Viewing affirmative mentions of localization of IL2 (H. sapiens) in leukocyte

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Paradisi et al. (1995)IL-2leukocyteThese findings confirm IL-2 to be in seminal plasma, show increased IL-2 secretion in the infertile group, demonstrate negative correlations of IL-2 levels with main spermiogram parameters, and indicate no correlation with leukocyte count.
Hirunpetcharat et al. (1988)IL-2PBMLThis method is based on the principle that PHA-stimulated PBML, as effector cells, secrete interleukin 2 (IL-2) into soft agar containing mouse 3-day Con A blasts as IL-2 dependent responder cells.
Gastl et al. (1992)IL-2leukocyteFluorescence-activated cell sorter analysis of SK-RC-29 cells releasing IFN-gamma showed increased expression of major histocompatibility complex class I antigen, beta 2-microglobulin, and ICAM-1, as well as induction of major histocompatibility complex class II antigen expression [human leukocyte antigen(HLA)-DR, -DP], but no changes in these cell surface markers were observed with SK-RC-29 cells releasing IL-2.
Helm et al. (1993)Interleukin 2leukocytesInterleukin 2 secretion by phytohemagglutinin-stimulated mononuclear leukocytes was deficient when compared with six healthy donors (< 300 pg/ml vs 2108 +/- 336 pg/ml).
Bishara et al. (1998)IL-2leukocyteOf the four SFM tested, only Biotarget- was as effective as SCM in supporting leukocyte proliferation and IL-2 secretion.
Kovacs et al. (1993)IL-2-treatedleukocytesCONCLUSION: Mediators that induce connective tissue production are secreted by IL-2-treated peripheral blood leukocytes.
Panelli et al. (2004)IL-2immune cellSince IL-2 has no direct anti-cancer effects, it is believed that cancer regression is mediated either by a direct modulation of immune cell effector functions or through the mediation of soluble factors released as a result of IL-2 administration.
Touw et al. (1985)IL 2leukocytesIn the latter cases, feeder leukocytes alone, releasing some IL 2, stimulated growth suboptimally at different cell concentrations.
Schildhauer et al. (2006)IL-2PBMCWhile the spontaneous generation of cytokines was not influenced, the IL-2 release from stimulated PBMC was significantly decreased in contrast to other analyzed cytokines after contact to the curing CBC compared to control incubations without CBC.
Nayeem et al. (1992)lymphokineleukocyteThe difference between means leukocyte migration inhibition of the above two with regards to release of lymphokine was highly significant (P less than 0.001).
Boccaletti et al. (1996)interleukin-2leukocytesWe tested IFN-gamma, TNF-alpha and interleukin-2 (IL-2), which are presumably released by infiltrating leukocytes in the melanoma lesional environment, on three melanoma cell lines.
Janele et al. (2006)IL-2leukocytesIn this study on peripheral blood leukocytes of healthy male subjects, we scrutinized the influence of prior sex hormones (for 24 h) with and without later addition of cortisol (for another 24 h) on stimulated secretion of TNF, IL-2, IL-4, IL-6, IL-10, and interferon-gamma (IFN-gamma).
Guan et al. (1987)lymphokineleucocytesInhibition of migration by gluten derived peptides appears to result from the release of lymphokine by leucocytes specifically from coeliac patients.
Dozmorov et al. (2007)IL-2immune cellIncluded are early immune cell response (PTCRA, PPIB), immune response via IL-2 (DGKE) and NF-?
Keller et al. (2010)IL-2leucocyteFunctional analysis such as proliferation assays, IL-2 secretion assays, and calcium influx experiments were performed using irradiated, glutaraldehyde-fixed, CM-pre-incubated, human leucocyte antigen (HLA)-DR-matched or -mismatched antigen-presenting cells (APCs), and HLA-blocking antibodies.
Kroemer and Martínez (1991)lymphokineleukocytesMany, especially systemic, autoimmune diseases are accompanied by a dysregulation of lymphokine secretion at the level of circulating leukocytes or cells situated outside of the local inflammatory event, thus reflecting regulatory disorders that may either have a genetic or an acquired basis.
Jeras et al. (2010)IL-2immune cellTherefore a concomitant use of IL-2 and IL-15 seems to be of benefit in adoptive immune cell preparation and transfer [46].
