Viewing affirmative mentions of binding of CD8A (H. sapiens) in T cells

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Moebius et al. (1991)CD8T lymphocytesThus, in contrast to CD8 alpha/beta+/CD8 alpha/alpha+ T lymphocytes, cytolytic activity of CD8 alpha/beta-/CD8 alpha/alpha+ T cell clones was not inhibited by anti-CD8 monoclonal antibodies and the latter were not induced to proliferate following CD3/CD8 cross-linking.
Kent et al. (1996)CD8T-cellThese CTL, as reflected by studies of cytolytic lines and derived T-cell clones, were CD8+, did not recognize allogeneic targets, and recognized the SIV proteins in the context of class I major histocompatibility complex molecules.
Friedman et al. (2004)CD8T cellCD8 T cell clones isolated from the male donor were significantly less effective in recognizing target cells compared to cells isolated from the female donor and appeared to recognize subdominant epitopes.
Papadopoulos et al. (1996)CD8T-cellStructural characterization of HLA-I-bound self-peptides presented by the human beta-cell line HP-62 was performed to identify possible tissue-specific autoantigens in the context of CD8+ T-cell/HLA-I interactions.
Migueles et al. (2003)CD8T-cellFurthermore, CD8(+) T-cell recognition of autologous viral variants was preserved in most cases.
Oh et al. (2004)CD8T cellsCritical to the development of tumor-specific vaccines is finding and characterizing novel antigens to be recognized by CD8(+) T cells.
Gao and Jakobsen (2000)CD8T-cellMolecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor.
Sinnathamby et al. (2009)CD8T cellsFurthermore, we demonstrate that recombinant L. monocytogenes (Lm)-infected antigen-presenting cells can prime and expand epitope-specific CD8 T cells in vitro and such CD8 T cells recognize not only peptide-loaded targets but also ovarian and breast tumor cells presenting endogenous epitopes.
Shore et al. (2008)CD8alphaT cellsTo further characterize the pMHCI/CD8alphabeta interaction, binding of class I tetramers to CD8alphabeta on the surface of T cells was assessed in the presence of anti-CD8 mAbs.
Wakim et al. (2008)CD8T cellsThe results revealed that memory CD8+ T cell responses can be initiated within peripheral tissues through a tripartite interaction that includes CD4+ T cells and recruited dendritic cells.
Gajewski et al. (2006)CD8T lymphocytesIt is now little disputed that most if not all cancer cells express antigens that can be recognized by specific CD8(+) T lymphocytes.
Behrens et al. (2004)CD8T cellsWe further review the evidence that CD4 and CD8 T cells must recognize antigen on the same dendritic cell, and examine why this corecognition is required.
Cook et al. (2003)CD8T cellsJurkat T cells and primary CD4+ T cells expressing a CD8 alpha/CD28 chimeric receptor containing a mutation at tyrosine 200 in the cytoplasmic tail were unable to fully induce HIV-1 proviral transcription in response to CD8 alpha/28 receptor cross-linking in comparison to CD28 costimulation.
Miura et al. (2002)CD8T cellsThis syndrome, termed autologous GVHD, is associated with autoreactive CD8(+) T cells that recognize major histocompatibility complex (MHC) class II determinants in association with a peptide from the invariant chain.
Boothby et al. (2001)CD8T cellsCD8; naive vs. memory) to which it binds, and that point to potential pitfalls of extrapolating from tissue culture-adapted models to the regulation of T cells in vivo.
Moreau-Aubry et al. (2000)CD8T cellA processed pseudogene codes for a new antigen recognized by a CD8(+) T cell clone on melanoma.
Winchester (1999)CD8T-cellOne of these is the three-cell model of CD8 T-cell interaction, in which a dendritic cell presents a peptide from an immunogenic protein to both a CD4 and CD8 T-cell clone, providing a cognitive interaction that disrupts tolerance and results in the expansion of the cytotoxic T-cell clone.
Lillehoj and Trout (1994)CD8T cellCD8+ T cell-coccidia interactions.
Farace et al. (1994)CD8T cellThis V beta 19+ CD8+ T cell clone was shown to specifically recognize the autologous tumor cells in vitro, as determined in cytokine release assays.
