Viewing affirmative mentions of gene expression of IL2 (H. sapiens) in macrophages

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Solbach et al. (1982)Il-2macrophageMacrophages are also required for Il-2 production, but the macrophage requirement can be bypassed by a soluble macrophage product as found in supernatants of lymphocyte cultures stimulated with lipopolysaccharide (LPS), the biological activity presumably representing Interleukin-1 (Il-1).
Paetkau et al. (1980)IL2macrophagesFinally, IL2 does not adequately restore a secondary response to the purified protein derivative of tuberculin (PPD) in adherent-cell-depleted cultures, indicating that macrophages, in addition to being required for IL2 production, have other functions.
Corley (1982)IL2macrophageEvidence is presented that argues that soluble macrophage derived factors released as a result of T cell-macrophage interaction are insufficient, even in the presence of antigen, to promote growth of IL2 producing cells.
Okada et al. (1981)IL-2macrophagesIn a clone (38-B) that did not show any IL-2 activity in culture supernatants, the addition of macrophages induced IL-2 production in the presence of phytohemagglutinin, suggesting that interleukin-1 induced IL-2 production in T hybrid cells.
Bossé et al. (1996)IL-2 mRNAmacrophageThe expression of IL-2 mRNA was detected by reverse transcriptase polymerase chain reaction (RT-PCR) in total RNA extracted from purified eosinophils stimulated with granulocyte-macrophage colony-stimulating factor (GM-CSF), with or without calcium ionophore (A23187).
Helgestad et al. (1990)IL-2macrophageThe production of known T-cell derived lymphokines such as IL-2, B-cell growth factor(s), alpha-interferon or granulocyte/macrophage colony stimulating or inhibiting factor(s) was not detected.
Bhalla et al. (1986)IL-2macrophagesIn contrast to its effects on IL-2 production, 1,25-(OH)2D3 caused a dose-dependent increase in the production of interleukin-1 (IL-1) by monocyte/macrophages.
Neveu (1993)interleukin-2macrophageLesions of right or left neocortex induced opposite effects on various immune parameters including mitogen-induced lymphoproliferation, interleukin-2 production, macrophage activation or natural killer cell activity.
Lipkowitz et al. (1984)IL 2macrophagesThe production of IL 2 by T lymphocytes cultured with NAGO-treated macrophages closely paralleled the induction of IL 2 receptors on the T lymphocytes.
Lipkowitz et al. (1984)IL 2macrophagesDespite early expression of receptors for IL 2 and early production of IL 2 by T lymphocytes during activation, T lymphocytes were not committed to proliferate in the absence of IL 2 until more than 24 hr of incubation with NAGO-treated macrophages had elapsed.
Nakamura et al. (1991)IL-2macrophagesThe expression of p75 IL-2 receptor on CD4+ T cells was induced by coculture with macrophages.
Voitenok and Varivotskaya (1984)TCGFmacrophagesThe presence of macrophages was non-essential for enhancement of TCGF production by PSI.
Tatsumi and Yabe (1986)IL 2macrophagesAdherent macrophages appeared to inhibit rather than enhance IL 2 production in this system.
Benson and Ziegler (1989)IL-2macrophageIn order to understand the mechanism of immunosuppression by cyclosporine, its effects on macrophage-mediated antigen-specific T cell activation (IL-2 production) were studied in vitro.
Antille et al. (2008)IL-2macrophageAmicrobial pustulosis of the folds was characterized by a higher expression of interleukin (IL) 1alpha, IL-2 receptor alpha, macrophage colony-stimulating factor, insulin-like growth factor binding protein 1, brain-derived neurotrophic factor, tumour necrosis factor (TNF) alpha and a lower expression of CD14, IL-1beta, IL-12, soluble TNF receptors I and II, growth-regulated oncogene alpha, fibroblast growth factor 4 and vascular endothelial growth factor as compared to the controls.
Ammar et al. (1993)IL2macrophagesIL2-R alpha chain inhibitory factor (p29) produced by HIV-infected macrophages: cell target and mode of action.
Propst et al. (1993)interleukin 2macrophageThe levels of tumour necrosis factor alpha (TNF-alpha), neopterin, interleukin 2-receptor and granulocyte-macrophage colony stimulating factor were higher in patients with spontaneous bacterial peritonitis, but without statistical significance, whereas no differences were found between the interferon gamma, interleukin-2 and interleukin-1 levels.
Hermann et al. (1992)IL-2macrophagesOnly T-cells, predominately expressing IL-2 receptors, and macrophages infiltrated the tumors.