Tang et al. (1999)lymphokineimmune cellsCONCLUSION: Our study demonstrated the involvement of activated immune cells and release of lymphokine(s) in more than half of the diabetic epiretinal membranes tested and revealed that the processes of immune responses and the biological effects of lymphokines(s) may play an important part in the development of epiretinal membranes of PDR, especially in young-onset and type I diabetes.
Rouveix et al. (1986)lymphokineleukocyteThe lymphokine involved, namely the leukocyte aggregating factor (LAgF) was released by non pulse exposure to the mitogen for up to 72 hr with a maximum at 48 hr.
Tang and Le-Ruppert (1995)lymphokineimmune cellsCONCLUSION: Our study demonstrated the involvement of activated immune cells and release of lymphokine(s) in more than half of the diabetic epiretinal membranes tested and revealed that the processes of immune responses and the biological effects of lymphokine(s) may play an important part in the development of epiretinal membranes of PDR, especially in young-onset and type I diabetes.
Alegre et al. (1991)IL-2leukocytesIn vitro experiments on human peripheral blood leukocytes indicated that PTX alone or in synergy with methylprednisolone (m-PDS) also inhibited the release of TNF and IL-2 induced by OKT3.
Watzl et al. (1991)IL-2leukocyteWe investigated the in vitro effects of both psychoactive and nonpsychoactive marijuana components on leukocyte secretion of the immunoregulatory cytokines interleukin-1 alpha (IL-1), tumor necrosis factor alpha (TNF), interferon-gamma (IFN) and interleukin-2 (IL-2).
Szigeti et al. (1984)lymphokineleukocyteSoluble membrane fractions derived from Raji cells trigger lymphocytes of Epstein-Barr virus (EBV)-seropositive, but not EBV-seronegative, individuals to release a lymphokine that inhibits leukocyte migration.
Kelly et al. (1982)lymphokineLeukocytesLeukocytes of scleroderma patients were found to be hyporesponsive to E-type prostaglandin (i.e., lymphokine secretion by these cells was not inhibited at concentrations of PGE2 between 2.8 X 10(-8) and 2.8 X 10(-5) M).
Ezeamuzie and Assem (1985)lymphokineleucocytesA human histamine releasing lymphokine (histamine releasing factor, HRF) was studied for its ability to release slow reacting substance (SRS) alongside histamine from human leucocytes.
Namazi (2005)IL-2immune cellsBased on the immunopathogenesis of psoriasis, this paper introduces three novel, potential treatments for this clinical conundrum: (i) cannabinoids, which exert inhibitory effects on antigen processing and macrophage/T-cell interaction and also on the release of IL-2, TNF-alpha and nitric oxide from immune cells; (ii) loratadine, which is an antihistamine capable of increasing [corrected] the cAMP/cGMP ratio and the production of leukotriene B4; and (iii) allopurinol, which scavenges free radicals, inhibits the production of TNF-alpha, and downregulates the expression of intercellular adhesion molecule-1 and P2X7 receptors on monocytes/macrophages, which are involved in antigen presentation and production of the inflammatory response, respectively.
Gandhi et al. (2010)IL-2immune cellsIn MS, chemokines act as chemoattractants: recruiting immune cells and the proinflammatory cytokines they secrete, such as IL-2, IFN?
Ezeamuzie and Assem (1985)lymphokineleucocytesRelease of slow reacting substance (SRS) from human leucocytes by lymphokine.
Nayeem et al. (1991)LymphokineleukocyteLymphokine release by T lymphocytes in response to both DDMP and whole amoebic lysate (WAL) was performed by leukocyte migration inhibition test.
Guo et al. (2003)IL-2leukocytesAs compared with the pretreatment condition the proliferation of bone marrow in 8 cases become better; the leukocytes, granulocytes, hemoglobin and platelets of peripheral blood increased 1.59 x 10(9)/L, 0.72 x 10(9)/L, 40 g/L and 47 x 10(9)/L respectively (P < 0.01, respectively); the ratio of CD(4)/CD(8) of T cell subsets increased from 1.12 to 1.42 while the expression of HLA-DR antigen decreased from 29.2 to 15.2 (P < 0.01, respectively); TNF alpha, IFN gamma and IL-2 secreted by peripheral blood mononuclear cells (PBMNCs) decreased obviously from 267, 784 and 92 to 152, 570 and 51 U/ml on the average respectively (P < 0.01, respectively).