Udaka et al. (1993)CD8T-cellA ubiquitous protein is the source of naturally occurring peptides that are recognized by a CD8+ T-cell clone.
McConkey et al. (1992)CD8T cellMoreover, crosslinking of Thy-1, CD4, or CD8 leads to potentiation of T cell receptor-mediated cell death, effects that appear to involve protein tyrosine kinase activation.
Emmrich et al. (1986)T811T-cellWe have concentrated on the analysis of CD8 cells and have found that BMA 030, when cross-linked together with anti-CD8 (T811), induced proliferation more than 100-fold greater than BMA 030 alone, whereas cross-linking with antibodies to other T-cell membrane antigens (HLA-A, B, or CD5) provided no or marginal synergistic signals.
Fernandez-Sesma et al. (1996)T-cell receptorT cellsWe produced a bispecific antibody (3F12) which binds influenza virus M2 protein and the T-cell receptor and can redirect staphylococcal enterotoxin B-activated T cells to kill influenza virus-infected cells and inhibit virus replication in vitro.
Cao (2010)HLA-T-cell receptorT-cellCurrent insight into the pathophysiology of this condition seems to be autoimmune-mediated postnatal cell death of hypocretin neurons occurring by organ-specific autoimmune targeting with HLA-T-cell receptor interactions.
Parmiani et al. (2002)CD8T cellsSo far, only a limited number of TAA peptides, mostly those recognized by CD8(+) T cells in melanoma patients, have been clinically tested.
Emmrich et al. (1986)CD8T-cellWe hypothesize that, in antigen-induced T-cell activation, CD8 and Ti/CD3 become cross-linked by their simultaneous binding to class I-associated structures.
Berger et al. (2000)CD8T cellsWhile the requirement of antigen-specific CD8(+) T cells is known, the precise role of CD4(+) T cells as regards specific priming, numbers needed, and interaction with CD8(+) T cells is less clear.
Stanciu et al. (1996)CD8T cellAlthough the cell separation procedure had no effect on interleukin-2 receptor (IL-2R, CD25) expression, it induced production of IL-4 by both T cell subsets selected positively, implying cell activation by ligation of CD4 and CD8 molecules.
Li et al. (1998)CD8T cellsThese results suggested that the DE loop region of the CD8 protein is an important functional epitope mediating CD8-MHC class I interaction and the activation of CD8(+) T cells, a finding that is consistent with the recently reported crystal structure of the CD8-MHC class I complex.
Li et al. (1995)CD8T cellIn this study, we found that the capacity of epithelial cells to induce CD8+ suppressor T cell activation appeared to be linked to the binding of CD8 molecules on the T cell surface.
Cruz et al. (2006)CD8T-cellHowever, it is likely that the association with high or low CD8+ T-cell counts is not dependent on the HLA-A*01 specificity itself but rather on another putative marker inherited in linkage with particular haplotypes, depending on the recombination history of the region.
Salter et al. (1990)CD8T-cellA binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2.
Mittler et al. (1991)CD8T cellsPhysical associations between CD45 and CD4 or CD8 occur as late activation events in antigen receptor-stimulated human T cells.
Mittler et al. (1991)CD8T cellsThe kinetics of association between CD4 or CD8 and CD45 was measured by fluorescence resonance energy transfer and confirmed by immunoprecipitation of dithiobis succinimidylpropionate or disuccinimidyl suberate cross-linked 125I-labeled resting or activated T cells.
Vani et al. (2007)CD8T cellA CD8+ T cell clone specific for antigen also recognizes peptidomimics present in anti-idiotypic antibody: implications for T cell memory.
Shiroishi et al. (2003)CD8T cellFinally, we show that ILT2 and ILT4 effectively compete with CD8 for MHCI binding, raising the possibility that ILT2 modulates CD8+ T cell activation by blocking the CD8 binding as well as by recruiting inhibitory molecules through its immunoreceptor tyrosine-based inhibitory receptor motif.
Abidi et al. (2008)CD8T-cellWe address the question of whether or not the antibody-mediated ligation of CD8 alone induces transcriptional remodeling in a T-cell clone, using serial analysis of gene expression.
