Viewing affirmative mentions of positive regulation of IL2 (H. sapiens) in monocytes

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Ulmer and Flad (1982)Il-2monocytesDose-response experiments with various numbers of monocytes added to the system showed the following: the higher the density of a cell population, the higher the number of monocytes required for help in the stimulation of Il-2 production.
Klein et al. (1983)IL2monocytesThis combined with the fact that IL2 participates in T colony formation suggests that monocytes induce T colony formation through IL2 production.
Roosnek et al. (1985)IL2monocyteThus, analogous to induction of IL2 production, the acquisition of responsiveness to IL2 can be completely monocyte dependent, but a 10-fold increase in lectin concentration completely abolishes the requirement for accessory cells.
Tsuchida and Sakane (1988)IL-2monocyteActivation signal requirements for the induction of the IL-2 responsiveness in purified subsets of human resting T cells, T4+ or T8+, have been investigated under the monocyte-depleted conditions.
Misago et al. (1993)IL-2monocytesIn addition, the expression of IL-2 receptor (CD25) on monocytes was more enhanced in cultures containing IL-2 than in cultures without IL-2.
Vakkila and Hurme (1990)IL-2monocytesWe studied the mechanisms by which human blood-derived dendritic cells (DC) and monocytes induce IL-2R and stimulate IL-2 secretion in autologous and allogeneic mixed luecocyte reaction (auto- and allo-MLR, respectively).
Jacobson et al. (1996)IL-2monocytesHowever, delayed type hypersensitivity responses to common recall antigens were markedly augmented, and there were IL-2 dose-dependent increases in circulating Natural Killer cells, eosinophils, monocytes, and CD4+ T cells.
Ellner (1991)interleukin-2monocytesIncreased expression and release of interleukin-2 receptors and transforming growth-factor beta are associated with and may contribute to such suppression by monocytes.
Zabel et al. (1990)IL 2monocytesIn the interferon group we found measurable gamma-interferon serum levels, an increase in the spontaneous production of IL 2 by peripheral lymphocytes, and an increase in the spontaneous production of IL 1 and an in the phagocytic capacity of monocytes.
Kitas et al. (1988)IL-2MonocyteMonocyte depletion and partial reconstitution resulted in an increase of both proliferation and IL-2 production, which was more marked in RA patients, suggesting that depressed IL-2 production may relate in part to monocyte effects.
Holter et al. (1986)IL 2monocytesThe present report describes the inducibility of IL 2 receptors on human peripheral blood monocytes.
Liao et al. (1995)Interleukin 2monocytesInterleukin 2 (IL-2) activity of peripheral blood monocytes (PBMC) stimulated by PHA was increased significantly in the patients treated with ES.
Ennen et al. (1989)IL 2monocytesThe priming of monocytes by IL 2 was dependent on the interaction of IL 2 with the monocytic IL 2 receptor, as shown by inhibition experiments with anti-IL 2 receptor monoclonal antibodies.
Ennen et al. (1991)IL 2monocytesThe priming of monocytes by IL 2 was dependent on the interaction of IL 2 with the monocytic IL 2 receptor as shown by inhibition experiments with anti IL 2 R monoclonal antibody.
Ennen et al. (1991)interleukin 2monocytesThe effect of interleukin 2 (IL2) on the capability of human monocytes to secrete reactive oxygen species triggered via Fc-gamma receptor (Fc-gamma R) function had been investigated by measurement of chemiluminescence (CL).
Vakkila and Hurme (1990)IL-2monocytesThe stimulatory properties of monocytes were more complicated: although they stimulated the proliferation in allogeneic MLR, the proliferation rates, duration, and amount of IL-2 secretion were different than in DC-induced MLR.
Flescher et al. (1989)IL-2monocyteThree PAO inhibitors have an enhancing effect on IL-2 production which is again monocyte dependent.
Nakabo and Pabst (1998)IL-2MonocytesMonocytes, purified by elutriation and adherence, were activated with IL-2 or interferon-gamma (IFN-gamma) in the presence or absence of sphingosine or another inhibitor for 18 h.
Guinan et al. (1989)IL-2monocytesEC, but not DF or blood monocytes, could markedly augment IL-2 concentrations, up to 30-fold or more.
Strieter et al. (1989)IL-2PBMAM phi exhibited statistically greater (p less than 0.05) TNF production in response to both IL-2 and LPS as compared to PBM.
