Viewing affirmative mentions of gene expression of IL2 (H. sapiens)

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Khanna et al. (2003)IL-2Th1 cellsTh1 cells produce IL-2, which is essential for proper cellular immunity.
Mitsuishi et al. (2003)IL-2Th1 cellsOur results show that the higher dose of oral cimetidine was more effective in treating multiple viral warts, that cimetidine activates Th1 cells to produce IL-2 and IFN-c and that their expression correlates with wart remission.
Taylor-Robinson (1997)IL-2Th1 cellsBy dose-response analysis, I demonstrate here that Th1 cells produce optimal levels of IL-2 and a proliferative response, and no detectable NO, when stimulated with relatively low concentrations of antigen or mitogen in vitro.
de Waal Malefyt (1997)IL-2T-helper 1 cellsT-helper 1 cells produce interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), and develop following priming with IL-12.
Mattern et al. (1994)IL-2Th1 cellThe proliferation is accompanied by the expression of mRNA for the Th1 cell-derived lymphokines IFN-gamma and IL-2, but not for the Th2 lymphokines IL-4, IL-5, or IL-10.
Agostini et al. (1997)IL-2Th1 cellsThe impairment of interleukin-2 (IL-2) production occurs very early after human immunodeficiency virus (HIV) infection as a consequence of the quantitative depletion of Th1 cells.
Singh and Rai (2001)interleukin-2Th1 cellsInterferon-gamma (IFN-gamma) is the signature cytokine of Th1 cells, which also produce interleukin-2 (IL-2) and tumor necrosis factor-beta (TNF-beta).
Salazar et al. (2010)IL-2Th1 cellA key cytokine for IL-2 production and Th1 cell differentiation is IL-12 [30, 31].
Nagase et al. (1996)IL-2Th1 cellsCyclosporin A, which totally blocks IL-2 production of Th1 cells, barely or only partially inhibited PMA- or aCD3-induced proliferation of F1.
Katsikis et al. (1995)IL-2Th1 cellsHence some human Th1 cells are capable of producing both pro-inflammatory (IL-2, IFN-gamma) and anti-inflammatory (IL-10) cytokines, therefore the function of these cells may not be accurately encapsulated by the 'Th1' terminology.
Yano et al. (2003)IL-2Th1 cellsTh1 cells preferentially produce IL-2 and IFN-gamma, resulting in a cellular response that helps to eliminate infected cells.
Lundqvist et al. (1996)IL-2Th1 cellsAll three jejunal IEL subpopulations (CD4-CD8-TCR-gamma delta+, CD4+TCR-alpha beta+, CD8+TCR-alpha beta+) expressed the same four cytokines, IL-2, IL-8, IFN-gamma, and TNF-alpha, indicating that CD4+TCR-alpha beta+ IEL are Th1 cells and that TCR-gamma delta+ IEL and CD8+TCR-alpha beta+ IEL include cytotoxic effector cells.
Aframian et al. (1996)IL-2Th1 cellsHence, three genes characteristically expressed in Th1 cells, encoding IL-2, IFN-gamma, and TNF-beta, are similarly regulated by cell-mediated suppression.
Chavey et al. (2007)IL-2Th1 cellsTh1 cells produce IL-2 and IFN-?
Kurt-Jones et al. (1987)lymphokineTh1 cellsMoreover, the unresponsiveness of Th1 cells to BSF-1/IL-4 may be related to lower levels of expression of surface receptors for this lymphokine.
Schlaak et al. (1992)IL-2Th1 cellsFurthermore, the Th2 cytokine IL-10 inhibited the antigen-specific proliferative response and IFN-gamma and IL-2 production by the Th1 cells.
Taylor-Robinson (1997)IL-2Th1 cellInhibition of IL-2 production by nitric oxide: a novel self-regulatory mechanism for Th1 cell proliferation.
Taylor-Robinson (1997)IL-2Th1 cellsHere, it is demonstrated that the inhibition of Th1 cell proliferation by the NO donor S-nitroso-N-acetyl penicillamine (SNAP) can be reversed by the addition of rIL-2 but not of rIFN-gamma, suggesting that the inhibition of Th1 cells by NO may be preventing the production of IL-2.
Hwang et al. (2005)IL-2Th1 cellsIL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508.
Hwang et al. (2005)IL-2Th1 cellsHere, we report that T-bet(S508) is required for the optimal repression of IL-2 production in developing Th1 cells.
Yang et al. (2006)IL-2Th1 cellCONCLUSION: Angelica sinensis polysaccharide could regulate the immune response through upregulating IL-2, IFN-gamma expression and activating Th1 cell.
Ohkuri et al. (2009)IL-2Th1 cellsMoreover, it was shown that ligation of MAGE-A4-reactive Th1 cells with the cognate peptide caused the production of IFN-gamma and IL-2.