Abidi et al. (2008)CD8T-cellEven though it fails to induce overt phenotypic changes, we find that CD8 ligation profoundly alters transcription in the T-cell clone, at a scale comparable to that induced by antibody-mediated ligation of CD3.
Abidi et al. (2008)CD8T-cellOur results imply that CD8 ligation alone is incapable of activating the T-cell clone because it fails to fully induce NFAT-dependent transcription.
Blancou et al. (2007)CD8T lymphocytesWe propose a rapid and reliable method to identify autoantigen-derived epitopes recognized by human CD8(+) T lymphocytes in T1D patients.
Deschoolmeester et al. (2010)CD8T cellsIn order for CD8+ T cells to recognize antigens, these need to be exposed on the tumor cells in association with the human leukocyte antigen (HLA) class I proteins.
Slingluff and Speiser (2005)CD8T cellsThese findings directed efforts toward identifying the molecular nature of tumor antigens recognized by CD8 and CD4 T cells.
Beverley (2008)T-cell receptorT-cellLigation of the T-cell receptor by peptides bound to MHC antigens and presented by dendritic cells, together with signals produced by the activated innate immune system, initiate T-cell responses.
Lemus and Karol (2008)T-cell receptorT-cellAn immunogen must have epitopes that can be recognized by antigen-presenting cells and a T-cell receptor, and it must be degradable.
Rzepczyk (1989)T-cell receptorT-cellEnormous progress has been made in recent years in understanding the molecular basis of the interaction of peptides, the major histocompatibility complex and the T-cell receptor.
Denkers et al. (1993)CD8T-cellCD8+ T-cell interactions with Toxoplasma gondii: implications for processing of antigen for class-I-restricted recognition.
Maeurer et al. (2002)T-cell receptorT cellsOur results suggest ways to optimize the identification and expansion of antigen-specific T cells with different requirements for the costimulatory CD8 molecule in facilitating T-cell receptor binding to peptide variants.
Caccamo et al. (2002)CD8T lymphocytesIdentification of epitopes of Mycobacterium tuberculosis 16-kDa protein recognized by human leukocyte antigen-A*0201 CD8(+) T lymphocytes.
Connolly et al. (1990)CD8T-cellSince endogenous class I molecules were expressed by all of the transfected cell lines, these findings provide direct genetic evidence that CD8 and the alpha beta T-cell receptor must interact with the same class I molecule.
Trappeniers et al. (2010)T-cell receptorT-cellThe influence of these modifications on the interaction with the T-cell receptor of NKT cells was investigated, as well as the capacity of the amino-modified analogues to induce a cytokine response after in vivo administration.
Pandolfi et al. (2009)CD8T-cellsLater, with the development of monoclonal antibodies, it became possible to recognize, within the T-cells, functional populations: CD4(+) and CD8(+).
Kerry et al. (2005)CD8T cellsMemory CD8 T cells require CD8 coreceptor engagement for calcium mobilization and proliferation, but not cytokine production.
Kerry et al. (2005)CD8T cellsSurprisingly, like naive cells, memory CD8(+) T cells required CD8 engagement for calcium mobilization and optimum proliferation.
Tsygankov et al. (1993)CD8T cellIt has been shown, however, that ligation of CD4 and CD8 can also inhibit T cell activation in an MHC-independent way.
Wong et al. (2008)CD8T-cellsCD8+ T-cells and their interaction with other cells in damage to islet beta-cells.
Kuntzen et al. (2007)CD8T-cellIn contrast to studies in HIV and SIV, however, only 11% of these were associated with detectable CD8+ T-cell responses.
Kaplan et al. (1989)CD8T lymphocytesThe molecular details of immunoregulatory phenomena associated with CD8+ T lymphocytes have not been clearly elucidated.
Ando et al. (2004)CD8T-cellHemophagocytic syndrome associated with CD8 positive T-cell chronic lymphocytic leukemia.
Gianfrani et al. (2003)CD8T cellCeliac disease association with CD8+ T cell responses: identification of a novel gliadin-derived HLA-A2-restricted epitope.
Ferguson et al. (2008)CD8T cellsThe ability of CD8+ T cells to recognize melanoma tumors has led to the development of immunotherapeutic approaches that use the antigens CD8+ T cells recognize.