Ruscetti et al. (1980)TCGFmonocyteThese results suggest that TCGF production: a) requires protein synthesis; b) requires binding of the stimulating agent; c) can occur in a non-dividing cell, probably a terminally differentiated T-cell, without the need for cellular proliferation; and d) needs the assistance of an adherent cell which probably is a monocyte-macrophage.
Janský et al. (1996)IL2monocytesWith the continuation of the cold water immersions (three times a week for a duration of 6 weeks) a small, but significant, increase in the proportions of monocytes, lymphocytes with expressed IL2 receptors (CD25) and in plasma tumour necrosis factor alpha content was induced.
Roosnek et al. (1985)IL 2monocytesFurthermore, after depletion of monocytes IL 2 production by peripheral T cells became almost completely dependent on the presence of thiols in the culture medium.
Wahl et al. (1987)interleukin 2MonocyteMonocyte interleukin 2 receptor gene expression and interleukin 2 augmentation of microbicidal activity.
Wahl et al. (1987)IL 2monocytesWe used cDNA encoding for the human IL 2 receptor to evaluate IL 2 receptor gene expression in resting and activated monocytes.
Bosco et al. (1994)IL-2monocytesFinally, the augmented expression of IL-2R gamma in IL-2- and IFN gamma-treated monocytes was associated with an increased IL-2-binding activity, compared with that of unstimulated cells.
Sanarico et al. (2006)IL-2monocytesDCs differentiated in the presence of IL-2 secreted significantly more IL-1beta, TNF-alpha, and IL-12 p70 in response to lipopolysaccharide stimulation and induced allogeneic, naïve T cells to release a significantly higher amount of interferon-gamma if compared with DCs obtained by culturing monocytes with GM-CSF and IL-4.
Triozzi et al. (1991)interleukin-2monocytesBoth methods of depleting monocytes enhanced interleukin-2 (IL-2) driven, LAK-cell expansion; LAK expansion, however, was significantly greater after depletion with NWA than after PME.
Garcia-Mauriño et al. (1997)IL-2monocytesWe have also achieved enhanced production of IL-2 and IL-6 using CGP 52608, a specific ligand of the putative nuclear melatonin receptor RZR/ROR, raising the possibility of direct effects of melatonin on gene regulation in both Th1 cells and monocytes.
Espinoza-Delgado et al. (1990)IL-2monocytesStimulation of monocytes with IL-2 induced a significant increase in c-fms mRNA relative to medium control that was observed as early as 6 h after IL-2 stimulation.
Chouaib and Fradelizi (1982)IL2monocytesOn the other hands in humane inhibition of IL2 production was also mediated by an excess of monocytes.
Herrmann et al. (1985)interleukin 2monocytesGamma interferon induced surface expression of interleukin 2 (IL-2) receptors on normal human monocytes and the monocytoid cell lines U937 and HL60.
Childerstone et al. (1989)IL2monocytesThe results suggest that epitope-linked clusters of monocytes, TT-sensitized CD4 and SP-sensitized CD4 cells enable IL2 released by the TT-sensitized CD4 cells to stimulate the SP-sensitized CD4 cells that produce inadequate amounts of IL2.
Herrmann et al. (1989)IL-2monocyteFunctional consequences of monocyte IL-2 receptor expression.
Sodhi and Basu (1992)interleukin-2monocytesRole of human blood monocytes in up-regulation of lymphokine (interleukin-2)-activated killer cell activity with cisplatin and FK-565.
Zatz et al. (1985)IL-2monocyteAugmentation of IL-2 production by aspirin and/or TF5 was prevented by monocyte depletion of the PBL population.
Zatz et al. (1985)IL-2monocyteThese results are interpreted as demonstrating (a) that TF5 and aspirin augment, by distinct mechanisms, IL-2 production by normal human PBL, (b) that the effects of both of these agents are mediated directly or indirectly via a monocyte population and (c) that aspirin, in addition to its analgesic and anti-inflammatory properties, may act as a modulator of immunological responsiveness, either alone or in combination with other biological response modifiers such as thymosin.
de Faucal et al. (1984)IL2monocytesThese data suggest that, in SLE, the inhibition of IL2 production is mediated by prostaglandin, possibly produced by monocytes.
Petersen et al. (1987)IL-2monocyteIt is concluded that high-affinity receptors mediate binding, uptake and degradation of IL-2 in activated human T- and B-lymphocytes and in monocyte-macrophages.
Nii et al. (1988)IL-2monocytesStudies were made to determine whether freshly isolated monocytes from healthy donors could influence the induction of lymphokine (IL-2)-activated killer (LAK) activity.
