Viewing affirmative mentions of localization of IL2 (H. sapiens)

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Vose (1987)IL-2Helper T cellsHelper T cells can be induced to proliferate upon exposure to cells of the autologous tumour and to secrete detectable levels of interleukin 2 (IL-2).
Pinkston et al. (1987)IL 2helper T lymphocytesActive pulmonary sarcoidosis is characterized by the alveolar accumulation of activated helper T lymphocytes that are spontaneously releasing IL 2 and proliferating at an enhanced rate.
Theobald et al. (1989)IL-2helper T lymphocytesAssessment of human allospecific IL-2-secreting helper T lymphocytes in limiting dilution cultures using restimulation and split well analysis.
Moretti et al. (1992)IL-2helper T lymphocytesBACKGROUND: After marrow transplantation, the interaction of helper T lymphocytes from the donor with the patient alloantigens leads to cellular activation and release of IL-2 as initial events of the graft versus host reaction.
Hamai et al. (1998)IL-2helper T cellsCONCLUSION: The fact that PBMCs from recurrent aborters spontaneously secrete IL-2 suggests that helper T cells are activated in recurrent aborters.
Cukrová et al. (1998)IL-2helper T lymphocyteThe utility of IL-2 secreting helper T lymphocyte precursors (HTLp) frequency testing has been evaluated for detecting alloreactivity.
Lu and Durkin (1997)Interleukin-2helper T-cellsInterleukin-2 (IL-2), secreted principally by activated helper T-cells, plays a pivotal role in the generation and regulation of the immune response.
Pawelec et al. (1986)interleukin 2helper T cellsTo investigate potential functional changes in alloantigen-specific proliferative CD3+, CD4+, CD8-, Leu-8-, interleukin 2 (IL 2)-secreting noncytotoxic in vitro primed human helper T cells, a set of 12 clones was studied sequentially throughout their finite life spans.
Burton et al. (1990)IL-2helper T cellsThe association of ICAM-1 with the IL-2 receptor may facilitate the paracrine IL-2-mediated stimulation of T cells expressing IL-2 receptors by augmenting homotypic T-T-cell interaction, by receptor-directed focusing of IL-2 release by helper T cells, and by focusing IL-2 receptors of the physically linked cells to the site of lymphocyte function-associated antigen 1-ICAM-1-IL-2 receptor interaction.
Clouse et al. (1989)interleukin 2helper T cellsA limiting-dilution analysis technique was developed which enumerates human T cells with the capacity to secrete T-cell growth factors such as interleukin 2 after contact with herpes simplex virus type 1 (HSV-1) or cytomegalovirus (CMV) antigens (operationally defined as virus-reactive helper T cells [HTL]).
Aussel et al. (1990)IL-2helper T lymphocytesRecently, we have shown that phytohaemagglutinin, CD3 and CD2 mAbs, which are potent in vitro activators of helper T lymphocytes, markedly inhibit phosphatidylserine synthesis concomitantly as they induce the secretion of IL-2.
Yoshizaki et al. (1983)IL 2helper T cellAn IL 2-dependent helper T cell clone, d4, secreted BCGF with the m.w. of 50K.
Heeg et al. (1988)IL-2helper T lymphocytesHigh-dose irradiated stimulator cells induced high numbers of clonally developing helper T lymphocytes to secrete IL-2.
Maestroni (1999)IL-2T-helper cellActivation of MLT receptors enhances the release of T-helper cell cytokines, such as gamma-interferon and interleukin-2 (IL-2), as well as activation of novel opioid cytokines which crossreact immunologically with both interleukin-4 and dynorphin B.
Li et al. (1999)interleukin-IIT-helper cellsAfter treatment, the activity of NK cells and the count of T-suppressor cells were significantly increased (P < 0.01), the count of T-helper cells, the secretion of interleukin-II and TH/TS ratio were significantly reduced (P < 0.01).
Miller et al. (1986)lymphokinehelper T cellsEven when IL 2 is supplied, and lymphokine production measured by assay of a second factor, IL 3, the large majority of individual activated helper T cells remain dependent on further antigenic exposure for their continued maturation into lymphokine-secreting effectors.
