Viewing affirmative mentions of positive regulation of IL2 (H. sapiens) in lymphocytes

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Azogui et al. (1983)IL 2lymphocytesIrradiation of patients' lymphocytes in vitro with low dose gamma-rays partially restored the IL 2 production after 6 mo of evolution.
Mossalayi et al. (1986)IL2PBLThe same dose of Imuthiol also stimulated IL2 production by human PBL.
Silveira-Lacerda et al. (2010)IL-2lymphocytesFor the first time, we show that, at low concentration (10-100 microg L(-1)), the cis-[RuCl(2)(NH(3))(4)]Cl compound induces peripheral blood lymphocytes proliferation and also stimulates them to IL-2 production.
Kalashnikova and Pukhal'ski? (1993)interleukin-2lymphocytesDose-dependent modifying of mitogen-induced interleukin-2 (IL-2) release by human peripheral blood lymphocytes (PBL) treated with dexamethasone (Dx) was demonstrated.
Grote et al. (1987)IL-2lymphocyteThis degree of lymphocyte purity was important since phagocytes were inhibitory to 12-O-tetradecanoylphorbol 13-acetate/calcium ionophore (TPA/A23187)-induced IL-2 production when their concentration exceeded 15% of the total cells.
Yamamoto et al. (1985)Interleukin 2lymphocytesInterleukin 2 mRNA induction in human lymphocytes: analysis of the synergistic effect of a phorbol ester and phytohemagglutinin.
Yamamoto et al. (1985)IL2lymphocytesInduction of interleukin 2 (IL2) mRNA synthesis in human tonsillar lymphocytes was studied by quantifying the relative levels of IL2 mRNA in the lymphocytes stimulated under various conditions by the dot hybridization method.
Yamamoto et al. (1985)IL2 mRNAlymphocytesTwo-step culture experiments showed that prior exposure of the lymphocytes to TPA for 1 h at 37 degrees C resulted in a remarkable increase of IL2 mRNA on subsequent stimulation with PHA.
Efrat et al. (1984)interleukin-2lymphocytesStimulation of human lymphocytes with phytohemagglutinin results in the induction of messenger RNA encoding interleukin-2 (IL-2), a lymphokine possessing immuno-regulatory properties.
Valerio et al. (1994)TCGFlymphocytesThe effects of indomethacin on PHA-induced TCGF activity and the effects of adherent cells (macrophages) from group A and group C on TCGF production of normal group-matched non-adherent cells (lymphocytes) were also studied.
Nomori et al. (1985)TCGFPBLPBL activated with human T-cell growth factor (TCGF), lymphokine-activated killer (LAK) cells, significantly augmented the inhibition of colony formation of K562 cells, compared to the control lymphocytes.
Bartz et al. (1995)interleukin 2lymphocytesOne CsA analog with antiviral activity costimulated the phytohemagglutinin-induced production of interleukin 2 by human lymphocytes.
Galanis et al. (2004)IL-2lymphocytesLaboratory analysis of tumor samples revealed the presence of IL-2 plasmid DNA in six of eight patients posttreatment, increased IL-2 expression in tumor cells in four of eight patients posttreatment, and increased tumor infiltration by CD8-positive lymphocytes in five of eight patients posttreatment.
Lopez et al. (1991)interleukin-2lymphocytesThymic hormones have been shown to exhibit immunorestorative effects in vivo and in vitro, and to enhance the expression of high affinity interleukin-2 (IL-2) receptors on normal human lymphocytes stimulated with phytohemagglutinin.
Hu et al. (1990)IL-2lymphocytesThe results show that PA in a concentration range from 0.01 to 100 micrograms/ml obviously augmented in vitro IL-2 production, IL-2 receptor expression and responsiveness to IL-2 of human lymphocytes in the presence of PHA, and that these enhancing effects of PA were dose-dependent.
Chen et al. (1994)interleukin-2lymphocytesGlutathione increases interleukin-2 production in human lymphocytes.
Chen et al. (1994)IL-2PBLIL-2 production from PBL was markedly increased at the presence of exogenous GSH (0.5-8 mmol/l) or 2-ME (12.5-50 mumol/l) which corresponded to 1.57-2.82 nmol/10(6) cells and 1.41 - 1.80 nmol/10(6) cells of intracellular concentrations of GSH, respectively.
