Viewing affirmative mentions of binding of Cd4 (M. musculus) in T cells

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Aebischer et al. (2000)CD4T cellsHere we propose that phagocytes and epithelial cells stimulated either by direct interaction with CD4(+) T cells or by soluble mediators such as cytokines or neuropeptides are the ultimate effector populations in protective immunity induced by vaccination.
Duan et al. (1996)CD4T cellsIn constrast, cross-linking of surface CD4 resulted in deficient tyrosine phosphorylation of cellular proteins in MRL T cells.
Rollenhagen et al. (2004)CD4T cellsHere, we used Salmonella strains expressing differential amounts of a fluorescent model antigen during infection to show that, in a mouse typhoid fever model, CD4 T cells preferentially recognize abundant Salmonella antigens.
Maroto et al. (1999)CD4T lymphocytesIn this study, we report on the use of a transgenic mouse model to test the role of CD4-MHC class II interactions for the susceptibility of CD4+ T lymphocytes to AICD, and for the survival of resting CD4+ T cells in peripheral lymphoid organs.
Maroto et al. (1999)CD4T cellsOur results show for the first time that interactions between CD4 and MHC class II molecules are required for the survival of resting CD4+ T cells in peripheral lymphoid organs.
Xue and Perlman (1997)CD4T cellsIn conclusion, these studies identify epitopes recognized by MHV-specific CD4 T cells in the infected CNS and show that these cells are preferentially located at the site of infection in mice with clinical disease.
Li et al. (1998)CD4T-cellRecent studies of CD4 structure and function have revealed possible mechanisms for CD4 self-association, with implications for its role in T-cell activation.
Li et al. (1998)CD4T-cellHere, the authors discuss the formulation of a hypothetical three-dimensional model of CD4 oligomerization and how it impacts on the understanding of T-cell function and rational drug design targeting specific CD4 surface functional sites.
Amano et al. (1995)CD4T cellsAccumulated studies revealed that CD4+T cells were initially required for diabetes in NOD mice, whereas interaction of CD4+T/CD8+T cells is not fully understood.
McCarthy et al. (1988)CD4T-cellHere, we address the possibility that CD4 engagement influences T-cell receptor (TCR) expression on developing thymocytes.
Nagata and Yoon (1992)CD4T-cellOn the basis of these observations, we concluded that CD4+ and CD8+ T-cells interact differently with beta-cells at different stages in T-cell--mediated beta-cell destruction.
Ehst et al. (2003)CD4T cellsDevelopment of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection.
Secor (2006)CD4T cellsBecause interaction with host CD4(+) T cells is a characteristic of schistosome as well as HIV-1 infections, bi-directional disease effects may be sufficiently different from sequelae caused by either infectious agent alone to warrant alteration of public health approaches in areas of co-endemnicity.
Bolton et al. (2008)CD4T cellsWe briefly consider how CD4 T cells that recognize allopeptide can provide help for effector and regulatory responses and highlight the implications for promoting graft survival.
Veillette and Fournel (1990)CD4T-lymphocytesOur studies indicate that cross-linking of CD4 is capable of activation of p56lck in fibroblasts in a manner analogous to that previously reported for T-lymphocytes.
Janeway et al. (1987)L3T4T cellWhile these studies do not provide definitive evidence for a physical association between L3T4 and the T cell receptor, they do place certain constraints on current models and suggest new possibilities for understanding T cell recognition and development.
Yi and O'Connell (2002)CD4T cellsOur results demonstrated that interaction of CD4+ T cells and autologous macrophages was required for their optimal activation in response to pig xenogeneic stimulation.
Garcia and Miller (1997)CD4T cellsStimulation of resting mouse splenic CD4 T cells by cross-linking CD3 to CD4 leads to increases in tyrosine phosphorylation of five such proteins, of which three are likely to be dimeric forms of zeta as judged by behavior on two-dimensional gels.
Desbarats et al. (1996)CD4T cellsFas (CD95) expression and death-mediating function are induced by CD4 cross-linking on CD4+ T cells.