Streeck et al. (2008)CD8T cellsTherefore, we hypothesized that reduction in the functional avidity of the interaction between CD8+ T cells with their respective epitope resulting from amino acid substitutions will also affect the expression of PD-1 on those cells, indicating weaker activation of these epitope-specific CD8+ T cells.
Streeck et al. (2008)CD8T cellsFinally, the appearance in the patients' blood of viruses that had made changes in the specific epitopes recognized by the CD8+ T cells to avoid being killed by these cells, also reversed the exhaustion of the T cells recognizing these particular epitopes.
Friedman et al. (2004)CD8T cellProstein-specific CD8 T cell clones specifically recognized prostein-expressing targets, including prostate tumor cell lines expressing the relevant HLA alleles.
Varghese and Kane (2008)CD8T cellsIn this study, we show that in human CD8(+) T cells, TCR complex signaling activates CD8 adhesion molecule function, resulting in a CD8 interaction with MHC-I that is sufficient to maintain firm T cell adhesion under shear conditions.
Yokoyama et al. (2005)CD8T lymphocytesFatal rapidly progressive interstitial pneumonitis associated with amyopathic dermatomyositis and CD8 T lymphocytes.
Saksena et al. (2008)CD8T lymphocytesHuman immunodeficiency virus interactions with CD8+ T lymphocytes.
Bushkin et al. (1988)CD8T lymphocytesPhysical association between the CD8 and HLA class I molecules on the surface of activated human T lymphocytes.
Bushkin et al. (1988)CD8T cellsAccordingly, anti-CD8 monoclonal antibodies precipitated a heterodimer containing polypeptides of 32 and 43 kDa from the lysates of activated T cells.
Cruz et al. (2004)CD8T cellsIn the normal population, results showed a strong statistically significant association of the HLA-A*01 with high numbers of CD8(+) T cells and a less powerful association with the HLA-A*24 with low numbers of CD8(+) T cells.
Sadagopal et al. (2005)CD8T cellsMost animals recognized two CD8 and one CD4 epitope and had frequencies of IFN-gamma-responding T cells from 0.01 to 0.3% of total CD8 or CD4 T cells.
Kansas and Engleman (1987)CD8T cellsThus, at least 3 phenotypically distinct subsets of T cells interact sequentially to generate suppression of B cell differentiation induced in the AMLR: CD4+,Leu8+ suppressor/inducer cells, CD8+,Leu8+ suppressor-amplifier cells and CD8+,Leu8- suppressor-effector cells.
Cruz et al. (2008)CD8T-lymphocyteResults described in this work showed that a conserved region around the microsatellite D6S105, defined by the markers PGBD1-ZNF193-ZNF165, is associated with CD8+ T-lymphocyte numbers and with the severity of the clinical expression in Portuguese HH patients.
Nath et al. (2003)CD8T cellsCell stimulation dramatically increased the amount of binding, with the highest levels of binding on CD4(+) and CD8(+) T cells.
Buslepp et al. (2003)CD8T cellsEven in the absence of direct CD8 binding, stimulation of AHIII 12.2 T cells with "CD8-independent" p1049/A2 produces p56(lck) activation and calcium flux.
Nakamura et al. (2007)CD8T lymphocytesHuman leukocyte antigen (HLA) typing revealed A24 positivity, suggesting this molecule was interacting with CD8(+) T lymphocytes.
Rist et al. (2009)T-cell receptorT-cellMore importantly, cross-reactive TRBV13(+) clonotypes displayed markedly lower T-cell receptor binding affinity and a distinct pattern of peptide recognition, presumably mimicking a structure presented on the HLA DR4 allotype.
Appay et al. (2006)CD8T cellA collection of predicted Melan-A cross-reactive peptides, identified from a combinatorial peptide library, was used to probe functional antigen recognition of PBMC ex vivo and Melan-A-reactive CD8(+) T cell clones.
Ferguson and Engelhard (2010)CD8T cellsPrevious work from this laboratory showed that generation of memory CD8 T cells by different immunization routes correlates with control of tumors growing in distinct sites.
