Viewing affirmative mentions of gene expression of IL2 (H. sapiens) in monocytes

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Chouaib and Fradelizi (1982)IL2monocytesOn the other hands in humane inhibition of IL2 production was also mediated by an excess of monocytes.
Toossi et al. (1989)IL-2monocytesIn the presence of small numbers (5%) of Leu 11-enriched cells, however, monocytes down-regulated IL-2 production of Leu 11-depleted cell cultures.
Herrmann et al. (1985)interleukin 2monocytesGamma interferon induced surface expression of interleukin 2 (IL-2) receptors on normal human monocytes and the monocytoid cell lines U937 and HL60.
Ulmer and Flad (1982)Il-2monocytesThe results show that T-lymphocytes from fractions 2, 3, and 4 from the density gradient (high density lymphocytes) which contain up to 75% Fcmu receptor-bearing cells, and less than 0.2% monocytes could be stimulated by PHA for the production of Il-2 only in the presence of additional monocytes.
Ulmer and Flad (1982)Il-2monocytesDose-response experiments with various numbers of monocytes added to the system showed the following: the higher the density of a cell population, the higher the number of monocytes required for help in the stimulation of Il-2 production.
Ulmer and Flad (1982)Il-2monocytesHowever, the production of Il-2 by high-density lymphocytes did not reach the Il-2 production by low-density T-lymphocytes even in the presence of high numbers of additional monocytes.
Braun and Harris (1986)IL2MonocyteMonocyte functional assessments included immunoregulatory activity in phytohemagglutinin-stimulated (PHA) lymphoblastogenesis assays, natural killer (NK) assays, Interleukin 2 (IL2) production assays and, quantitation of opsonized zymosan-induced chemiluminescence responses.
Childerstone et al. (1989)IL2monocytesThe results suggest that epitope-linked clusters of monocytes, TT-sensitized CD4 and SP-sensitized CD4 cells enable IL2 released by the TT-sensitized CD4 cells to stimulate the SP-sensitized CD4 cells that produce inadequate amounts of IL2.
Klein et al. (1983)IL2MonocytesMonocytes, IL1, or PMA are known to be crucial requirements for IL2 production by PHA-stimulated T cells.
Klein et al. (1983)IL2monocytesThis combined with the fact that IL2 participates in T colony formation suggests that monocytes induce T colony formation through IL2 production.
Roosnek et al. (1985)IL2monocyteThus, analogous to induction of IL2 production, the acquisition of responsiveness to IL2 can be completely monocyte dependent, but a 10-fold increase in lectin concentration completely abolishes the requirement for accessory cells.
Tao et al. (1991)IL-2monocytesT2 did not affect IL-2 receptor expression by T cells, IL-1 production by monocytes, or the capacity of monocytes to present antigen.
Roosnek et al. (1987)IL2monocytesIn contrast, CLB-T3/4.2a, a mouse monoclonal antibody of the same isotype with a high avidity (much greater than OKT3) for the CD3 complex, induces IL2 receptor expression and IL2 responsiveness only at very low concentrations (less than 5 ng/ml), yet in the presence of monocytes this antibody induces proliferation within a similar dose range as WT32.
Misago et al. (1993)IL-2monocytesIn addition, the expression of IL-2 receptor (CD25) on monocytes was more enhanced in cultures containing IL-2 than in cultures without IL-2.
Dohlsten et al. (1988)IL2monocytesWhen stimulated with the polyclonal activator staphylococcal enterotoxin A in the presence of autologous monocytes, these two subsets exhibited a striking difference in production of interleukin 2 (IL2) and interferon-gamma (IFN-gamma).
Kaplan and Cohn (1986)IL-2monocytesThus, the defect in lepromatous nonresponder patients does not result from a simple lack of IL-2 production or suppression by monocytes and/or their products.
de Faucal et al. (1984)IL2monocytesThese data suggest that, in SLE, the inhibition of IL2 production is mediated by prostaglandin, possibly produced by monocytes.