Kubbies et al. (1990)IL-2lymphocyteThese data indicate that increased IL-2 levels are probably due to increased cell activation rates but are not the primary cause of improvement of human lymphocyte proliferation.
Wiranowska-Stewart and Hadden (1986)IL-2lymphocytesBoth drugs were found to have significant enhancing activity on PHA induction of IL-2 by human lymphocytes over a wide range of concentrations.
Wiranowska-Stewart and Hadden (1986)IL-2lymphocyteThe actions of these compounds to enhance IL-2 production may explain their effects on PHA-induced lymphocyte proliferation.
Devi and Das (1994)IL-2lymphocytesInterestingly, the production of the lymphokine Interleukin-2 (IL-2) was elevated in Molt-4 cells, but it was reduced in the normal human lymphocytes.
Rola-Pleszczynski et al. (1986)IL-2lymphocytesInterleukin 2 (IL-2) and interferon-gamma (IFN) production by human lymphocytes was significantly enhanced in the presence of leukotriene B4 (LTB4) and indomethacin.
Hayakawa et al. (1990)IL-2lymphocyteThe same culture method also induced an increase in OKT3 and IL-2 receptor positive lymphocyte population in LAK cells and TIL.
Johnson and Magazine (1988)IL 2lymphocyteThe data indicate that the induction of IL 2, but not IFN gamma, is a requirement for SEA induced lymphocyte proliferation.
Dornand et al. (1986)IL 2lymphocytesMoreover, in this concentration range, ouabain stimulated in a dose-dependent manner the accumulation of IL 2 in the supernatant of Con A-stimulated lymphocytes (optimum for 0.05 microM corresponding to half inhibition of lymphocyte proliferation).
McGrath et al. (1987)interleukin-2lymphocytePhytohemagglutinin (PHA)-stimulated lymphocyte production of interleukin-2 (IL-2) increased significantly in the combined RA and normal groups.
Creemers et al. (1986)interleukin-2lymphocytesIncreased interleukin-2 receptor expression after mitogen stimulation on CD4- and CD8-positive lymphocytes and decreased interleukin-2 production in HTLV-III antibody-positive symptomatic individuals.
Zunich and Kirkpatrick (1988)interleukin-2lymphocytesIncreases in interleukin-2 receptor expression were seen on lymphocytes collected on one occasion from each of two patients 30 min postinfusion.
Yamamoto et al. (1985)Interleukin 2lymphocytesInterleukin 2 mRNA induction in human lymphocytes: analysis of the synergistic effect of a calcium ionophore A23187 and a phorbol ester.
Yamamoto et al. (1985)IL2lymphocytesInduction of interleukin 2 (IL2) mRNA in human tonsillar lymphocytes under various conditions was examined by cytoplasmic dot hybridization using a 32P-labeled IL2 cDNA probe to study the signal transduction mechanisms which lead to IL2 gene expression.
Yamaue et al. (1994)interleukin-2lymphocytesEnhanced interleukin-2 production in human tumor-infiltrating lymphocytes engineered by 3'-truncated interleukin-2 gene.
Sarna et al. (1994)IL-2TDLNK activity and phenotype and LAK activity increased in response to IL-2, with no advantage for TDL.
Devi and Das (1993)IL-2lymphocytesThe IL-2 level was also enhanced in the Molt-4 but inhibited in normal lymphocytes.
Pack et al. (2002)IL-2HPBLLA dramatically increased the induction of IL-2 mRNA and IL-2 protein secretion in PMA/IoM-stimulated HPBL, whereas it inhibited these in HPBL stimulated with PHA.
Nagel et al. (1988)IL2lymphocytesThe results suggest that decreased expression of both IL2 and IL2R mRNA contributes to the low synthesis of IL2 and membrane IL2R, respectively, and is partially responsible for the diminished proliferative activity observed in lymphocytes from the elderly.
