Viewing negative mentions of binding of Cd4 (M. musculus) in T cells

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Mostaghel et al. (1998)CD4T cellsSurprisingly, we find that CD4+ T cells from the class II mutant mice, having been selected in the absence of a productive class II-CD4 interaction, fail to functionally engage CD4 even when subsequently provided with a wild-type class II ligand.
Bardos et al. (2003)CD4T cellsThe CD4+CD25- T cells, which did not bind to magnetic beads, were collected from the flow through the washing steps (purity >98%).
Killeen et al. (1993)CD4T cellIn vivo experiments show that, whereas helper T cell development is impaired in CD4-deficient mice, high level expression of a transgenic CD4 that cannot bind lck rescues development of this T cell subset.
Riberdy et al. (1998)CD4T cellWe have generated transgenic mice expressing class II molecules that cannot interact with CD4 but that are otherwise competent to present peptides to the T cell receptor.
Qi and Staerz (1998)CD4T cellsAs a consequence CD4+ T cells with specificity to Hab-coated stimulator cells cannot engage their CD4 molecules and are no longer activated.
Malcomson et al. (1997)CD4T lymphocytesApoptosis induced by gamma-irradiation, but not CD4 ligation, of peripheral T lymphocytes in vivo is p53-dependent.
Radvanyi et al. (1993)CD4T cellsUnder the same conditions, cross-linking other T cell surface determinants such as CD4, CD8, or class I MHC on preactivated T cells had no effect.
Haring et al. (2008)CD4T cellsConstitutive expression of IL-7 receptor alpha does not support increased expansion or prevent contraction of antigen-specific CD4 or CD8 T cells following Listeria monocytogenes infection.
Zuñiga-Pflücker et al. (1989)CD4T cellsSince F(ab')2 and Fab anti-CD4 fail to deplete CD4+/CD8- in adult mice, these results strongly argue that the absence of CD4+/CD8- T cells is not due to depletion, but rather, is caused by a lack of positive selection, attributable to an obstructed CD4-MHC class II interaction.
Nicholas et al. (1990)CD4CTLMurine CD4+ CTL were highly cytolytic for RS virus-infected cells, but they did not recognize target cells infected with any of the recombinant vaccinia viruses expressing the seven RS virus structural proteins.
Li et al. (2006)CD4T cellsRemoval of certain glycan(s) near a T cell epitope cluster of gp120 did not alter its reactivity with CD4 and mAbs, but could modulate the recognition of these epitopes by CD4 T cells.
Schrezenmeier and Fleischer (1988)CD4T cellHowever, recent experimental evidence argues against a negative regulatory effect of these molecules, since, e.g., simultaneous cross-linking of TCR and CD4 leads to enhanced T cell activation.
Xu et al. (2010)CD4T cellsCD4+ T cells were purified from the splenocytes by negative selection with a CD4+ T Cell Isolation Kit and using a magnetic-activated cell sorter (MACS) system (Miltenyi Biotec, Bergisch Gladbach, Germany) according to the manufacturer's protocol.
Ocaña-Morgner et al. (2008)CD4T cellsThis report shows that DCs from Plasmodium yoelii-infected mice are able to present antigens associated with MHC-II, but do not establish strong interactions with naïve CD4+ T cells.
Fowell et al. (1997)CD4T cellsSimilarly, CD4+ TCR transgenic T cells primed on antigen-presenting cells expressing mutant MHC class II molecules unable to bind CD4 did not differentiate into Th2 cells.
Ostlie et al. (2003)CD4T cellsB6 mice develop anti-TAChR Ab that cross-react with mouse muscle AChR, but their CD4+ T cells do not cross-react with mouse AChR sequences.
Huang et al. (2010)CD4T cellsAlthough Tim-3–expressing CD4+ T cells have previously been shown to interact with the Tim-3 ligand, inhibit effector Th1 cells during the normal immune response, and induce peripheral tolerance (Kuchroo et al., 2003; Sabatos et al., 2003; Sánchez-Fueyo et al., 2003; Zhu et al., 2005), their role in inducing tumor immune evasion has not been recognized.
Nethe et al. (2005)CD4T-cellsMoreover, non-functional HIV-1 mutants and HIV-1 mutants that could only bind CD4, but not enter the T-cells, did not restrict superinfection of HIV-1 in these cells.
Lee et al. (2010)CD4T cellsIn support of this hypothesis, OT-II CD4+ T cells selected via a T–T interaction failed to express PLZF.
Lynch and Shevach (1992)CD4T cellsEnriched populations of CD4-CD8- thymocytes from newborn mice, purified by negative selection with anti-CD4, anti-CD8, and anti-TCR alpha beta mAbs were found to contain approximately 20% gamma delta T cells that were p55IL-2R-.
Aliahmad and Kaye (2006)CD4T cellsOne of the puzzling features of positive selection is how specificity of the TCR controls lineage commitment, as both helper and cytolytic T cells utilize the same antigen-receptor components, with the exception of the CD4 or CD8 coreceptors themselves.
Weber et al. (1995)CD4T cellsThe results demonstrate that the majority of CD4 T cells that participate in primary alloresponses and essentially all the CD4 T cells that participate in secondary alloresponses recognize I-A conformers that depend on the presence of peptide and do not recognize the SDS-unstable I-A expressed by T2 transfectants.