Nii et al. (1988)IL-2monocytesUp- and down-regulation of human lymphokine (IL-2)-activated killer cell induction by monocytes, depending on their functional state.
Epling-Burnette et al. (1993)IL-2MonocytesMonocytes were also found to release GM-CSF in response to IL-2 using a CSF-dependent cell line, Mo7e.
Espinoza-Delgado et al. (1994)interleukin-2monocyteInhibitory cytokine circuits involving transforming growth factor-beta, interferon-gamma, and interleukin-2 in human monocyte activation.
Hellstrand et al. (1993)IL-2MonocytesMonocytes, recovered directly from peripheral blood by counter-current centrifugal elutriation (CCE), were shown to provide two regulatory signals for induction of interferon-gamma (IFN-gamma) in natural killer (NK) cells in response to interleukin-2 (IL-2): an upregulating signal and an inhibitory signal.
Rambaldi et al. (1987)IL2monocytesInterferon-gamma induces surface expression of interleukin 2 (IL2) receptors on human monocytes and the monocytic cell line U937.
Meuer et al. (1987)interleukin 2monocyteThis defect results in a lack of interleukin 2 production, which is critically dependent on a monocyte-derived signal.
Bosco et al. (2000)IL-2-inducedmonocytesIncubation of monocytes with the PTK inhibitor herbimycin A (HA) resulted in the dose-dependent suppression of IL-2-induced monocyte tumoricidal activity.
Granelli-Piperno et al. (1989)IL-2monocytesSepharose anti-CD3 did not induce IL-2, although the levels of IL-2 protein and mRNA were 10 to 30 times higher with PMA than with monocytes.
Granelli-Piperno et al. (1989)IL-2monocytesSepharose conjugated anti-CD3, monocytes, and PMA each could induce the p55 component of the IL-2R as well as responsiveness to exogenous IL-2.
Strieter et al. (1989)interleukin-2PBMIn this study, we demonstrate that human AM phi, as well as PBM, can be induced to express biologically active TNF-alpha after challenge with interleukin-2 (IL-2).
Numerof et al. (1988)IL-2monocytesIn addition, Leu M3+ monocytes obtained through FACS, but not CD16+ NK cells, produced both IL-1 alpha and IL-1 beta in response to IL-2.
Allen et al. (1990)interleukin 2monocyteExpression of interleukin 2 receptors by monocytes from patients with acquired immunodeficiency syndrome and induction of monocyte interleukin 2 receptors by human immunodeficiency virus in vitro.
Wahl et al. (1987)interleukin 2monocytesActivation of human peripheral blood monocytes results in the expression of interleukin 2 (IL 2) receptors, which are absent on resting monocytes.
Verwilghen et al. (1990)IL2monocyteIL2 responsiveness could be induced with immobilized anti-CD5 mAb in cultures of purified T cells, but was enhanced by the addition of monocytes, by monocyte culture supernatant, or by the combination of IL1 and IL6.
Hashimoto et al. (1991)IL-2monocytesWith ionomycin, monocytes play a role, in part, in inducing IL-2 production, IL-2R expression and proliferation.
Maestroni (1999)IL-2monocytesThe finding that MLT stimulates IL-12 production from human monocytes only if incubated in presence of IL-2 further supports this concept.
Holter et al. (1987)IL 2monocyteThis response as well as the observed induction of monocytic IL 2 receptors by LPS may point to a functional role for this receptor during monocyte/macrophage responses to microbial infections.
Toossi et al. (1990)IL 2monocytesDepletion of adherent monocytes increased the IL 2 activity of supernatants of PPD-stimulated T cell cultures from patients by 30-fold.
Kovacs et al. (1989)IL-2monocytesIL-2 induction of IL-1 beta mRNA expression in monocytes.
Granelli-Piperno et al. (1989)IL-2monocytesTo pursue the functional relevance of the "supraoptimal" levels of IL-2 that are induced by PMA, anti-CD3-induced lymphoblasts were isolated free of monocytes and challenged with lymphokines.
Vecchiarelli et al. (1998)IL-2monocytesAddition of a monoclonal antibody which binds the Cryptococcus neoformans capsule to suspensions of human monocytes, T lymphocytes, and cryptococcal cells (i) enhances interleukin-1beta (IL-1beta), tumor necrosis factor alpha, and IL-2 production; (ii) reduces IL-10 secretion; and (iii) promotes T-cell proliferation.
Chen and Dong (1997)IL-2monocytesThe highest IL-2 induced cytotoxicity of monocytes was found in those pretreated with PWM.