Morin et al. (1992)CD4T lymphocytesAntibody binding of CD3, CD4, or CD8 molecules can induce cytoplasmic calcium mobilization in T lymphocytes, usually interpreted as indicating signal transduction.
Palomo et al. (1996)CD4T-cellLigation of CD4 concomitant to activation induces primary CD4+ T-cell adhesion and pseudopodia formation in vitro.
Palomo et al. (1996)CD4T-cellThese results indicate that CD4 ligation induces CD4+ T-cell adhesion and motility, mainly in the memory/activated subset, which might be relevant for immune responses in vivo.
Zhong et al. (2001)CD4T cellThese studies highlight the importance of synergistic interactions between CD4(+) and CD8(+) T cell subsets in the generation of optimal antiviral immunity.
Sawada et al. (1998)CD4T cellT cell line-tropic (T-tropic) HIV type 1 strains enter cells by interacting with the cell-surface molecules CD4 and CXCR4.
Ruderman et al. (1995)CD4T cellEarly murine Lyme carditis has a macrophage predominance and is independent of major histocompatibility complex class II-CD4+ T cell interactions.
Denning et al. (2003)CD4T cellsThese data support a novel model controlling the differentiation of regulatory Th cells and suggest that interactions between CD4 and class II MHC may a useful target for re-educating T cells as a treatment for inflammatory diseases.
Adleman and Wofsy (1993)CD4T-cellIn particular, the hypothesis implies that the unresolved CD4+ T-cell lymphopenia seen in the first several years of HIV infection is the "natural" consequence of the interaction of a selective CD4+ T-cell depleting virus and a nonselective T-cell replacing homeostatic mechanism.
Michel and Acuto (1996)CD4T cellOur data suggest a link between antigen-induced T cell adhesion and late responses and also suggest that signals mediated by TCR and CD4 coengagement may induce a greater activation and/or recruitment of molecules involved in T cell adhesion.
Vignali et al. (1992)CD4T cellDuring antigen presentation, a close association between CD4 and the T cell receptor (TCR) occurs as a result of interacting with the same major histocompatibility complex class II molecule.
Kitchen et al. (2005)CD4T cellWe have previously demonstrated that costimulation of purified human CD8+ T cells induces de novo expression of the CD4 molecule and that ligation of CD4 on this cell type modulates CD8+ T cell activity in vitro.
Lode et al. (2000)CD4T-cellThree lines of evidence show that CD4(+) T-cell help was mediated by CD40/CD40L interaction but not by endogenous IL-2 production.
Lode et al. (2000)CD4T cellsThese results suggest that help provided by CD4(+) T cells via CD40/CD40L interactions in our tumor model is crucial for effective immunotherapy with an IL-2 immunocytokine.
Fujiwara and Yokoyama (1994)L3T4T cellsIt can be assumed that activated L3T4- T cells interact with antigen-specific L3T4+ T cells and lead to enhanced IL-2 production.
Cosgrove et al. (1992)CD4T cellsHowever, subtle differences are seen in their ability to engage CD4 molecules on immature thymocytes, and in the profile of receptors on T cells selected into the periphery.
Brett et al. (1991)CD4T cellsThe results in this study have important implications for vaccine design, inasmuch as they indicate that the same dominant CD4 T cell determinants on NP presented by vaccination with NP are also recognized by T cells from mice exposed to infectious virus.
Pont et al. (1987)L3T4T cellAntibody binding to L3T4a inhibits Ia-independent mouse T cell proliferation.
Ottaway (1987)L3T4T cellsStudies of the effect of selective, complement-mediated killing of cells with Thy 1, L3T4 and Lyt 2 monoclonal antibodies showed that the majority of the VIP bound by the lymphocytes was accounted for by binding to L3T4+, Lyt 2- T cells.
Lechler et al. (1985)L3T4T lymphocytesFour features of accessory cell function were explored: antigen processing, interaction with accessory molecules (LFA-1, L3T4), influence of Ia density, and ability to stimulate resting, unprimed T lymphocytes.