Müller and Takeshita (1991)IL-2macrophagesWhile many macrophages and lymphocytes expressed IL-2 receptors in cases with typical granulomas there was no such CD25 expression in cases without any epitheloid cell formation.
Larsson and Coutinho (1984)IL 2macrophagesI-A antigens appear, therefore, to play two distinct roles in the induction of IL 2 production: (a) I-A molecules are directly involved in mediating activation signals to the macrophages at the level of IL 1 production; (b) I-A epitopes act as restricting elements in specific antigen recognition by T helper cells at the level of IL 2 production, a requirement which is overcome by lectin.
Yoshimura et al. (1996)IL-2macrophageThe granulocyte-macrophage colony-stimulating factor and soluble IL-2 receptor production by PHA-stimulated PBMC was suppressed at high concentrations of LVFX.
Cox et al. (2008)interleukin-2macrophageThe samples were tested using a statistically qualified nine-color intracellular cytokine staining assay measuring interleukin-2 (IL-2), tumor necrosis factor alpha, macrophage inflammatory protein 1beta, and gamma interferon production and expression of CD107a.
Uchiyama et al. (1987)IL-2macrophagesReconstituted cell cultures of nylon wool column-passed T cells and macrophages produced IL-2 by TSST-1 stimulation and, furthermore, the accessory activity of the macrophages could be partially replaced by a macrophage-derived factor containing interleukin 1.
Fiedler et al. (1987)IL-2macrophageInhibition by macrophage-secreted prostaglandins was excluded by failure to correct the IL-2 production and proliferation defects in the presence of indomethacin.
Krakauer (1985)interleukin 2macrophageA macrophage-derived factor that inhibits the production and action of interleukin 2.
Murzenok and Netukova (1994)interleukin 2macrophagesA rectal temperature increase being the same, there were similar and transient changes in epithelial and endothelial cells and macrophages, a rise in the proliferative activity of thymocytes and synthesis of IL-1-like activity, and a decrease in the interleukin 2 (IL-2) production by cultured splenic cells.
Sato et al. (1988)IL-2MacrophagesMacrophages from active SLE had a suppressive effect on IL-2 production.
Sztein and Serrate (1989)IL-2macrophagesHowever, macrophages are an absolute requirement during the exposure to the mitogen after preincubation with thymosins for the manifestation of TF5- and T alpha 1-mediated enhancing effects on IL-2 production and IL-2R expression.
Arima et al. (1992)Interleukin-2macrophageInterleukin-2 production by primary adult T cell leukemia tumor cells is macrophage dependent.
Arima et al. (1992)IL-2macrophagesDepletion of macrophages in the tumor cell cultures resulted in a sharp decline in tumor cell IL-2 production, while re-addition of macrophages reconstituted this response.
Arima et al. (1992)IL-2macrophageMacrophage-derived factors including IL-6 and IL-1 also reconstituted IL-2 production in these macrophage depleted cultures.
Yang et al. (2002)IL-2macrophageIt is hypothetically possible that IL-4 might indirectly affect IL-2 production by Thp cells via macrophage-derived PPARgamma ligands.
Murray et al. (1985)IL-2macrophageTo test the hypothesis that deficient interleukin 2 (IL-2) secretion may underlie the impaired capacity of T cells from patients with Acquired Immunodeficiency Syndrome (AIDS) and the AIDS-related complex (ARC) to generate the macrophage-activating lymphokine, gamma interferon (IFN-gamma), we used five specific microbial antigens to examine IL-2 production.
Markus et al. (2007)IL-2macrophagesOtherwise, the release of TNF-alpha from activated macrophages suppresses the nocturnal melatonin surge, allowing a full cell migration and inhibiting IL-2 production.
Hagiwara et al. (1996)IL-2macrophagesPhenotypic analysis of freshly isolated cytokine-secreting cells showed that T cells were the primary source of IL-2, IL-4, and IFN-gamma while CD14+ macrophages/monocytes were the dominant source of IL-10 in vivo.
Dornand et al. (1987)IL-2macrophagesThe compounds, which do not inhibit interleukin-1 (IL-1) production in stimulated macrophages, lower interleukin-2 (IL-2) synthesis in activated T helper cells.
Bacchetta et al. (1990)IL-2macrophageFurthermore, different modes of activation resulted in simultaneous production of IL-5, IL-2, IFN-gamma, granulocyte/macrophage-CSF, and transcription of the TNF-beta gene by the host-reactive clones, indicating that the lack of IL-4 production is not related to the mode of activation.