Miller et al. (1986)lymphokineHelper T cellsHelper T cells at this early stage of activation can therefore proliferate when given IL 2 alone, but lymphokine secretion involves a second antigen-dependent step.
de Groen (1989)lymphokinehelper T cellsIts predominant immunologic effect is inhibition of lymphokine production and secretion by helper T cells.
Theobald et al. (1990)interleukin-2-secretinghelper T lymphocyteFrequency, specificity, and phenotype of clonally growing human alloreactive interleukin-2-secreting helper T lymphocyte precursors.
Maestroni (1999)IL-2T-helper cellActivation of MLT receptors enhances the release of T-helper cell type 1 (Th1) cytokines, such as gamma-interferon and interleukin-2 (IL-2), as well as of novel opioid cytokines which crossreact immunologically with both interleukin-4 (IL-4) and dynorphin B.
Maestroni (1998)interleukin-2T-helper cellActivation of melatonin receptors enhances the release of T-helper cell type 1 (Th1) cytokines, such as gamma-interferon and interleukin-2, as well as of novel opioid cytokines which crossreact immunologically with both interleukin-4 and dynorphin B.
Stam et al. (1993)lymphokinehelper T cellsMurine helper T cells can be divided into at least two groups, Th1 and Th2, based on the patterns of lymphokine secretion after antigenic or mitogenic stimulation.
Lemire (2000)IL-2helper T cellAt a cellular and molecular level, the hormone preferentially targets helper T cell activity (Th1) by inhibiting the secretion of both IL-2 and IFN-gamma by Th1 and by suppressing the secretion pro-Th1 cytokine IL-12 by antigen-presenting cells.
Young and Steinman (1990)cell growth factorhelper T cellsThese primary responses, which are accompanied by the release of T cell growth factor(s), are induced in the absence of CD4+ helper T cells and are not inhibited by anti-CD4 mAb.
Guerrero and Reiter (1992)interleukin-2T-helper cellsMoreover, the release of opioid peptides and interleukin-2 by T-helper cells may also participate in this mechanism by activating, at least natural killer activity and antibody-dependent cellular cytotoxicity.
Hawthorne and Hawkey (1989)interleukin-2helper T cellMore recently, cyclosporin A, with its selective action on interleukin-2 release and/or synthesis, and inhibition of helper T cell function, has been shown to be helpful in Crohn's disease.
Arai et al. (1992)lymphokinehelper T cellTwo types of helper T cell (Th) clones (Th1 and Th2) are defined on the basis of different patterns of cytokine (lymphokine) secretion.
Morris et al. (1993)IL-2helper T cellsThese findings indicate that the immune response in ARF and ARHD patients is skewed to produce activated helper T cells that release IL-2 which drives the accumulation of more T helper cells.
Yu et al. (2003)IL-2T-helper cellsIn fact, SOCS3 mRNA levels are inversely correlated with the amount of IL-2 secretion and proliferative responses of differentiating T-helper cells, suggesting mutually antagonistic effects of SOCS3 and IL-2 and feedback regulation of T-cell activation by SOCS3.
Forman and Puré (1991)interleukin 2-inducedhelper T cellsT-independent and T-dependent B lymphoblasts: helper T cells prime for interleukin 2-induced growth and secretion of immunoglobulins that utilize downstream heavy chains.
Poo et al. (1988)lymphokinehelper T cellsReceptor-directed focusing of lymphokine release by helper T cells.
McCoy et al. (1999)interleukin-2helper T cellThe ability of a macrophage hybridoma to function as an antigen-presenting cell was examined by the stimulation of a soluble protein antigen-specific helper T cell hybridoma to secrete interleukin-2.
DeBruyne et al. (1998)IL-2helper T lymphocytesLimiting dilution analysis revealed transient infiltration of IL-2 secreting, donor-reactive, helper T lymphocytes (HTL) and cytotoxic T lymphocytes (CTL) in vIL-10 expressing grafts on day 7, that decreased significantly by day 14.
Clements et al. (1998)interleukin-2helper T cellThe costimulatory activity of a THC-exposed macrophage hybridoma was investigated by its ability to elicit interleukin-2 secretion by a helper T cell hybridoma activated with immobilized monoclonal anti-CD3 antibody.
Akçakaya et al. (1994)lymphokinehelper T-cellsInterleukin 4, (IL4) known as a lymphokine secreted by type II helper T-cells, is thought to regulate IgG and IgE secretions.