Kaye et al. (1989)CD4T-cellTwo other T-cell surface proteins, CD4 and CD8, which bind non-polymorphic regions of class II and class I MHC molecules respectively, are also involved in these recognition events and play an integral role in thymic selection.
Ratcliffe et al. (1992)CD4T cellT cell receptor aggregation, but not dimerization, induces increased cytosolic calcium concentrations and reveals a lack of stable association between CD4 and the T cell receptor.
Pan et al. (1998)CD4T cellsOptimum function of HLA-DR molecules in transgenic mice requires efficient interaction between the class II molecules on APCs and CD4 on T cells.
Gebe et al. (2003)CD4T cellsSignificant structural avidity for T cell recognition, as measured by MHC class II tetramer binding to CD4(+) T cells was only observed in mice immunized with the non-self antigens.
Ismail and Bretscher (2001)CD4T cellMore antigen-dependent CD4(+) T cell / CD4(+) T cell interactions are required for the primary generation of Th2 than of Th1 cells.
Mittler et al. (1989)CD4T-cellT-cell receptor-CD4 physical association in a murine T-cell hybridoma: induction by antigen receptor ligation.
Müller and Kyewski (1995)CD4T cellsRescue of CD4 lineage T cells in the absence of TcR/CD4 co-engagement by MHC class II in this experimental system supports the stochastic/selective model of T cell lineage commitment.
Haas et al. (1991)CD4T cellFurthermore, a non-alpha-helical peptide from this region (A3, 528-543) was capable of priming mice with different H-2 haplotypes for both peptide A3 and native RT CD4+ T cell recognition.
Serbina et al. (2001)CD4T cellAs tuberculosis is frequently associated with HIV infection and a subsequent loss of CD4(+) T cells, understanding the interaction between CD4(+) and CD8(+) T cell subsets during the immune response to M. tuberculosis is imperative for the design of successful vaccination strategies.
Potter et al. (2001)CD4T cellsUpon productive interaction of CD4 T cells with antigen-presenting cells (APCs), receptors and intracellular proteins translocate and form spatially segregated supramolecular activation clusters (SMACs).
Riberdy et al. (1998)CD4T cellsDisruption of the CD4-major histocompatibility complex class II interaction blocks the development of CD4(+) T cells in vivo.
Portolés et al. (1999)CD4T lymphocytesAntibody-induced CD3-CD4 coligation inhibits TCR/CD3 activation in the absence of costimulatory signals in normal mouse CD4(+) T lymphocytes.
Portolés et al. (1999)CD4T lymphocytesThe effect of CD3-CD4 coligation on CD3-mediated activation of normal mouse CD4(+) T lymphocytes has been analyzed in the absence of exogenous lymphokines.
Garcia and Miller (1998)CD4T cellsCD4 T cells from old mice have baseline levels of Zap-70 activity similar to those seen in activated T cells from young mice, and these levels do not increase after CD3/CD4 cross-linking.
Zhang et al. (2000)CD4T cellIt is concluded that the further cross-linking of anti-CD4 antibodies is important for inducing CD4+ T cell apoptosis.
Luo and Sefton (1990)CD4T-cellCross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site.
Fragoso et al. (2003)CD4T cellAb cross-linking of CD4 induces an extensive membrane patching on the T cell surface, which is related to lipid raft aggregation.
Duke-Cohan et al. (1993)CD4T cellsWe have developed a bispecific antibody that recognizes the CD4 and CD29 antigens simultaneously and that was examined for its ability to target CD4+CD29bright T cells.
Gui et al. (1999)CD4T cellPeripheral CD4+ T cell maturation recognized by increased expression of Thy-1/CD90 bearing the 6C10 carbohydrate epitope.
Collins et al. (1992)CD4T cellWe conclude that the association between CD4 and the TCR/CD3 complex during T cell activation plays an important role in CD4-dependent responsiveness and this association requires the interaction of CD4 with p56lck.