Cheng et al. (1996)IL-2macrophageProstate-specific antigen (PSA) levels in the cell culture media were monitored after transfecting CWR22 cells with candidate therapeutic genes, including the cytokines human interleukin 2 (IL-2) and granulocyte-macrophage colony-stimulating factor (GM-CSF), both as complementary DNAs [cDNAs]).
Ganguly et al. (2001)IL-2macrophagesInhibition of proliferation at higher concentrations of the alkaloid is due to inhibition of IL-2 production and activation of macrophages, which have a cytostatic effect.
Marcinkiewicz et al. (1996)IL-2macrophageIn this study, we have re-examined the potential role of nitric oxide in mediating the macrophage-dependent suppression of IL-2 synthesis.
Griswold et al. (1985)IL-2macrophagesAF (2 microM) inhibited antigen presentation by splenic macrophages to sensitized (DNFB) lymph node cells in vitro and also inhibited production of IL-2 and IL-1 by lymphocytes and macrophages, respectively.
Abramson et al. (1983)interleukin 2macrophagesTo investigate mechanisms by which antigen, macrophages, and interleukin 2 (IL2) participate in the induction of secondary T-cell proliferative responses, trinitrophenyl (TNP) was presented in three distinct modes: (i) TNP-modified peripheral blood mononuclear cells (TNP-PBMC), (ii) TNP-PBMC cell sonicates, and (iii) TNP-ovalbumin (TNP-OVA).
Pavlenko et al. (2004)AldesleukinmacrophageA phase I trial of pVAX/PSA, together with cytokine granulocyte/macrophage-colony stimulating factor (GM-CSF) (Molgramostim) and IL-2 (Aldesleukin) as vaccine adjuvants, was carried out in patients with hormone-refractory prostate cancer.
Chelstrom et al. (1992)IL-2macrophageComparative analysis of the anti-leukemic potential of interleukin 1 beta (IL-1 beta), interleukin 2 (IL-2), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF alpha), granulocyte colony stimulating factor (G-CSF), granulocyte-macrophage colony stimulating factor (GM-CSF), and their combination.
Farrar et al. (1981)IL 2macrophageThese findings are consistent with the hypothesis that the induction of CTL involves a linear cell-factor interaction in which IL 1 (macrophage-derived) stimulates T cells to produce IL 2, which in turn stimulates other T cells to produce immune interferon and become cytotoxic.
Hoshino et al. (1986)IL-2macrophagesDose and time of exposure-dependent suppressive effects were demonstrated in vitro on PHA blastogenesis of mononuclear cells, IL-2 production of T cells and IL-1 production of macrophages when these human immunocytes were treated with 1,25(OH)2D3.
Ettinghausen et al. (1987)IL-2macrophageIL-2 produced a significant decline in circulating erythroid (BFU-E) and granulocytic/macrophage (CFU-C) progenitors, which rebounded after the discontinuation of IL-2 therapy.
Lesur et al. (2000)IL-2macrophageImmunodepletions of IL-2, granulocyte-macrophage colony stimulating factor, and a combination of both cytokines from BAL fluids of ARDS patients significantly restored PMN apoptosis.
Masuno et al. (1986)interleukin 2macrophageThe ability of PBL to produce lymphokines (interleukin 2 and macrophage activating factor) was significantly impaired in the SCLC group but not in the non-SCLC group.
Taub et al. (1996)IL-2macrophageWe demonstrate here that the beta chemokines, recombinant human macrophage inflammatory protein-1 alpha and -1 beta, RANTES (regulated upon activation, normally T cell expressed and secreted), and macrophage chemotactic peptide-1, are capable of directly costimulating purified human T cell and human T cell clone proliferation and IL-2 production in the presence of anti-CD3 mAb, but not phorbol esters, in vitro.
Fonteneau et al. (1997)IL-2macrophageLysis and secretion of IFN-gamma, and for most clones' secretion of TNF-alpha, required lower Ag densities, by one or two logs, than IL-2 and granulocyte-macrophage CSF secretion. 3) In a significant fraction of IFN-gamma-secreting cells, IL-2 production is not induced. 4) A large fraction of cloned cells is refractory to lymphokine gene activation for about 2 wk after previous stimulation.
Lambert et al. (2007)interleukin-2macrophageThe alpha,beta-unsaturated aldehydes in cigarette smoke (acrolein and crotonaldehyde) inhibited production of interleukin-2 (IL-2), IL-10, granulocyte-macrophage colony-stimulating factor, interferon-gamma, and tumor necrosis factor-alpha by human T cells but did not inhibit production of IL-8.
