Viewing affirmative mentions of positive regulation of IL2 (H. sapiens)

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Kaufmann and Rosenberg (1984)interleukin-2CTLWe have investigated the effect of cyclosporin (Cys) on the maturation of cytotoxic T lymphocytes (CTL), and on the induction of interleukin-2 (IL-2) secretion using two bifunctional CTL hybridomas.
Palm et al. (1998)interleukin 2cytotoxic T-cellImmunological variables of the cellular and humoral immune axis showed that 1) total lymphocyte counts and the distribution of lymphocyte subpopulations, including helper T-cell/suppressor cytotoxic T-cell ratios (CD4/CD8 ratios), did not change compared with baseline or healthy control subjects; 2) proliferation of peripheral mononuclear cells (PMC) was not impaired by morphine treatment; 3) interleukin 2 production increased after 4 wk of treatment with morphine; and 4) immunoglobulin (Ig) production was reduced before initiation of therapy in pain patients and decreased further during morphine treatment, whereas Ig concentrations in the circulation remained at normal levels.
Guarini et al. (1995)interleukin-2CTLThis study was designed to assess whether transfer of the interleukin-2 (IL-2) gene into human tumor cells could generate cytotoxic T lymphocytes (CTL) directed specifically against the autologous tumor.
Blank et al. (1987)interleukin-2cytotoxic T lymphocyteTrophoblast does not cause the cytotoxic T lymphocyte generation due to the lack of ability to stimulate interleukin-2 production.
Farrar et al. (1981)IL2CTLThe production of immune interferon as well as the generation of CTL requires T cells, alloantigen, and IL2.
Farrar et al. (1981)IL 2CTLThese data suggest that: 1) the regulation of immune interferon production is based on a T to T cell interaction mediated by IL 2, and 2) immune interferon production may be required for IL 2 induction of CTL.
Ozery et al. (1989)IL2CTLThe independent triggering of specific killing and IL2 secretion in the monoclonal cytolytic hybridomas suggests that in CTL distinct signals stimulate killing activity and IL2 production.
Donnelly et al. (1986)IL-2cytotoxic T-cellSera from 22 patients with either lymphadenopathy syndrome (LAS), acquired immune deficiency syndrome (AIDS)-related complex (ARC), or acquired immune deficiency syndrome were examined for their effect on the interleukin-2 (IL-2)-induced proliferative response of an IL-2-dependent cytotoxic T-cell line, CTL-20.
Efrat and Kaempfer (1984)IL-2cytotoxic T lymphocytesA qualitative difference in the requirement of mouse helper and cytotoxic T lymphocytes for interleukin 2 (IL-2) was revealed by offering such cells IL-2 synthesized in Xenopus laevis oocytes that had been microinjected with messenger RNA (mRNA) encoding human IL-2.
Efrat and Kaempfer (1984)IL-2cytotoxic T lymphocytesA qualitative difference in the interleukin 2 (IL-2) requirement of helper and cytotoxic T lymphocytes.
Aviner et al. (2005)interleukin 2CTLsWe extend this approach to human cells, by preparing CTLs in two major steps: primary culture in the absence of interleukin 2, leading to death by neglect of antihost clones, and addition of interleukin 2 and subsequent dilution of antihost clones as a consequence of the expansion of the anti-third-party clones.
Ichino and Ishikawa (1983)TCGF-CLCTLA subpopulation of TCGF-CL was Leu-2a positive and Leu-3a negative CTL.
Braakman et al. (1986)IL-2CTLThe increase of influenza virus-specific CTL activity after addition of exogenous IL-2 does not affect the restriction pattern of the CTL response.
Ting et al. (1984)IL 2cytotoxic T lymphocytesThe optimal concentration of interleukin 2 (IL 2) for maintaining the in vitro growth of T cells was quite different from that required for the induction of cytotoxic T lymphocytes (CTL) in nu/nu spleen cells.
Ting et al. (1984)IL 2CTLWe suggest that during antigen sensitization, the initial endogenous production of lower levels of IL 2 provided the second signal for the differentiation and proliferation of CTL.
Morisaki et al. (1994)Interleukin-2CTLInterleukin-2 (IL-2) and IL-4 secretion was induced in both CD4+ and CD8+ CTL after stimulation by melanoma cells.
Kitahara et al. (1987)interleukin 2cytotoxic T lymphocyteEstablishment of interleukin 2 dependent cytotoxic T lymphocyte cell line specific for autologous brain tumor and its intracranial administration for therapy of the tumor.
