Viewing affirmative mentions of gene expression of IL2 (H. sapiens) in immune system

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Chen et al. (1994)IL-2immune systemIt is suggested that GSH may exert its effects on the immune system via the regulation of IL-2 synthesis.
Donnelly et al. (1986)IL-2immune systemBecause of the multipotential role of IL-2 in the immune system, enhancement of IL-2 production by NPT-15392 may be a central pathway whereby this compound augments many lymphoid effector functions.
Bessler et al. (1986)IL-2immune systemIn addition, a lower stimulatory activity for interleukin-2 (IL-2) production was found in the maternal serum, suggesting an additional mechanism for the suppression of the maternal immune system during pregnancy.
Bessler et al. (1986)IL-2immune systemThe possibility that a fetal humoral factor is involved in the regulation of the immune system via the stimulation of IL-2 production is discussed.
Kaplan and Moy (2000)Interleukin-2immune systemInterleukin-2 (IL-2) is a cytokine produced chiefly by activated T lymphocytes and has effects on various components of the immune system.
Hinoshita et al. (1990)IL-2immune systemThese results indicate that the immune system of regulating IL-2 production is impaired in patients with nephrotic syndrome.
Goto et al. (2008)IL-2immune systemIn view of the importance of vitamin A in the human immune system and the central role of interleukin-2 (IL-2) in the proliferation of T-lymphocytes, we examined the effects of all-trans-retinoic acid (ATRA) on the protein and gene expression of IL-2 in the human T-cell line HUT-78 when stimulated with either 12-O-tetradecanoylphorbol-13-acetate (TPA) or phytohemagglutinin (PHA).
Nagaraj et al. (2004)IL-2immune systemBecause of the serious toxicity of systemically administered IL-2 observed in clinical practice [17] it can be expected that local expression of IL-2 is less harmful to the patient than systemic administration to trigger the immune system.
Sule et al. (2001)IL-2immune systemIL-2 can now be produced in unlimited quantities by recombinant DNA technology and used therapeutically to modulate the immune system in a number of diseases.
Kawami et al. (1993)interleukin 2immune systemsTo ascertain whether the tumor cells can regulate the host immune systems through the production of the cytokines or their receptors, we examined the expressions of tumor necrosis factor alpha (TNF alpha), tumor necrosis factor beta (TNF beta), interleukin 2 (IL-2) and interleukin 2 receptor alpha chain (IL-2R alpha) on the human cancer cell lines by Northern blot analysis.
Saneto et al. (1987)IL-2immune systemWithin the immune system, IL-2 biological action is dependent strictly on the expression of the IL-2 receptor.
Hersey et al. (1986)IL2immune systemChanges in cortisol levels may explain some effects on the immune system, such as depression of IL2 and immunoglobulin production in vitro, and the differences noted in clinical responses during the present study compared with those observed with interferon alfa-2b given by intravenous (IV) injection in 5-day cycles.
Anderson and Sorenson (1994)IL-2immune systemIL-2 action and pharmacokinetics can be understood in the context of the effect IL-2 on high (alpha, beta, gamma trimer) vs intermediate (alpha, beta) vs low (beta only or alpha only) affinity IL-2 receptors on various cells of the immune system.
Matsumoto et al. (2001)IL-2immune systemsThus, the lesser IFNgamma production observed in patients' blood with high IL-12 p40 levels in response to BCG-CWS may reflect the production of p40 dimers or IL-23 instead of p70, or the presence of some unknown pathways to prohibit the interface between the innate and acquired immune systems.
Attema et al. (2002)cytokine IL-2immune systemControlled production of the cytokine IL-2 plays a key role in the mammalian immune system.
Cohen et al. (1997)IL-2immune systemSince IL-10 has been previously described as a direct inhibitor of Ag presentation and of IL-2 production, our finding that IL-2 is capable of inducing its own inhibitor demonstrates a feedback mechanism within the immune system that could limit ongoing T cell activation and possibly inflammation.
Sun et al. (2005)IL-2immune systemProduction of IL-2 and IFN-gamma by CD4+ T lymphocytes is important for the maintenance of a functional immune system in infected individuals.
Wollmann et al. (1994)interleukin-2immune systemsTo investigate the interaction between the neuroendocrine and immune systems in humans with uveitis, we measured serum levels of the predominant pineal hormone melatonin (MEL), prolactin (PRL) and interleukin-2 (IL-2).
