| Document |
Target |
Regulator |
Anatomy |
Sentence |
| Mostaghel et al. (1998) | | CD4 | T cells | Surprisingly, we find that CD4+ T cells from the class II mutant mice, having been selected in the absence of a productive class II-CD4 interaction, fail to functionally engage CD4 even when subsequently provided with a wild-type class II ligand. |
| Bardos et al. (2003) | | CD4 | T cells | The CD4+CD25- T cells, which did not bind to magnetic beads, were collected from the flow through the washing steps (purity >98%). |
| Killeen et al. (1993) | | CD4 | T cell | In vivo experiments show that, whereas helper T cell development is impaired in CD4-deficient mice, high level expression of a transgenic CD4 that cannot bind lck rescues development of this T cell subset. |
| Riberdy et al. (1998) | | CD4 | T cell | We have generated transgenic mice expressing class II molecules that cannot interact with CD4 but that are otherwise competent to present peptides to the T cell receptor. |
| Qi and Staerz (1998) | | CD4 | T cells | As a consequence CD4+ T cells with specificity to Hab-coated stimulator cells cannot engage their CD4 molecules and are no longer activated. |
| Malcomson et al. (1997) | | CD4 | T lymphocytes | Apoptosis induced by gamma-irradiation, but not CD4 ligation, of peripheral T lymphocytes in vivo is p53-dependent.
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| Radvanyi et al. (1993) | | CD4 | T cells | Under the same conditions, cross-linking other T cell surface determinants such as CD4, CD8, or class I MHC on preactivated T cells had no effect. |
| Haring et al. (2008) | | CD4 | T cells | Constitutive expression of IL-7 receptor alpha does not support increased expansion or prevent contraction of antigen-specific CD4 or CD8 T cells following Listeria monocytogenes infection.
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| Zuñiga-Pflücker et al. (1989) | | CD4 | T cells | Since F(ab')2 and Fab anti-CD4 fail to deplete CD4+/CD8- in adult mice, these results strongly argue that the absence of CD4+/CD8- T cells is not due to depletion, but rather, is caused by a lack of positive selection, attributable to an obstructed CD4-MHC class II interaction. |
| Nicholas et al. (1990) | | CD4 | CTL | Murine CD4+ CTL were highly cytolytic for RS virus-infected cells, but they did not recognize target cells infected with any of the recombinant vaccinia viruses expressing the seven RS virus structural proteins. |
| Li et al. (2006) | | CD4 | T cells | Removal of certain glycan(s) near a T cell epitope cluster of gp120 did not alter its reactivity with CD4 and mAbs, but could modulate the recognition of these epitopes by CD4 T cells.
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| Schrezenmeier and Fleischer (1988) | | CD4 | T cell | However, recent experimental evidence argues against a negative regulatory effect of these molecules, since, e.g., simultaneous cross-linking of TCR and CD4 leads to enhanced T cell activation. |
| Xu et al. (2010) | | CD4 | T cells | CD4+ T cells were purified from the splenocytes by negative selection with a CD4+ T Cell Isolation Kit and using a magnetic-activated cell sorter (MACS) system (Miltenyi Biotec, Bergisch Gladbach, Germany) according to the manufacturer's protocol. |
| Ocaña-Morgner et al. (2008) | | CD4 | T cells | This report shows that DCs from Plasmodium yoelii-infected mice are able to present antigens associated with MHC-II, but do not establish strong interactions with naïve CD4+ T cells. |
| Fowell et al. (1997) | | CD4 | T cells | Similarly, CD4+ TCR transgenic T cells primed on antigen-presenting cells expressing mutant MHC class II molecules unable to bind CD4 did not differentiate into Th2 cells. |
| Ostlie et al. (2003) | | CD4 | T cells | B6 mice develop anti-TAChR Ab that cross-react with mouse muscle AChR, but their CD4+ T cells do not cross-react with mouse AChR sequences. |
| Huang et al. (2010) | | CD4 | T cells | Although Tim-3–expressing CD4+ T cells have previously been shown to interact with the Tim-3 ligand, inhibit effector Th1 cells during the normal immune response, and induce peripheral tolerance (Kuchroo et al., 2003; Sabatos et al., 2003; Sánchez-Fueyo et al., 2003; Zhu et al., 2005), their role in inducing tumor immune evasion has not been recognized. |
| Nethe et al. (2005) | | CD4 | T-cells | Moreover, non-functional HIV-1 mutants and HIV-1 mutants that could only bind CD4, but not enter the T-cells, did not restrict superinfection of HIV-1 in these cells. |
| Lee et al. (2010) | | CD4 | T cells | In support of this hypothesis, OT-II CD4+ T cells selected via a T–T interaction failed to express PLZF. |
| Lynch and Shevach (1992) | | CD4 | T cells | Enriched populations of CD4-CD8- thymocytes from newborn mice, purified by negative selection with anti-CD4, anti-CD8, and anti-TCR alpha beta mAbs were found to contain approximately 20% gamma delta T cells that were p55IL-2R-. |
| Aliahmad and Kaye (2006) | | CD4 | T cells | One of the puzzling features of positive selection is how specificity of the TCR controls lineage commitment, as both helper and cytolytic T cells utilize the same antigen-receptor components, with the exception of the CD4 or CD8 coreceptors themselves. |
| Weber et al. (1995) | | CD4 | T cells | The results demonstrate that the majority of CD4 T cells that participate in primary alloresponses and essentially all the CD4 T cells that participate in secondary alloresponses recognize I-A conformers that depend on the presence of peptide and do not recognize the SDS-unstable I-A expressed by T2 transfectants. |
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