Rambaldi et al. (1987)interleukin 2monocytesInterferon-gamma induces expression of the interleukin 2 receptor gene in human monocytes.
Rambaldi et al. (1987)interleukin 2monocytesInterferon-gamma induces surface expression of interleukin 2 (IL2) receptors on human monocytes and the monocytic cell line U937.
Krutmann et al. (1990)interleukin-2monocytesIn addition, they suggest that interleukin-2 production is the T-cell activation step most sensitive to inhibition when UVB-irradiated monocytes are employed as accessory cells.
Kaplan and Cohn (1985)IL-2monocytesThus, the defect in lepromatous non-responder patients does not result from a simple lack of IL-2 production or suppression by monocytes and/or their products.
Meuer et al. (1987)interleukin 2monocyteThis defect results in a lack of interleukin 2 production, which is critically dependent on a monocyte-derived signal.
Flescher et al. (1989)IL-2monocytesPre-incubation with spermidine, but not any of three diamines tested, suppresses PHA-stimulated IL-2 production and this effect requires monocytes.
Flescher et al. (1989)IL-2monocyteThree PAO inhibitors have an enhancing effect on IL-2 production which is again monocyte dependent.
Bosco et al. (1995)IL-2monocytesHuman monocytes express functional IL-2 receptors (IL-2R) and are directly activated by IL-2 to exert effector and secretory functions.
Iho et al. (1985)IL 2monocytesFurthermore, 1,25(OH)2D3 suppressed interleukin 1 (IL 1) production of monocytes (Mo), and the agent-treated Mo were unable to promote IL 2 production of non-adherent cells (NAC).
Dong et al. (1991)IL-2monocyteThese findings suggest that CI-959 selectively inhibits some lymphocyte functions, as opposed to monocyte functions, and that among these is the production of IL-2.
Ruscetti et al. (1980)TCGFmonocyteThese results suggest that TCGF production: a) requires protein synthesis; b) requires binding of the stimulating agent; c) can occur in a non-dividing cell, probably a terminally differentiated T-cell, without the need for cellular proliferation; and d) needs the assistance of an adherent cell which probably is a monocyte-macrophage.
Bosco et al. (1997)IL-2monocytesHuman monocytes express functional IL-2Rs and are directly activated by IL-2 to exert effector and secretory functions.
Janský et al. (1996)IL2monocytesWith the continuation of the cold water immersions (three times a week for a duration of 6 weeks) a small, but significant, increase in the proportions of monocytes, lymphocytes with expressed IL2 receptors (CD25) and in plasma tumour necrosis factor alpha content was induced.
Harris et al. (1996)interleukin 2monocyteRESULTS: H. pylori urease induced monocyte expression of surface interleukin 2 receptors and increased expression of HLA-DR, phenotypic changes consistent with activation.
El-Mohandes et al. (1995)IL-2PBMUsing dual fluorescence microfluorometry, the percentage and intensity of expression of HLA-DR, CD4 antigens, Fc gamma and IL-2 receptors (IL-2R) on Leu-M3+ and Leu-M5+ CBM were compared to PBM.
Ellner (1991)interleukin-2monocytesIncreased expression and release of interleukin-2 receptors and transforming growth-factor beta are associated with and may contribute to such suppression by monocytes.
Toossi et al. (1990)interleukin 2monocytesExpression of functional interleukin 2 receptors by peripheral blood monocytes from patients with active pulmonary tuberculosis.
Zabel et al. (1990)IL 2monocytesIn the interferon group we found measurable gamma-interferon serum levels, an increase in the spontaneous production of IL 2 by peripheral lymphocytes, and an increase in the spontaneous production of IL 1 and an in the phagocytic capacity of monocytes.
Roosnek et al. (1985)IL 2monocytesFurthermore, after depletion of monocytes IL 2 production by peripheral T cells became almost completely dependent on the presence of thiols in the culture medium.