Wang et al. (2011)IL-2immune cellsIn contrast to chemotherapy drugs, which have a suppressive effect on immune cells, CIK cells not only kill tumor cells directly, but also can themselves secrete many cytokines, such as IL-2, TNF-?
Surcel et al. (1989)interleukin-2leukocyteFrancisella tularensis-specific T-cell clones are human leukocyte antigen class II restricted, secrete interleukin-2 and gamma interferon, and induce immunoglobulin production.
Sibbitt (1991)lymphokineimmune cellsBecause both cytokines and oncogenes products are necessary for expansion of immune cells, it is possible that inappropriate activation of oncogenes might influence cytokine and lymphokine secretion as well as the expression of immune response genes necessary for the development of autoimmunity in a susceptible individual.
Harris et al. (1997)IL-2immune cellsThe early release of mediators such as IL-2 likely emanate from the endolymphatic sac and result in potentiation and regulation of the response and may assist in changes in the SMV, including expression of ICAM-1, which aid in the egress of immune cells from the systemic circulation.
Waters et al. (1984)interleukin 2leukocytesA CB6F1 murine T-cell hybridoma, FN1-18, secreting interleukin 2 in response to presentation of keyhole limpet hemocyanin (KLH) by syngeneic cells in the context of an I-E gene complementation product, also exhibited a major histocompatibility complex-restricted response to KLH presented by human leukocytes.
Sedo et al. (2005)IL-2leukocytes, and a similar effect has been noted upon IL-2 release by mouse leukocytes [71].
Pawelec et al. (1984)Interleukin-2leukocyteDespite having an OKT4+, OKT-, Leu8- phenotype, and secreting Interleukin-2 after contact with stimulatory cells, these clones strongly suppressed proliferative responses of cloned PLT reagents as well as unprimed lymphocytes in mixed leukocyte cultures.
Dillner et al. (1987)lymphokineleukocyteTen synthetic peptides containing 18-22 residues deduced from the amino-acid sequences of the EBV-encoded latent-infection-associated membrane protein (LMP) and the 2 principal nuclear antigens, EBNA-1 and EBNA-2, were tested for their ability to induce lymphokine release from sensitized T-cells of EBV-seropositive donors, as measured by the leukocyte migration inhibition assay (LMI).
Mathur and Kremer (1993)interleukin-2leukocyteAlveolar macrophages from patients with sarcoidosis have been observed to release high levels of tumor necrosis factor-alpha and interleukin-2 and to exhibit enhanced expression of leukocyte function antigen 1 and intercellular adhesion molecule 1.
Morgan et al. (1998)IL-2leukocyteThe following variables were studied: haemolysis (haematocrit, free plasma haemoglobin, haptoglobins), platelet activity (platelet counts, Beta-thromboglobulin), leukocyte count, cytokine release (IL-2, IL-6, IL-8), complement activation (C3a and C5a), blood and blood product requirements, urine output on bypass, post-operative blood urea, duration of ventilation, intensive care and hospital stay.
Daniel et al. (2010)IL-2PBLFrequencies of CD3(+)CD4(+)CD25(+) PBL producing IL-2, IL-4, IL-10, IL-12, and/or IFN-gamma, and of CD3(+)CD4(+)CD28(-) PBL secreting IL-2 and/or IL-4 were lower in HIV(+) than in HIV(-) patients (p
Hartwig et al. (2002)IL-2WBCMATERIAL AND METHODS: We investigated the secretion of interleukin (IL)-1beta, IL-2, IL-6, IL-8, tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) and quantified the appropriate expression of corresponding mRNA in PC with regard to different levels of WBC contamination and storage times.
Graham and Secombes (1990)lymphokineleucocytesCellular requirements for lymphokine secretion by rainbow trout Salmo gairdneri leucocytes.
Orlova and Shirshev (2009)IL-2leukocytesLeptin increased the expression of HLA-DR on T lymphocytes, stimulated the production of TNF-alpha and IL-6, and did not affect secretion of IL-2, IL-4, and IL-10 by mononuclear leukocytes.
Czarniecki (1993)Interleukin-2immune cellsSoluble factors such as Interleukin-2 and Interferon-gamma released by T cells and Interleukin-1, Interleukin-6 and TNF released by monocytes have been shown to play key roles in proliferation, activation and differentiation of immune cells.