Viewing affirmative mentions of binding of CD4 (H. sapiens) in T cells

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Jung and Schluesener (1991)CD4T lymphocyteUsing a synthetic peptide corresponding to amino acids 5-16 of mutated p21ras proteins with an exchange of the normal glycine at position 12 by valine, it is shown here that human CD4+ T cells specifically recognize the mutated protein sequence and can be generated as antigen-specific T lymphocyte lines.
Lifson and Engleman (1989)CD4T-cellIn this report we have attempted to review our knowledge of the role(s) of CD4 in human T-cell function and the consequences of interactions between CD4 molecules and the human immunodeficiency virus (HIV).
Lifson and Engleman (1989)CD4T cellsOn activated CD4+ T cells, CD4 molecules can also interact directly with the T-cell receptor complex to influence the immune response.
Shishido et al. (1998)CD4T-cellThe CD4+ T-cell clones developed against SLA class II-negative PAECs recognized strain-specific porcine xenoantigens indirectly.
Tamma et al. (1996)CD4T cellsThese findings suggest that (i) gp 120 and jacalin compete with each other for CD4 binding and (ii) jacalin might be a useful surrogate marker for quantitative as well as qualitative deficiency of CD4+ T cells in HIV-1 infection.
Cucchiarini et al. (1995)CD4T-cellThese results highlight the key role of intracytoplasmic gp-CD4 interaction, explaining in vitro the CD4 down-regulation in T-cell lines.
Platt et al. (1997)CD4T-cellApparent infectivity of T-cell-tropic HIV-1 in culture is limited by productive associations with CD4 and is influenced in an interdependent manner by CD4 affinities of viral gp120-gp41 complexes and quantities of cell surface CD4.
Jin et al. (2004)CD4T cellCD4 and Nef could be cross-linked by a chemical cross-linker, 3,3-dithiobis[sulfosuccinimidyl-propionate], in control T cell membranes, but not in PMA-treated T cell membrane, suggesting that CD4 and Nef interacted with each other in T cells, and the phosphorylation disrupted the CD4-Nef interaction.
Barzaga-Gilbert et al. (1992)CD4T cellThis indicates that species-specific interactions between class II molecules and CD4 expressed on peripheral T cells are not sufficient to account for the low xenogeneic response and that intrinsic differences in T cell receptor structures or the need for species specificity in the interaction between CD4 and class II molecules during positive selection are also important.
Zarling et al. (1990)CD4T cellsFunctional impairment and selective depletion of CD4+ T cells, the hallmark of AIDS, are at least partly caused by human immunodeficiency virus (HIV-1) type 1 binding to the CD4 molecule and infecting CD4+ cells.
Dudhane et al. (1996)CD4T lymphocytesIt binds to CD4 cell surface markers and destroys T lymphocytes that express the receptor.
Bachelder et al. (1995)CD4T lymphocytesWhile this Fab does not bind to CD4-positive T-cell lines or to human T lymphocytes, it recognizes cell surface-expressed CD4 following the incubation of these cells with a recombinant form of HIV-1 gp120 or with HIV-1 virions.
Marschner et al. (2002)CD4T cellsLigation of human CD4 interferes with antigen-induced activation of primary T cells.
Marschner et al. (2002)CD4T cellAnalysis of the consequences of interactions between CD4 and gp120 have yielded contradictory results presumably because most of these studies have focused on T cell clones of questionable relevance to the in vivo target of the virus.
Marschner et al. (2002)CD4T cellHere, we analyzed the effects of CD4 ligation on freshly isolated cells of human CD4 transgenic mice, and show that huCD4 preligation, in the absence of human CXCR4, has an inhibitory effect on both early and late T cell activation events.
Oyaizu et al. (1993)CD4T cellsHere we show that (1) patient PMBCs undergo marked spontaneous apoptosis; (2) stimulation of T cells of patients as well as normal donors results in increased apoptosis; and (3) cross-linking of CD4 molecules is sufficient to induce apoptosis in CD4+ T cells if cross-linking is performed in unfractioned PBMCs, but not if CD4 molecules are cross-linked in purified T-cell preparations.
Algeciras et al. (1998)CD4T cellsImmediately after CD4 cross-linking, CD4+ T cells are rendered susceptible to apoptosis mediated by TNF or FasL.