Malec et al. (1988)IL-2monocytesThe single VER dose induced a significant, but transient increase in T, T helper, T suppressor lymphocytes and monocytes, and decrease in IL-1 and IL-2 generation as well as diminished Tac antigen expression.
Wahl et al. (1984)lymphokinemonocytesT-Lymphocyte fractions were unable to respond to antigen challenge, but both proliferation and lymphokine production could be restored by the addition of monocytes.
Hammerstrøm (1979)LymphokinemonocytesLymphokine activation did not induce additional LPS responsiveness in the monocytes.
Hammerstrøm (1979)lymphokinemonocyteWhile LPS is ineffective as an induction signal of monocyte cytotoxicity to tumour cells in this system, it enhances the expression of cytotoxicity induced by prolonged in vitro culture or lymphokine activation.
Schäfer et al. (1992)interleukin-2monocyteHuman choriogonadotropin (hCG) and placental lactogen (hPL) inhibit interleukin-2 (IL-2) and increase interleukin-1 beta (IL-1 beta), -6 (IL-6) and tumor necrosis factor (TNF-alpha) expression in monocyte cell cultures.
Ribbens et al. (2000)interleukin-2monocytesCD40-CD40 ligand (CD154) engagement is required but may not be sufficient for human T helper 1 cell induction of interleukin-2- or interleukin-15-driven, contact-dependent, interleukin-1beta production by monocytes.
Rocklin et al. (1986)lymphokinemonocytesWe previously have found that monocytes from patients with allergic rhinitis and/or asthma produce less PGE2 than cells from normal subjects in response to a histamine-induced lymphokine.
Atkins et al. (1978)lymphokinemonocytesNo evidence was found that Ag-antibody complexes or (in the case of sensitized monocytes) cytophilic antibodies play a role in the activity of this lymphokine which appears to act selectively on monocytes rather than on granulocytes.
Zaitseva et al. (1995)IL-2 mRNAmonocytesFollowing depletion of monocytes and B cells, B. abortus increased IFN-gamma and IL-2 mRNA expression in purified T cells compared with expression in unstimulated cells.
Umetsu et al. (1987)IL-2monocytesThis IL-2-inductive signal can be delivered by both Leu-4 nonresponder and Leu-4 responder monocytes, indicating that delivery of this IL-2 inductive signal is independent of anti-CD3 mAb binding by monocytes.
Bettens et al. (1990)IL2monocyteIL2 production induced by soluble monocyte products was measured in CD4 and CD8 T cells as specific IL2 mRNA expression and with a biological assay.
Mangan et al. (1992)IL-2monocytesIn this study, we show that EP promotes the survival of monocytes by blocking programmed cell death (apoptosis), enhancing the production of the immunostimulatory cytokine interleukin-1 (IL-1) and stimulating the increased expression of HLA-DR and IL-2 receptors, which are cell membrane proteins that facilitate antigen presentation and IL-2 regulation, respectively.
Cruikshank et al. (1987)LymphokinemonocytesLymphokine activation of T4+ T lymphocytes and monocytes.
Guarcello et al. (1990)IL-2PBMCWhile only a pharmacological concentration (10(-5) M) of PS significantly increased IL-2 receptor expression in activated human PBMC, simultaneous treatment of PBMC with inactive doses of PS and the pharmacological activator of PKC (phorbol myristate acetate, PMA, 10(-8) M) resulted in a synergistic stimulation of Tac+ cells.
Chatila et al. (1987)interleukin 2monocytesSuch preparations fail to respond to optimal concentrations of the lectin phytohemagglutin (PHA) or interleukin 2 (IL-2), indicating the functional depletion of monocytes (Mo.) and of activated T cells, respectively.
Rinnooy Kan et al. (1986)IL-2monocytesSuch depleted monocytes exhibit a fourfold reduction in their ability to promote both internalization of T3 and production of IL-2.
Matsubara et al. (1995)IL-2PBMIn a patient receiving PP only, PBM IL-2 production increased again and PBM IL-1 beta production maintained the high value through the next day.
Gregory and Edgington (1985)lymphokinemonocyteSome T cell clones mediated PCA induction exclusively by lymphokine production, whereas other clones delivered induction signals by direct cellular collaboration with the monocyte effector cells.
Amento et al. (1985)interleukin 2monocyteInterleukin 1 production by the human monocyte cell line U937 requires a lymphokine induction signal distinct from interleukin 2 or interferons.
Flescher et al. (1991)IL-2monocytesWe found that ALD enhanced the proliferation and IL-2 production of T cells in the absence of monocytes.