Veillette et al. (1989)CD4T-cellHere, we present evidence that cross-linking of the CD4 receptor induces a rapid increase in the tyrosine-specific protein kinase activity of p56lck and is associated with the rapid phosphorylation of one of the subunits (zeta) of the T-cell receptor complex on tyrosine residues.
Li et al. (1998)CD4T cellsThese studies demonstrate that interaction of CD4(+) T cells with intrinsic renal cells expressing MHC II is required for development of cell-mediated immune renal injury.
Wang and Yeh (1997)CD4T cellRecent evidence supports the importance of coaggregation of CD4 and TcR for effective T cell activation.
Finco et al. (1997)CD4T cellTo address the question of whether cross-linking of CD4/HIV gp120 complexes by antibodies were sufficient to induce T cell depletion in vivo, we developed an animal model of continuous interaction between human CD4 (hCD4), gp120 and anti-gp120 antibodies in the absence of other viral factors.
Sitkovsky et al. (2008)CD4T cellsCancerous tissue protection from tumor-recognizing CD8(+) and CD4(+) T cells (antitumor T cells) limits the therapeutic potential of immunotherapies.
Li and Green (2007)CD4T cellMurine AIDS requires CD154/CD40L expression by the CD4 T cells that mediate retrovirus-induced disease: Is CD4 T cell receptor ligation needed?
Kotturi et al. (2010)CD4T cellHere, we defined coverage as the extent or degree to which different ethnic populations worldwide recognize the CD4+ T cell epitope set.
Rey et al. (2004)CD4T cellsIn PP, SIgA associates with and is internalized by dendritic cells in the subepithelial dome region, whereas the interaction with CD4(+) T cells is limited to surface binding.
Hershkoviz et al. (1996)CD4T cellsKeratinocytes-associated chemokines and enzymatically quiescent heparanase induce the binding of resting CD4+ T cells.
Rayat et al. (2003)CD4T-cellThe degree of phylogenetic disparity of islet grafts dictates the reliance on indirect CD4 T-cell antigen recognition for rejection.
Phillips et al. (2006)CD4T cellsThis effect is due in part to deletion of host CD8 and CD4 T cells that recognize alloantigen by direct presentation.
Phillips et al. (2006)CD4T cellsThe fate of host CD4 T cells that recognize alloantigen by indirect presentation, however, is unclear.
Phillips et al. (2006)CD4T cellsMETHODS: We studied Tg361 TCR transgenic CD4 T cells that recognize alloantigen by indirect presentation.
Maekawa et al. (2006)CD4T cellsCD4 is a coreceptor for binding of T cells to APC and the primary receptor for HIV.
Gieni et al. (1996)CD4T cellsThe strain differences in IL-12 production were observed only in antigen-driven responses (and not in responses induced by bacterial products), and were dependent upon an interaction between CD4 T cells and lymph node adherent cells.
Mostaghel et al. (1998)II-CD4T cellsSurprisingly, we find that CD4+ T cells from the class II mutant mice, having been selected in the absence of a productive class II-CD4 interaction, fail to functionally engage CD4 even when subsequently provided with a wild-type class II ligand.
Campbell et al. (2001)CD4T cellsCD4 ligation promotes the IL-4-independent development of IL-4-producing clones from naive CD4(+) T cells.
Flynn and Stockinger (2003)CD4T-cellTumor and CD4 T-cell interactions: tumor escape as result of reciprocal inactivation.
Linderman et al. (2010)CD4T cellMany fundamental questions remain regarding the dynamics of DC-CD4+ T cell interactions leading to priming.
Müller and Kyewski (1993)CD4T cellsThis generation of CD4 single-positive T cells occurs also in MHC class II-deficient mice and thus is independent of CD4-MHC class II interactions.
Greenstein et al. (1987)L3T4T cellIt appears that the L3T4-Ia interaction influences T cell activation during suboptimal antigenic stimulation.
König et al. (2002)CD4T cellThe importance of interactions between CD4 and molecules encoded by the class II major histocompatibility complex (MHC) for thymic T cell selection has been clearly established, however, the role of CD4-MHC class II interactions in T helper (TH) cell differentiation, in the maintenance of homeostasis in the peripheral immune system, and in the generation of memory TH cells is largely unclear.