Nagaraj et al. (2004)interleukin-2immune systemHuman cytokine-induced killer cells have enhanced in vitro cytolytic activity via non-viral interleukin-2 gene transfer Modulation of the immune system by genetically modified immunological effector cells is of potential therapeutic value in the treatment of malignancies.
Brod (2000)IL-2immune systemAutoimmunity is unregulated hyperimmunity to organ-specific proteins, inducing rapid turnover of antigen-specific T cells of the acquired immune system with ultimate exhaustion and loss of acquired immunity IL-2 and IFN-gamma production and proliferative decline, conforming to the limited capacity of clonal division (Hayflick phenonmenon).
Wilson et al. (1990)Interleukin 2immune systemLevels of Interleukin 2 (IL2), IL2 receptors (IL2R) and free radical scavengers were measured in 25 Graves' disease patients prior to and following an 8 week course of Carbimazole therapy in an attempt to understand the mechanism by which the drug acts on the immune system.
Emilie et al. (1990)IL-2immune systemTo document the in vivo interactions occurring between the immune system and HIV replicating cells, we analyzed using in situ hybridization the production of IL-1 beta, IL-6, IL-2, and INF-gamma in eight hyperplastic lymph nodes from HIV-1 infected patients.
Crispín and Tsokos (2009)IL-2immune systemThe regulation of IL-2 production is central to our understanding of the immune system.
van den Berg et al. (1998)IL-2immune systemCONCLUSIONS: These data suggest that the functional effects of CsA in transplant recipients can be quantitatively determined and that the capacity of CD4+ T cells to produce IL-2 upon stimulation constitutes a functional parameter of CsA effects on the immune system.
Belghiti et al. (1986)lymphokineimmune systemGenetic factors and a disregulation of the immune system with lymphokine production may be responsible for these renal changes.
Kahan (1985)lymphokineimmune systemDue to its relatively specific inhibition of lymphokine generation by T helper cells, the drug displays relatively high therapeutic efficacy for the immune system.
Tovar et al. (2002)IL-2immune systemHowever, IL-2 production and mRNA expression from stimulated lymphocytes were unaffected by supplementation, probably because the deficiency was not severe enough to affect the immune system.
Podtschaske et al. (2007)IL-2immune systemThe multiple auto- and paracrine functions of IL-2 raise the question about the accurate execution of the IL-2 gene expression program which is essential for the function of the adaptive immune system and T cell homeostasis.
Gayá et al. (1991)lymphokineimmune systemThere is growing evidence to suggest a regulatory role of IL-4 in the immune system affecting both proliferation and lymphokine production.
Donskov (2007)IL-2immune systemFirst, which properties of the immune system are responsible for the dramatic tumor regression seen in some patients with mRCC following IL-2 administration?
Takaishi et al. (1990)IL-2immune systemIt is thought that the enhancement of IL-2 production by PBMCs and the decrease in the percentage of CD8+ cells (cytotoxic/suppressor cell) are associated with abnormalities in the immune system.
Gottlieb (1991)interleukin-2immune systemAn immunomodulator, IMREG-1, derived from human leukocyte dialysates exerts a variety of effects on the cell-mediated immune system, including acceleration and amplification of delayed hypersensitivity to recall antigens, modulation of gamma-interferon production in response to antigen, and enhanced expression of the p55 portion of the receptor for interleukin-2 on CD4+ cells.
Glaudemans et al. (2010)IL-2immune systemThese results strongly indicate that CXCR3-dependent activation of mTORC1 directly links stimulation of the Th1 lymphocytes’ immune system with the proliferative response of intimal cells in vascular remodelling: a process that is followed by expression of activation markers on T-cell surface such as the IL-2 receptor, CD25-CD122-CD132 heterotrimer [50].
Kazi et al. (1997)IL-2immune systemWe concluded that beta-carotene increased the number of IL-2R+ T lymphocytes and CD4+ lymphocytes, which in turn may produce IL-2 only in patients with cancer who may already have some deficiency in their immune system.
Brooks et al. (1990)lymphokineimmune systemThe functional significance of segregating lymphokine production to unique T cell subsets is still being evaluated, but undoubtedly plays a key role in the regulatory mechanisms of the immune system.
