from blood and lung lavage of patients versus control subjects (p < 0.005).