Pantuck et al. (2004)IL-2cytotoxic T-cellSystemic immune modulation in this patient included (1) up-regulation of IL-2 (CD25) and T cell (TcR alphabeta) receptors, (2) increase in the CD4/CD8 ratio (2.5-fold) (3) augmentation of T-helper type 1 cell (TH1) (interferon-gamma and tumor necrosis factor-alpha) but not TH2 (IL-4) cytokine mRNA expression, (4) induction of natural killer cell activity and MHC independent MUC-1 specific cytotoxic T-cell activity, and (5) normalization of mRNA expression of T-cell-associated signal transduction molecules TcR-zeta and p56lck.
Gullberg and Larsson (1982)IL2cytotoxic T lymphocyteStimulation of mixed lymphocyte cultures with ultraviolet (UV)-irradiated stimulator cells leads to selective activation of Lyt-2+ cytotoxic T lymphocyte precursors (CTL-P) to acquire interleukin 2 (IL2) reactivity: (a) no proliferative response, nor IL2 production was observed in these cultures; (b) upon addition of preformed IL2-conditioned media (IL2-CM), a vigorous proliferative response was observed; (c) the IL2-dependent proliferation was reduced by approximately 90% after depletion of Lyt-2+ responder cells; and (d) specific CTL were generated upon the initial triggering by UV-irradiated stimulators and IL2 expansion.
Hess (1985)IL-2cytotoxic T cellTaken together, our results suggest that: (1) exogenous IL-2 can overcome the immunosuppressive effect of CsA on the proliferative response in MLR to alloantigens; (2) at high levels of CsA, IL-2 cannot overcome the immunosuppressive effect of CsA on the induction of cytotoxic T-lymphocytes; (3) there are doses of CsA at least in vitro, that allow for the activation of the cytotoxic T cell, presumably with the acquisition of a receptor for IL-2 but without the clonal amplification due to inhibition of IL-2 production; and (4) time-sequential studies revealed that the development of responsiveness to IL-2 by the precursor cytotoxic T cell occurs 4-18 hr after exposure to the stimulating alloantigen with clonal expansion if IL-2 is present.
van Elsas et al. (1997)IL-2-transfectedCTLStimulation of autologous PBMC responders with the IL-2-transfected clone 518/IL2.14 specifically induced CTL lines reactive with all cell lines derived from the autologous patient.
Norose and Yano (1996)IL-2CTLsIL-6 production and sIL-2R secretion of CTLs were enhanced when CTLs were stimulated with P-36.
Pawelec and Bühring (1990)IL 2cytotoxic T cellTwenty-four CD4+ alloreactive helper T cell clones and eight CD8+ cytotoxic T cell clones from five different donors, all of which were dependent on alloantigen and IL 2 for continued growth, were analyzed by FACS for cell surface expression of HLA-DR, -DQ, and -DP epitopes using monoclonal antibodies against monomorphic and polymorphic determinants.
Foster et al. (2004)IL-2CTLWe found that CTL can be readily expanded ( > 200-fold) from cryopreserved stocks by nonspecific stimulation in the presence of allogeneic feeder cells and interleukin-2 (IL-2).
Mazzone et al. (1999)IL-2cytotoxic T lymphocytesThese data show that patients with ischemic heart disease have an increase in circulating cytotoxic T lymphocytes and in IL-2 plasma levels, irrespective of their clinical presentation, compared to normal control subjects, whereas IL-6 is elevated only in patients with AIS.
Palacios et al. (1981)IL-2cytotoxic T cellsFrom these results we concluded the following: (1) Both the heavy and the light chains of Dr antigens participate actively in the activation of T cells by rendering resting T cells sensitive to IL-2 and by inducing production of the growth factor in TNP-and FITC-conjugated autologous cell cultures. (2) The heavy and light chains of the DR antigens play an essential role in the induction of cytotoxic T cells specific for hapten-labeled self structures, most likely by enabling cytotoxic T cells to respond to Il-2 and by inducing the IL-2 producer T cells to synthesize the growth factor.
Rahman et al. (1995)interleukin-2cytotoxic T-lymphocyteThese results suggest a new parasite (bacterium)-oriented mechanism for enhancing antigen-driven host cytotoxic T-lymphocyte immunity which does not include promotion of interleukin-2 production.
Takatsu et al. (1986)IL 2CTLThese results suggested that both IL 2 and "helper" factors other than IL 2 are required for CTL generation from PNA+ thymocytes.
Kwong and Teh (1987)recombinant IL-2CTLThis factor (IL-X) synergized with excess human recombinant IL-2(rIL-2) in the polyclonal activation of BDF1 or D2 CTL precursors.
von Boehmer and Kisielow (1984)IL 2CTLUp to 40% of CTL clones obtained early during in vitro culture can be stimulated by antigen in the absence of extrinsic interleukin 2 (IL 2) whereas all late clones require exogenous IL 2.