Dobozin et al. (1986)interleukin-2immune systemA comprehensive evaluation of the cellular immune system (total T-cell, helper cell, suppressor cell, and natural killer cell numbers; in vitro interleukin-2 production, T-cell responses to mitogens and antigens, serum beta 2 microglobulin levels, and delayed hypersensitivity skin tests) was performed on 36 HTLV-III seronegative and 16 HTLV-III seropositive healthy homosexual men, 48 asymptomatic homosexual men with the chronic lymphadenopathy syndrome, 41 patients with AIDS, and 29 heterosexual controls without any known risk factors for AIDS.
Rothenberg et al. (1990)IL-2immune systemThe ability to express the growth hormone IL-2 upon stimulation gives T lymphocytes one of their major effector functions in the immune system.
Xu et al. (2001)interleukin-2immune systemAs an important cytokine of the immune system, interleukin-2 (IL-2) can induce the expression of various genes, one of which is the tumor necrosis factor-beta (TNF-beta).
Faist et al. (1990)IL-2CMIThe in vitro test of CMI revealed that there was a higher LP capacity in PBMC's of PIndo (p less than 0.05); the postoperative profile of IL-2 synthesis was not statistically different between the groups.
?yszkiewicz and Pajtasz-Piasecka (2002)interleukin 2immune system[Contribution of interleukin 2 and interleukin 12 receptors in signal transduction during cell activation of the immune system].
Niederkorn and Streilein (1986)lymphokineimmune systemSince immune privilege seems to be a physiologic property of the anterior chamber, it is suspected that local features within this site conspire to insure that antigens placed therein interact with the immune system in a manner that bypasses lymphokine production, thus allowing for the induction of ACAID and selective suppression of DTH.
Basham et al. (2008)IL-2immune systemIn the immune system, both STAT5A and STAT5B regulate IL-2 signaling, with a stronger contribution of STAT5B through regulation of both IL-2R?
Marks (1989)interleukin-2immune systemImmunological effects including reductions in natural killer cell activity, superoxide and interleukin-2 production make osteopetrotic mutants potential models for studying the role of the immune system in osteoclast biology.
Uhlin et al. (2005)IL-2immune systemWe analyzed the capacity of exogenous IL-2 and IL-15, which are physiologically produced by cells of the adaptive and innate immune system, respectively, to modulate proliferation, responsiveness to repeated stimulation and apoptotic programs triggered in specific CTL by either fully or partially agonistic peptide ligands.
Jaffe et al. (1988)IL-2immune systemProstaglandins exert immunosuppressive effects at several steps on both afferent and efferent phases in the cell-mediated immune system: reduction of Ia expression in antigen-presenting cells, inhibition of IL-1 and IL-2 production, and activation of suppressor cells.
Redman et al. (1994)IL-2immune systemInterleukin-1 (IL-1) plays a central role in the immune system, partly by stimulating the production of interleukin-2 (IL-2) and other cytokines by lymphocytes.
Groenewegen et al. (1985)lymphokineimmune systemIn vivo MHC class II antigen expression by canine endothelial cells is therefore dependent on factors, probably the lymphokine gamma-interferon produced by the immune system, whose secretion is inhibited by cyclosporin A.
Aiuti and Mezzaroma (2006)IL-2immune systemFinally, an imbalance in the production of cytokines such as TNF, IL-2 and IL-7 may also be a crucial event for the induction of immune system failure.
Sharp and Koutedakis (1992)IL-2immune systemAcute exercise of varying severity and corresponding levels of long term competition and training have been found to affect various components of the immune system including lymphocyte subsets, immunoglobulin levels, the mononuclear phagocytic system, polymorphonuclear leukocytes and cytokines, especially IL-1, IL-2, IL-6 and TNF.
Ferencík and Stvrtinová (1997)IL-2immune systemSeveral immunoregulatory cytokines, including IL-1, IL-2, IL-6, IFN-gama and TNF are produced not only in the immune system but in the neuroendocrine system as well.
Viallard et al. (2001)IL-2immune systemIn this context, the simultaneous elevations of type 1 cytokines (IL-2 and IFN-gamma) and LIF production by the same cells may be an attempt by the immune system to limit the exacerbation of a type 2 dominant response.
Bhave and Carson (2009)IL-2immune systemThe IL-21R shares the common receptor gamma-chain with IL-2, IL-4, IL-7, IL-9, and IL-15, is widely expressed on immune cells, and mediates a variety of effects on the immune system.