Wakasugi et al. (1984)IL 2monocyteThree leukemic cells could not only stimulate T cells to proliferate and produce IL 2 in the presence of mitogens, but also under appropriate culture conditions these cells could produce IL 1, which could not be distinguished from normal human monocyte derived IL 1 by gel filtration and isoelectric focusing.
Wahl et al. (1987)interleukin 2MonocyteMonocyte interleukin 2 receptor gene expression and interleukin 2 augmentation of microbicidal activity.
Wahl et al. (1987)interleukin 2monocytesActivation of human peripheral blood monocytes results in the expression of interleukin 2 (IL 2) receptors, which are absent on resting monocytes.
Wahl et al. (1987)IL 2monocytesWe used cDNA encoding for the human IL 2 receptor to evaluate IL 2 receptor gene expression in resting and activated monocytes.
Wahl et al. (1987)IL 2monocytesThus monocytes when activated undergo a series of morphologic, phenotypic, and functional changes, including the expression of IL 2 receptors, which may provide an important immunoregulatory pathway.
Bosco et al. (1994)IL-2monocytesRegulation by interleukin-2 (IL-2) and interferon gamma of IL-2 receptor gamma chain gene expression in human monocytes.
Slivnick et al. (1990)interleukin-2monocytesThe cellular immune defect appears to be the result of enhanced sensitivity to suppressor monocytes and T-suppressor cells, in addition to abnormal interleukin-2 production.
Cogoli et al. (1993)IL-2monocytesOur data suggest that (1) IL-2 is produced independently of IL-1, (2) IL-1 production is triggered only when monocytes (and lymphocytes?)
Sauerwein et al. (1986)IL-2monocytesThe reason for the synergistic IgM production to PWM + IL-2 in tonsil cells is the relative lack of monocytes and the low number of T8+-suppressor cells.
Kitas et al. (1988)IL-2MonocyteMonocyte depletion and partial reconstitution resulted in an increase of both proliferation and IL-2 production, which was more marked in RA patients, suggesting that depressed IL-2 production may relate in part to monocyte effects.
Chouaib et al. (1984)IL 2monocytesWe have shown in a previous study that in humans monocytes can transmit opposite signals to the IL 2-producing cells.
Martin et al. (1986)IL 2monocytesBy itself, antibody 9.3 had no detectable effect on either IL 2 receptor expression or IL 2 release, and did not cause T cell proliferation even when monocytes were present and exogenous IL 2 was provided, indicating that binding of antibody 9.3 does not provide a primary signal for T cell activation.
Holter et al. (1986)IL 2monocytesIFN-gamma is found to double both the number of positive cells and the number of binding sites, whereas IL 2 has no influence on the IL 2 receptor expression on monocytes.
Bosco et al. (1994)interleukin-2monocytesThe gamma subunit of the interleukin-2 receptor is expressed in human monocytes and modulated by interleukin-2, interferon gamma, and transforming growth factor beta 1.
Zatz et al. (1985)IL-2monocyteAugmentation of IL-2 production by aspirin and/or TF5 was prevented by monocyte depletion of the PBL population.
Zatz et al. (1985)IL-2monocyteThese results are interpreted as demonstrating (a) that TF5 and aspirin augment, by distinct mechanisms, IL-2 production by normal human PBL, (b) that the effects of both of these agents are mediated directly or indirectly via a monocyte population and (c) that aspirin, in addition to its analgesic and anti-inflammatory properties, may act as a modulator of immunological responsiveness, either alone or in combination with other biological response modifiers such as thymosin.
Epling-Burnette et al. (1993)interleukin-2monocytesHuman monocytes express interleukin-2 receptor beta (IL-2R beta) constitutively; however, the function of these receptors has not been fully delineated.
Yao et al. (2006)interleukin-2monocytesAn enzyme-linked immunosorbent assay-based method was used for the measurement of interleukin-2 (IL-2) production by peripheral blood monocytes (PBMCs) treated with VEGI72-251.
Granelli-Piperno et al. (1989)IL-2monocytesDespite these differences in IL-2 production, the amount of DNA synthesis and the number of lymphoblasts were comparable when monocytes or PMA were used as the accessory stimulus, and the responses were equally sensitive to inhibition by an anti-IL-2R antibody.
