Viewing affirmative mentions of regulation of IL2 (H. sapiens) in NK cells

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Toossi et al. (1989)interleukin 2large granular lymphocytesRegulation of human T-cell production of interleukin 2 by Leu 11 (CD16) positive large granular lymphocytes.
Yamauchi and Bloom (1993)IL-2NK cellsThe results suggest that (1) L-cystine or thiol containing compounds such as L-cysteine, 2-ME, or GSH are necessary for effective IL-2-activation of human NK cells, (2) these compounds must be functional proton-donors, i.e., reducing agents, implying regulation of the IL-2 activation pathway by oxidation-reduction, and (3) GSH synthesis is necessary for the activation.
Kasahara et al. (1983)IL 2LGLAn atypical T cell subset (OKT3-, Leu-1-, OKT11+) rather than the myeloid subset of LGL (Leu-M1+ or OKMI+) was the source of LGL-derived IL 2, whereas the latter subset and/or another subset of OKT8+ cells appear to regulate this IL 2 production.
Serrate et al. (1987)interleukin 2natural killer cellModulation of human natural killer cell cytotoxic activity, lymphokine production, and interleukin 2 receptor expression by thymic hormones.
Almallah et al. (2000)IL2NK cellThe aim of this study therefore was to evaluate the possible mechanism(s) involved in this inhibition, and in particular the alteration of production of interleukin 2 (IL2) and the arachidonic acid metabolite leukotriene B4 (LTB4), both known to modulate NK cell activity.
Casale et al. (1992)IL2NK cellsIn the present study, we assessed the effects of carbaryl (CA, an antiCHE insecticide) and alpha-naphthol (NA, the major metabolite of CA) on both target cell killing per se and IL2 enhancement of target cell killing by human NK cells.
Hellstrand and Hermodsson (1990)IL-2NK cellThe effects of histamine on baseline NKCC and on NK cell responsiveness to IL-2 were related to counteraction of monocyte-mediated NK cell suppression.
Piccolella et al. (1986)interleukin-2natural killer cellEffects of dexamethasone on human natural killer cell cytotoxicity, interferon production, and interleukin-2 receptor expression induced by microbial antigens.
Lissoni et al. (1994)IL-2NK cellOn this basis, we have evaluated the influence of low-dose IL-2 on lymphocyte and NK cell numbers in cancer patients treated with the anthracycline drug, epirubicin.
Clark et al. (2000)IL-2NK cellsHere we investigate the effects of local cationic lipid-mediated IL-2 gene transfer on intratumoral accumulation and activation of NK cells in a SCID mouse tumor model.
Rey et al. (1984)interleukin 2natural killer cellsTheir relation with interleukin 2 activity production and natural killer cells in cancer patients.
Smyth and Ortaldo (1991)IL-2large granular lymphocytesThe effects of IL-6 and IL-2 on highly purified, human peripheral blood large granular lymphocytes (LGL) were investigated and compared.
Paliard et al. (1989)IL-2NK cellMost of the TCR alpha beta+ and TCR gamma delta+ CTL-clones isolated in IL-2 lysed the NK cell sensitive target cell K562.
Yoon et al. (1990)interleukin-2LGLWe studied the role of interleukin-2 (IL-2) receptor subunits in the activation of leukemic CD3+ large granular lymphocytes (LGL).
Gherman et al. (1989)interleukin-2natural killer cellEffect of interleukin-2 on the monomeric IgG-induced inhibition of human natural killer cell activity.
Frank et al. (1995)IL-2natural killer cellsOne of the most important cytokines involved in immune response regulation is interleukin 2 (IL-2), a potent activator of the proliferation and function of T lymphocytes and natural killer cells.
Lanier et al. (1988)IL-2NK cellsPreviously, it has been uncertain whether all NK cells or only a subset are responsive to IL-2.
Ponti et al. (2002)IL-2-mediatedNK cellsWe studied here the functional role of CREB in the IL-2-mediated transcriptional regulation of c-fos in human NK cells.
Tam et al. (1999)IL-2NK cellsHowever, the cytotoxicity of NK cells is dependent on cytokines such as interleukin 2 (IL-2).
Dybkaer et al. (2007)IL2NK cellsWe also observed a change in the expression profile of transcripts on this pathway on IL2 activation with downregulation of many of the transcripts mentioned above and upregulation of receptors (TGFBR1,TGFBR2 and TGFBR3) and the R-SMAD (SMAD2) in activated NK cells.
Dybkaer et al. (2007)IL2NK cellsUpon IL2 stimulation of NK cells, signal transduction from tyrosine phosphorylation of the IL2R?
Wu et al. (1994)interleukin-2NK cell[Effect of acupuncture on interleukin-2 level and NK cell immunoactivity of peripheral blood of malignant tumor patients].
Michaëlsson et al. (2008)IL-2NK cellsHere, we investigated the effects of combined IL-2 therapy and antiretroviral therapy (ART) on the number, frequency, phenotype, and interferon (IFN)-gamma production of NK cells in individuals with early HIV-1 infection.