Noma et al. (1990)IL2lymphocytesThe induction of OVA-specific IL2 responsiveness in patient lymphocytes was markedly suppressed on the addition of culture supernatant from OVA-stimulated normal T cells, but Df-specific IL2 responsiveness of the lymphocytes from Df-sensitized patients with bronchial asthma was not suppressed by the same supernatant.
Noma et al. (1990)IL2lymphocytesThese observations suggest that the culture supernatant of normal T lymphocytes stimulated with OVA contained an antigen-specific factor suppressing the induction of IL2 responsiveness of OVA-stimulated patient lymphocytes.
Tadmori et al. (1986)IL 2lymphocyteAntibody 9.6, added during the first 4 hr after lymphocyte stimulation, markedly inhibited IL 2 mRNA accumulation induced by low but synergistic combination of PHA (5 micrograms/ml) and TPA (1.0 ng/ml).
Hirano et al. (1984)interleukin 2 mRNAlymphocytesPhorbol ester increases the level of interleukin 2 mRNA in mitogen-stimulated human lymphocytes.
Gramatzki et al. (1985)IL-2lymphocytesCharacterization of cell lines enhancing IL-2 production by human phytohemagglutinin-stimulated lymphocytes.
Zehavi-Willner and Shalit (1989)interleukin-2lymphocytesEnhancement of interleukin-2 production in human lymphocytes by two new quinolone derivatives.
Zehavi-Willner and Shalit (1989)IL-2PBLBoth antimicrobial agents markedly increased IL-2 production in PHA-stimulated PBL cultures.
Haregewoin et al. (1985)IL-2lymphocytesStudies of the composition of lymphocytes in dermal infiltrates subsequent to injection of killed M. leprae revealed that in both tuberculoid and lepromatous patients, early accumulation of cell staining for both IL-2 receptor and IL-2 were seen.
Jooné et al. (2003)IL-2lymphocytesMechanistic studies revealed that stimulation of the proliferative response of lymphocytes by oxihumate is associated with an increased production of IL-2, as well as expression of the IL-2 receptor in the setting of decreased production of IL-10.
Müller-Quernheim et al. (1996)interleukin 2lymphocytesThere is mounting evidence that activated interleukin 2 (IL-2)-releasing lymphocytes play a central role in the immunopathogenesis of sarcoidosis by directing inflammatory reactions and granuloma formation.
Ridgway and Borzy (1989)interleukin-2lymphocytesElevated production of interleukin-2 by lymphocytes from children with acute leukemia.
Mori et al. (1989)IL-2lymphocytesThere was a significant correlation (p less than 0.05) between the P. acnes-induced production of IL-2 by alveolar lymphocytes and the blastogenesis of alveolar lymphocytes in untreated sarcoidosis patients.
Mori et al. (1989)IL-2lymphocytesOur data indicate that P. acnes stimulates IL-2 production and IL-2 receptor induction in alveolar lymphocytes from patients with active sarcoidosis.
Huang et al. (1987)interleukin-2LymphocytesLymphocytes from patients with recurrent disease showed elevated interleukin-2 (IL-2) production and a tendency towards increased response to mitogens in comparison to those without recurrence.
Huang et al. (1987)IL-2lymphocytesThus, elevated IL-2 synthesis in pretreatment lymphocytes predicts a poorer prognosis.
Oudrhiri et al. (1985)IL 2lymphocytesMechanism of accessory cell requirement in inducing IL 2 responsiveness by human T4 lymphocytes that generate colonies under PHA stimulation.
Praditpornsilpa et al. (2003)IL-2lymphocyteUpregulation of IL-2 but not IL-15 by allorecognition in human mixed lymphocyte culture.
Yamamoto et al. (1986)IL2 mRNAlymphocytesProstaglandin E2, which is known to elevate intracellular cAMP level, also inhibited IL2 mRNA induction in the lymphocytes stimulated with PHA and TPA.
Yamamoto et al. (1986)IL2 mRNAlymphocytesAddition of alpha-methylornithine and methylglyoxal bis (guanyl hydrazone), which inhibit polyamine synthesis, did not affect the induction of IL2 mRNA in the lymphocytes stimulated with PHA and TPA, indicating that polyamine synthesis is not necessary for IL2 mRNA induction.