Prat et al. (2000)IL-2monocytesDespite such up-regulation, these IFN-gamma-treated HBECs, in contrast to human microglia and PB monocytes, did not sustain allogeneic CD4+ cell proliferation, supported only low levels of IL-2 and IFN-gamma production, and did not stimulate IL-2 receptor expression.
Johnson and Jenkins (1994)IL-2monocyteIL-2 production by previously activated CD8+ T cells depends on the monocyte-derived costimulatory signal, although memory CD4+ T cells respond well to either the monocyte-derived costimulus or B7-derived costimulation.
Lamperi and Carozzi (1985)TCGFmonocyteThe mechanism by which such a material may act appears unclear, but it is possible to suppose an inhibiting activity on the production of TCGF by lympho-monocyte cells which under normal conditions could be considered as an early erythropoiesis regulatory factor.
Misago et al. (1993)IL-2monocyteEven in purified monocyte cultures with added IL-2, a 3-fold increase in M-CSF production was observed at an IL-2 concentration of 50 ng/ml.
Holter et al. (1987)IL 2monocytesExpression of functional IL 2 receptors by lipopolysaccharide and interferon-gamma stimulated human monocytes.
Isacson et al. (1992)IL-2monocytesNone of the following parameters, tested prior to initiation of the therapy and 1-2 days after termination of each course of IL-2, correlated with the clinical response: WBC counts (total and differential), levels of blood CD4 and CD8 T cells, NK cells, monocytes and B cells, production of IL-1 and IL-1 inhibitor by monocytes, responsiveness to 3 mitogens, NK/LAK cell activity, and serum levels of IL-1 alpha, IL-2, soluble IL-2 receptor, and TNF alpha.
Neckers and Cossman (1983)IL-2monocyteOur study has revealed that (i) monocytes, or a monocyte substitute such as the phorbol ester tetradecanoylphorbol 13-acetate, are required for transferrin receptor expression after mitogen exposure; (ii) the presence of IL-2 receptors is necessary for transferrin receptor induction; (iii) antibody to the IL-2 receptor inhibits thymidine incorporation (DNA synthesis) in lymphocytes, but only if administered before transferrin receptors have appeared; and (iv) antitransferrin receptor antibody inhibits DNA synthesis but has minimal effect on IL-2 receptor expression.
Bonder et al. (2002)IL-2monocytesEndogenous interferon-alpha production by differentiating human monocytes regulates expression and function of the IL-2/IL-4 receptor gamma chain.
Gallo et al. (1992)IL-2PBMOBefore and after treatment, the following were studied: (1) serum levels of antibodies against GM1, asialo-GM1 (aGM1), GM2 and GD1b; (2) serum levels of interleukin (IL)-1 beta, IL-2, soluble IL-2 receptor (sIL-2R), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma); (3) IL-1 beta and TNF-alpha production by peripheral blood monocytes (PBMO).
Espinoza-Delgado et al. (1990)interleukin 2monocytesExpression and role of p75 interleukin 2 receptor on human monocytes.
Scheinberg et al. (1990)IL-2monocytesThe data show that Tenoxicam inhibits the neutrophil and monocyte functional chemotactic response in vitro, and to some extent in vivo for monocytes, but has no effect on the expression of IL-2 receptors or IL-1 release.
Scheinberg et al. (1990)IL-2monocyteIn the present study we examined the immune pharmacological effects of this compound on lymphocyte function by determining its effect on the expression of IL-2 receptors, on monocyte function by looking at chemotaxis and IL-1 release and on neutrophil function by evaluating the chemotactic response to a standard stimulus. 3.
Vecchiarelli et al. (1998)IL-2monocytesAddition of a monoclonal antibody which binds the Cryptococcus neoformans capsule to suspensions of human monocytes, T lymphocytes, and cryptococcal cells (i) enhances interleukin-1beta (IL-1beta), tumor necrosis factor alpha, and IL-2 production; (ii) reduces IL-10 secretion; and (iii) promotes T-cell proliferation.