Corbeil and Richman (1995)CD4T cellsProductive infection and subsequent interaction of CD4-gp120 at the cellular membrane is required for HIV-induced apoptosis of CD4+ T cells.
Molina-Pinelo et al. (2006)CD4T-cellAll variables with statistical association with CD4 T-cell loss were analyzed using multivariate Cox proportional hazards regression models.
Orloff et al. (1991)CD4T cellsHIV-1 binding to CD4 T cells does not induce a Ca2+ influx or lead to activation of protein kinases.
van Bleek et al. (2003)CD4T cellsIdentification of immunodominant epitopes derived from the respiratory syncytial virus fusion protein that are recognized by human CD4 T cells.
Skov et al. (2003)CD4T-cellInteraction between the CD4 receptor and the major histocompatibility complex class II molecule is important for T-cell activation.
Bosch et al. (2005)CD4T cellsThus, the inhibition of the specific interaction between gp120 and CD4 protein could be an effective strategy to inhibit HIV binding to CD4(+) T cells, and the mechanism by which CD4(+) T cells lacking the appropriate coreceptor may be converted in HIV carriers.
Bérubé et al. (1996)CD4T cellsWe have previously postulated that the binding of the human immunodeficiency virus type 1 (HIV-1) to cell surface CD4 induces signal transduction pathways that down-modulate production of progeny virions in acutely infected T cells (M.
Chhabra (2009)CD4T cellsWe here discuss the current approaches used for immune based cancer therapy, role of natural MHC class II-restricted CD4 T cells in tumor immunity, factors limiting the engagement of natural CD4 T cells in cancer immunotherapy protocols alongside CD8 T cells, and recent advances in TCR engineering approach to address these limitations.
Liakou et al. (2008)CD4T cellsThese CD4(+)ICOS(hi) T cells produced IFN-gamma (IFNgamma) and could recognize the tumor antigen NY-ESO-1.
Bernhard et al. (2004)CD4T cellCD4 is a cell surface protein involved in T cell activation and the binding of the human immunodeficiency virus to HIV target cells.
Fernando et al. (2007)CD4T-cellThe studies here demonstrate that cell-surface expression of Env on APCs and non-APCs as part of the vaccine action causes an inhibition of antigen-induced CD4(+) T-cell activation and proliferation mediated by CD4 binding and suggests a potential mechanism for reduced activity of Env-containing HIV vaccines.
Zepp et al. (1991)CD4T-cellSoluble CD4 (sCD4) molecules offer a novel experimental approach to investigate the relevance of CD4 interaction with its putative intrathymic receptor for T-cell maturation.
Zepp et al. (1991)CD4T-cellBeyond that, analysis of T-cell receptor (TCR) expression in the low density CD4CD8 DP population revealed a slight decrease of alpha beta-TCR surface expression, suggesting a possible role of CD4 engagement in the generation of TCR in man.
Odum et al. (1991)CD4T cellsSince class II is the natural ligand for CD4, the present data suggest that class II is induced on activated T cells to regulate CD4 function, possibly by specific interaction with the CD4-associated p56lck protein tyrosine kinase.
Hurez et al. (1994)CD4T cellsAnti-CD4 antibodies isolated from IVIg by affinity-chromatography bound to human CD4+ T cells.
Umetsu et al. (1990)CD4T cellInduction of proliferation of human follicular (B type) lymphoma cells by cognate interaction with CD4+ T cell clones.
Wasik (1992)CD4T lymphocytesPreferential interaction of the CD4+29+/45RA-subset of human CD4+ T lymphocytes with an antibody against the cell-membrane ganglioside GD3.
Willey et al. (1994)CD4T-cellA known macrophage-tropic HIV-1 isolate, also unable to infect the T-cell line, bound CD4 with similarly slow reaction kinetics.
Baier-Bitterlich et al. (1995)CD4T-cellCrosslinking of the CD4 coreceptor can inhibit subsequent T-cell activation via the T-cell antigen receptor (TCR)/CD3 complex.
Harcourt et al. (1998)CD4T lymphocyteHIV-1 variation diminishes CD4 T lymphocyte recognition.
Rojo et al. (1989)CD4T-cellThis association occurs when the T-cell receptor is cross-linked by certain anti-variable region antibodies that appear to induce a conformational change in the receptor such that it associate with CD4.