Keller et al. (2009)CD8T cellsThis finding is of physiological importance because B cells with the ability to cross-present Ag to specific CD8(+) T cells may be killed by these cells, preventing the generation of neutralizing Ab responses.
Roberts et al. (2009)CD8T cellsDifferent Hu patients harbored 1 of 2 kinds of HuD-specific CD8+ T cells: classical IFN-gamma-producing CTLs or unusual T cells that produced type 2 cytokines, most prominently IL-13 and IL-5, and lacked cytolytic activity.
Chen et al. (2009)CD8T-cellsHLA-A11-transgenic mice immunized with these epitopes could specifically induce interferon-gamma (IFNgamma) production, cytotoxicity and peptide/HLA-A11 tetramer binding in CD8(+) T-cells.
Betts and Harari (2008)CD8T cellsRECENT FINDINGS: It has become clear that multiple functions and phenotypic markers of T cells must be assessed to accurately characterize the complexity of CD4 and CD8 T cell responses.
Wahl et al. (2007)CD8T cellsHence, IL-10-producing CD8 T cells are generated in a type I IFN-dependent manner if the three cell types (CD8 T cells, NKT cells, and ligand-presenting HC) specifically and closely interact.
Kinet et al. (2007)CD8T lymphocytesMoreover, Glut-1 is induced by TCR engagement, resulting in massive increases in glucose uptake and binding of HTLV-1 and -2 envelopes to both CD4 and CD8 T lymphocytes.
Zehbe et al. (2007)CD8T cellsFurther analysis showed that the HPV16 E6-reactive CD8 T cells were of high avidity defined by blocking with an anti-CD8-alpha specific monoclonal antibody.
Bansal et al. (2007)CD8T-cellThese data suggest that viral fitness costs associated with CD8 T-cell pressure is an important factor determining differences in the viral load among HIV-infected patients.
Schmitz-Winnenthal et al. (2006)CD8T cellsSpecific immune recognition of pancreatic carcinoma by patient-derived CD4 and CD8 T cells and its improvement by interferon-gamma.
Fougeray et al. (2006)CD8T cellIt is known to induce maturation of monocyte-derived dendritic cells in vitro and is used as a vaccine adjuvant to induce CD4 Th1 and CD8 T cell responses in vivo.
Devine et al. (2006)CD8alphaT cellThe partial rescuing of binding with wild-type CD8beta compared with wild-type CD8alpha is consistent with models in which either the topology of CD8alphaalpha and CD8alphabeta binding to MHC class I is different or CD8alphabeta is capable of binding in both the T cell membrane proximal and distal positions.
Buisson and Triebel (2005)CD8T-cellIt is known to induce maturation of monocyte-derived dendritic cells in vitro and is used as a vaccine adjuvant to induce CD4 T helper type 1 responses and CD8 T-cell responses in vivo.
Chen et al. (2004)CD8T cellsIn this study, mycobacterial Hsp65 is demonstrated to have the ability to help cross-present an exogenous protein by dendritic cells (DC) to CD8 T cells without the need for complex formation between Hsp65 and the protein.
Vigneron et al. (2004)CD8T lymphocytesHere, CD8 T lymphocytes were found to recognize a nonameric peptide on melanoma cells that comprises two noncontiguous segments of melanocytic glycoprotein gp100(PMEL17).
Woll et al. (2004)CD8T cellsE75 peptide-specific CD8 T cells were detected directly in the peripheral blood of patients by staining with E75-HLA-A2 dimers and CD8 antibodies.
Gamadia et al. (2004)CD8T cellsThe underlying mechanism of this association could be the generation of CMV-specific CD8 T cells capable of cross-reacting with alloantigens present on graft and host, respectively.
Castiglione et al. (2004)CD8T cellsAs predictive parameters of disease progression we found that HIV-1 accumulates "bit" mutations mainly in the peptide sequences recognized by cytotoxic CD8 T cells, indicating that cell-mediated immunity plays a major role in viral control.
Chang (2003)CD8T cellCellular immune response does seem to play a role in the virologic outcome during acute infection based on strong association of a sustained vigorous and multispecific antiviral CD4 and CD8 T cell response with HCV clearance during acute infection.