Schnorr et al. (2001)IL-2lymphocytesIn both vaccine groups, peripheral blood lymphocytes isolated at 6 and 24 weeks after vaccination showed significantly higher expression of activation markers upon in vitro stimulation, and a sustained increase in IL-2 production.
Otterness and Bliven (1982)IL-2lymphocyteIts immunosuppressive effects might therefore be explained by an inhibition of some initial step of lymphocyte activation which interferes with the T lymphocyte's ability to progress on to cell division and IL-2 production after stimulation.
Ye et al. (2001)IL-2 genePBLsRESULTS: The morphology of IL-2-transduced 3AO and IL-2R-transduced PBLs remained unchanged. 3AO cells could be transfected with the IL-2 gene and expressed IL-2 mRNA, and PBLs could be transfected with the IL-2R gene and expressed IL-2R mRNA.
Isacson et al. (1992)IL-2lymphocytesThe only prognostic parameter was the greater increase in the level of IL-2 receptor (Tac)-bearing lymphocytes in the responding patients after 1-3 cycles of IL-2.
Bowlin and Sunkara (1988)interleukin 2lymphocytesSwainsonine, an inhibitor of glycoprotein processing, enhances mitogen induced interleukin 2 production and receptor expression in human lymphocytes.
Bowlin and Sunkara (1988)IL-2lymphocyteSwainsonine, an inhibitor of mannosidase II, enhanced Con A induced lymphocyte IL-2 receptor expression, IL-2 production, and proliferation.
Bauer et al. (2000)IL-2lymphocyteIn addition, caregivers had blunted mitogen-induced lymphocyte proliferation, lower mitogen-induced IL-2 production, and reduced lymphocyte sensitivity to glucocorticoids.
Zeitz et al. (1989)IL-2lymphocytesHigh mitogen-stimulated IL-2 production of lamina propria lymphocytes was only partially inhibited in CsA-treated animals.
Kawakami et al. (1989)IL-2lymphocytesIL-4 regulates IL-2 induction of lymphokine-activated killer activity from human lymphocytes.
James and Graeff (1987)IL-2lymphocytesAlthough Leu-2+ lymphocytes in the lamina propria had increased IL-2 receptor expression, suppressor function of lamina propria T cells was similar to that of spleen cells, and was not enhanced by addition of exogenous IL-2.
Schiller et al. (1993)IL-2lymphocyteSignificant increases in lymphocyte-activated killer cell cytotoxicity, antibody cellular cytotoxicity, and serum IL-2 receptor were also observed following both IL-2 and IL-2 plus IFN-alpha.
Singh et al. (1992)IL-2lymphocyteThe effects of purified protein A from Staphylococcus aureus Cowan I stain on induction of lymphokine (IL-2) activated killer (LAK) activity were studied in normal as well as melanoma patient's lymphocyte.
Colquhoun et al. (1993)IL-2lymphocytesIL-4 inhibits IL-2 induction of LAK cytotoxicity in lymphocytes from a variety of lymphoid tissues.
Bub et al. (2003)Interleukin-2lymphocytesInterleukin-2 secretion by activated lymphocytes and the lytic activity of natural killer cells were significantly increased by both juices.
Jelínková et al. (2000)interleukin-2lymphocyteInterestingly, the concentration of circulating soluble interleukin-2 receptors, molecules indicating lymphocyte activation, was only increased in sera from patients with active celiac disease (2943.0 +/- 214.1 pg/ml), and the level in sera from treated patients and healthy controls was comparable (1936 +/- 349 and 1416 +/- 111.7 pg/ml).
Chrul et al. (2000)IL-2lymphocytesThe aim of the study was to estimate whether an elevated serum concentration of soluble interleukin-2 receptor (sIL-2R) is caused by increased expression of IL-2 receptors on the surface of lymphocytes T (CD3+CD25+). 20 children with lipoid nephrosis and 15 healthy children served as control were evaluated.
Sugimoto et al. (1989)IL-2lymphocyteIn the present study, we investigated 18 patients with HAM: five HTLV-I carriers without myelopathy and 13 normal control subjects seronegative for HTLV-I to determine if soluble IL-2 receptors (IL-2R), a marker of lymphocyte activation, were increased in serum and bronchoalveolar lavage (BAL) fluid from HAM patients.