Nakamura et al. (1998)IL-2NK cellThe suppressive effect on NK cell activity and IL-2 concentrations was measured with serum obtained from 30 pregnant and 30 nonpregnant women during an IVF-ET procedure.
Umehara and Bloom (1990)IL-2LGLTherefore, these data clearly show that the IL-2-IL-2R beta interaction is responsible, and probably completely so, for the proliferative and cytolytic-promoting effects of IL-2 on LGL.
Nagler et al. (1990)IL-2NK cellsThe IL-2 binding data thus substantiated the phenotypic and functional studies and definitively show that the differential responsiveness of CD16- and CD16+ NK cells to IL-2 is manifested through different affinity IL-2 receptors.
Bhat et al. (2007)IL-2NK cellsTo test whether other factors can modulate NK cell killing activity and subsequently killing frequency, we stimulated freshly isolated human NK cells with IL-2, IL-15, IFN-?
Phillips et al. (1989)IL-2NK cellsCollectively, results from the present studies directly implicate the p75 IL-2R as the structure predominantly responsible for IL-2 activation of NK cells.
Jantscheff et al. (1999)Vero-IL2NK cellsThe failure of other mechanisms (complement, antibody-dependent cell cytotoxicity or cytotoxic T lymphocytes) to destroy xenogenic, histoincompatible Vero cells in vitro suggests that NK cells also might be responsible for the killing of Vero-IL2 in vivo and for the failure to detect the transgene at the application site.
Heiskala et al. (1991)interleukin-2natural killer cellsRole of CD16 (Fc receptor III) and interleukin-2 in the reactivation of natural killer cells after inhibitory target cell contact.
de la Barrera et al. (1990)IL-2NK cellThe ability to respond to physiological NK regulators such as IL-2 and IFNs, or to the IFN-inducer PIC was impaired in HIV+ He, especially in HIV+ LAS individuals, suggesting that the inability of these cells to increase NK cell activity after appropriate induction was due to an intrinsic defect.
Dybkaer et al. (2007)IL2NK cellIt also allowed us to observe the sequential immunostimulatory effects of IL2 on NK cells improving our understanding of the biology and molecular mediators behind NK cell activation.
Zheng et al. (2008)IL-2NK cellHowever, the roles of IL-2 and IL-15 in regulating these two NK cell subsets remain elusive.
Zheng et al. (2008)IL-2NK cellIn this study, we comparatively analyzed the effects of IL-2 and IL-15 on two NK cell subsets.
Reddy et al. (1984)interleukin-2natural killer cellDifferential effects of interferon-alpha 2 and interleukin-2 on natural killer cell activity in patients with acquired immune deficiency syndrome.
Lai et al. (2001)interleukin-2natural killer cellsMicroinvasive Nd:YAG laser therapy of early glottic carcinoma and its effect on soluble interleukin-2 receptor, interleukin-2, and natural killer cells.
Trzonkowski et al. (2006)IL2NK cellsThe numbers of Treg cells in peripheral blood, their influence on CD8+ T and NK cells and production of IL2 as well as apoptosis intensity of Treg cells were measured.
Trisler and Specter (1994)IL-2natural killer cellHuman natural killer cell activity is only affected at the highest concentration tested (10 micrograms THC/ml) while lymphokine-(IL-2)-activated natural killer cell activity is affected throughout the range of 1-10 micrograms THC/ml.
Ueno et al. (1985)interleukin 2natural killer cellDifferential effects of recombinant human interferon-gamma and interleukin 2 on natural killer cell activity of peripheral blood in early human development.
Schantz et al. (1992)interleukin-2NK cellThis phase II study in patients with advanced head and neck cancer evaluated the efficacy of combination systemic recombinant interleukin-2 (IL-2) and interferon-alpha (INF-a) and evaluated laboratory correlates between tumor response and a) tumor differentiation and b) NK cell activation.
Ghoneum et al. (1987)lymphokinenatural killer cellEffect of methylcholanthrene on human natural killer cell cytotoxicity and lymphokine production in vitro.
Shephard et al. (1994)IL-2NK cellsModerate exercise increases the cytolytic action of NK cells, but there is a prolonged fall of cytolytic activity after exhausting or psychologically stressful exercise; again these responses probably reflect altered IL-2 levels or receptor expression.
Tseng et al. (2010)IL-2NK cellsHMSCs are significantly more sensitive to lysis by IL-2 treated NK cells than their differentiated counterparts and they trigger significant release of IFN-?
Chakraborty et al. (1996)IL-2NK cellsIn oral cancer patients an altered response to low doses of Prl (1-5O ng/ ml) was observed in IL-2-stimulated NK cells, which also revealed malignancy- associated loss of IL-2 response.
Isacson et al. (1992)IL-2NK cellsNone of the following parameters, tested prior to initiation of the therapy and 1-2 days after termination of each course of IL-2, correlated with the clinical response: WBC counts (total and differential), levels of blood CD4 and CD8 T cells, NK cells, monocytes and B cells, production of IL-1 and IL-1 inhibitor by monocytes, responsiveness to 3 mitogens, NK/LAK cell activity, and serum levels of IL-1 alpha, IL-2, soluble IL-2 receptor, and TNF alpha.