Mellado et al. (1998)IL-2Th1 cellsAdministration of human growth hormone at the time of gp120 immunization provokes a change in the cytokine production pattern, with lower IL-4 and higher gamma-IFN and IL-2 synthesis levels, indicating a preferential switch in stimulation from Th2 to Th1 cells.
Garcia-Maurińo et al. (1997)IL-2Th1 cellsWe have also achieved enhanced production of IL-2 and IL-6 using CGP 52608, a specific ligand of the putative nuclear melatonin receptor RZR/ROR, raising the possibility of direct effects of melatonin on gene regulation in both Th1 cells and monocytes.
Taylor-Robinson (1997)IL-2Th1 cellsDose-response studies showed that Th1 cells produce optimal levels of IL-2 and a proliferative response, and no detectable NO, when stimulated with relatively low concentrations of antigen or mitogen in vitro.
Zhao et al. (2010)IL-2Th1 cellsWithin the CD4+ T helper (Th) of patients with SLE, activated Th2 cells overproduce interleukin-6 (IL-6), IL-10, IL-13, and tumor necrosis factor-a whereas Th1 cells underproduce IL-2, interferon-gamma (IFN-?)
Tsuji et al. (2005)IL-2Th1 cellsIn contrast to gene-modified Tc1 cells, Th1 cells produced high amounts of interleukin-2 (IL-2) in addition to IFN-gamma, which is beneficial for induction of antitumor cellular immunity.
Schulze-Koops et al. (1998)IL-2Th1 cellsCONCLUSION: Clinical improvement in patients with RA treated with a non-depleting Mab to CD4 may be related to a decrease in the function of IL-2 and IFN-gamma producing Th1 cells.
Go et al. (1993)IL-2Th1 cellsThe helper function of Th1 cells in particular can be inactivated by inducing the T cell into a state of nonresponsiveness in which the T cell is no longer capable of producing IL-2 or proliferating in an autocrine way to a conventional antigenic stimulus.
Sands (2007)IL-2Th1 cellsIn the early 1990s, animal models of immunologic disease demonstrated that T helper (Th) cell populations segregated according to distinct cytokine profiles.68 Th1 cells are characterized by the expression of IL-2, interferon-?
Gallego et al. (2003)IL-2T-helper 1 cellsWe studied the intracellular expressions of interleukin-2 (IL-2), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) in T-helper 1 cells (Th1 response) of B-CLL.
Yasui et al. (1998)IL-2Th1 cellsWe provide evidence that repression of IL-2 gene expression in Th2 cells and partial repression in Th1 cells are mediated by ZEB, a zinc finger, E box-binding transcription factor.
Shin et al. (2010)IL-2Th1 cellsThe typical secretory products of Th1 cells are IL-2, IL-12, TNF-?
O'Garra et al. (1997)IL-2Th1 cellsTh1 cells, important for cell-mediated immunity by their production of IL-2, IFN-gamma and lymphotoxin, have been implicated in the immunopathology of certain organ-specific autoimmune diseases whereas a role as regulators has been suggested for IL-4 and IL-10 producing Th2 cells.
Dayer and Burger (1999)IL-2Th1 cellsDuring the course of this interaction, Th1 cells produce IL-2 and IL-17, which act on T cells in an autocrine or paracrine fashion, and interferon-?
Murakami et al. (2004)interleukin-2Th1 cellsThe Th1 cells produce interferon gamma and interleukin-2 (IL-2), and are involved in cell-mediated immunity.
Simon et al. (1992)IL-2Th1 cellsAdditional work has shown this acquired unresponsiveness of Th1 cells to represent a long-lasting form of clonal anergy that results from a block in their ability to produce IL-2.
Yang and Raimundo (2010)IL-2Th1 cellsTwo important populations of CD4 T cells can be identified in the response to mycobacterial infection: Th1 cells produce interleukin 2 (IL-2) and ?
Gollob et al. (1996)IL-2Th1 cellsThese results demonstrate an early correlation of gene transcription for IL-4 and IFN-gamma, with the development of IL-4 SC and Th1 cells, and a lack of a correlation at these early time points for expression of IL-2, IL-5 and IL-10.
Kim et al. (2005)IL-2Th1 cellsHowever, the endo-polysaccharide did not affect the proliferation of T cells, the IL-2 expression of Th1 cells, or the IL-4 expression of Th2 cells.
Raziuddin et al. (1998)IL-2Th1 cellRESULTS: PBMC from patients with BD produced higher levels of IL-4, IL-10, and IL-13 (Th2 cell response), almost normal levels of IL-2 (Th1 cell response), but highly deficient IFN-gamma and IL-12 (Th1 cell response).
Suarez-Pinzon and Rabinovitch (2001)IL-2Th1 cellsApproaches that attempt to correct underlying immunoregulatory defects in autoimmune diabetes include interventions aimed at i) deleting beta cell autoreactive Th1 cells and cytokines (IFNgamma and IL-2) and/or ii) increasing regulatory Th2 cells and/or Th3 cells and their cytokine products (IL-4, IL-10 and TGFbeta1).