Douglas et al. (2000)CD4T cellsA new method for binding of human CD4+ T cells to microwell plates was developed, which allowed for specific quantitative assessment of eosinophil adhesion to individual CD4+ T cells in culture.
Podolin et al. (2000)CD4T-cellUpon administration of these mAbs to mice that express a human CD4 transgene, but not mouse CD4 (HuCD4/Tg mice), clenoliximab and keliximab exhibited similar kinetics of binding to CD4, and induced the same degree of CD4 modulation from the cell surface, although only keliximab mediated CD4+ T-cell depletion.
Hayball et al. (1997)CD4T cellsOur data support a role for the MHC class II dimer of heterodimers in amplifying the proliferative response of T cells to antigen by dint of the superdimers having a higher affinity for CD4 than the nominal class II alpha beta heterodimers.
Hauss et al. (1995)CD4T cellsCharacteristics of antigen-independent and antigen-dependent interaction of dendritic cells with CD4+ T cells.
Tateyama et al. (2000)CD4T lymphocytesCD4 T lymphocytes are primed to express Fas ligand by CD4 cross-linking and to contribute to CD8 T-cell apoptosis via Fas/FasL death signaling pathway.
Portevin et al. (2009)CD4T cellsInterestingly; we demonstrated that like such antibodies, 3a-G1 dendrimers specifically interacts with CD4+ T cells.
Horak et al. (1990)CD4T cellsThus, the signal transduction in T cells generated through the surface engagement of CD4 is similar to that observed for the class of growth factor receptors possessing endogenous tyrosine kinase activity.
Chao et al. (2008)CD4T cellWe conducted a longitudinal analysis of men who have sex with men (MSM) enrolled in the Multicenter AIDS Cohort Study (MACS) to define associations between self-reported use of marijuana, cocaine, poppers and amphetamines, and CD4 and CD8 T cell parameters in both HIV-uninfected and HIV-infected MSM.
Koga (1996)CD4T cellsNon-infected CD4 T cells present in the vicinity of an infected cell may be killed through several mechanisms that involve gp120-CD4 interactions.
Hashimoto et al. (1997)CD4T cellsWe have previously demonstrated that CD4 cross-linking (CD4XL) results in apoptosis of CD4+ T cells and augmentation of Fas antigen (CD95, APO-1) expression in CD4+ and CD8+ T cells.
Ayouba et al. (2008)CD4T cellsIn our last experiment (9), 24h-cultures supernatants from CD4 negative cells were added during the interaction between CD4 positive T cells infected with HIV-1/LAI and CD4 negative BeWo cells.
Brett et al. (1997)CD4T cellsInterestingly, the anti-CD4 antibody induced a differential effect on activated CD4+ T cell clones compared with resting CD4+ T cells with respect to degree of CD4 cross-linking required to induce functional effects in the T cell.
Tsygankov et al. (1993)CD4T cellIt has been shown, however, that ligation of CD4 and CD8 can also inhibit T cell activation in an MHC-independent way.
Goldstein et al. (2008)CD4T cellThese data suggest that GILT-expressing melanoma cells could prove to be very promising for direct antigen presentation and CD4+ T cell recognition, and may have direct implications for the design of cancer vaccines.
Hivroz et al. (1993)CD4T lymphocytesHuman immunodeficiency virus binds to CD4 T lymphocytes by interaction between its envelope glycoprotein gp120 and the CD4 molecule.
Louisirirotchanakul et al. (1998)CD4T-cellSera from HIV-1-positive subjects, consisting of subtypes B (n = 24) and E (n = 138), were characterized in relation to the neutralization of primary isolates and T-cell line-adapted (TCLA) strains and binding to monomeric gp120, the CD4/gp120 binding site (BS), and V3 peptides.
Fournel et al. (1993)CD4T cellInhibition of human T cell response to staphylococcal enterotoxin B by prior ligation of surface CD4 molecules.
Perno et al. (1992)CD4T-lymphocytesInhibitors of HIV binding on CD4 receptors have similar activity in M/M and T-lymphocytes, while AZT and other dideoxynucleosides (ddN) are in general more active against HIV in M/M than in T-lymphocytes.
Schäfer and Burger (1991)CD4T-cellIdentification and functional characterization of guinea-pig CD4: antibody binding transduces a negative signal on T-cell activation.