Van Laethem et al. (2007)CD4T cellWe hypothesized that MHC specificity might be imposed on a broader alphabetaTCR repertoire during thymic selection by CD4 and CD8 coreceptors that bind and effectively sequester the tyrosine kinase Lck, thereby preventing T cell receptor (TCR) signaling by non-MHC ligands that do not engage either coreceptor.
Frandji et al. (1998)CD4T cellsIgE-independent IL-4 production by mast cells as a result of cognate interaction with CD4 T cells could be critical for the development of type 2 responses.
Aguirre and Miller (2002)CD4T cellsTherefore, in order to mediate resistance to infection, primed CD4(+) T cells must interact with the replenishable perivascular microglial subset that lies in close proximity to cerebral vasculature.
Saizawa et al. (1987)CD4T-cellThese findings provide further evidence for a physical association of the T-cell receptor complex and CD4.
Arora et al. (2006)CD4T cellsIn this study, we investigated whether simvastatin can exercise a Th2-promoting effect through modulation of function of dendritic cells (DCs) without direct interaction with CD4+ T cells.
Jayarapu et al. (2009)CD4T-cellIn this report we show that MHC-II-restricted Chlamydia-specific CD4 T-cell clones recognize infected upper reproductive tract epithelial cells as early as 12 h postinfection.
König and Zhou (2004)CD4T cellHelper T cells express CD4 coreceptors, which recognize conserved domains on proteins expressed by the class II major histocompatibility complex, the same proteins that present antigen to the T cell receptor.
König and Zhou (2004)CD4T cellSignaling pathways induced by engagement of CD4 independently of T cell receptor signaling mediate these regulatory functions.
Slansky and Jordan (2010)CD4T cellThey show that the CD4 co-receptor engagement does not contribute to the physical association, but is required for optimal signaling into the T cell.
Oriss et al. (2005)CD4T cellsIn this study, we have characterized the DCs from the lung draining lymph nodes of mice immunized for allergic airway inflammation or tolerance and examined their interactions with CD4(+) T cells.
Hazlett (2002)CD4T cellsAdditionally, in the susceptible mouse model, CD4(+) T cells interact with Langerhans cells and B7/CD28 ligation appears critical for antigen presentation and the susceptibility response.
Logan et al. (2004)CD4T-cellAlthough the mechanism responsible for this effect remains to be elucidated, the unexpected expression of CD4, a molecule that functions as both a coreceptor with the T-cell receptor and ligand for the pro-inflammatory cytokine IL-16, has the potential to influence experimental outcomes.
González et al. (1995)CD4T cellsWe have assessed in vitro whether the absence of T cells in the natural environment of F1 hybrid mice influences the ability of their B cells to participate in an allogeneic interaction with CD4+ cells from parental mice.
Coulombe et al. (1999)CD4T cellIn conclusion, the MHC class I+, II- islet allograft paradoxically leads to a change in the donor-reactive CD4 T cell subset and not in the CD8 subset.
Romano et al. (1999)CD4T-cellThese differences suggest that CD4 may have a different secondary structure in these species, which may affect binding of class II and subsequent T-cell activation, as well as binding of viral pathogens.
Maroto et al. (1999)CD4T lymphocytesRequirement for efficient interactions between CD4 and MHC class II molecules for survival of resting CD4+ T lymphocytes in vivo and for activation-induced cell death.
Xue and Perlman (1997)CD4T lymphocytesPreviously, we showed that the transmembrane (M) and surface (S) glycoproteins were recognized by splenic CD4 T lymphocytes harvested from mice infected intraperitoneally with mouse hepatitis virus, strain JHM (MHV-JHM), whereas only the S protein was recognized by splenocytes derived from mice with MHV-induced chronic demyelination.
Rudy and Lew (1993)CD4T cellsContinuous 'tonic' recognition of self is maintained throughout adult life by, among others, a subset of 'autoreactive' CD4+ T cells recognizing 'dominant' determinants derived from self-antigens.