Viewing negative mentions of binding of CD4 (H. sapiens) in T cells

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Jin et al. (2004)CD4T cellCD4 and Nef could be cross-linked by a chemical cross-linker, 3,3-dithiobis[sulfosuccinimidyl-propionate], in control T cell membranes, but not in PMA-treated T cell membrane, suggesting that CD4 and Nef interacted with each other in T cells, and the phosphorylation disrupted the CD4-Nef interaction.
Wang et al. (1995)CD4T cellsBoth CD4 and CD8 T cells were suppressed, indicating that the suppression did not require interactions with CD4 molecules.
Siegrist (2001)CD4T cellThe apparent impairment of CD4 and CD8 T-cell function in early life seems to result from suboptimal antigen-presenting cells-T cell interactions, which can be overcome by use of specific adjuvants or delivery systems.
Heemskerk et al. (2006)CD4T cellAdenovirus-specific CD4+ T cell clones recognizing endogenous antigen inhibit viral replication in vitro through cognate interaction.
Lambert et al. (2005)CD4T cellsRESULTS: The CD4dimCD8+ T cells had decreased fluorescence intensity for CD4 but not for CD8.
Bitmansour et al. (2002)CD4T cellThese analyses revealed 1) optimal peptides capable of eliciting specific responses by themselves at doses as low as 2 pg/ml, with each log increase in dose eliciting ever-increasing frequencies of responding cells over a 4- to 5-log range; 2) significant augmentation of response frequencies at all submaximal peptide doses by CD28- and CD49d-mediated costimulation; 3) differential dose response and costimulatory characteristics for IFN-gamma and IL-2 responses; and 4) no association of activation requirements with the CD27-defined CD4(+) T cell memory differentiation pathway.
Ramesh et al. (1992)CD4T cellStructural analysis of human anti-mouse H-2E xenorecognition: T cell receptor bias and impaired CD4 interaction contribute to weak xenoresponses.
Ruuls et al. (2008)CD4T cellsAlthough zanolimumab is of human IgG1 isotype, and is intrinsically capable of activating complement (as determined in plate-bound assays), the antibody did not bind or activate complement when bound to CD4 on primary T cells.
Topalian et al. (1994)CD4T-cellIn a second patient, a CD4+ T-cell clone cultured from a melanoma lesion recognized autologous tumor Ag presented by autologous EBV-B; no corss-reactivity was observed with the other tumor system investigated, nor with autologous CD4+ T cells specific for tetanus toxoid.
Jung et al. (1994)CD4T lymphocytesBoth CD8+ and CD4+ T lymphocytes do not recognize native viral proteins but processed peptides bound to MHC class I and class II, respectively.
Jalil et al. (2009)CD4T cellAlthough we have not observed significant association between CD4 T cell count and HPV positivity, probably due to our limited sample of cases, a trend to this association is already possible to identify.
Kalter et al. (1991)CD4T cellsHIV-1 infection of target monocytes or T cells by cell-free virus was blocked completely or partially by some mAb that prevent cell-cell interactions (CD4, HLA-DR, LFA-1, LFA-3), but not by others (ICAM-1, MAC-1, gp150.95, CD2, CD3, CD14).
Lecomte and Fischer (1992)CD4T cellsSince MHC class II expression did not influence the degree of conjugate formation by naive or memory CD4 T cells with B cells, CD4-MHC class II interaction does not appear to be involved in binding itself, but may down-regulate the adhesion of memory but not naive CD4 T cells.
Jalil et al. (2009)CD4T cellIn the global context, there was significant association between HPV positivity and viral load (P < .05), but there was no clear association between HPV positivity and CD4 T cell count (P = .067), as showed in Table 1.
Schweizer et al. (2008)CD4 moleculeT cellsThe chimeric CD4 molecule expressed well upon transfection in 293-T cells, and had the required specificities, as antibody S3.5, specific for human D1, failed to bind, whereas mAb GK1.5, specific for mouse D1, bound the chimeric molecule but not wild type human CD4 (data not shown).
Suchard et al. (2010)CD4T cellCD4+ T cell FOXP3 expression is negatively correlated with CD4+ T cell count and positively correlated with viral load
Ott et al. (1998)CD4T cellsLymphoid cells of the peripheral blood showed an immunophenotype of CD3-positive gamma/delta T cells with a negativity for CD4 and CD8.
Maldarelli et al. (2007)CD4T-cellNo significant differences between treatment arms were detected in median HIV-1 RNA reduction, and additional analyses (unpublished data) indicated that both the magnitude of HIV-1 RNA reduction and the level of persistent viremia were not associated with pretherapy CD4+ T-cell count, change in CD4+ T-cell count on therapy, age at enrollment, or gender.
Nabatov et al. (2007)CD4T lymphocyteA final concentration of 5 ÁM was utilized for all statins tested with no alterations to either CD4+ T lymphocyte cell counts or cell viabilities identified (data not shown), indicating lack of toxicity induced by statins.
Martinez-Picado et al. (2005)CD4T-cellWe could find no association between in vitro replication capacity and in vivo plasma viral load doubling time and CD4(+) and CD8(+) T-cell counts at each treatment interruption.
Coiras et al. (2007)CD4T lymphocytesResting CD4+ T lymphocytes were isolated from PBMCs by negative selection with CD4 Negative Isolation Kit (T helper/inducer cells) (Dynal Biotech, Oslo, Norway), according to the manufacturer's instructions.
Qi et al. (2008)CD4T cellsHere, using two-photon intravital imaging, we show that SAP deficiency selectively impairs the ability of CD4(+) T cells to stably interact with cognate B cells but not antigen-presenting dendritic cells.
Kinet et al. (2007)CD4T cellsThese data are in contradiction with that of Jones and colleagues who do not detect binding of the HTLV-2 SU to activated CD4 T cells [30], but several technical differences in the receptor binding assays are likely to explain this discrepancy.
Mackay et al. (2009)CD4T cellThus there was no CD4+ T cell recognition of dox-induced target LCLs (other than very weak base-line recognition of the CKL virus-coded EBNA1) until 48 h post-induction, followed by a slow rise that did not reach the long-term plateau value even by 168 h.
Mao et al. (2009)CD4T lymphocytesThese earlier studies did not utilize CD4+ T lymphocytes, a natural cell target for HIV infection.
Portoles and Janeway (1989)CD4T cellThe responses of a single cloned T cell line to three different class II major histocompatibility complex (MHC) ligands have been compared for avidity, determined by inhibition with anti-T cell receptor Fab fragments directed at two different receptor epitopes, and for ease of inhibition with anti-CD4 antibody.
Rits et al. (2008)CD4T-cellsNo significant association between CD4+ T-cells or RNA setpoint and the C1604G or A1650G polymorphism was observed (data not shown).
Tsoukas et al. (1985)CD3 receptorT cellThese data indicate that neither monocytes nor CD3 receptor cross-linking are required absolutely for resting T cell activation, provided that IL 2 is supplied exogenously.