Sugimoto et al. (1989)IL-2lymphocyteIn the present study, we investigated 13 patients with HAM to determine if they showed increased levels of soluble IL-2 receptors, a marker of lymphocyte activation, in bronchoalveolar lavage (BAL) fluid.
Selmaj et al. (1986)interleukin-2lymphocytesMultiple sclerosis: increased expression of interleukin-2 receptors on lymphocytes.
Sterkers et al. (1983)IL 2lymphocytesThese results suggest that a) different epitopes of the DR molecule can be involved during responses to influenza viruses and allogeneic antigens; b) the epitope recognized by L1-16 on the beta-chain of the DR molecule seem necessary for IL 2 production by lymphocytes after activation with influenza antigens; and c) class I-specific MoAb block DR-restricted proliferative responses of lymphocytes by an as yet unknown mechanism.
Yamakido et al. (1986)IL-2lymphocyteWhen N-CWS was administered to poison gas workers, IL-2 production and lymphocyte proliferation were significantly elevated, with a peak two weeks after administration.
Yamakido et al. (1986)IL-2lymphocytesN-CWS, by elevating IL-2 production of lymphocytes, is considered to have improved the depression of lymphocyte proliferation.
Yang et al. (2000)IL-2lymphocyteT lymphocyte activation is highlighted by the induction of interleukin-2 (IL-2) gene expression, which governs much of the early lymphocyte proliferation responses.
Noma et al. (1990)IL-2lymphocytesThe combined data indicate that induction of IL-2 responsiveness of peripheral blood lymphocytes on stimulation with nominal antigen may reflect an immune response to allergen in patients with allergy and a weak immunosuppressive effect of Ketotifen seems to block the response in the pathogenic process of allergic diseases.
Szamel et al. (1990)interleukin 2lymphocytesActivation signals in human lymphocytes: interleukin 2 synthesis and expression of high affinity interleukin 2 receptors require differential signalling for the activation of protein kinase C.
Szamel et al. (1990)interleukin 2lymphocytesWhile for synthesis and expression of interleukin 2 receptors a short term activation of protein kinase C is sufficient, long-term activation of the enzyme is necessary for interleukin 2 synthesis in human lymphocytes.
Podwi?ska et al. (1995)IL-2lymphocytesAbsorption of adherent cells from PBMC increased the ability of lymphocytes to produce IL-2.
Sia (1988)IL-2lymphocytesHigher levels of surface expression of the IL-2 binding sites on SA1.4 and SA1.23 as compared to the other clones are observed throughout the 7-day culture period that these lymphocytes are maintained in exogenous IL-2.
Georgoulias et al. (1986)IL2lymphocytesTCPA-containing LCM induced the expression of functional IL2-R and IL2 release by normal resting lymphocytes.
Wagner et al. (1998)IL2lymphocyteWhereas the presence of a lymphocyte infiltrate in tissue samples was associated with a TH1 cytokine mRNA profile (TNF-alpha, INF-gamma, IL12p35, IL12p40, IL2Rbeta, and IL2Rgamma), clinically and histologically regressive samples exhibited additionally increased transcript levels for GM-CSF, IL2, and IL15. mRNAs of TH2 cytokines IL4 and IL5 were detected only in a minor portion of progressive melanoma samples and regressive melanoma lesions.
Yoshizawa et al. (1994)IL2lymphocytesThe effect of oxatomide-treatment on the induction of IL2 responsiveness by Df-stimulated lymphocytes was studied in patients with bronchial asthma.
Hornicek et al. (1988)interleukin-2lymphocyteAlthough periodate oxidation stimulated nucleic acid synthesis and interleukin-2 production, no changes in phosphoinositide turnover could be detected when compared to control lymphocyte cultures.
Sekkat et al. (1988)IL-2PBLIrradiation (20 Gy), which enhances IL-2 synthesis by activated T-enriched PBL and Jurkat cells, also increases oxidative product formation, K+ flux, cGMP production, and induces cell membrane depolarization.