Belin et al. (1990)lymphokinecytotoxic T cellsCsA works via the inhibition of both lymphokine release and subsequent activation of cytotoxic T cells.
Berrios et al. (1996)IL-2CTLThe CD4+CTL clones were stimulated with dengue antigen or monoclonal antibody to CD3 in the presence of IL-7 or IL-2.
Akashi and Kuwano (2002)IL-2CTLIn the present study, we examined the mechanisms by which IL-2 treated CTL lyse normal target cells at the cellular and mRNA levels.
Stancovski et al. (1993)IL-2cytotoxic T cellSurface expression of the anti-Neu/HER2 chimeric genes in cytotoxic T cell hybridomas endowed them with specific Neu/HER2 recognition enabling their activation for IL-2 production and lysis of transformed cells overexpressing Neu/HER2.
Harris et al. (1988)lymphokinecytotoxic T lymphocytesThe role of extracellular calcium in antigen-induced lymphokine production and interleukin 2-induced proliferation of cloned cytotoxic T lymphocytes.
Takahashi et al. (1998)IL-2CTLAlthough OK-432 increased IL-2 receptor expression on RLMNCs, it showed no synergistic effect with IL-2 in developing CTL and LAK activity.
Peiper et al. (1997)IL-2CTLsTumor-infiltrating lymphocytes (TILs) were isolated from the primary tumor, and cytotoxic T lymphocytes (CTLs) were generated after activation on immobilized anti-CD3 monoclonal antibody (MAb) for 48 hr, expansion in low-dose IL-2 and repeated stimulation with irradiated MPanc-96 tumor cells.
Zier et al. (1983)IL-2CTLThe primary CTL were then restimulated with cells from a W +/ve HLA identical sib, S2, in the presence of IL-2.
Lynch and Miller (1994)IL-2CTLCells in these cultures were also demonstrated to produce IL-2 after stimulation with irradiated tumor cells, thereby indicating that these CTL have become independent of the requirement for CD4+ helper cells to survive and function either in vitro or in vivo.
Horvat et al. (1991)IL2CTLThese results suggest that both IL2 and IL4 are both produced and required by CD8+ cells during secondary MLTC, and suggest an additional cellular source of IL4 production besides CD4+ T cells during antigen-specific CTL responses.
Yanagisawa et al. (1987)IL-2CTLThese results suggest that the defective EBV-selective CTL generation was due to deficient IL-2 production.
Mitchell et al. (2007)IL-2CTLBoth agonists induced IL-2, TNF-alpha, IFN-gamma, and degranulation with M1.2-specific CTL.
Tarazona et al. (2000)IL-2cytotoxic T cellsThey are cytotoxic T cells with strong expression of intracytoplasmic perforin and granzyme, but with low proliferative capacity and defective IL-2 production.
Kelly et al. (2004)IL-2cytotoxic T lymphocytesAlternatively, lack of IL-2 rather than a defect in IL-12, may be responsible for insufficient expansion/activation of tumour specific cytotoxic T lymphocytes.
Saijo et al. (1999)IL-2cytotoxic T lymphocytesAutologous high-killing cytotoxic T lymphocytes against human lung cancer are induced using interleukin (IL)-1beta, IL-2, IL-4, and IL-6: possible involvement of dendritic cells.
Norose and Yano (1996)IL-2CTLsCTLs also produced high levels of interferon gamma (IFN-gamma) and IL-2, but not IL-4. mRNAs of IL-2 and IFN-gamma were detected by RT-PCR in the CTLs.
Ogata et al. (1987)cell-growth factorcytotoxic T cellThis substance, thymic stroma-derived T cell-growth factor (TSTGF), was capable of inducing the proliferation of various Th clones including 9-16 Th clone, but not of cytotoxic T cell clones.
Dröge et al. (1986)interleukin-2cytotoxic T lymphocyteThe experiments suggest that histamine supports the late phase of the cytotoxic T lymphocyte response by augmenting the interleukin-2 production.
Brignone et al. (2007)IL-2cytotoxic T lymphocytesA clinically effective therapeutic vaccine to fight viruses or tumour requires the generation and expansion of specific cytotoxic T lymphocytes (CTL) able to proliferate and/or secrete Th1-type cytokines such as IL-2, IFN?
Kaufmann and Berke (1983)IL 2CTLAnti-LFA-1 monoclonal antibody, a potent inhibitor of CTL and CTL hybridoma-mediated target cell lysis, abolishes antigen- or mitogen-induced IL 2 secretion by the CTL hybridomas.
Lu et al. (1999)IL-2cytotoxic T cellIn this report we investigate the mechanism(s) responsible for this PKC activation after IL-2 stimulation in the cytotoxic T cell line, CTLL-2.