Keenan et al. (1995)IL-2macrophageThis study assesses levels of IL-1 beta, IL-2 and TNF- alpha in peritoneal fluid and macrophage conditioned media of women with endometriosis.
van Oosterhout and Nijkamp (1990)interleukin-2macrophagePre-incubation of PBMC during 20 h with interleukin-2 (IL-2, 100 u ml-1) and granulocyte/macrophage-colony stimulating factor (GM-CSF, 100 u ml-1) significantly decreases beta-adrenoceptor agonist induced cAMP production by 35 +/- 8% and 37 +/- 11% respectively.
Scaife et al. (2006)IL2macrophagePhytohemagglutinin-P (PHA-P)-stimulated decidual CD8(+) T lymphocytes produced high levels of both interferon gamma and interleukin (IL) 8, and low levels of granulocyte-macrophage colony-stimulating factor (CSF2), IL1B, IL2, IL6, IL10, IL12, and tumor necrosis factor; these did not vary with gestational age.
Hofbauer et al. (2008)interleukin-2macrophageClinical phase I intratumoral administration of two recombinant ALVAC canarypox viruses expressing human granulocyte-macrophage colony-stimulating factor or interleukin-2: the transgene determines the composition of the inflammatory infiltrate.
Böni-Schnetzler et al. (1985)TCGFmacrophagesThis is further supported by the failure to reconstitute the suppressed mitogenic response with normal macrophages, which are involved in activation of TCGF producer T-cells.
Koo et al. (1991)IL-2macrophageTIL exposed to the four types of culture conditions, low or high dose IL-2, with or without irradiated autologous tumors, and exhibiting different lytic specificities, all expressed mRNA for interferon-gamma and tumor necrosis factor (TNF)-alpha, but not for IL-1-beta, IL-4, IL-6, and granulocyte-macrophage colony stimulating factor.
Andersson et al. (1993)IL-2macrophageThe production of IL-2, IL-3, IL-4, IL-5, IL-10, TNF-beta and granulocyte-macrophage colony-stimulating factor (GM-CSF) was down-regulated during the initial phase of the cultures up to 48 hr, but not at 48-96 hr.
Mehrotra et al. (2002)IL-2macrophageEthanolic extracts of B. diffusa roots inhibited human NK cell cytotoxicity in vitro, production of NO in mouse macrophage cells, IL-2 and TNF-alpha in human PBMCs.
Bodor and Habener (1998)IL-2macrophageIn the presence of the minimal NFAT DNA-binding domain, which is sufficient for both DNA binding and AP-1 complex formation, ICER and NFAT form NFAT/ICER ternary complexes on several NFAT/AP-1 DNA composite sites previously identified as essential for the expression of the immunoregulatory cytokines such as IL-2, IL-4, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor-alpha.
Valitutti et al. (1989)IL-2macrophagesThe expression of functional IL-2 receptor on activated macrophages depends on the stimulus applied.
Yamashita and Tanaka (1991)IL 2macrophagesIL 4 suppressed the production of IL 1 by monocytes/macrophages and the production of IL 2 and the expression of IL 2 receptors on T cells.
Schaafsma et al. (1991)interleukin-2macrophagesIn vivo production of interleukin-5, granulocyte-macrophage colony-stimulating factor, macrophages colony-stimulating factor, and interleukin-6 during intravenous administration of high-dose interleukin-2 in cancer patients.
Qiu et al. (1988)LymphokinemacrophageLymphokine production in human peripheral blood mononuclear cells (PBMNCs) was investigated by in situ hybridization with 35S-labelled RNA probes coding for interleukin 2 (IL-2), gamma-interferon (gamma-IFN) and granulocyte/macrophage colony stimulating factor (GM-CSF).
Ehlers and Smith (1991)IL-2macrophageComparison of neonatal and adult T cells revealed that both populations expressed the genes for interleukin 2 (IL-2) and its receptor, but only adult T cells were capable of transcribing mRNAs for IL-3, IL-4, IL-5, IL-6, interferon gamma, and granulocyte/macrophage colony-stimulating factor.
Lee et al. (1988)lymphokinemacrophageA HTLV-1 transformed T cell line has been demonstrated to constitutively produce and secrete a lymphokine with macrophage activating properties.
Hoves et al. (2006)IL-2MphiCytokine analysis revealed considerable levels of IL-10 in cocultures of T cells with Mphi, whereas high amounts of IL-2 and IFN-gamma were present in cocultures with DC.
Greenberger et al. (1984)lymphokinemacrophageEach was tested for production of a lymphokine(s) with properties of granulocyte-macrophage colony-stimulating factor (GM-CSF) using as target cells nonadherent cells from human long-term bone marrow cultures (LTBMC) or fresh marrow.