Yagi et al. (1990)CD4T cellBacterial proteins that mediate the association of a defined subset of T cell receptor:CD4 complexes with class II MHC.
Chuck et al. (1993)CD4T cellEffect of CD4 engagement on CD4-T cell receptor complexes.
Chuck et al. (1993)CD4T cellSuch alteration in CD4-TCR assembly may underly anti-Leu3a- and gp120-mediated inhibition of T cell antigen recognition and account for the negative effect of CD4 ligation on TCR-triggered responses.
Rudd et al. (1988)CD4T-cellThe potential importance of the association between the CD4 receptor and the PTK of T cells is discussed in relation to T-cell activation and HIV infectivity.
Zaitseva et al. (2005)CD4T cellsIncreased CXCR4-dependent HIV-1 fusion in activated T cells: role of CD4/CXCR4 association.
Pandolfi et al. (2009)CD4T-cellsLater, with the development of monoclonal antibodies, it became possible to recognize, within the T-cells, functional populations: CD4(+) and CD8(+).
Quaedackers et al. (2009)CD4T cellsEven after prolonged co-culture with ASC, the activated phenotype of bound CD4+ T cells persisted.
Tamma et al. (1997)CD4T cellsTo investigate the intracellular signaling events associated with CD4-gp120 interaction, we incubated CD4+ T cells from peripheral blood of HIV-negative healthy donors with HIV envelope protein gp160 alone or performed CD4XL with gp160 and anti-gp160 antibody.
Wainberg et al. (1988)CD4T lymphocytesHIV-1 preferentially infects T lymphocytes by binding to a membrane receptor protein, CD4, associated with helper function.
Jabado et al. (1997)CD4 moleculeT cellLigands binding to the CD4 molecule can inhibit TCR-mediated T cell activation.
Jabado et al. (1997)CD4T cellsBinding of HIV envelope glycoprotein gp160/gp120 or a CD4 mAb to the CD4+ T cells, prior to TCR/CD3 activation, inhibited the intracellular calcium elevation.
Hladik et al. (2007)CD4T cellsMany intraepithelial CD4+ T cells bound the green fluorescent virions (Figures 2A–2C).
Mittler et al. (1991)CD4T cellsPhysical associations between CD45 and CD4 or CD8 occur as late activation events in antigen receptor-stimulated human T cells.
Mittler et al. (1991)CD4T cellsThe kinetics of association between CD4 or CD8 and CD45 was measured by fluorescence resonance energy transfer and confirmed by immunoprecipitation of dithiobis succinimidylpropionate or disuccinimidyl suberate cross-linked 125I-labeled resting or activated T cells.
Nakamura et al. (1991)CD4T cellThese results strongly suggest that macrophage-T cell interaction through CD4 and/or class II molecules is essential for the expression of p75 IL-2 receptor and IL-2 responsiveness in human CD4+, but not CD8+ T cells.
Wang et al. (1999)CD4T lymphocytesThus, these effects of HIV upon binding to resting CD4+ T lymphocytes, which are not permissive for HIV replication, may significantly contribute to their depletion in vivo.
Tosi et al. (1996)CD4T cellsHuman erythrocytes bearing electroinserted full-length CD4 (RBC-CD4) can bind and fuse with a laboratory strain of human immunodeficiency virus type 1 (HIV-1) or with T cells infected by HIV-1.
Weiss et al. (2010)CD4T cellsViral replication and immune activation following TI increase interactions between HIV or envelope proteins and CD4 or HIV-co-receptors, and may favor the peripheral conversion of memory activated CD4 T cells into Treg [40].
Aucher et al. (2010)CD4T cellsThese results suggest that, although the presence of captured CD4 on the surface of CD8+ T cells allows for binding of the virus, this may not be enough to allow for productive infection of these cells by HIV.
Thompson et al. (1991)CD4T-cellCell surface engagement of CD4 leads to enzymatic activation of the associated p56lck and the phosphorylation of T-cell proteins on tyrosine residues.
Nath et al. (2003)CD4T cellsCell stimulation dramatically increased the amount of binding, with the highest levels of binding on CD4(+) and CD8(+) T cells.