Jayshree et al. (2009)IL2cytotoxic T lymphocytesCell extrinsic elements include factors contributing towards immune tolerance; some incriminated in the multistep carcinogenesis of HPV induced cervical cancer are: immunoregulatory enzyme indoleamine 2,3-dioxygenase expressing antigen presenting cells, low numbers of invariant Natural Killer T cells, anergic cytotoxic T lymphocytes, regulatory T cells (Tregs), an immunoregulatory microenvironment comprising of increased IL10, TGF and reduced IL2; reduced intralesional ratios of effectors (CD4 and CD8) vs.
Dröge et al. (1986)interleukin-2cytotoxic T lymphocytesHistamine augments interleukin-2 production and the activation of cytotoxic T lymphocytes.
Moschos et al. (2008)IL-2cytotoxic T cellsIL-2 was originally described as a "T cell growth factor" capable of expanding previously activated T cells, enhancing the cytotoxicity of antigen-specific cytotoxic T cells and NK cells.
Kobata et al. (1993)IL-2CTLThe results indicate that UV-B-irradiated Sa cells do not provide sufficient signals for the proliferation of the CTL while they can be recognized by CTL and induce high-affinity IL-2 receptor (IL-2R) expression on them.
Kanto et al. (1997)IL-2CTLTo optimize the IL-2 dose for CTL induction, low (50 U/ml) and high (500 U/ml) doses were tested and the lytic activities were compared.
Li and Fu (2001)IL-2CTLA significant increase of IL-2 secretions was detected during IL-4 mTC inducing CTL responses.
Li and Fu (2001)IL-2CTLCONCLUSION: IL-4 gene modification might enhance the tumor cell-specific CTL killing activities by inducing cell surface molecules expression and IL-2 secretion.
Nissen and Claësson (1987)interleukin 2cytotoxic T lymphocyteIn the present study we show that human beta 2-m as well as the proteolytically modified human form (M-beta 2-m) bind to murine lymphocytes expressing H-2 class I antigens; M-beta 2-m, when added at day 0 and 1 of culture in nanomolar concentrations to a one-way murine allogeneic mixed lymphocyte culture (MLC) augments the generation of specific cytotoxic T lymphocytes; M-beta 2-m increases the endogenous production of interleukin 2 in the MLC culture; monoclonal antibody which reacts with both the native beta 2-m and M-beta 2-m molecule blocks the augmentation of cytotoxic T lymphocyte production induced by M-beta 2-m; murine as well as human MLC responder cells can proteolytically modify native human beta 2-m; and the modifying activity of murine MLC responder cells was blocked in an intermediary step by an alloantibody, which reacts specifically with murine major histocompatibility complex, class I-associated beta 2-m.
Klarnet et al. (1989)IL-2cytotoxic T lymphocytesHelper-independent CD8+ cytotoxic T lymphocytes express IL-1 receptors and require IL-1 for secretion of IL-2.
Chao and Lin (2010)IL-2cytotoxic T lymphocytesSheeja et al. showed that the A. paniculata ethanol extract and andrographolide stimulated the cytotoxic T lymphocytes (CTL) activity through enhanced release of IL-2 and IFN?
Foa et al. (1987)lymphokineCTLWe tried to understand the role of Mitomycin C and Adriamycin in the increased killing of target cells by Cytotoxic T lymphocytes (CTL) and lymphokine activated killers (LAK).
Slavcev et al. (2002)IL-2cytotoxic T-cellLower frequencies of IL-2 producing helper, cytotoxic T-cell precursors and IL-4 producing CB cells were found, whereas the frequencies of IFN-gamma producing cells, as determined by ELISpot experiments, were equivalent to the frequencies of adult IFN-gamma producing cells.
Vassilev et al. (1996)lymphokinecytotoxic T-cellsCONCLUSION: The effect of increasing the cytolysis shows that these drugs are active, probably by increasing the lymphokine secretion and the generation of cytotoxic T-cells.
Ting and Hargrove (1987)interleukin 2CTLIn contrast, cloned CTL only required interleukin 2 to maintain their growth and cytotoxic activity.
Rogy et al. (2000)IL-2cytotoxic T lymphocytesThe release of interleukin 2 (IL-2) and Interferon-gamma (IFN-gamma) by naive T lymphocytes predominantly stimulates cytotoxic T lymphocytes, macrophages, and natural killer (NK) cells and increases the antigen-presenting potential of all these cell types.
Dijke et al. (2007)interleukin-2cytotoxic T lymphocyteIn addition, the mRNA levels of CD25, glucocorticoid-induced TNF receptor family-related gene, cytotoxic T lymphocyte-associated antigen 4, interleukin-2, and granzyme B were also significantly higher in rejecting EMB than in nonrejecting EMB (rejection grade<or=2).