Hadinedoushan et al. (2007)IL-2NK cellNK cell cytotoxicity was evaluated by flow cytometry, and IL-2, IL-10, transforming growth factor beta1 were measured in cell culture supernatant by ELISA method.
de Rham et al. (2007)IL-2NK cellsSeveral clinical trials have helped to assess the effect of IL-2 administration on activation and expansion of endogenous NK cells [29,30].
Umehara et al. (1993)IL-2-inducedNK cellsWe conclude that the IL-2-induced phosphorylation of the beta chain of the LFA-1 adhesion molecule in LAK cells and associated alteration in signal transduction may be important in the stimulation of LAK cell activity in NK cells.
Riederer et al. (2010)IL-2NK cellsWe have previously shown that transfection of HLA-E down-regulates the cytolytic response of TKD/IL-2-activated NK cells against tumor cells [54].
Vaquer et al. (1987)lymphokineNK cellsPresent studies in vitro suggest that modulation of lymphokine production may play a role in the adaptive response of NK cells in pregnancy.
Mariani et al. (2001)IL-2NK cellsIn this study we investigated whether the ability of T lymphocytes and NK cells to produce IL-8, either spontaneously or after activation, respectively with anti-CD3 monoclonal antibody or interleukin 2 (IL-2) was affected by age.
Yang et al. (1994)interleukin 2natural killer cellAbsence of responsiveness to interferon-gamma but not to interleukin 2 and depressed recycling as natural killer cell abnormalities in childhood lymphohistiocytic syndrome.
Mäenpää et al. (1993)IL-2NK cellsExpression of integrins and other adhesion molecules on NK cells; impact of IL-2 on short- and long-term cultures.
Shani et al. (1990)interleukin-2natural killer cellAt these doses statistically significant rises in gamma-interferon, natural killer cell activity, tumor necrosis factor and interleukin-2 (IL-2) levels as well as the expression of IL-2 receptors were noted.
Peng et al. (1999)IL-2natural killer cell[Changes and significance of natural killer cell, IL-2, IL-6 and TNF alpha of heroin addicts after detoxification].
Yoon et al. (1990)interleukin-2LGLWe studied the role of Fc receptors and interleukin-2 (IL-2) receptor subunits in anti-CD3 monoclonal antibody (MAb)-mediated cytotoxicity of CD3+ leukemic large granular lymphocytes (LGL).
Pintaric et al. (2008)IL-2NK cellsTherefore, we tested the influence of the immune regulatory cytokines IL-2, IL-12 and IL-18 on cytolytic activity, phenotype, IFN-gamma production and the accumulation of perforin in cytoplasm of peripheral blood mononuclear cells (PBMC) as well as purified NK cells.
Velilla et al. (2008)IL-2NK cellsEffect of low-dose IL-2 immunotherapy on frequency and phenotype of regulatory T cells and NK cells in HIV/HCV-coinfected patients.
Naume and Espevik (1991)IL-2natural killer cellsEffects of IL-7 and IL-2 on highly enriched CD56+ natural killer cells.
Gao and Wang (1989)IL-2NK cell[Assay of NK cell activity and IL-2 and IFNr production in vitro in patients with epidemic hemorrhagic fever].
Yücesoy et al. (1999)IL-2NK cellTo evaluate the effects of occupational long-term co-exposure to n-hexane, toluen, and methyl ethyl ketone (MEK) on NK cell activity and serum IL-2, gamma-IFN levels, we studied a group of workers employed in a shoe factory where the jobs include use of glues and adhesives containing mainly n-hexane, and at low concentrations, toluen and MEK. 2.
Sellar et al. (2006)IL-2natural killer cellIncreases were observed in adrenocorticotrophic hormone, cortisol, blood leukocytes, neutrophils, and natural killer cell concentrations and activity, whereas the ability of peripheral blood monouclear cells (PBMCs) to respond (interleukin-2 (IL-2) production) to stimulation was reduced 5 min after exercise in both groups (p < 0.05).
Bendall et al. (1995)IL-2NK cellsThere was a significant increase in the adhesion of NK cells to fibronectin in response to IL-2 treatment.
Shin et al. (2004)IL-2NK cellsThe modulated expression of KIR by IL-2 and TGF-beta can be associated with the changed NK-cytotoxic target-discriminating ability of NK cells upon their exposure to IL-2 and TGF-beta.
Chrul et al. (2006)IL-2natural killer cellsInfluence of interleukin IL-2 and IL-12 + IL-18 on surface expression of immunoglobulin-like receptors KIR2DL1, KIR2DL2, and KIR3DL2 in natural killer cells.
Matera and Mori (2000)IL-2NK cellsThe individual effect of PRL, IL-12, and IL-2 was specific for NK cells, and IL-2 and IL-12 were much more efficient than PRL.
Jurisi? et al. (2008)IL-2NK cellIn this study, we summarize the role of several cytokines, including IFN, IL-1, IL-2, IL-4, IL-7, IL-12 and IL-17, on NK cell function.