Walker et al. (1994)IL-2Th1 cellIn contrast, the analysis of the cytokine profile in sarcoidosis patients revealed a Th1 cell cytokine pattern characterized by increased concentrations of IL-2 and IFN-gamma but normal levels of IL-4 or IL-5.
Xiao et al. (2000)IL-2Th1 cellsRESULTS: The positive rate of mRNA expression for Th2-derived IL-4, IL-6, IL-10 in the study group were 18/23, 19/23 and 10/23 respectively, and those for IFN-gamma and IL-2 produced by Th1 cells were 1/23 and 13/23, respectively.
Staneková and Vare?ková (2010)IL-2Th1 cellsTh1 cells also produce IL-2, required for the proliferation of the virus-specific CD8+ CTLs.
Seymour et al. (1996)IL-2Th1 cellsIn general, Th1 cells produce IL-2 and IFN-gamma while Th2 cells produce IL-4, IL-5 and IL-6.
Tamura et al. (1993)IL-2Th1 cellThese findings support a hypothesis that Th2 cell clones use a signaling pathway for IL-4 production that is independent of protein tyrosine kinase, PIP2 breakdown or PKC, and that the [Ca2+]i elevation is the only pathway common to an IL-2 production of Th1 cell subset.
Rajnavölgyi et al. (1997)interleukin-2Th1 cellsDue to the stabilizing effect of the fusion peptide, peptides comprising the 306-341 or 317-341 H1 sequences are highly immunogenic and elicit a protective immune response which involves the production of antibodies and interleukin-2 and tumor necrosis factor producing effector Th1 cells both directed against the 317-329 region.
Yang et al. (2005)IL-2Th1 cellsCD4+ Th1 cells produce IFN-gamma, TNF-alpha, and IL-2.
Yang et al. (2005)IL-2Th1 cellsWhen SPHK1 expression was knocked down by SPHK1 short interfering RNA, the production of IL-2, TNF-alpha, and IFN-gamma by Th1 cells in response to TCR stimulation was enhanced.
Yang et al. (2005)IL-2Th1 cellsConsistently, overexpression of dominant-negative SPHK1 increased the production of IL-2, TNF-alpha, and IFN-gamma in Th1 cells.
Skapenko et al. (1999)IL-2Th1 cellsIn all patients a marked decrease in IL-2-producing cells and a significant increase in well-differentiated Th1 cells that produced IFN-gamma but not IL-2 were evident after priming with anti-CD3 and anti-CD28.
Lai et al. (1994)IL-2Th1 cellsThe IL-2 mRNA levels in Th1 cells from these patients with IgAN also correlated significantly with the IL-4 or IL-5 mRNA levels in their Th2 cells.
Hodge et al. (1995)IL-2Th1 cellsTh1 cells, characterized by the production of IL-2 and IFN-gamma, stimulate cellular immune responses important for protection against intracellular pathogens.
Cecere et al. (2004)IL-2Th1 cellThe specific Th1 cell defect is correlated with insufficient Th and CTL responses, and lower production of type 1 cytokine (IL-2, IFN-gamma, lymphokine-activated killer cells).
Stevens et al. (2006)IL-2Th1 cellsDO11.10 Th1 cells deficient in PKCtheta produced significantly less TNF-alpha and IL-2.
Zepp et al. (1996)interleukin 2T-helper 1 cellsMeasurements of cytokine secretion profiles demonstrated a preferential induction of interleukin 2- and gamma interferon-producing T-helper 1 cells and only low production of interleukin 10.
Suga et al. (1997)IL-2Th1 cellsThe Th1 cells produce IL-2 and IFN-gamma.
Fu et al. (2004)IL-2Th1 cellsThe mRNA expressions of IFN-gamma and IL-2 of the Th1 cells in all IRP patients were not higher than those in the other groups.
Erf (2004)interleukin-2Th1 cellsTh1 cells are characterized by their production of cytokines such as interferon-gamma (IFN-gamma), tumor-necrosis factor-alpha (TNF-alpha), and interleukin-2 that drive CMI responses.
Kráslová et al. (2003)interleukin-2Th1 cellsTh1 cells produce cytokines: interleukin-2, IFN-gamma, TNF-alpha, which are responsible for effective activation of CTL cells.
Sin et al. (2001)IL-2Th1CD40L also enhanced Th cell proliferative responses and production of Th1-type cytokines (IL-2 and IFN-gamma) and beta-chemokines (RANTES and MIP-1alpha) from splenocytes.
Larson and Horak (2006)IL-2Th1 cellsThe cytokine profile that has been used to describe subtypes of Th (CD4+) lymphocytes is Th1 and Th2; Th1 cells produce IL-2, IL-12, IFN-?
Ngo-Giang-Huong et al. (2001)interleukin 2Th1 cellFurthermore, IgG2 directed against Gag proteins was significantly associated with HIV-1 p24-specific Th1 cell production of interferon gamma and interleukin 2.