Stünkel et al. (1991)IL-2monocyteThe results of this study suggest that CIP modulates the immune response at two levels--the production of IL-2 by activated T cells and the production of IL-1 by activated monocyte/macrophages.
Bosco et al. (1994)IL-2monocytesFinally, the augmented expression of IL-2R gamma in IL-2- and IFN gamma-treated monocytes was associated with an increased IL-2-binding activity, compared with that of unstimulated cells.
DeFreitas et al. (1982)interleukin 2monocytesThe hybridomas were selected for their ability to produce interleukin 2 after exposure to TeT on semiautologous monocytes and for their ability to bind to TeT-pulsed semiautologous monocytes.
Barcova et al. (1998)IL-2monocytesgp41 envelope protein of human immunodeficiency virus induces interleukin (IL)-10 in monocytes, but not in B, T, or NK cells, leading to reduced IL-2 and interferon-gamma production.
Carson et al. (1994)IL-2monocytesUnlike IL-2, IL-15 is produced by activated monocytes/macrophages.
Schäfer et al. (1992)interleukin-2monocyteHuman choriogonadotropin (hCG) and placental lactogen (hPL) inhibit interleukin-2 (IL-2) and increase interleukin-1 beta (IL-1 beta), -6 (IL-6) and tumor necrosis factor (TNF-alpha) expression in monocyte cell cultures.
Bosco et al. (1994)IL-2-inducedmonocytesFurthermore, we show that transforming growth factor beta 1 (TGF beta 1) downmodulates, in a dose-dependent manner, basal and IL-2-induced, but not IFN gamma-induced, IL-2R gamma chain expression, and this effect may be responsible for TGF beta 1 suppressive activity on IL-2-activated monocytes.
Fujihara et al. (1996)IL-2 mRNAmonocyteUV-B irradiation of monocytes inhibited the expression of IL-2 mRNA in monocyte-stimulated allogeneic MLR.
Zarrabeitia et al. (1987)IL-2monocyteThe effect of 10(-9) M calcitriol was almost completely abolished by: a) monocyte depletion, b) inhibition of prostaglandin (PG) synthesis by indomethacin, and c) addition of exogenous interleukin-2 (IL-2).
Zaitseva et al. (1995)IL-2 mRNAmonocytesFollowing depletion of monocytes and B cells, B. abortus increased IFN-gamma and IL-2 mRNA expression in purified T cells compared with expression in unstimulated cells.
Malec et al. (1988)IL-2monocytesThe single VER dose induced a significant, but transient increase in T, T helper, T suppressor lymphocytes and monocytes, and decrease in IL-1 and IL-2 generation as well as diminished Tac antigen expression.
Strieter et al. (1989)interleukin-2PBMIn this study, we demonstrate that human AM phi, as well as PBM, can be induced to express biologically active TNF-alpha after challenge with interleukin-2 (IL-2).
Nabioullin et al. (1994)IL-2monocytesNKSF stimulated CD8+ cells to produce interferon gamma (IFN gamma) irrespective of the presence of added IL-2, and this effect was augmented by co-cultivation with monocytes.
Allen et al. (1990)interleukin 2monocytesExpression of interleukin 2 receptors by monocytes from patients with acquired immunodeficiency syndrome and induction of monocyte interleukin 2 receptors by human immunodeficiency virus in vitro.
Wahl et al. (1987)IL 2monocyteThe LPS-activated monocyte IL 2 receptor protein is expressed on the cell surface within a few hours after the detection of IL 2 receptor mRNA.
Rinnooy Kan et al. (1986)IL-2monocytesSuch depleted monocytes exhibit a fourfold reduction in their ability to promote both internalization of T3 and production of IL-2.
Carlin et al. (1989)IL-2monocytesInteraction was required between these populations for induction of IDO by IL-2, due to production of IFN-gamma by T lymphocytes, with subsequent IFN-gamma-mediated induction of IDO in monocytes.