Autiero et al. (1995)CD4T cellsThe finding that breast cancer cells express a protein able to interact with the CD4 domains involved in the recognition of class II major histocompatibility antigens suggests a possible mechanism by which a tumor may affect the activity of tumor-infiltrated CD4+ T cells.
Huang et al. (2008)CD4T-cellThe immunological parameters studied, which included the expression of CD28 and CD57 on T-cells, as well as T-cell proliferative potential, were selected because there existed a rationale for their association with CD4 count loss and viral load outcome during TI.
Oberg et al. (1997)CD4T lymphocytesLigation of cell surface CD4 inhibits activation-induced death of human T lymphocytes at the level of Fas ligand expression.
Faith et al. (1992)CD4T cellsAlthough the free CD4-binding region peptide of gp120 could inhibit polyclonal T-cell responses, only the carrier-bound peptide was able to modulate cloned T cells, suggesting a conformational requirement for functional inactivation through engagement of CD4.
Doyle and Strominger (1987)CD4T-cellThese observations have led to the speculation that CD4 binds to a monomorphic class II antigen determinant, thereby augmenting low affinity T-cell receptor-antigen interactions.
Doyle and Strominger (1987)CD4T-cellThus, the CD4 protein, even in the absence of T-cell receptor-antigen interactions, can interact directly with class II antigens to function as a cell surface adhesion molecule.
Basmaciogullari et al. (2000)CD4T cellWe previously demonstrated that gp17 binds to CD4 with high affinity and strongly inhibits T lymphocyte apoptosis induced by sequential cross-linking of CD4 and T cell receptor (TCR).
Gay et al. (1987)CD4T-cellThis result strongly indicates that CD4:HLA-DR binding occurs in this system and that this interaction augments T-cell activation.
Stanciu et al. (1996)CD4T cellAlthough the cell separation procedure had no effect on interleukin-2 receptor (IL-2R, CD25) expression, it induced production of IL-4 by both T cell subsets selected positively, implying cell activation by ligation of CD4 and CD8 molecules.
Chang and Woo (2003)CD4T lymphocytesIn order to find novel anti-HIV agents from natural products, 80 MeOH extracts of Korean plants were applied to a syncytia formation inhibition assay, which is based on the interaction between the HIV-1 envelope glycoprotein gp120/41 and the cellular membrane protein CD4 of T lymphocytes.
Meiring et al. (2005)CD4T cellEpitopes from two of these regions are recognized by HLA-DR1-restricted CD4(+) T cell lines and are conserved among different serosubtypes of meningococcal porin A.
Jauliac et al. (1998)CD4T cellTwo major pathways implicated in T cell activation are inhibited by binding of CD4 ligands to the CD4 molecule, i.e.
Kryworuchko et al. (2003)CD4T cellsThe treatment of CD4 T cells with HIV env or surface ligation of CD4 with anti-CD4 monoclonal antibodies inhibited the IL-2-induced activation of Jak-1 and Jak-3, as well as their targets, STAT5a and STAT5b.
Cefai et al. (1990)CD4T cellsAddition of purified soluble CD4 prevents binding of gps to T cells and overcomes all observed inhibitions.
Cefai et al. (1990)CD4T cellsThese results demonstrate that, in addition to their postulated role in the alteration of the interaction between CD4 on T lymphocytes and MHC class II molecules on APC, soluble HIV-1 envelope glycoproteins may directly and specifically impair the CD3/TcR-mediated activation of PLC in uninfected T cells via the CD4 molecule.
Ramduth et al. (2009)CD4T cellOnly 3/8 B clade CD4+ T cell epitopes were recognized by just 9/28 individuals of this clade C infected cohort.
Ramduth et al. (2009)CD4T cellsresponses by CD4+ T cells to pooled Gag peptides and to determine their association with viral load and CD4 count.
Sakihama et al. (1995)CD4T-cellSeveral models of the CD4-class II MHC interaction are offered, including the possibility that one or two CD4 molecules initially interact with class II MHC dimers and further associate to create larger complexes important for facilitating T-cell receptor crosslinking.
Carrel et al. (1989)CD4T-cellWhile the biochemical basis for the unique stimulatory activity of mAb B66 has yet to be defined, these findings provide direct evidence that cross-linking of CD4 alone may cause T-cell activation, thus supporting the notion that this glycoprotein can transduce independent positive signals upon binding to class II major histocompatibility complex molecules.