Yoshida et al. (2003)interleukin-2macrophageCocultivation of Ad4-1BBL-infected tumor cells with either T-LAK cells or PBMC resulted in significant elevation of interferon-gamma (IFN-gamma), interleukin-2 (IL-2), and granulocyte-macrophage colony-stimulating factor (GM-CSF) production.
Lambrecht et al. (1986)lymphokinemacrophageThe cell-mediated immunity state by detecting lymphokine in the macrophage electrophoresis mobility test (MEM-test) was supervised in 9 patients with gliomatous cerebral tumors and 12 normal subjects.
Berken (1982)lymphokinemacrophagesRecent immunological advances suggest that it should be possible to isolate antigens from cancer cells, produce antibodies against these antigens, bind the antibodies to the patient's macrophages and K lymphocytes, and reinject the bound cells into the patients to stimulate lymphokine synthesis and antibody-dependent cellular cytoxicity.
McCormack et al. (1981)lymphokinemacrophageAmplified lymphokine production phenomenon confirmed by a macrophage 2-D-[3H]deoxyglucose transport assay.
McCormack et al. (1981)lymphokinemacrophageThe amplified lymphokine production phenomenon was confirmed by using an improved macrophage 2-d-[(3)H]deoxyglucose uptake assay as an indicator of lymphokine activity.
Lundy and Lovett (1978)lymphokinemacrophageOne cell population potentiated by TBZ is the macrophage, either by direct activation or secondary to increased lymphokine production.
Gavalas et al. (1998)IL-2macrophagesIn contrast, compound 2 significantly increased the IL-1 activity of arthritic macrophages while reducing the ability of normal and arthritic splenocytes to produce or release IL-2.
Finocchiaro and Glikin (2008)interleukin-2macrophageThis approach combined suicide gene therapy with a subcutaneous vaccine composed by formolized tumor cells and irradiated xenogeneic cells producing human interleukin-2 and granulocyte-macrophage colony-stimulating factor.
Himes et al. (1996)IL-2macrophageWe have found that the human T leukemia/lymphotropic virus type 1 viral protein Tax can also strongly costimulate expression of interleukin-2 (IL-2), IL-3, and granulocyte-macrophage colony-stimulating factor (GM-CSF) mRNA in T cells activated with the phorbol ester phorbol myristate acetate (PMA) and calcium ionophore, which can mimic activation through the antigen specific T-cell receptor.
Jokhi et al. (1994)IL-2macrophageThese cells were examined by reverse transcriptase PCR for their expression of mRNAs for the following cytokines: granulocyte-macrophage (GM)-CSF, CSF-1, TNF-alpha, IFN-gamma, TGF-beta 1, leukemia-inhibitory factor (LIF), and IL-2.
Barth et al. (1996)IL-2macrophageMETHODS: We assessed TIL expression of interleukin-2 (IL-2), IL-4, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), granulocyte-macrophage colony stimulating factor (GM-CSF), IL-10, and transforming growth factor-beta (TGF-beta), and tumor cell expression of IL-10 and TGF-beta in situ in 49 primary colon carcinomas and 20 metastases using immunohistochemistry.
Feske et al. (2000)IL-2macrophageThis transient activation of NFAT was not sufficient to induce the expression of several cytokines, including IL-2, IL-3, IL-4, and IFN-gamma, whereas mRNA levels for macrophage inflammatory protein-1alpha, GM-CSF, and IL-13 were only moderately reduced.
Lauener et al. (1990)IL2macrophageNone of the other recombinant lymphokines tested (IL1, IL2, IL3, IL5, IL6, interferon-gamma, tumor necrosis factor alpha and beta, granulocyte-macrophage colony-stimulating factor) decreased CD14 expression.
Sabbatini et al. (2010)IL-2-inducedmacrophageOur data suggest a potential link between macrophage activation and IL-2-induced modulation of cytokines release.
Makhoul et al. (1987)interleukin-2macrophageMitogenic doses of membranes purified from Mycoplasma pneumoniae as well as concanavalin A (ConA) were tested for their ability to induce production of interleukin-2 (IL-2) and granulocyte-macrophage colony-stimulating activity (GM-CSA) by human peripheral blood mononuclear cells.
Chatila et al. (1990)lymphokinemacrophageThe levels of interferon gamma mRNA were moderately decreased, while those of granulocyte-macrophage colony stimulating factor, a lymphokine the production of which is not restricted to T cells, were unaffected.